Methotrexate

420 interactions 996 cited references
Also sold as: Jylamvo Otrexup Rasuvo Reditrex Rheumatrex® Trexall Trexall® Xatmep
About Methotrexate

Methotrexate is an antimetabolite used to treat severe psoriasis, rheumatoid arthritis, and certain cancers. Read the full Methotrexate drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Methotrexate Abacavir Ziagen Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Clindamycin ANTIROBE Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Omeprazole Gastrobim Increased methotrexate exposure and an increased risk of methotrexate toxicity Details Methotrexate Acarbose Prandase® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Acetazolamide Diamox® Sequels® Increased methotrexate exposure, an increased the risk of methotrexate-related severe AR, may also subsequently reduce active meta... Details Methotrexate Adalimumab Injection Abrilada Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Albendazole Albendamax Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Allopurinol Aloprim Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Allopurinol Injection Aloprim Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Ambrisentan Letairis Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Amoxicillin Amoxi Drop Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Ampicillin Amcill® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Ampicillin Injection Omnipen-N® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Apixaban Eliquis Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Asciminib Scemblix Increased BCRP substrate exposure and an increased risk of BCRP substrate-related adverse effects Details Methotrexate Aspirin Acuprin® Increased methotrexate exposure, an increased risk of methotrexate toxicity, reduced active metabolite formation and possibly redu... Details Methotrexate Aspirin Rectal Aspirin Increased methotrexate exposure, an increased risk of methotrexate toxicity, reduced active metabolite formation and possibly redu... Details Methotrexate Atovaquone Mepron Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Azacitidine Onureg Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Azithromycin AzaSite Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Bicalutamide Casodex Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Asparaginase Erwinia Chrysanthemi Injection Erwinaze Decreased or elimination of methotrexate antineoplastic activity Details Methotrexate Azacitidine Injection Onureg Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Bexarotene Targretin An increased risk of hepatotoxicity, an increased methotrexate exposure, an increased risk of methotrexate-related severe adverse... Details Methotrexate Bexarotene Topical Targretin An increased risk of hepatotoxicity, an increased methotrexate exposure, an increased risk of methotrexate-related severe adverse... Details Methotrexate Bortezomib Boruzu Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Bromfenac Ophthalmic Bromday® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Busulfan Injection Busulfex Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Capecitabine Xeloda Increased 5-fluorouracil toxicity Details Methotrexate Capmatinib Tabrecta Increased BCRP substrate exposure and an increased risk of adverse reactions Details Methotrexate Captopril Capoten® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details

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