Moxifloxacin with Sucralfate Interaction Details
Brand Names Associated with Moxifloxacin
- Avelox®
- Moxifloxacin
Brand Names Associated with Sucralfate
- Carafate®
- Sucralfate
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Jan 04, 2024
Interaction Effect
Decreased moxifloxacin effectiveness
Interaction Summary
Moxifloxacin is capable of forming chelate complexes with sucralfate, potentially reducing the gastrointestinal absorption of moxifloxacin. Decreased absorption may result in lower systemic levels than desired, therefore compromising the efficacy of the quinolone. Moxifloxacin should be administered at least four hours before or eight hours after sucralfate administration.
Severity
Moderate
Onset
Rapid
Evidence
Probable
How To Manage Interaction
Moxifloxacin should be administered at least four hours before or eight hours after sucralfate.
Mechanism Of Interaction
Decreased moxifloxacin absorption due to chelation
Literature Reports
A) Concomitant administration of moxifloxacin and sucralfate and/or oral aluminum-containing antacids significantly reduces the bioavailability of moxifloxacin. A single-center, randomized, non-blinded, 2-way crossover study involving 12 male subjects investigated the effect of concomitant aluminum (sucralfate) and moxifloxacin administration. Moxifloxacin 400 mg orally administered either alone or with aluminum 190 mg (Sucralfat-Ratio Pharm(R) 1000) administered immediately before and 5, 10, 15 and 24 hours after the dose of moxifloxacin. A 2-week washout phase separated the treatment periods. The bioavailability of moxifloxacin was reduced with concomitant administration of aluminum, slowed down the absorption rate, and reduced plasma concentration. The authors conclude that concomitant administration of polyvalent metallic cations, such as aluminum, should be avoided. If administration of these medications cannot be avoided, staggered administration of these medications is recommended to avoid a loss of therapeutic efficacy due to sub-therapeutic plasma concentrations of moxifloxacin .
Moxifloxacin Overview
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Moxifloxacin is used to treat certain infections caused by bacteria such as pneumonia, and skin, and abdominal (stomach area) infections. Moxifloxacin is also used to prevent and treat plague (a serious infection that may be spread on purpose as part of a bioterror attack. Moxifloxacin may also be used to treat bronchitis or sinus infections but should not be used for these conditions if there are other treatment options available. Moxifloxacin is in a class of antibiotics called fluoroquinolones. It works by killing the bacteria that cause infections.
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Antibiotics such as moxifloxacin will not work for colds, flu, or other viral infections. Using antibiotics when they are not needed increases your risk of getting an infection later that resists antibiotic treatment.
Sucralfate Overview
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Sucralfate is used to treat and prevent the return of duodenal ulcers (ulcers located in first part of the small intestine). Treatment with other medications, such as antibiotics, may also be necessary to treat and prevent the return of ulcers caused by a certain type of bacteria (H. pylori) Sucralfate is in a class of medications called protectants. It sticks to damaged ulcer tissue and protects against acid and enzymes so healing can occur.
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Definitions
Severity Categories
Contraindicated
These drugs, generally, should not be used together simultaneously due to the high risk of severe adverse effects. Combining these medications can lead to dangerous health outcomes and should be strictly avoided unless otherwise instructed by your provider.
Major
This interaction could result in very serious and potentially life-threatening consequences. If you are taking this drug combination, it is very important to be under close medical supervision to minimize severe side effects and ensure your safety. It may be necessary to change a medication or dosage to prevent harm.
Moderate
This interaction has the potential to worsen your medical condition or alter the effectiveness of your treatment. It's important that you are monitored closely and you potentially may need to make adjustments in your treatment plan or drug dosage to maintain optimal health.
Minor
While this interaction is unlikely to cause significant problems, it could intensify side effects or reduce the effectiveness of one or both medications. Monitoring for changes in symptoms and your condition is recommended, and adjustments may be made if needed to manage any increased or more pronounced side effects.
Onset
Rapid: Onset of drug interaction typically occurs within 24 hours of co-administration.
Delayed: Onset of drug interaction typically occurs more than 24 hours after co-administration.
Evidence
Level of documentation of the interaction.
Established: The interaction is documented and substantiated in peer-reviewed medical literature.
Theoretical: This interaction is not fully supported by current medical evidence or well-documented sources, but it is based on known drug mechanisms, drug effects, and other relevant information.
How To Manage The Interaction
Provides a detailed discussion on how patients and clinicians can approach the identified drug interaction as well as offers guidance on what to expect and strategies to potentially mitigate the effects of the interaction. This may include recommendations on adjusting medication dosages, altering the timing of drug administration, or closely monitoring for specific symptoms.
It's important to note that all medical situations are unique, and management approaches should be tailored to individual circumstances. Patients should always consult their healthcare provider for personalized advice and guidance on managing drug interactions effectively.
Mechanism Of Interaction
The theorized or clinically determined reason (i.e., mechanism) why the drug-drug interaction occurs.
Disclaimer: The information provided on this page is for informational purposes only and should not be considered medical advice. Always consult with a qualified healthcare professional regarding your specific circumstances and medical conditions.
Where Does Our Information Come From?
Information for our drug interactions is compiled from several drug compendia, including:
The prescribing information for each drug, as published on DailyMED, is also used.
Individual drug-drug interaction detail pages contain references specific to that interaction. You can click on the reference number within brackets '[]' to see what reference was utilized.
The information posted is fact-checked by HelloPharmacist clinicians and reviewed quarterly.