Moxifloxacin with Toremifene Interaction Details
Brand Names Associated with Moxifloxacin
- Avelox®
- Moxifloxacin
Brand Names Associated with Toremifene
- Fareston®
- Toremifene
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Jan 04, 2024
Interaction Effect
Increased risk of QT-interval prolongation
Interaction Summary
Moxifloxacin has been associated with QT-interval prolongation. Coadministration with another drug known to prolong the QT-interval should be avoided because of risk for additive effects on the QT-interval that can lead to serious cardiac adverse effects, including torsade de pointes. Elderly patients receiving treatment with IV moxifloxacin may be at an increased risk for QT prolongation. If concurrent use is not avoidable, do not exceed the recommended dose or infusion rate of moxifloxacin and monitor for changes in the QT-interval.
Severity
Major
Onset
Unspecified
Evidence
Theoretical
How To Manage Interaction
Moxifloxacin has been associated with QT-interval prolongation. Coadministration with another drug known to prolong the QT-interval should be avoided because of risk for additive effects on the QT-interval that can lead to serious cardiac adverse effects, including torsade de pointes. Elderly patients receiving treatment with IV moxifloxacin may be at an increased risk for QT prolongation. If concurrent use is not avoidable, do not exceed the recommended dose or infusion rate of moxifloxacin and monitor for changes in the QT-interval.
Mechanism Of Interaction
Additive effects on QT-interval
Moxifloxacin Overview
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Moxifloxacin is used to treat certain infections caused by bacteria such as pneumonia, and skin, and abdominal (stomach area) infections. Moxifloxacin is also used to prevent and treat plague (a serious infection that may be spread on purpose as part of a bioterror attack. Moxifloxacin may also be used to treat bronchitis or sinus infections but should not be used for these conditions if there are other treatment options available. Moxifloxacin is in a class of antibiotics called fluoroquinolones. It works by killing the bacteria that cause infections.
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Antibiotics such as moxifloxacin will not work for colds, flu, or other viral infections. Using antibiotics when they are not needed increases your risk of getting an infection later that resists antibiotic treatment.
Toremifene Overview
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Toremifene is used to treat breast cancer that has spread to other parts of the body in women who have experienced menopause ('change of life'; end of monthly menstrual periods). Toremifene is in a class of medications called nonsteroidal antiestrogens. It works by blocking the activity of estrogen (a female hormone) in the breast. This may stop the growth of some breast tumors that need estrogen to grow.
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Definitions
Severity Categories
Contraindicated
These drugs, generally, should not be used together simultaneously due to the high risk of severe adverse effects. Combining these medications can lead to dangerous health outcomes and should be strictly avoided unless otherwise instructed by your provider.
Major
This interaction could result in very serious and potentially life-threatening consequences. If you are taking this drug combination, it is very important to be under close medical supervision to minimize severe side effects and ensure your safety. It may be necessary to change a medication or dosage to prevent harm.
Moderate
This interaction has the potential to worsen your medical condition or alter the effectiveness of your treatment. It's important that you are monitored closely and you potentially may need to make adjustments in your treatment plan or drug dosage to maintain optimal health.
Minor
While this interaction is unlikely to cause significant problems, it could intensify side effects or reduce the effectiveness of one or both medications. Monitoring for changes in symptoms and your condition is recommended, and adjustments may be made if needed to manage any increased or more pronounced side effects.
Onset
Rapid: Onset of drug interaction typically occurs within 24 hours of co-administration.
Delayed: Onset of drug interaction typically occurs more than 24 hours after co-administration.
Evidence
Level of documentation of the interaction.
Established: The interaction is documented and substantiated in peer-reviewed medical literature.
Theoretical: This interaction is not fully supported by current medical evidence or well-documented sources, but it is based on known drug mechanisms, drug effects, and other relevant information.
How To Manage The Interaction
Provides a detailed discussion on how patients and clinicians can approach the identified drug interaction as well as offers guidance on what to expect and strategies to potentially mitigate the effects of the interaction. This may include recommendations on adjusting medication dosages, altering the timing of drug administration, or closely monitoring for specific symptoms.
It's important to note that all medical situations are unique, and management approaches should be tailored to individual circumstances. Patients should always consult their healthcare provider for personalized advice and guidance on managing drug interactions effectively.
Mechanism Of Interaction
The theorized or clinically determined reason (i.e., mechanism) why the drug-drug interaction occurs.
Disclaimer: The information provided on this page is for informational purposes only and should not be considered medical advice. Always consult with a qualified healthcare professional regarding your specific circumstances and medical conditions.
Where Does Our Information Come From?
Information for our drug interactions is compiled from several drug compendia, including:
The prescribing information for each drug, as published on DailyMED, is also used.
Individual drug-drug interaction detail pages contain references specific to that interaction. You can click on the reference number within brackets '[]' to see what reference was utilized.
The information posted is fact-checked by HelloPharmacist clinicians and reviewed quarterly.