Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

100% Pure Glucomannan Ingredients & Drug Interactions

by NutraBio

100% Pure Glucomannan label
See full label image
Powder Category: Botanical With Nutrients
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking 100% Pure Glucomannan against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

100% Pure Glucomannan is a dietary supplement by NutraBio with 1 active ingredient. Its ingredients are commonly taken for weight loss and appetite control, constipation, high cholesterol.Based on those ingredients, 2,022 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Glucomannan. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against 100% Pure Glucomannan by NutraBio

Ask about any prescription or over-the-counter medication and we check it for interactions with 100% Pure Glucomannan by NutraBio — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of 100% Pure Glucomannan by NutraBio

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: glucomannan, a water-soluble dietary fiber derived from the konjac plant. It works by absorbing water in your digestive tract and forming a thick, gel-like substance that adds bulk to stool and slows digestion.

The product contains absolutely no other inactive ingredients or fillers — it's just the fiber itself in powder form.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: weight management and digestive health.
  • We looked for evidence on: Constipation, Obesity, Hyperlipidemia, Diabetes, Metabolic syndrome, appetite control — and 2 related terms.
  • The strongest evidence on file: Glucomannan is rated "Possibly Effective" for Constipation (Natural Medicines).
  • Also on file: Glucomannan is rated "Possibly Effective" for Diabetes, Hyperlipidemia.
  • Also on file: Glucomannan is rated "Insufficient Reliable Evidence To Rate" for Obesity, Metabolic syndrome.

Glucomannan has Possibly Effective ratings for constipation, diabetes blood sugar control, and high cholesterol (hyperlipidemia). For high blood pressure, the evidence isn't established well enough to rate it.

This means the research suggests it may help with those three conditions, but more study is needed to be certain.

The evidence, ingredient by ingredient Glucomannan

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Glucomannan is generally well tolerated when you drink plenty of water with it — in fact, water is essential. The main concern is choking or blockage of your esophagus or intestines, especially if you swallow the dry powder or don't drink enough liquid.

Common side effects include abdominal pain, bloating, gas, diarrhea, constipation, nausea, and vomiting, particularly if you take more than 3 grams daily. During pregnancy, there isn't enough reliable safety data — talk with your doctor or pharmacist.

The same goes for breastfeeding; caution is advised because we know little about its safety in that situation.

Side effects, ingredient by ingredient Glucomannan

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Glucomannan.
  • The most serious interaction on file is rated Moderate.
  • For scale: 2,023 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start, check any oral medications you take with your pharmacist or doctor. Glucomannan has a Moderate interaction with oral drugs in general because it may decrease how well your body absorbs them.

Taking it at least 2 hours before or after your medications can help lower this risk.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Glucomannan is a soluble fiber that may help with constipation, blood sugar, or cholesterol — but only if you take it with plenty of water and away from your medications. If you're on any oral drugs, check with your pharmacist or doctor first, because this fiber can reduce how well medications are absorbed.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Oct 22, 2015.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about 100% Pure Glucomannan, straight from the product label.

Brand NutraBio
Barcode (UPC) 649908514907
Net contents 5.3 oz.
Market status On market
Date entered into DSLD Oct 22, 2015
DSLD ID 51476
Product type Botanical With Nutrients
Supplement form Powder
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Kosher, No Allergies, Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for 100% Pure Glucomannan by NutraBio, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Gram(s)
Maximum serving Sizes:
2 Gram(s)
Servings per container
125
UPC/BARCODE
649908514907
IngredientAmount% DV
Glucomannan2000 mg--

Other ingredients: Absolutely None

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, take 1 serving (2 scoops) daily with at least 8 oz. of water 30-45 minutes before meals, or as directed by your physician.

1 serving - mixed with - 8-16 oz. - favorite beverage - 30-45 min. - before meals

Formulation

Allergen Free - Non-GMO - Gluten Free - BSE/TSE Free - Non-IRR-ETO

Vegetarian

~ No Fillers ~ No Excipients ~ No Additives

Allergen Free

~ Free of Harmful Impurities

Precautions

Warning: Not intended for use by persons under the age of 18. Keep out of the reach of children.

If you are pregnant, breast feeding, have known medical conditions (including kidney or liver disease) or are taking prescription or OTC medication(s) consult with your health care practitioner before using this product.

Glucomannan (Konjac Root Extract) is an expanding fiber and should be taken with sufficient drinking water.

General Statements

Manufactured in a GMP & FDA Inspected Facility

Weight Management

Pharmaceutical Grade ~ HPLC Lab Tested for Potency

Powder

Serving scoop included (may settle to the bottom during shipping.)

Since 1996

125 Servings

Formula

Fiber

Konjac Root Extract

OU

Seals/Symbols

TRUE LABEL FULL LABEL DISCLOSURE

OU

FDA Statement of Identity

Dietary Supplement

Storage

Store in cool dry place.

FDA Disclaimer Statement

+ These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

General

51490-002 B20357-000

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

100% Pure Glucomannan by NutraBio label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

100% Pure Glucomannan label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in 100% Pure Glucomannan by NutraBio

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Gram(s) Dosage formPowder Servings per container125 Amounts shown are per serving.

Glucomannan

Interacts with
2,022 drugs
2000 mg per serving Form: Konjac root extract

Glucomannan is a soluble fiber from the konjac root that swells into a gel in your stomach, which may help with mild weight loss, constipation, and mo...

Glucomannan monograph & interactions

Other (inactive) ingredients: Absolutely None. These complete the product’s ingredient list but are not active constituents.

Interaction report

100% Pure Glucomannan by NutraBio Drug Interactions

Want to check YOUR meds against 100% Pure Glucomannan?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2,022Drugs
2,022 Moderate

Ingredients driving the most interactions

Glucomannan 2,022

Individual Drug Interactions

The ingredients in 100% Pure Glucomannan interact with 2,022 drugs. Click any drug to see the details.

1 of the 1 ingredient in 100% Pure Glucomannan interact with drugs. Each result below shows which ingredient is responsible. Glucomannan

Each ingredient & the kinds of drugs it affects

For each ingredient in 100% Pure Glucomannan with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Glucomannan1 drug type · 2,022 drugs

Oral Drugs

Theoretically, glucomannan may decrease absorption of drugs taken orally.
Due to its viscosity and bulking effects, there is concern that glucomannan can decrease the absorption of oral drugs. A small clinical study in healthy volunteers shows that taking glyburide 2.5 mg plus glucomannan 3.9 grams with breakfast reduces plasma levels of glyburide when compared with breakfast and glyburide alone. In addition, animal research demonstrates this effect on amoxicillin, but shows increased absorption of metronidazole. This mouse model also demonstrates that metronidazole elimination is prolonged, but amoxicillin elimination is enhanced by 38%; glucomannan may also affect the distribution of some drugs. To avoid changes in absorption, take glucomannan 30-60 minutes after taking oral drugs.

Likelihood Probable Evidence B
Glucomannan full monograph & interactions
The maker

Brand information

Manufacturer and brand details for 100% Pure Glucomannan, from the product label.

NutraBio

See all NutraBio products
Name
NutraBio Labs, Inc.
Street Address
564 Lincoln Blvd.
City
Middlesex
State
NJ
ZipCode
08846
Phone Number
732-748-8606
Web Address
www.nutrabio.com
Pharmacist Counseling Corner

100% Pure Glucomannan by NutraBio: Common Questions

Does 100% Pure Glucomannan by NutraBio interact with any medications?
Yes. Based on its ingredients, 100% Pure Glucomannan has a known interaction with 2,022 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
100% Pure Glucomannan contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Do I really need to drink that much water with it?
Yes. Glucomannan absorbs water and swells in your digestive tract — that's how it works. Without enough liquid, it can cause choking or blockage, which is serious. Take it with a full glass of water or other liquid every time.
Can I take it at the same time as my other medications?
No. Because glucomannan may reduce how well your body absorbs oral drugs, it's safest to take it at least 2 hours away from any other medication. Talk with your pharmacist about the best timing for your specific prescriptions.
Will it make me bloated or gassy?
It can. Abdominal pain, bloating, gas, diarrhea, and constipation are common, especially if you take more than 3 grams a day. Starting with a smaller dose and increasing slowly, plus drinking plenty of water, may help your body adjust.
Is it safe to use while I'm pregnant or breastfeeding?
There isn't enough reliable safety data for pregnancy, so talk with your doctor before using it. For breastfeeding, we know little about its safety — again, your doctor or pharmacist can give you personalized advice based on your situation.
What is glucomannan and where does it come from?
Glucomannan is a water-soluble dietary fiber from the konjac plant. It absorbs water in your digestive tract and forms a thick gel that adds bulk to stool and slows digestion, which is why it may help with constipation and blood sugar control.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if 100% Pure Glucomannan is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

100% Pure Glucomannan label
Go deeper

The Full Monographs Behind 100% Pure Glucomannan’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Glucomannan

Interacts with 2,022 drugs

Glucomannan is a soluble fiber from the konjac root that swells into a gel in your stomach, which may help with mild weight loss, constipation, and modestly lowering cholesterol. It is gener...

Read the full Glucomannan monograph →
Sources

Sources & How We Checked

100% Pure Glucomannan's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 15 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Glucomannan 15 references
  1. Henry DA, Mitchell AS, Aylward J, et al. Glucomannan and risk of oesophageal obstruction. Br Med J 1986;292:591-2. PubMed
  2. Shima K, Tanaka A, Ikegami H, et al. Effect of dietary fiber, glucomannan, on absorption of sulfonylurea in man. Horm Metab Res 1983;15:1-3. PubMed
  3. Villaverde, A. F., Benlloch, S., Berenguer, M., Miguel, Rayon J., Pina, R., and Berenguer, J. Acute hepatitis of cholestatic type possibly associated with the use of glucomannan (amorphophalus konjac). J Hepatol. 2004;41(6):1061-1062. PubMed
  4. Yoshida, M., Vanstone, C. A., Parsons, W. D., Zawistowski, J., and Jones, P. J. Effect of plant sterols and glucomannan on lipids in individuals with and without type II diabetes. Eur.J Clin Nutr. 2006;60(4):529-537. PubMed
  5. Wood, R. J., Fernandez, M. L., Sharman, M. J., Silvestre, R., Greene, C. M., Zern, T. L., Shrestha, S., Judelson, D. A., Gomez, A. L., Kraemer, W. J., and Volek, J. S. Effects of a carbohydrate-restricted diet with and without supplemental soluble fiber
  6. Vanderbeek, P. B., Fasano, C., O'Malley, G., and Hornstein, J. Esophageal obstruction from a hygroscopic pharmacobezoar containing glucomannan. Clin Toxicol.(Phila) 2007;45(1):80-82. PubMed
  7. Bernstein, J. A., Crandall, M. S., and Floyd, R. Respiratory sensitization of a food manufacturing worker to konjac glucomannan. J Asthma 2007;44(8):675-680. PubMed
  8. Shichijo, K., Kobayashi, Y., Fueki, R., Shimoyama, K., and Masaya, M. [2 cases of konjac bronchial asthma found outside the "konnyaku" producing district]. Arerugi 1969;18(2):97-100.
  9. Carabin IG, Lyon MR, Wood S, et al. Supplementation of the diet with the functional fiber PolyGlycoplex is well tolerated by healthy subjects in a clinical trial. Nutr J 2009;8:9. PubMed
  10. Lyon MR, Reichert RG. The effect of a novel viscous polysaccharide along with lifestyle changes on short-term weight loss and associated risk factors in overweight and obese adults: an observational retrospective clinical program analysis. Altern Med Rev
  11. Lyon M, Wood S, Pelletier X, et al. Effects of a 3-month supplementation with a novel soluble highly viscous polysaccharide on anthropometry and blood lipids in nondieting overweight or obese adults. J Hum Nutr Diet 2011;24(4):351-9. PubMed
  12. Han Y, Zhang L, Liu XQ, Zhao ZJ, Lv LX. Effect of glucomannan on functional constipation in children: a systematic review and meta-analysis of randomised controlled trials. Asia Pac J Clin Nutr 2017;26(3):471-7.
  13. Health Canada Safety Alert. Health Canada Advises Canadians that natural health products containing glucomannan may cause serious choking if used with insufficient fluid. January 29, 2010. Alert # RA-110003825. https://healthycanadians.gc.ca/recall-alert-
  14. Mortensen A, Aguilar F, Crebelli, et al. EFSA Panel on Food Additives and Nutrient Sources added to Food. Re-evaluation of konjac gum (E 425 i) and konjac glucomannan (E425 ii) as food additives. EFSA Journal 2017;15(6):4864.
  15. Zhang Y, Aldamarany WAS, Song G, et al. Influence of konjac glucomannan and its derivatives on the oral pharmacokinetics of antimicrobial agent in antibiotics cocktails: Keep vigilant on dietary fiber supplement. Int J Biol Macromol 2023;251:126306. PubMed

See these in context on the Glucomannan monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team