Naproxen

309 interactions 807 cited references
Also sold as: Aleve Aleve® Anaprox Anaprox® Anaprox® DS EC-Naprosyn® Flanax® Naprelan Naprelan® Naprosyn Naprosyn® Wal-Proxen
About Naproxen

Naproxen is an NSAID pain reliever used to reduce pain, swelling, and stiffness from arthritis and other conditions. Read the full Naproxen drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketorolac Ketorolac Injection Ketorolac Nasal Spray Ketorolac Ophthalmic Pemetrexed Injection Abciximab
4 Contraindicated 228 Major 66 Moderate 11 Minor
All (309) Contraindicated (4) Major (228) Moderate (66) Minor (11)

Contraindicated

Naproxen Ketorolac Acular Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Naproxen Ketorolac Injection Acular Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Naproxen Ketorolac Nasal Spray Sprix Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Naproxen Ketorolac Ophthalmic Acular Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details

Major

Naproxen Amitriptyline Elavil An increased risk of bleeding Details Naproxen Sertraline An increased risk of bleeding Details Naproxen Apixaban Eliquis An increased risk of bleeding Details Naproxen Aspirin Acuprin® An increased risk of bleeding, decreased renal function, and an increased risk of gastrointestinal adverse events Details Naproxen Aspirin Rectal Aspirin An increased risk of bleeding, decreased renal function, and an increased risk of gastrointestinal adverse events Details Naproxen Betrixaban Bevyxxa® An increased risk of bleeding Details Naproxen Anagrelide Agrylin An increased risk of bleeding Details Naproxen Bromfenac Ophthalmic Bromday® Increased risk of bleeding Details Naproxen Budesonide Entocort Increased risk of gastrointestinal ulcer or bleeding Details Naproxen Budesonide Nasal Spray Rhinocort Increased risk of gastrointestinal ulcer or bleeding Details Naproxen Budesonide Oral Inhalation Pulmicort Increased risk of gastrointestinal ulcer or bleeding Details Naproxen Clopidogrel Plavix An increased risk of bleeding Details Naproxen Cyclosporine Injection Atopica An increased risk of cycloSPORINE nephrotoxicity Details Naproxen Cyclosporine Ophthalmic Cequa An increased risk of cycloSPORINE nephrotoxicity Details Naproxen Dabigatran Pradaxa® An increased risk of bleeding Details Naproxen Dabigatran Etexilate An increased risk of bleeding Details Naproxen Dalteparin Injection Fragmin An increased risk of bleeding Details Naproxen Deflazacort Emflaza Increased risk of gastrointestinal ulcer or bleeding Details Naproxen Dexamethasone Injection Decadron Increased risk of gastrointestinal ulcer or bleeding Details Naproxen Dexamethasone Ophthalmic Dexacidin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) Increased risk of gastrointestinal ulcer or bleeding Details Naproxen Diclofenac Ophthalmic Voltaren® Eye Drops Increased risk of bleeding Details Naproxen Diclofenac Topical (Actinic Keratosis) Pennsaid Increased risk of bleeding Details Naproxen Diclofenac Topical (Arthritis Pain) Pennsaid® Increased risk of bleeding Details Naproxen Diclofenac Transdermal Patch Flector Increased risk of bleeding Details Naproxen Digoxin Cardoxin® Increased digoxin exposure and prolonged half-life of digoxin Details Naproxen Dipyridamole Permole® An increased risk of bleeding Details Naproxen Edoxaban Savaysa An increased risk of bleeding Details Naproxen Emtricitabine Emtriva Increased emtricitabine exposure and an increased risk of emtricitabine-related adverse effects Details Naproxen Enoxaparin Lovenox An increased risk of bleeding Details Naproxen Enoxaparin Injection Lovenox An increased risk of bleeding Details Naproxen Epoprostenol Flolan An increased risk of bleeding Details Naproxen Etodolac Lodine Increased risk of bleeding Details Naproxen Fenoprofen Fenopron Increased risk of bleeding Details Naproxen Flurbiprofen Ansaid Increased risk of bleeding Details Naproxen Flurbiprofen Ophthalmic Ocufen Increased risk of bleeding Details Naproxen Fondaparinux Arixtra An increased risk of bleeding Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.