Scopolia - Trelegy Ellipta (Fluticasone Furoate, Umeclidinium, Vilanterol) Interaction
Herbal: Scopolia
Also Known As: Scopolia carniolica, Belladonna Scopola, Escopolia, Glockenbilsenkraut, Japanese Belladonna, Russian Krainer Tollkraut, Scopola, Scopoliae Rhizoma, Scopolie
Drug: Fluticasone Furoate, Umeclidinium, Vilanterol
Brand names:
Trelegy Ellipta
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
May 25, 2025
Interaction Details
Fluticasone Furoate, Umeclidinium, Vilanterol is classified as belonging to the following category: Anticholinergic Drugs
The alkaloid constituents of scopolia, including hyoscyamine, scopolamine, and atropine, could potentiate the effects and adverse effects of anticholinergic drugs.
Interaction Rating
Likelihood of Occurrence
ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
References
- McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
Scopolia Overview
Scopolia is a plant genus that belongs to the Solanaceae family, which also includes tomato, potato, and tobacco. There are several species of Scopolia plants, including Scopolia carniolica, Scopolia japonica, and Scopolia tangutica. These plants are native to Asia and Europe and are known for their poisonous properties as they contain several dangerous alkaloids, such as L-hyoscyamine, atropine, and scopolamine, all of which are strong anticholinergics. These alkaloids have well known medicinally properties and are even available as prescription drugs to treat a variety of conditions, including motion sickness and spasms of the gastrointestinal (GI) tract. However, scopolia is generally considered unsafe when used for self-medication and should only be used under the supervision of a healthcare professional.
Fluticasone Furoate, Umeclidinium, Vilanterol Overview
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The combination of fluticasone, umeclidinium, and vilanterol is used to control wheezing, shortness of breath, coughing, and chest tightness caused by chronic obstructive pulmonary (COPD; a group of diseases that affect the lungs and airways, that includes chronic bronchitis and emphysema). It is also used in adults to control wheezing, shortness of breath, coughing, and chest tightness caused by asthma. Fluticasone is in a class of medications called steroids. Umeclidinium is in a class of medication called anticholinergics. Vilanterol is in a class of medications called long-acting beta-agonists (LABAs). The combination of fluticasone, umeclidinium, and vilanterol works by relaxing and opening air passages in the lungs, making it easier to breathe.
Scopolia - More Interactions
Scopolia interacts with 198 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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