Rivaroxaban

75 interactions 3 explained in plain English

Also sold as: Xarelto Xarelto®

About Rivaroxaban

Rivaroxaban is a blood thinner that treats and prevents blood clots in the legs, lungs, and other areas. Read the full Rivaroxaban drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Defibrotide Injection Orlistat Enoxaparin Injection Nintedanib Aspirin Edoxaban

1 Contraindicated 68 Major 6 Moderate

All (75) Contraindicated (1) Major (68) Moderate (6)

Contraindicated

Rivaroxaban Defibrotide Injection Defitelio Increased risk of bleeding Details

Major

Rivaroxaban Abametapir Explained Increased exposure of CYP3A4 substrate Details Rivaroxaban Sertraline Explained Increased risk of bleeding Details Rivaroxaban Apixaban Eliquis Explained An increased risk of bleeding and can cause serious, potentially fatal bleeding Details Rivaroxaban Aspirin Acuprin® Increased risk of bleeding Details Rivaroxaban Aspirin Rectal Aspirin Increased risk of bleeding Details Rivaroxaban Betrixaban Bevyxxa® Increased risk of bleeding Details Rivaroxaban Abiraterone Abirtega Increased rivaroxaban exposure Details Rivaroxaban Anagrelide Agrylin Increased risk of bleeding Details Rivaroxaban Bromfenac Ophthalmic Bromday® An increased risk of bleeding Details Rivaroxaban Caplacizumab-Yhdp Injection Cablivi An increased risk of bleeding Details Rivaroxaban Capmatinib Tabrecta Increased P-gp substrate exposure and an increased risk of increased adverse reactions Details Rivaroxaban Clopidogrel Plavix An increased risk of bleeding Details Rivaroxaban Dabigatran Pradaxa® An increased risk of bleeding Details Rivaroxaban Dabigatran Etexilate An increased risk of bleeding Details Rivaroxaban Dalteparin Injection Fragmin An increased risk of bleeding Details Rivaroxaban Diclofenac Ophthalmic Voltaren® Eye Drops An increased risk of bleeding Details Rivaroxaban Diclofenac Topical (Actinic Keratosis) Pennsaid An increased risk of bleeding Details Rivaroxaban Diclofenac Topical (Arthritis Pain) Pennsaid® An increased risk of bleeding Details Rivaroxaban Diclofenac Transdermal Patch Flector An increased risk of bleeding Details Rivaroxaban Dipyridamole Permole® Increased risk of bleeding Details Rivaroxaban Doxorubicin Adriamycin Reduced rivaroxaban exposure Details Rivaroxaban Doxycycline Injection Acticlate An increased risk of bleeding Details Rivaroxaban Edoxaban Savaysa Increased risk of bleeding Details Rivaroxaban Encorafenib Braftovi Reduced rivaroxaban exposure Details Rivaroxaban Enoxaparin Lovenox An increased risk of bleeding Details Rivaroxaban Enoxaparin Injection Lovenox An increased risk of bleeding Details Rivaroxaban Epoprostenol Flolan Increased risk of bleeding Details Rivaroxaban Etodolac Lodine An increased risk of bleeding Details Rivaroxaban Fenoprofen Fenopron An increased risk of bleeding Details Rivaroxaban Flurbiprofen Ansaid An increased risk of bleeding Details Rivaroxaban Flurbiprofen Ophthalmic Ocufen An increased risk of bleeding Details Rivaroxaban Fondaparinux Arixtra An increased risk of bleeding Details Rivaroxaban Fondaparinux Injection Arixtra An increased risk of bleeding Details Rivaroxaban Heparin An increased risk of bleeding Details Rivaroxaban Heparin Injection Lipo-Hepin® An increased risk of bleeding Details Rivaroxaban Ibrutinib Imbruvica Increased risk of bleeding Details Rivaroxaban Ibuprofen Addaprin An increased risk of bleeding Details Rivaroxaban Iloprost Aurlumyn Increased risk of bleeding Details Rivaroxaban Ketoconazole Topical Extina® Foam Increased rivaroxaban exposure Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.