Sucralfate

18 interactions
Also sold as: Carafate Carafate®
About Sucralfate

Sucralfate is a protective medication used to treat and prevent duodenal ulcers in the first part of the small intestine. Read the full Sucralfate drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Digoxin Dolutegravir Ketoconazole Topical
3 Major 14 Moderate 1 Minor
All (18) Major (3) Moderate (14) Minor (1)

Major

Sucralfate Digoxin Cardoxin® Reduced digoxin exposure Details Sucralfate Dolutegravir Juluca® (as a combination product containing dolutegravir, rilpivirine) Reduced dolutegravir exposure and reduced efficacy of dolutegravir Details Sucralfate Ketoconazole Topical Extina® Foam Decreased ketoconazole exposure Details

Moderate

Sucralfate Delafloxacin Baxdela Decreased delafloxacin efficacy Details Sucralfate Delafloxacin Injection Baxdela Decreased delafloxacin efficacy Details Sucralfate Furosemide Injection Disal Decreased antihypertensive and natriuretic effects of furosemide Details Sucralfate Gemifloxacin Factive Decreased gemifloxacin absorption Details Sucralfate Levofloxacin Levaquin Decreased levofloxacin effectiveness Details Sucralfate Levofloxacin Injection Levaquin Decreased levofloxacin effectiveness Details Sucralfate Levothyroxine Ermeza Reduced efficacy of levothyroxine Details Sucralfate Moxifloxacin Avelox Decreased moxifloxacin effectiveness Details Sucralfate Moxifloxacin Injection Avelox Decreased moxifloxacin effectiveness Details Sucralfate Moxifloxacin Ophthalmic Moxeza® Decreased moxifloxacin effectiveness Details Sucralfate Naproxen Aleve Delayed absorption of naproxen Details Sucralfate Ofloxacin Floxin® Decreased ofloxacin effectiveness Details Sucralfate Ofloxacin Ophthalmic Ocuflox Decreased ofloxacin effectiveness Details Sucralfate Ofloxacin Otic Floxin® Otic Decreased ofloxacin effectiveness Details

Minor

Sucralfate Lansoprazole Prevacid Reduced lansoprazole bioavailability Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.