Pazopanib with Vonoprazan Interaction Details
Brand Names Associated with Pazopanib
- Pazopanib
- Votrient®
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Dec 20, 2023
Interaction Effect
Increased CYP3A substrates exposure
Interaction Summary
Vonoprazan is a weak CYP3A inhibitor and may increase the exposure of CYP3A substrates where minimal concentration changes may lead to serious toxicities. A single oral dose of midazolam 2 mg (a CYP3A4 substrate) administered following vonoprazan, increased midazolam AUC 93% compared to administration of midazolam alone. When vonoprazan is used in combination with clarithromycin, a strong CYP3A inhibitor, the risk of increased exposure and side effects further increases. Frequently monitor concentrations and/or adverse reactions related to CYP3A substrates. Dosage reduction may be needed.
Severity
Major
Onset
Unspecified
Evidence
Theoretical
How To Manage Interaction
Frequently monitor concentrations and/or adverse reactions related to CYP3A substrates. Vonoprazan may increase the exposure of CYP3A4 substrates where minimal concentration changes may lead to serious toxicities. Dosage reduction of a CYP3A substrate may be needed.
Mechanism Of Interaction
Inhibition of CYP3A-mediated metabolism by vonoprazan
Literature Reports
A) When a single oral dose of midazolam 2 mg (a CYP3A4 substrate) was administered following vonoprazan 20 mg twice daily for 7 days (N=20), midazolam AUC increased 93% compared to administration of midazolam alone .
Pazopanib Overview
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Pazopanib is used to treat advanced renal cell carcinoma (RCC, a type of cancer that begins in the cells of the kidneys) in adults. Pazopanib is in a class of medications called kinase inhibitors. It works by slowing or stopping the spread of cancer cells.
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Definitions
Severity Categories
Contraindicated
These drugs, generally, should not be used together simultaneously due to the high risk of severe adverse effects. Combining these medications can lead to dangerous health outcomes and should be strictly avoided unless otherwise instructed by your provider.
Major
This interaction could result in very serious and potentially life-threatening consequences. If you are taking this drug combination, it is very important to be under close medical supervision to minimize severe side effects and ensure your safety. It may be necessary to change a medication or dosage to prevent harm.
Moderate
This interaction has the potential to worsen your medical condition or alter the effectiveness of your treatment. It's important that you are monitored closely and you potentially may need to make adjustments in your treatment plan or drug dosage to maintain optimal health.
Minor
While this interaction is unlikely to cause significant problems, it could intensify side effects or reduce the effectiveness of one or both medications. Monitoring for changes in symptoms and your condition is recommended, and adjustments may be made if needed to manage any increased or more pronounced side effects.
Onset
Rapid: Onset of drug interaction typically occurs within 24 hours of co-administration.
Delayed: Onset of drug interaction typically occurs more than 24 hours after co-administration.
Evidence
Level of documentation of the interaction.
Established: The interaction is documented and substantiated in peer-reviewed medical literature.
Theoretical: This interaction is not fully supported by current medical evidence or well-documented sources, but it is based on known drug mechanisms, drug effects, and other relevant information.
How To Manage The Interaction
Provides a detailed discussion on how patients and clinicians can approach the identified drug interaction as well as offers guidance on what to expect and strategies to potentially mitigate the effects of the interaction. This may include recommendations on adjusting medication dosages, altering the timing of drug administration, or closely monitoring for specific symptoms.
It's important to note that all medical situations are unique, and management approaches should be tailored to individual circumstances. Patients should always consult their healthcare provider for personalized advice and guidance on managing drug interactions effectively.
Mechanism Of Interaction
The theorized or clinically determined reason (i.e., mechanism) why the drug-drug interaction occurs.
Disclaimer: The information provided on this page is for informational purposes only and should not be considered medical advice. Always consult with a qualified healthcare professional regarding your specific circumstances and medical conditions.
Where Does Our Information Come From?
Information for our drug interactions is compiled from several drug compendia, including:
The prescribing information for each drug, as published on DailyMED, is also used.
Individual drug-drug interaction detail pages contain references specific to that interaction. You can click on the reference number within brackets '[]' to see what reference was utilized.
The information posted is fact-checked by HelloPharmacist clinicians and reviewed quarterly.