Goji - Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine Interaction
Herbal: Goji
Also Known As: Lycium chinense, Lycium barbarum, Barberry Matrimony Vine, Chinese Boxthorn, Chinese Wolfberry, Di Gu Pi, Digupi, Duke of Argyll's Teaplant, Duke of Argyll's Teatree, Goji Berry, Gouqi, Gou Qi Zi, Gouqizi, Himalayan Goji, Jus de Goji, Kuko, Lyciet Commun, Lyciet de Barbar
Drug: Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine
Brand names:
Multi Symptom Cold Relief
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Oct 06, 2024
Interaction Details
Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine is classified as belonging to the following category: Cytochrome P450 2D6 (Cyp2D6) Substrates
Theoretically, goji berry might inhibit CYP2D6 and reduce metabolism of CYP2D6 substrates.
In vitro research shows that goji berry juice inhibits CYP2D6 enzymes. Concomitant use with goji may decrease metabolism and increase levels of CYP2D6 substrates. However, this has not been reported in humans.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
References
- Liu R, Tam TW, Mao J, et al. In vitro activity of Lycium barbarum (Goji) against major human phase I metabolism enzymes. Complement Integr Med. 2016;13(3):257-265.
Interaction Details
Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine is classified as belonging to the following category: Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, goji berry might inhibit CYP3A4 and reduce metabolism of CYP3A4 substrates.
In vitro research shows that goji berry juice inhibits CYP3A4 enzymes. Concomitant use with goji may decrease metabolism and increase levels of CYP3A4 substrates. However, this has not been reported in humans.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
References
- Liu R, Tam TW, Mao J, et al. In vitro activity of Lycium barbarum (Goji) against major human phase I metabolism enzymes. Complement Integr Med. 2016;13(3):257-265.
Goji Overview
Goji berries, also known as wolfberries, are a type of fruit native to China that grows on the goji (Lycium barbarum) shrub. Goji berries have a sweet, slightly sour taste and are often used in dried form as a snack or added to cereals, yogurt, and other dishes. They are rich in antioxidants, vitamins, and minerals, and are purported to have anti-inflammatory, immune-boosting, and anti-aging properties. They are also a good source of protein and fiber. Dietary supplements containing goji are sometimes standardized for their polysaccharide content.
Goji - More Interactions
Goji interacts with 974 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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Dr. Brian Staiger, PharmD
In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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