Tazemetostat with Desogestrel Interaction Details
Brand Names Associated with Tazemetostat
- Tazemetostat
- Tazverik®
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Dec 19, 2023
Interaction Effect
Decreased plasma levels of hormonal contraceptives
Interaction Summary
Concomitant use of tazemetostat and with CYP3A substrates, including hormonal contraceptives, may result in decreased concentrations and reduced efficacy of CYP3A substrates. Coadministration of tazemetostat with midazolam (a sensitive CYP3A substrate) decreased midazolam AUC by 40% and Cmax by 21%. Tazemetostat may render some hormonal contraceptives ineffective. Advise females of reproductive potential using tazemetostat to use effective non-hormonal contraception during treatment and for 6 months after the final dose.
Severity
Major
Onset
Unspecified
Evidence
Theoretical
How To Manage Interaction
Concomitant use of tazemetostat with CYP3A substrates, including hormonal contraceptives, may result in decreased concentrations and reduced efficacy of CYP3A substrates. Tazemetostat may render some hormonal contraceptives ineffective. Advise females of reproductive potential using tazemetostat to use effective non-hormonal contraception during treatment and for 6 months after the final dose.
Mechanism Of Interaction
Increased CYP3A4-mediated contraceptive metabolism
Literature Reports
A) Concomitant use of tazemetostat 800 mg twice daily with oral midazolam (a sensitive CYP3A substrate) in patients decreased midazolam AUC(0 to12) by 40% and Cmax by 21% .
Tazemetostat Overview
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Tazemetostat is used to treat epithelioid sarcoma (a rare, slow-growing soft tissue cancer) in adults and children 16 years of age and older that has spread to nearby tissues or to other parts of the body and cannot be treated successfully with surgery. It is also used to treat certain types of follicular lymphoma (FL; a type of cancer that begins in the white blood cells) in adults whose cancer that has returned or did not respond to at least two other medications. Tazemetostat is also used to treat follicular lymphoma in adults that has returned or did not respond to treatment when no other treatment options are available. Tazemetostat is in a class of medications called EZH2 inhibitors. It helps to stop the spread of cancer cells.
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Definitions
Severity Categories
Contraindicated
These drugs, generally, should not be used together simultaneously due to the high risk of severe adverse effects. Combining these medications can lead to dangerous health outcomes and should be strictly avoided unless otherwise instructed by your provider.
Major
This interaction could result in very serious and potentially life-threatening consequences. If you are taking this drug combination, it is very important to be under close medical supervision to minimize severe side effects and ensure your safety. It may be necessary to change a medication or dosage to prevent harm.
Moderate
This interaction has the potential to worsen your medical condition or alter the effectiveness of your treatment. It's important that you are monitored closely and you potentially may need to make adjustments in your treatment plan or drug dosage to maintain optimal health.
Minor
While this interaction is unlikely to cause significant problems, it could intensify side effects or reduce the effectiveness of one or both medications. Monitoring for changes in symptoms and your condition is recommended, and adjustments may be made if needed to manage any increased or more pronounced side effects.
Onset
Rapid: Onset of drug interaction typically occurs within 24 hours of co-administration.
Delayed: Onset of drug interaction typically occurs more than 24 hours after co-administration.
Evidence
Level of documentation of the interaction.
Established: The interaction is documented and substantiated in peer-reviewed medical literature.
Theoretical: This interaction is not fully supported by current medical evidence or well-documented sources, but it is based on known drug mechanisms, drug effects, and other relevant information.
How To Manage The Interaction
Provides a detailed discussion on how patients and clinicians can approach the identified drug interaction as well as offers guidance on what to expect and strategies to potentially mitigate the effects of the interaction. This may include recommendations on adjusting medication dosages, altering the timing of drug administration, or closely monitoring for specific symptoms.
It's important to note that all medical situations are unique, and management approaches should be tailored to individual circumstances. Patients should always consult their healthcare provider for personalized advice and guidance on managing drug interactions effectively.
Mechanism Of Interaction
The theorized or clinically determined reason (i.e., mechanism) why the drug-drug interaction occurs.
Disclaimer: The information provided on this page is for informational purposes only and should not be considered medical advice. Always consult with a qualified healthcare professional regarding your specific circumstances and medical conditions.
Where Does Our Information Come From?
Information for our drug interactions is compiled from several drug compendia, including:
The prescribing information for each drug, as published on DailyMED, is also used.
Individual drug-drug interaction detail pages contain references specific to that interaction. You can click on the reference number within brackets '[]' to see what reference was utilized.
The information posted is fact-checked by HelloPharmacist clinicians and reviewed quarterly.