Valerian - Denosumab Interaction

Interaction Details

Pharmacist Analysis

While there is no known interaction between valerian and the drug in question here, it does have potential interactions with other drugs that are important to be aware of.

For example, valerian may enhance the effects of central nervous system depressants, such as alcohol, benzodiazepines, and barbiturates. This means that combining valerian with these drugs can lead to excessive sedation and other side effects, such as dizziness and impaired coordination.

Similarly, if you take a drug that causes you to feel tired (e.g., Benadryl), valerian may enhance that effect.

Valerian may also interact with certain medications metabolized by the liver, such as statins and some antidepressants, as it can affect the liver enzymes that break down these drugs. For example, valerian may affect drugs metabolized via the CYP3A4 enzyme.

This can result in increased levels of these medications in the bloodstream, leading to potential side effects and toxicity.

We have hundreds of interactions listed for valerian that you can find in this interaction tool, but as always, if you are taking any prescription medications, it is important to talk to your healthcare provider before using valerian or any other supplements to ensure they are safe and appropriate for you.

Denosumab Overview

• Denosumab injection (Prolia) is used

  • to treat osteoporosis (a condition in which the bones become thin and weak and break easily) in women who have undergone menopause (''change of life;'' end of menstrual periods) who have an increased risk for fractures (broken bones) or who cannot take or did not respond to other medication treatments for osteoporosis.

  • to treat men who have an increased risk for fractures (broken bones) or who cannot take or did not respond to other medication treatments for osteoporosis.

  • treat osteoporosis that is caused by corticosteroid medications in men and women who will be taking corticosteroid medications for at least 6 months and have an increased risk for fractures or who cannot take or did not respond to other medication treatments for osteoporosis.

  • to treat bone loss in men who are being treated for prostate cancer with certain medications that cause bone loss,

  • to treat bone loss in women with breast cancer who are receiving certain medications that increase their risk for fractures.

• Denosumab injection (Xgeva) is used

  • to reduce the risk of fractures in people who have multiple myeloma (cancer that begins in the plasma cells and causes bone damage), and in people who have certain types of cancer that began in another part of the body but has spread to the bones.

  • in adults and some adolescents to treat giant cell tumor of bone (GCTB; a type of bone tumor) that cannot be treated with surgery.

  • to treat high calcium levels that are caused by cancer in people who did not respond to other medications.

  Denosumab injection is in a class of medications called RANK ligand inhibitors. It works to prevent bone loss by blocking a certain receptor in the body to decrease bone breakdown. It works to treat GCTB by blocking a certain receptor in the tumor cells which slows the tumor growth. It works to treat high calcium levels by decreasing bone breakdown as the breakdown of bones releases calcium.

Valerian - More Interactions

Valerian interacts with 878 drugs

Interaction Rating Key

These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.