Thiothixene

15 interactions 2 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Metoclopramide Nasal Spray Metoclopramide Injection Hydromorphone Rectal Hydromorphone Injection Hydroxychloroquine Lithium Carbonate
2 Contraindicated 12 Major 1 Moderate
All (15) Contraindicated (2) Major (12) Moderate (1)

Contraindicated

Thiothixene Metoclopramide Injection Gimoti An increased risk of extrapyramidal reactions and neuroleptic malignant syndrome Details Thiothixene Metoclopramide Nasal Spray Gimoti An increased risk of extrapyramidal reactions and neuroleptic malignant syndrome Details

Major

Thiothixene Acetaminophen And Codeine Capital® & Codeine Explained An increased risk of paralytic ileus Details Thiothixene Buprenorphine Belbuca Explained Increased risk of respiratory and CNS depression and an increased risk of paralytic ileus Details Thiothixene Cabergoline Dostinex® Reduced efficacy of cabergoline and reduced efficacy of dopamine-2 receptors Details Thiothixene Glucagon Injection Baqsimi Increased risk of gastrointestinal side effects Details Thiothixene Glucagon Injection / Solution Baqsimi Increased risk of gastrointestinal side effects Details Thiothixene Glucagon Nasal Powder Baqsimi Increased risk of gastrointestinal side effects Details Thiothixene Glycopyrronium Topical Cuvposa® An increased risk of anticholinergic side effects Details Thiothixene Hydromorphone Injection Dilaudid Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Thiothixene Hydromorphone Rectal available generically Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Thiothixene Hydroxychloroquine Plaquenil An increased risk of seizures Details Thiothixene Lithium Carbonate Lithobid Weakness, dyskinesias, increased extrapyramidal symptoms, encephalopathy, and brain damage Details Thiothixene Morphine Injection Astramorph® PF Increased risk of urinary retention, severe constipation, and paralytic ileus Details

Moderate

Thiothixene Clonidine Transdermal Patch Catapres Induction or exacerbation of orthostatic regulation disturbances Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.