Drug & supplement interaction

American Ivy + Amiloride, Hydrochlorothiazide

Amiloride, Hydrochlorothiazide brand names: Moduretic, Amilzide, Moduret 25, Amil-Co.

Moderate Interaction
Medically reviewed by · Updated February 2024
The bottom line Moderate

American Ivy has a moderate interaction with Amiloride, Hydrochlorothiazide. The berries of American ivy contain up to 2% oxalic acid, which can be toxic because it has the potential to cause kidney failure by precipitating solid calcium oxalate.

Read the full interaction report
SeverityModerate
LikelihoodUnlikely
EvidenceC
What do Severity, Likelihood & Evidence mean?
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Interaction report

American Ivy and Amiloride, Hydrochlorothiazide

Here is the interaction we found between these two, with the evidence behind it.

Moderate

Thiazide Diuretics

Why this applies to Amiloride, Hydrochlorothiazide

Amiloride, Hydrochlorothiazide falls under Thiazide Diuretics — the group American Ivy interacts with.

The berries of American ivy contain up to 2% oxalic acid, which can be toxic because it has the potential to cause kidney failure by precipitating solid calcium oxalate. Thiazide diuretics are often prescribed to decrease urinary calcium levels and prevent the formation of calcium oxalate kidney stones. Consequently, the berries of American ivy and thiazide diuretics may have opposing effects in this context, as the diuretics work to lower urinary calcium levels while the oxalic acid in the berries could potentially increase the risk of kidney stone formation. It is important to note that medicinal supplements utilizing American ivy generally only make use of the bark, not the berries.
Severity Moderate Likelihood Unlikely Evidence C

Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans..

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the simple version: your water pill (the hydrochlorothiazide part) actually helps your kidneys hold onto less calcium in the urine, which is one reason doctors use it to prevent calcium oxalate kidney stones. The trouble with American ivy is its berries, which contain oxalic acid. That oxalic acid can join up with calcium and form crystals, so in theory the berries could push in the opposite direction from your medication and nudge up your stone risk.

The good news is this is a low-likelihood, theory-based concern, and most American ivy supplements use the bark, not the toxic berries. The berries themselves are considered poisonous and shouldn't be eaten at all. Before trying any American ivy product, just run it past your pharmacist or doctor first.

Contact Dr. Brian directly if you have additional questions on this interaction

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

American Ivy Also Interacts With Other Medications

American Ivy has 55 moderate known drug interactions in our database — the Amiloride, Hydrochlorothiazide one above is one of them. If you take anything else, check it against the full list below.

Moderate 55 No known interaction 2,775 (incl. Amiloride, Hydrochlorothiazide)
Taking anything else?

Check Another of Your Medications Against American Ivy

Covers the 2,830 medications we’ve checked against American Ivy. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Amiloride, Hydrochlorothiazide

This page covers American Ivy only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Amiloride, Hydrochlorothiazide page lists 236 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Asarabacca (major) and Dolomite (major).

By severity: 10 major · 199 moderate · 27 minor.

From our pharmacist’s overview on the Amiloride, Hydrochlorothiazide page

“The typical Moduretic (amiloride with hydrochlorothiazide) patient is managing blood pressure long term, and the supplements that crowd reaches for (herbal blood pressure aids, potassium, calcium) are exactly what fills this list. It deserves a careful read, not a skim.”

Reviewed by 2 · Jul 18, 2026

Open the Amiloride, Hydrochlorothiazide interaction page

How much people look this up

Where American Ivy and Amiloride, Hydrochlorothiazide Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement American Ivy
Steady interest

#1,315 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Amiloride, Hydrochlorothiazide
Top 10%

#244 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About American Ivy

What is American Ivy?

American Ivy
  • Digestive upset
  • To stimulate sweating
  • Traditional tonic use
  • Skin and swelling complaints (topical folk use)

American Ivy (Virginia creeper) is mainly an ornamental climbing vine with a long history of folk use for digestion and sweating, but there is very little human evidence to support any health benefit. Its berries contain oxalic acid and are considered poisonous, and the plant can irritate the skin. Because safety data is limited, talk with your pharmacist or doctor before using it.

Read the full American Ivy monograph & all interactions
Medication

About Amiloride and Hydrochlorothiazide

What Is Amiloride and Hydrochlorothiazide Used For?

Brand names: Moduretic, Amilzide, Moduret 25, Amil-Co

Amiloride hydrochloride and hydrochlorothiazide tablets are used for patients with high blood pressure (hypertension) or congestive heart failure who tend to develop low potassium (hypokalemia) when taking a thiazide or other diuretic alone — or for whom keeping potassium levels in a normal range is especially important, such as people taking digoxin or those with significant heart rhythm problems.

The tablets may be used on their own or alongside other blood pressure medicines, such as methyldopa or beta blockers. This combination product is not intended as the first-choice treatment for swelling (edema) or high blood pressure unless low potassium is a specific concern.

See full Amiloride and Hydrochlorothiazide drug information
Keep checking

Other Drugs & American Ivy

Browse every other medication we’ve checked against American Ivy — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
55Moderate
0Minor
2,774No known interaction
55 Moderate 2,774 No interaction
Moderate

55 interactions

No interaction 2,774 drugs checked — show the list

We also checked American Ivy against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,774 medications checked with no known interaction — see the full American Ivy list.

See the full American Ivy interactions page
See every supplement checked against Amiloride, Hydrochlorothiazide, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
American Ivy monograph › Uses, safety, and every drug interaction in one place Amiloride, Hydrochlorothiazide supplement interactions › Every supplement checked against Amiloride, Hydrochlorothiazide, ranked by severity Amiloride and Hydrochlorothiazide drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking American Ivy and Amiloride, Hydrochlorothiazide Together: Common Questions

Can you take American Ivy with Amiloride, Hydrochlorothiazide?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the American Ivy and Amiloride, Hydrochlorothiazide interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Amiloride, Hydrochlorothiazide and American Ivy?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.