Mesalamine with Tan-Shen Interaction Details
Brand Names Associated with Mesalamine
- 5-ASA
- Apriso®
- Asacol HD®
- Asacol®
- Delzicol®
- Lialda®
- Mesalamine
- mesalazine
- Pentasa®
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Nov 25, 2023
Interaction Effect
Increased free salicylate serum concentration and decreased tan-shen (Danshen) concentration
Interaction Summary
In vitro data suggests that the concurrent presence of tan-shen (Danshen) and salicylate in serum increased the free serum concentration of salicylate and decreased the concentration of Danshen. Until human bioavailability studies are performed, caution is advised when using these two substances concomitantly.
Severity
Moderate
Onset
Rapid
Evidence
Theoretical
How To Manage Interaction
The clinical significance of the increased free salicylate concentrations and decreased tan-shen (Danshen) concentrations, when taken concomitantly is unknown. Patients taking salicylates and tan-shen concurrently should be monitored closely for changes in therapeutic effects and adverse effects. If noted, adjustment to therapies is advised.
Mechanism Of Interaction
Displacement of salicylate from protein binding sites by tan-shen (Danshen)
Literature Reports
A) The simultaneous presence of both Danshen and salicylate in serum samples (in vitro) increased free salicylate and decreased Danshen concentrations. When concentrations of salicylate were sub-therapeutic (less than 150 micrograms/milliliter (mcg/ml)), no significant changes were noted in the Danshen components. However, once therapeutic concentrations of salicylate (greater than 150 mcg/ml) were introduced, significant reductions in Danshen free activity was noted (p less than 0.05). Concentrations of free salicylate increased from 43.2 mcg/ml (control) to 68.6 mcg/ml when Danshen extract was added .
Mesalamine Overview
-
Mesalamine is used to treat ulcerative colitis (a condition which causes swelling and sores in the lining of the colon [large intestine] and rectum) and also to maintain improvement of ulcerative colitis symptoms. Mesalamine is in a class of medications called anti-inflammatory agents. It works by stopping the body from producing a certain substance that may cause inflammation.
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Definitions
Severity Categories
Contraindicated
These drugs, generally, should not be used together simultaneously due to the high risk of severe adverse effects. Combining these medications can lead to dangerous health outcomes and should be strictly avoided unless otherwise instructed by your provider.
Major
This interaction could result in very serious and potentially life-threatening consequences. If you are taking this drug combination, it is very important to be under close medical supervision to minimize severe side effects and ensure your safety. It may be necessary to change a medication or dosage to prevent harm.
Moderate
This interaction has the potential to worsen your medical condition or alter the effectiveness of your treatment. It's important that you are monitored closely and you potentially may need to make adjustments in your treatment plan or drug dosage to maintain optimal health.
Minor
While this interaction is unlikely to cause significant problems, it could intensify side effects or reduce the effectiveness of one or both medications. Monitoring for changes in symptoms and your condition is recommended, and adjustments may be made if needed to manage any increased or more pronounced side effects.
Onset
Rapid: Onset of drug interaction typically occurs within 24 hours of co-administration.
Delayed: Onset of drug interaction typically occurs more than 24 hours after co-administration.
Evidence
Level of documentation of the interaction.
Established: The interaction is documented and substantiated in peer-reviewed medical literature.
Theoretical: This interaction is not fully supported by current medical evidence or well-documented sources, but it is based on known drug mechanisms, drug effects, and other relevant information.
How To Manage The Interaction
Provides a detailed discussion on how patients and clinicians can approach the identified drug interaction as well as offers guidance on what to expect and strategies to potentially mitigate the effects of the interaction. This may include recommendations on adjusting medication dosages, altering the timing of drug administration, or closely monitoring for specific symptoms.
It's important to note that all medical situations are unique, and management approaches should be tailored to individual circumstances. Patients should always consult their healthcare provider for personalized advice and guidance on managing drug interactions effectively.
Mechanism Of Interaction
The theorized or clinically determined reason (i.e., mechanism) why the drug-drug interaction occurs.
Disclaimer: The information provided on this page is for informational purposes only and should not be considered medical advice. Always consult with a qualified healthcare professional regarding your specific circumstances and medical conditions.
Where Does Our Information Come From?
Information for our drug interactions is compiled from several drug compendia, including:
The prescribing information for each drug, as published on DailyMED, is also used.
Individual drug-drug interaction detail pages contain references specific to that interaction. You can click on the reference number within brackets '[]' to see what reference was utilized.
The information posted is fact-checked by HelloPharmacist clinicians and reviewed quarterly.