Meloxicam and Mifepristone: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Mifepristone
Meloxicam
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased NSAID exposure
Interaction Deep Dive
Concurrent use miFEPRIStone (CYP2C8/CYP2C9 inhibitor) with a drug whose metabolism is largely or solely mediated by CYP2C8/CYP2C9, such as NSAIDs is likely to result in increased NSAIDs exposure. Use the smallest recommended doses when given concomitantly with NSAIDs, and closely monitor patients for adverse effects. Additionally, wait at least 2 weeks after stopping miFEPRIStone before initiating NSAIDs1.
Why it happens (mechanism)
Inhibition of CYP2C8-mediated metabolism by miFEPRIStone; inhibition of CYP2C9-mediated metabolism by miFEPRIStone
Literature reports
1 report — tap to read
a) In healthy subjects, concomitant use of a single 40 mg dose of fluvastatin (a CYP2C8/2C9 substrate) with miFEPRIStone, 1200 mg once daily for 10 days may result in increased fluvastatin AUC and Cmax by 3.57-fold and 1.76-fold, respectively 1.
Common questions
Can I take Meloxicam and Mifepristone together?
Increased NSAID exposure Always confirm with your pharmacist or prescriber before making any change.
How serious is the Meloxicam and Mifepristone interaction?
It is rated moderate. Can be significant — usually manageable with monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
From our Q&A
Real reader questions about these medications, each personally answered by our pharmacist:
Questions for your pharmacist
- Does my dose of Meloxicam or Mifepristone need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there anything you'd monitor while I'm on both?
References (1)
- Product Information: KORLYM(R) oral tablets, mifepristone oral tablets. Corcept Therapeutics Incorporated (per Dailmed), Redwood City, CA, 2024. DailyMed
Keep reading about Mifepristone
Keep reading about Meloxicam
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
Check another combination
Our instant two-drug interaction checker is almost here.
Still have questions about this combination?
Every question gets a real answer from a licensed pharmacist — free, and usually within a day.
Ask the pharmacist