Larch Arabinogalactan - Prednisolone Interaction

Herbal: Larch Arabinogalactan
Also Known As: Larix decidua, Larix europaea

Drug: Prednisolone
Brand names: Prednisolone, Sterane, Delta Cortef, Cortalone, Pred Forte, Solupred

Medical Content Editor
Last updated May 25, 2025

Interaction Details

Prednisolone is classified as belonging to the following category: Immunosuppressants

Theoretically, larch arabinogalactan might interfere with immunosuppression therapy due to immunostimulant effects. Immunosuppressant drugs include azathioprine (Imuran), basiliximab (Simulect), cyclosporine (Neoral, Sandimmune), daclizumab (Zenapax), muromonab-CD3 (OKT3, Orthoclone OKT3), mycophenolate (CellCept), tacrolimus (FK506, Prograf), sirolimus (Rapamune), prednisone (Deltasone, Orasone), corticosteroids (glucocorticoids), and other drugs.

Interaction Rating

Moderate

Likelihood of Occurrence

Possible

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists

References

  • D'Adamo P. Larch arabinogalactan. J Naturopath Med 1996;6:33-7.
  • Kelly GS. Larch arabinogalactan: Clinical relevance of a novel immune-enhancing polysaccharide. Alt Med Rev 1999;4:96-103.
  • Dion C, Chappuis E, Ripoll C. Does larch arabinogalactan enhance immune function? A review of mechanistic and clinical trials. Nutr Metab (Lond) 2016;13:28.

Larch Arabinogalactan Overview

Arabinogalactans are long, densely branched, high-molecular weight polysaccharides found in many plants, with the highest concentrations in larch trees. Larch arabinogalactan, specifically obtained from the western larch (Larix occidentalis) and eastern larch (Larix laricina), is approximately 98% arabinogalactan. This polysaccharide has a range of potential health benefits, including serving as a soluble, non-viscous fiber that ferments in the gut, potentially increasing beneficial gut bacteria like Lactobacillus. Additionally, larch arabinogalactan has been investigated for its possible role in drug delivery systems due to its water solubility and numerous hydroxyl groups, which may enhance the bioavailability of drugs like ibuprofen. Moreover, preliminary research suggests immunostimulatory effects, such as increased natural killer cell activity and enhanced immune response to certain vaccines.
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Prednisolone Overview

  • Prednisolone is used alone or with other medications to treat the symptoms of low corticosteroid levels (lack of certain substances that are usually produced by the body and are needed for normal body functioning). Prednisolone is also used to treat certain conditions that affect the blood, skin, eyes, central nervous system, kidneys, lungs, stomach, and intestines. It is also used to treat allergic reactions; and certain types of arthritis; multiple sclerosis (a disease in which the nerves do not function properly); and to help prevent transplant rejection (attack of the transplanted organ by the body) in certain adults who have received a transplant. Prednisolone is also sometimes used to treat symptoms from certain types of cancer. Prednisolone is in a class of medications called corticosteroids. It works by reducing swelling and redness and by changing the way the immune system works.

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Larch Arabinogalactan - More Interactions

Larch Arabinogalactan interacts with 112 drugs

Interaction Rating Key

These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.

Major The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur.
Moderate Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur.
Minor Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction.
Unknown No interactions have been reported or no interaction data is currently available.

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Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Drug descriptions are provided by MedlinePlus.

Dr. Brian Staiger, PharmD

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Dr. Brian Staiger, PharmD

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