Moxifloxacin with Lanthanum Carbonate Interaction Details
Brand Names Associated with Moxifloxacin
- Avelox®
- Moxifloxacin
Brand Names Associated with Lanthanum Carbonate
- Fosrenol®
- Lanthanum
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Jan 04, 2024
Interaction Effect
Reduced bioavailability of quinolone antibiotics
Interaction Summary
Use caution with coadministration of lanthanum and oral quinolone antibiotics, as reduced quinolone bioavailability may occur. Ciprofloxacin Cmax and AUC were reduced by 56% and 54%, respectively, when coadministered with lanthanum. lf concurrent use is required, administer oral quinolones at least 1 hour before or 4 hours after lanthanum. If only a short course of treatment with a quinolone is needed, consider eliminating the lanthanum doses normally scheduled near quinolone administration to improve quinolone absorption.
Severity
Moderate
Onset
Unspecified
Evidence
Probable
How To Manage Interaction
Use caution with coadministration of lanthanum and oral quinolone antibiotics, as reduced quinolone bioavailability may occur. If concurrent use is required, administer oral quinolones at least 1 hour before or 4 hours after lanthanum. If only a short course of treatment with a quinolone is needed, consider eliminating the lanthanum doses normally scheduled near quinolone administration to improve quinolone absorption.
Mechanism Of Interaction
Binding of lanthanum carbonate with anionic groups of quinolone antibiotics
Literature Reports
A) Ciprofloxacin Cmax and AUC were reduced by 56% and 54%, respectively, when a single dose of ciprofloxacin 750 mg oral was administered to healthy subjects treated with a lanthanum carbonate 3 g/day regimen in a randomized, 2-way crossover study .
Moxifloxacin Overview
-
Moxifloxacin is used to treat certain infections caused by bacteria such as pneumonia, and skin, and abdominal (stomach area) infections. Moxifloxacin is also used to prevent and treat plague (a serious infection that may be spread on purpose as part of a bioterror attack. Moxifloxacin may also be used to treat bronchitis or sinus infections but should not be used for these conditions if there are other treatment options available. Moxifloxacin is in a class of antibiotics called fluoroquinolones. It works by killing the bacteria that cause infections.
-
Antibiotics such as moxifloxacin will not work for colds, flu, or other viral infections. Using antibiotics when they are not needed increases your risk of getting an infection later that resists antibiotic treatment.
Lanthanum Carbonate Overview
-
Lanthanum is used to reduce blood levels of phosphate in people with kidney disease. High levels of phosphate in the blood can cause bone problems. Lanthanum is in a clsas of medications called phosphate binders. It binds phosphorus that you get from foods in your diet and prevents it from being absorbed into your blood stream.
Return To Our Drug Interaction Homepage
Feedback, Question Or Comment About This Information?
Ask Dr. Brian Staiger, PharmD, our medical editor, directly! He's always more than happy to assist.
Definitions
Severity Categories
Contraindicated
These drugs, generally, should not be used together simultaneously due to the high risk of severe adverse effects. Combining these medications can lead to dangerous health outcomes and should be strictly avoided unless otherwise instructed by your provider.
Major
This interaction could result in very serious and potentially life-threatening consequences. If you are taking this drug combination, it is very important to be under close medical supervision to minimize severe side effects and ensure your safety. It may be necessary to change a medication or dosage to prevent harm.
Moderate
This interaction has the potential to worsen your medical condition or alter the effectiveness of your treatment. It's important that you are monitored closely and you potentially may need to make adjustments in your treatment plan or drug dosage to maintain optimal health.
Minor
While this interaction is unlikely to cause significant problems, it could intensify side effects or reduce the effectiveness of one or both medications. Monitoring for changes in symptoms and your condition is recommended, and adjustments may be made if needed to manage any increased or more pronounced side effects.
Onset
Rapid: Onset of drug interaction typically occurs within 24 hours of co-administration.
Delayed: Onset of drug interaction typically occurs more than 24 hours after co-administration.
Evidence
Level of documentation of the interaction.
Established: The interaction is documented and substantiated in peer-reviewed medical literature.
Theoretical: This interaction is not fully supported by current medical evidence or well-documented sources, but it is based on known drug mechanisms, drug effects, and other relevant information.
How To Manage The Interaction
Provides a detailed discussion on how patients and clinicians can approach the identified drug interaction as well as offers guidance on what to expect and strategies to potentially mitigate the effects of the interaction. This may include recommendations on adjusting medication dosages, altering the timing of drug administration, or closely monitoring for specific symptoms.
It's important to note that all medical situations are unique, and management approaches should be tailored to individual circumstances. Patients should always consult their healthcare provider for personalized advice and guidance on managing drug interactions effectively.
Mechanism Of Interaction
The theorized or clinically determined reason (i.e., mechanism) why the drug-drug interaction occurs.
Disclaimer: The information provided on this page is for informational purposes only and should not be considered medical advice. Always consult with a qualified healthcare professional regarding your specific circumstances and medical conditions.
Where Does Our Information Come From?
Information for our drug interactions is compiled from several drug compendia, including:
The prescribing information for each drug, as published on DailyMED, is also used.
Individual drug-drug interaction detail pages contain references specific to that interaction. You can click on the reference number within brackets '[]' to see what reference was utilized.
The information posted is fact-checked by HelloPharmacist clinicians and reviewed quarterly.