Manchurian Thorn - Interferon Alfa-2b Interaction

Interaction Details

Interferon Alfa-2b is classified as belonging to the following category: Hepatotoxic Drugs

Animal research suggests that high doses of Manchurian thorn can induce liver damage. Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage.
Some of these drugs include acarbose (Precose, Prandase), amiodarone (Cordarone), atorvastatin (Lipitor), azathioprine (Imuran), carbamazepine (Tegretol), cerivastatin (Baycol), diclofenac (Voltaren), felbamate (Felbatol), fenofibrate (Tricor), fluvastatin (Lescol), gemfibrozil (Lopid), isoniazid, itraconazole, (Sporanox), ketoconazole (Nizoral), leflunomide (Arava), lovastatin (Mevacor), methotrexate (Rheumatrex), nevirapine (Viramune), niacin, nitrofurantoin (Macrodantin), pioglitazone (Actos), pravastatin (Pravachol), pyrazinamide, rifampin (Rifadin), ritonavir (Norvir), rosiglitazone (Avandia), simvastatin (Zocor), tacrine (Cognex), tamoxifen, terbinafine (Lamisil), valproic acid, and zileuton (Zyflo).

Interaction Rating

Likelihood of Occurrence

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists

References

• Burgos R, Hancke J, Caceres DD, et al. Hepatotoxic effect of Aralia mandshurica dried root extract in pigs. Phytotherapy Res 1997;11(1):59-61.
• Burgos R, Hancke J, Wikman G, et al. Toxicological assessment of Aralia mandshurica (Araliaceae) root extract after subchronic administration in rats. A biochemical and histological study. Phytotherapy Res 1994;8(1):1-9.

Interferon Alfa-2b Overview

• Interferon alfa-2b injection is used to treat a number of conditions.

• Interferon alfa-2b injection is used

  • alone or in combination with ribavirin (Copegus, Rebetol, Ribasphere) to treat chronic (long-term) hepatitis C infection (swelling of the liver caused by a virus) in people who show signs of liver damage,

  • to treat chronic hepatitis B infection (swelling of the liver caused by a virus) in people who show signs of liver damage,

  • to treat hairy cell leukemia (a white blood cell cancer),

  • to treat genital warts,

  • to treat Kaposi's sarcoma (a type of cancer that causes abnormal tissue to grow on different parts of the body) related to acquired immunodeficiency syndrome (AIDS),

  • to treat malignant melanoma (a cancer that begins in certain skin cells) in certain people who have had surgery to remove the cancer,

  • along with another medication to treat follicular non-Hodgkin's lymphoma (NHL; a slow-growing blood cancer).

• Interferon alfa-2b is in a class of medications called immunomodulators. Interferon alfa-2b works to treat hepatitis C virus (HCV) and hepatitis B virus (HBV) by decreasing the amount virus in the body. Interferon alfa-2b may not cure hepatitis B or hepatitis C or prevent you from developing complications from these infections such as cirrhosis (scarring) of the liver, liver failure, or liver cancer. It also may not prevent the spread of hepatitis B or C to other people. It is not known exactly how interferon alfa-2b works to treat cancer or genital warts.

Manchurian Thorn - More Interactions

Manchurian Thorn interacts with 414 drugs

Interaction Rating Key

These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.