Meloxicam with Mifepristone Interaction Details
Brand Names Associated with Meloxicam
- Meloxicam
- Mobic®
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Nov 11, 2023
Interaction Effect
Increased exposure to the NSAID
Interaction Summary
Concomitant administration of an NSAID that is a CYP2C9 substrate with mifepristone, a CYP2C9 inhibitor, may lead to increased exposure to the NSAID. Although not specifically studied with NSAIDs, coadministration of a single 40 mg fluvastatin dose (a CYP2C8/2C9 substrate) in healthy subjects receiving mifepristone (Korlym(TM)) 1200 mg orally once daily led to significantly increased fluvastatin exposure, with geometric mean ratios (with/without coadministration) of fluvastatin AUC and Cmax of 3.57 and 1.76, respectively. The lowest dose of the NSAID should be used when given concomitantly with mifepristone (Korlym(TM)), and patients should be monitored closely for NSAID adverse effects. Due to the long terminal half-life of mifepristone after reaching steady state, allow at least 2 weeks following cessation of mifepristone (Korlym(TM)) before increasing the NSAID dose.
Severity
Moderate
Onset
Unspecified
Evidence
Theoretical
How To Manage Interaction
When using mifepristone together with an NSAID, use the lowest possible dose of the NSAID and monitor the patient closely for adverse effects; concomitant use may lead to increased exposure to the NSAID. Due to the long terminal half-life of mifepristone after reaching steady state, allow at least 2 weeks following cessation of mifepristone (Korlym(TM)) before increasing the NSAID dose.
Mechanism Of Interaction
Inhibition of CYP2C9-mediated NSAID metabolism
Meloxicam Overview
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Meloxicam is used to relieve pain, tenderness, swelling, and stiffness caused by osteoarthritis (arthritis caused by a breakdown of the lining of the joints) and rheumatoid arthritis (arthritis caused by swelling of the lining of the joints). Meloxicam is also used to relieve the pain, tenderness, swelling, and stiffness caused by juvenile rheumatoid arthritis (a type of arthritis that affects children) in children 2 years of age and older. Meloxicam is in a class of medications called nonsteroidal anti-inflammatory drugs (NSAIDs). It works by stopping the body's production of a substance that causes pain, fever, and inflammation.
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Definitions
Severity Categories
Contraindicated
These drugs, generally, should not be used together simultaneously due to the high risk of severe adverse effects. Combining these medications can lead to dangerous health outcomes and should be strictly avoided unless otherwise instructed by your provider.
Major
This interaction could result in very serious and potentially life-threatening consequences. If you are taking this drug combination, it is very important to be under close medical supervision to minimize severe side effects and ensure your safety. It may be necessary to change a medication or dosage to prevent harm.
Moderate
This interaction has the potential to worsen your medical condition or alter the effectiveness of your treatment. It's important that you are monitored closely and you potentially may need to make adjustments in your treatment plan or drug dosage to maintain optimal health.
Minor
While this interaction is unlikely to cause significant problems, it could intensify side effects or reduce the effectiveness of one or both medications. Monitoring for changes in symptoms and your condition is recommended, and adjustments may be made if needed to manage any increased or more pronounced side effects.
Onset
Rapid: Onset of drug interaction typically occurs within 24 hours of co-administration.
Delayed: Onset of drug interaction typically occurs more than 24 hours after co-administration.
Evidence
Level of documentation of the interaction.
Established: The interaction is documented and substantiated in peer-reviewed medical literature.
Theoretical: This interaction is not fully supported by current medical evidence or well-documented sources, but it is based on known drug mechanisms, drug effects, and other relevant information.
How To Manage The Interaction
Provides a detailed discussion on how patients and clinicians can approach the identified drug interaction as well as offers guidance on what to expect and strategies to potentially mitigate the effects of the interaction. This may include recommendations on adjusting medication dosages, altering the timing of drug administration, or closely monitoring for specific symptoms.
It's important to note that all medical situations are unique, and management approaches should be tailored to individual circumstances. Patients should always consult their healthcare provider for personalized advice and guidance on managing drug interactions effectively.
Mechanism Of Interaction
The theorized or clinically determined reason (i.e., mechanism) why the drug-drug interaction occurs.
Disclaimer: The information provided on this page is for informational purposes only and should not be considered medical advice. Always consult with a qualified healthcare professional regarding your specific circumstances and medical conditions.
Where Does Our Information Come From?
Information for our drug interactions is compiled from several drug compendia, including:
The prescribing information for each drug, as published on DailyMED, is also used.
Individual drug-drug interaction detail pages contain references specific to that interaction. You can click on the reference number within brackets '[]' to see what reference was utilized.
The information posted is fact-checked by HelloPharmacist clinicians and reviewed quarterly.