Pioglitazone

60 interactions 3 explained in plain English

Also sold as: Actos Actos® Oseni® (as a combination product containing Alogliptin, Pioglitazone)

About Pioglitazone

Pioglitazone is used with a diet and exercise program and sometimes with other medications, to treat type 2 diabetes (condition in which the body does not use insulin normally and therefore cannot control the amount of sugar in the blood). Pioglitazone is in a class of medications called thiazolidinediones. It works by… Read the full Pioglitazone drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Insulin Glulisine (Rdna Origin) Injection Moxifloxacin Ofloxacin Otic Amlodipine Chloroquine Octreotide

29 Major 31 Moderate

All (60) Major (29) Moderate (31)

Major

Pioglitazone Atogepant Qulipta Reduced atogepant exposure Details Pioglitazone Cariprazine Vraylar Explained Effects on the cariprazine exposure has not been evaluated and the net effect is unclear Details Pioglitazone Abiraterone Abirtega Increased pioglitazone exposure and an increased risk of severe hypoglycemia Details Pioglitazone Amlodipine Amvaz® Reduced amLODIPine exposure Details Pioglitazone Chloroquine Aralen® Hypoglycemia Details Pioglitazone Delafloxacin Baxdela Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Pioglitazone Delafloxacin Injection Baxdela Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Pioglitazone Furosemide Injection Disal An increased risk of hyperglycemia and an increased insulin requirement Details Pioglitazone Gatifloxacin Ophthalmic Zymar® Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Pioglitazone Gemfibrozil Lopid Increased pioglitazone exposure Details Pioglitazone Gemifloxacin Factive Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Pioglitazone Hydroxychloroquine Plaquenil Enhanced hypoglycemic effect of antidiabetics and an increased risk of hypoglycemia Details Pioglitazone Ifosfamide Injection Ifex Increased neurotoxic and nephrotoxic effects Details Pioglitazone Insulin Degludec (Rdna Origin) Injection Ryzodeg® (as a combination product containing Insulin Degludec and Insulin Aspart) Increased risk of fluid retention and heart failure; increased risk of hypoglycemia Details Pioglitazone Insulin Detemir (Rdna Origin) Injection Levemir Increased risk of fluid retention and heart failure; increased risk of hypoglycemia Details Pioglitazone Insulin Glulisine (Rdna Origin) Injection Apidra Increased risk of fluid retention and heart failure; increased risk of hypoglycemia Details Pioglitazone Lanreotide Injection Somatuline An increased risk of hypoglycemia and impaired glucose regulation Details Pioglitazone Levofloxacin Levaquin Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Pioglitazone Levofloxacin Injection Levaquin Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Pioglitazone Lumateperone Caplyta Reduced lumateperone exposure Details Pioglitazone Moxifloxacin Avelox Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Pioglitazone Moxifloxacin Injection Avelox Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Pioglitazone Moxifloxacin Ophthalmic Moxeza® Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Pioglitazone Nifedipine Adalat® Reduced NIFEdipine exposure Details Pioglitazone Octreotide Bynfezia An increased risk of hypoglycemia and impaired glucose regulation Details Pioglitazone Octreotide Injection Bynfezia An increased risk of hypoglycemia and impaired glucose regulation Details Pioglitazone Ofloxacin Floxin® Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Pioglitazone Ofloxacin Ophthalmic Ocuflox Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Pioglitazone Ofloxacin Otic Floxin® Otic Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details

Moderate

Pioglitazone Lisinopril Prinivil Explained An increased risk of hypoglycemia Details Pioglitazone Atenolol Tenormin Explained Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Pioglitazone Acebutolol Sectral® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Pioglitazone Benazepril Lotensin An increased risk of hypoglycemia Details Pioglitazone Atorvastatin Atorvaliq Decreased pioglitazone serum concentrations Details Pioglitazone Betaxolol Betoptic S Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Pioglitazone Betaxolol Ophthalmic Betoptic® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Pioglitazone Bisoprolol Zebeta® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Pioglitazone Captopril Capoten® An increased risk of hypoglycemia Details Pioglitazone Clopidogrel Plavix Increased exposure of pioglitazone Details Pioglitazone Enalapril Epaned An increased risk of hypoglycemia Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.