Venetoclax Interactions
Venetoclax is used alone or in combination with obinutuzumab (Gazyva) or rituximab (Rituxan) to treat certain types of chronic lymphocytic leukemia (CLL; a type of cancer that begins in the white blood cells) or certain types of small lymphocytic lymphoma (SLL; a type of cancer that begins mostly in the lymph nodes). It is also used in combination with either azacitidine (Vidaza), decitabine (Dacogen), or cytarabine as a first treatment for acute myeloid leukemia (AML; a type of cancer that begins in the white blood cells) in people 75 years of age or older, or in adults who have medical conditions that prevents them from being treated with other chemotherapy medications. Venetoclax is in a class of medications called B-cell lymphoma-2 (BCL-2) inhibitors. It works by blocking the action of a certain protein in the body that helps cancer cells survive. This helps to kill cancer cells.
Brand Names Associated with Venetoclax
- Venclexta®
- Venetoclax
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- Contraindicated
- Major
- Carvedilol
- Diltiazem
- Ciprofloxacin
- Everolimus
- Amiodarone
- Carbamazepine
- Fluconazole
- Verapamil
- Capmatinib
- Dabrafenib
- Talazoparib
- Nilotinib
- Ivosidenib
- Lapatinib
- Adagrasib
- Aliskiren
- Aprepitant
- Atazanavir
- Belzutifan
- Betrixaban
- Bosentan
- Colchicine
- Crizotinib
- Cyclosporine
- Dabigatran Etexilate
- Digoxin
- Doxorubicin
- Doxorubicin Hydrochloride Liposome
- Dronedarone
- Duvelisib
- Efavirenz
- Elagolix
- Enzalutamide
- Erythromycin
- Fedratinib
- Fexinidazole
- Fexofenadine
- Flibanserin
- Fluvoxamine
- Fosnetupitant
- Fosphenytoin
- Glecaprevir
- Imatinib
- Larotrectinib
- Lefamulin
- Lenacapavir
- Letermovir
- Loperamide
- Lorlatinib
- Maraviroc
- Moderate
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What Do The Severity Ratings Mean?
Contraindicated
These drugs, generally, should not be used together simultaneously due to the high risk of severe adverse effects. Combining these medications can lead to dangerous health outcomes and should be strictly avoided unless otherwise instructed by your provider.
Major
This interaction could result in very serious and potentially life-threatening consequences. If you are taking this drug combination, it is very important to be under close medical supervision to minimize severe side effects and ensure your safety. It may be necessary to change a medication or dosage to prevent harm.
Moderate
This interaction has the potential to worsen your medical condition or alter the effectiveness of your treatment. It's important that you are monitored closely and you potentially may need to make adjustments in your treatment plan or drug dosage to maintain optimal health.
Minor
While this interaction is unlikely to cause significant problems, it could intensify side effects or reduce the effectiveness of one or both medications. Monitoring for changes in symptoms and your condition is recommended, and adjustments may be made if needed to manage any increased or more pronounced side effects.
Disclaimer: The information provided on this page is for informational purposes only and should not be considered medical advice. Always consult with a qualified healthcare professional regarding your specific circumstances and medical conditions.
Drug interaction information is compilated from several drug compendia, including:
- Gold Standard Drug Database
- Micromedix
- Lexicomp
- PubMed
The information posted is fact-checked by HelloPharmacist clinicians and reviewed quarterly.