Caffeine - Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride Interaction Details

There are multiple interactions reported between these two agents.

Interaction Details

Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride is classified as belonging to the following category: Antidiabetes Drugs

Theoretically, taking caffeine with antidiabetes drugs might interfere with blood glucose control.
Data are conflicting. Reports claim that caffeine might increase or decrease blood sugar.

Interaction Rating

Minor

Likelihood of Occurrence

Unlikely

Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

References

Watson JM, Jenkins EJ, Hamilton P, et al. Influence of caffeine on the frequency and perception of hypoglycemia in free-living patients with type 1 diabetes. Diabetes Care 2000;23:455-9.
Bell DG, Jacobs I, Ellerington K. Effect of caffeine and ephedrine ingestion on anaerobic exercise performance. Med Sci Sports Exerc 2001;33:1399-403.
Kühne T, Wallace E, Herzig D, et al. Combined intake of caffeine and low-dose glucose to reduce exercise-related hypoglycaemia in individuals with type 1 diabetes on ultra-long-acting insulin degludec: A randomized, controlled, double-blind, cross-over tr

Interaction Details

Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride is classified as belonging to the following category: Metformin (Glucophage)

Theoretically, metformin might increase the levels and adverse effects of caffeine.
Animal research suggests that metformin can reduce caffeine metabolism. However, this effect has not been reported in humans.

Interaction Rating

Minor

Likelihood of Occurrence

Possible

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists

References

Mohiuddin, M., Azam, A. T., Amran, M. S., and Hossain, M. A. In vive effects of gliclazide and metformin on the plasma concentration of caffeine in healthy rats. Pak.J Biol Sci 5-1-2009;12(9):734-737.

Caffeine - More Interactions

Caffeine interacts with 647 drugs

Interaction Rating Key

These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.

Major	The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur.
Moderate	Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur.
Minor	Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction.
Unknown	No interactions have been reported or no interaction data is currently available.