European Barberry - Diclegis (Doxylamine Succinate, Pyridoxine Hydrochloride) Interaction
Herbal: European Barberry
Also Known As: Berberis vulgaris, Agracejo, Barberry, Berberidis Cortex, Berberidis Radicis Cortex, Berberidis Radix, Berbéris Commun, Berberry, Berbis, Common Barberry, Lebanon barberry, Mountain Grape, Oregon Grape, Pipperidge, Piprage, Sauerdorn, Sow Berry, Vinettier
Drug: Doxylamine Succinate, Pyridoxine Hydrochloride
Brand names:
Diclegis, Bonjesta

Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
May 04, 2025
Interaction Details
Doxylamine Succinate, Pyridoxine Hydrochloride is classified as belonging to the following category: Anticholinergic Drugs
Theoretically, taking European barberry with anticholinergic drugs might cause additive effects.
In vitro evidence suggests that European barberry might have anticholinergic properties.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
References
- Shamsa F, Ahmadiani A, Khosrokhavar R. Antihistaminic and anticholinergic activity of barberry fruit (Berberis vulgaris) in the guinea-pig ileum. J Ethnopharmacol 1999;64:161-6.
European Barberry Overview

Doxylamine Succinate, Pyridoxine Hydrochloride Overview
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The combination of doxylamine and pyridoxine is used to treat nausea and vomiting in pregnant women whose symptoms have not improved after changing their diet or using other non-medicine treatments. Doxylamine is in a class of medications called antihistamines. It works by blocking the action of certain natural substances in the body that may contribute to nausea and vomiting. Pyridoxine (vitamin B6) is a vitamin. It is given because a lack of pyridoxine in the body may also be a factor in causing nausea and vomiting during pregnancy.
European Barberry - More Interactions
European Barberry interacts with 1183 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
Unknown | No interactions have been reported or no interaction data is currently available. |
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
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Drug descriptions are provided by MedlinePlus.