Pioglitazone Interactions
Pioglitazone is used with a diet and exercise program and sometimes with other medications, to treat type 2 diabetes (condition in which the body does not use insulin normally and therefore cannot control the amount of sugar in the blood). Pioglitazone is in a class of medications called thiazolidinediones. It works by increasing the body's sensitivity to insulin, a natural substance that helps control blood sugar levels. Pioglitazone is not used to treat type 1 diabetes (condition in which the body does not produce insulin and, therefore, cannot control the amount of sugar in the blood) or diabetic ketoacidosis (a serious condition that may develop if high blood sugar is not treated).
Over time, people who have diabetes and high blood sugar can develop serious or life-threatening complications, including heart disease, stroke, kidney problems, nerve damage, and eye problems.Taking medication(s), making lifestyle changes (e.g., diet, exercise, quitting smoking), and regularly checking your blood sugar may help to manage your diabetes and improve your health. This therapy may also decrease your chances of having a heart attack, stroke, or other diabetes-related complications such as kidney failure, nerve damage (numb, cold legs or feet; decreased sexual ability in men and women), eye problems, including changes or loss of vision, or gum disease. Your doctor and other healthcare providers will talk to you about the best way to manage your diabetes.
Brand Names Associated with Pioglitazone
- Actoplus Met® (as a combination product containing Metformin, Pioglitazone)
- Actoplus Met® XR (as a combination product containing Metformin, Pioglitazone)
- Actos®
- Duetact® (as a combination product containing Glimepiride, Pioglitazone)
- Oseni® (as a combination product containing Alogliptin, Pioglitazone)
- Pioglitazone
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- Major
- Metformin
- Hydrochlorothiazide
- Furosemide
- Insulin Glargine, Recombinant
- Glipizide
- Topiramate
- Insulin Lispro, Recombinant
- Insulin Aspart, Recombinant
- Glimepiride
- Hydroxychloroquine
- Ciprofloxacin
- Chlorthalidone
- Nifedipine
- Glyburide
- Gemfibrozil
- Abiraterone Acetate
- Acarbose
- Chloroquine
- Chlorothiazide
- Moderate
- Atorvastatin
- Metoprolol
- Clarithromycin
- Carvedilol
- Clopidogrel
- Lisinopril
- Atenolol
- Propranolol
- Benazepril
- Ramipril
- Ketoconazole
- Acebutolol
- Amprenavir
- Atazanavir
- Betaxolol
- Bisoprolol
- Bitter Melon
- Captopril
- Carteolol
- Celiprolol
- Darunavir
- Minor
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What Do The Severity Ratings Mean?
Contraindicated
These drugs, generally, should not be used together simultaneously due to the high risk of severe adverse effects. Combining these medications can lead to dangerous health outcomes and should be strictly avoided unless otherwise instructed by your provider.
Major
This interaction could result in very serious and potentially life-threatening consequences. If you are taking this drug combination, it is very important to be under close medical supervision to minimize severe side effects and ensure your safety. It may be necessary to change a medication or dosage to prevent harm.
Moderate
This interaction has the potential to worsen your medical condition or alter the effectiveness of your treatment. It's important that you are monitored closely and you potentially may need to make adjustments in your treatment plan or drug dosage to maintain optimal health.
Minor
While this interaction is unlikely to cause significant problems, it could intensify side effects or reduce the effectiveness of one or both medications. Monitoring for changes in symptoms and your condition is recommended, and adjustments may be made if needed to manage any increased or more pronounced side effects.
Disclaimer: The information provided on this page is for informational purposes only and should not be considered medical advice. Always consult with a qualified healthcare professional regarding your specific circumstances and medical conditions.
Drug interaction information is compilated from several drug compendia, including:
- Gold Standard Drug Database
- Micromedix
- Lexicomp
- PubMed
The information posted is fact-checked by HelloPharmacist clinicians and reviewed quarterly.