Major interaction on record — check this product against your medications before combining. Based on 5 of 6 ingredients. Check your meds →
Dietary supplement

2 Reduce Desire Ingredients & Drug Interactions

by Renew Life

2 Reduce Desire label
See full label image
Tablet Or Pill Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking 2 Reduce Desire against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

2 Reduce Desire is a dietary supplement by Renew Life with 6 active ingredients. Its ingredients are commonly taken for muscle recovery and sports performance, gut health and 'leaky gut', recovery from severe illness or injury.Based on those ingredients, 1,427 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Ashwagandha extract, GABA, Velvet Bean extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against 2 Reduce Desire by Renew Life

Ask about any prescription or over-the-counter medication and we check it for interactions with 2 Reduce Desire by Renew Life — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of 2 Reduce Desire by Renew Life

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 6 active ingredients.

2 Reduce Desire contains six ingredients, including five with known active effects: L-Glutamine, GABA (gamma-aminobutyric acid), L-Tyrosine, Ashwagandha extract, and Velvet Bean extract (which contains the amino acid levodopa). There's also a Proprietary Botanical Blend we couldn't verify.

These are supported by inactive ingredients like cane juice extract, xylitol, citric acid, and silica that serve as fillers and flavor.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Strong

Strong clinical evidence supports its ingredients for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Sickle cell disease — rated "Effective" (Glutamine) (Natural Medicines).
  • On file: Phenylketonuria (PKU) — rated "Effective" (Tyrosine) (Natural Medicines).
  • On file: HIV/AIDS-related wasting — rated "Possibly Effective" (Glutamine) (Natural Medicines).
  • On file: Critical illness (trauma) — rated "Possibly Effective" (Glutamine) (Natural Medicines).
  • On file: Postoperative recovery — rated "Possibly Effective" (Glutamine) (Natural Medicines).

The product mixes ingredients with varying evidence strength. L-Glutamine is effective for sickle cell disease but only possibly effective for HIV/AIDS-related wasting and recovery from surgery.

L-Tyrosine is effective for phenylketonuria (PKU) and possibly effective for cognitive function and memory. Ashwagandha is possibly effective for insomnia, anxiety, and stress.

GABA, Velvet Bean extract, and the Proprietary Botanical Blend all lack reliable evidence—the data we hold rates them insufficient to establish whether they work for their listed uses. No ingredient in this product has been rated effective for "reducing desire" specifically.

The evidence, ingredient by ingredient Glutamine Gamma-aminobutyric Acid (gaba) Tyrosine Ashwagandha Cowhage

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-Glutamine is rated likely safe in pregnancy and generally well tolerated orally, though people with kidney or liver disease need medical supervision. Common side effects include belching, bloating, constipation, diarrhea, flatulence, nausea, and vomiting.

GABA is often well tolerated short-term but long-term safety isn't well studied; avoid supplemental doses unless your doctor advises otherwise, and avoid while breastfeeding. Common effects are drowsiness, nausea, and muscle weakness.

L-Tyrosine has insufficient safety data; avoid supplemental doses without medical advice and use caution while breastfeeding. Side effects include fatigue, headache, heartburn, and nausea.

Ashwagandha is likely unsafe in pregnancy (traditionally linked to miscarriage risk) and should be avoided while breastfeeding. Though generally well tolerated short-term, rare serious cases of liver problems have been reported.

Common effects are diarrhea, nausea, and vomiting. Velvet Bean extract contains an active drug-like compound (levodopa) and should be used carefully with professional guidance; avoid in pregnancy and while breastfeeding because levodopa can reduce milk supply.

Common effects are diarrhea, flatulence, and headache.

Side effects, ingredient by ingredient Glutamine Gamma-aminobutyric Acid (gaba) Tyrosine Ashwagandha Cowhage

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 5 of the 5 matched ingredients can interact with medications — Gamma-aminobutyric Acid (gaba), Glutamine, Ashwagandha, Cowhage, Tyrosine.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: seizure medications; immunosuppressants / transplant drugs; diabetes medications; Parkinson's medications.
  • For scale: 1,428 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your pharmacist if you take: blood pressure medications (Major risk with methyldopa; Moderate risk with other antihypertensive drugs), monoamine oxidase inhibitors or MAOIs (Major risk), levodopa supplements or Parkinson's drugs (Major risk), diabetes medications (Moderate risk), thyroid hormones, antipsychotics, tricyclic antidepressants, benzodiazepines or other anti-anxiety drugs, CNS depressants like opioids or sedatives, anticonvulsants, anesthesia medications, or immunosuppressants.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with strong clinical evidence behind its ingredients' uses. Major medication interactions have been identified, and safety information is well characterized.

This product pairs several amino acids and botanicals with multiple documented medication interactions—most seriously with blood pressure drugs, antidepressants, and diabetes medications. If you take any prescription drugs, especially for high blood pressure, mood, blood sugar, thyroid function, or seizure control, check with your pharmacist or doctor before starting.

The Proprietary Botanical Blend also couldn't be verified for safety or interactions.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 22, 2016.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about 2 Reduce Desire, straight from the product label.

Brand Renew Life
Barcode (UPC) 631257906304
Net contents 60 Chewable Orange Tablet(s)
Market status On market
Date entered into DSLD Sep 22, 2016
DSLD ID 65031
Product type Other Combinations
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for 2 Reduce Desire by Renew Life, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
Servings per container
60
UPC/BARCODE
631257906304
IngredientAmount% DV
Calories7 Calorie(s)--
Total Carbohydrates0.9 Gram(s)1%
L-Glutamine0 NP--
GABA0 NP--
L-Tyrosine0 NP--
Proprietary Botanical Blend400 mg--
Ashwagandha extract0 NP--
Velvet Bean extract0 NP--

Other ingredients: organic Cane juice extract, Xylitol, Stearate, Orange juice crystals, Citric Acid, Vegetable Stearate, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

KEEP OUT OF REACH OF CHILDREN.

WARNING: Do not use this product if you are pregnant or nursing. Consult your physician before using this or any product if you are trying to conceive, taking medication or have a medical condition.

Not for prolonged use. Do not exceed recommended dose.

TAMPER EVIDENT: DO NOT USE IF SAFETY SEAL IS BROKEN OR MISSING.

Formulation

Contains no GMOs, yeast, wheat, soy, gluten, salt, dairy, animal products, fillers or artificial ingredients

General Statements

Quality and Purity Guaranteed

MADE IN USA

30-Day Program

Manufactured in a GMP facility.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

Renew Life The Digestive Care Experts

Suggested/Recommended/Usage/Directions

Directions: Chew 1 tablet, twice daily. Best if taken between meals. Please read accompanying literature.

Storage

Store in a dry place at 59-86(0) F (15-30(0) C).

General

#15583 010114

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

2 Reduce Desire by Renew Life label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

2 Reduce Desire label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in 2 Reduce Desire by Renew Life

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

L-Glutamine

Interacts with
50 drugs
0 NP per serving

Glutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle c...

L-Glutamine monograph & interactions

GABA

Interacts with
419 drugs
0 NP per serving

GABA is a calming chemical messenger (neurotransmitter) that your body makes on its own, and it is sold as a supplement for stress, anxiety, and sleep...

GABA monograph & interactions

L-Tyrosine

Interacts with
21 drugs
0 NP per serving

L-tyrosine is an amino acid your body uses to make brain chemicals like dopamine and norepinephrine. Some studies suggest it may help mental performan...

L-Tyrosine monograph & interactions

Proprietary Botanical Blend

400 mg per serving

Ashwagandha extract

Interacts with
1,372 drugs
0 NP per serving

Ashwagandha is an Ayurvedic herb most often taken to help with stress, anxiety, and sleep, and some small studies suggest it may help, though the evid...

Ashwagandha extract monograph & interactions

Velvet Bean extract

Interacts with
193 drugs
0 NP per serving

Cowhage (Mucuna pruriens) is a tropical legume best known as a natural source of L-dopa, the compound the body turns into dopamine. It is most studied...

Velvet Bean extract monograph & interactions

Other (inactive) ingredients: Organic Cane juice extract, Xylitol, Stearate, Orange juice crystals, Citric Acid, Vegetable Stearate, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

2 Reduce Desire by Renew Life Drug Interactions

Want to check YOUR meds against 2 Reduce Desire?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,427Drugs
17 Major 980 Moderate 430 Minor

Ingredients driving the most interactions

Ashwagandha extract 1,372
GABA 419
Velvet Bean extract 193
L-Glutamine 50
L-Tyrosine 21

Individual Drug Interactions

The ingredients in 2 Reduce Desire interact with 1,427 drugs. Click any drug to see the details.

5 of the 6 ingredients in 2 Reduce Desire interact with drugs. Each result below shows which ingredient is responsible. Ashwagandha extract GABA Velvet Bean extract L-Glutamine L-Tyrosine

Each ingredient & the kinds of drugs it affects

For each ingredient in 2 Reduce Desire with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Ashwagandha extract10 drug types · 1,372 drugs

Antidiabetes Drugs

Theoretically, taking ashwagandha with antidiabetes drugs might increase the risk of hypoglycemia.
There is preliminary clinical evidence suggesting that ashwagandha might lower blood glucose levels. Theoretically, ashwagandha might have additive effects when used with antidiabetes drugs and increase the risk of hypoglycemia.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, taking ashwagandha with antihypertensive drugs might increase the risk of hypotension.
Animal research suggests that ashwagandha might lower systolic and diastolic blood pressure. Theoretically, ashwagandha might have additive effects when used with antihypertensive drugs and increase the risk of hypotension.

Likelihood Possible Evidence D
Benzodiazepines

Theoretically, taking ashwagandha might increase the sedative effects of benzodiazepines.
There is preliminary evidence that ashwagandha might have an additive effect with diazepam (Valium) and clonazepam (Klonopin). This may also occur with other benzodiazepines.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, taking ashwagandha might increase the sedative effects of CNS depressants.
Ashwagandha seems to have sedative effects. Theoretically, this may potentiate the effects of barbiturates, other sedatives, and anxiolytics.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Ashwagandha has been linked to cases of acute hepatitis, liver failure, hepatic encephalopathy, autoimmune hepatitis, the need for liver transplantation, and death due to liver failure.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, taking ashwagandha might decrease the effects of immunosuppressants.
Ashwagandha has demonstrated immunostimulant effects in humans. Animal research has shown that ashwagandha can attenuate the immunosuppression caused by cyclophosphamide.

Likelihood Possible Evidence D
Thyroid Hormone

Ashwagandha might increase the effects and adverse effects of thyroid hormone.
Concomitant use of ashwagandha with thyroid hormones may cause additive therapeutic and adverse effects. Preliminary clinical research and animal studies suggest that ashwagandha boosts thyroid hormone synthesis and secretion. In one clinical study, ashwagandha increased triiodothyronine (T3) and thyroxine (T4) levels by 41.5% and 19.6%, respectively, and reduced serum TSH levels by 17.4% from baseline in adults with subclinical hypothyroidism.

Likelihood Probable Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, ashwagandha might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that ashwagandha extract induces CYP1A2 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that ashwagandha extract induces CYP3A4 enzymes.

Likelihood Possible Evidence D
Serotonergic Drugs

Some animal studies have reported that ashwagandha can enhance serotonergic transmission by altering certain serotonin (5-HT) receptors. However, there is no evidence to suggest that ashwagandha increases the risk of serotonin-related effects, and there have been no published case reports of serotonin syndrome when combined with other serotonergic drugs. Nevertheless, due to the lack of extensive studies on the matter and the fact that ashwagandha appears to affect serotonergic pathways, it would be prudent to exercise caution when combining it with drugs that affect serotonin. [References: - Effects of Withania somnifera (Ashwaga ndha) on Stress and the Stress-Related Neuropsychiatric Disorders Anxiety, Depression, and Insomnia. Curr Neuropharmacol. 2021 Sep 14; 19: 1468–1495. - A Prospective, Randomized Double-Blind, Placebo-Controlled Study of Safety and Efficacy of a High-Concentration Full-Spectrum Extract of Ashwagandha Root in Reducing Stress and Anxiety in Adults. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573577/]

Likelihood Possible Evidence C
Ashwagandha extract full monograph & interactions

GABA2 drug types · 419 drugs

Antihypertensive Drugs

Theoretically, taking GABA with antihypertensive drugs might increase the risk of hypotension.
Some clinical research shows that GABA can decrease blood pressure in patients with hypertension.

Likelihood Possible Evidence B
Cns Depressants

Theoretically, GABA might have additive sedative effects when used in conjunction with CNS depressants. However, it is unclear if this concern is clinically relevant.
Endogenous GABA has well-established relaxant effects and GABA(A) receptors have an established physiological role in sleep. However, the effects of GABA supplements are unclear, as it is unknown whether exogenous GABA crosses the blood-brain barrier. Although there have been limited reports of drowsiness or tiredness with GABA supplements, these effects have not been widely reported in clinical studies. Additionally, intravenous GABA 0.1-1 mg/kg has been shown to induce anxiety in a dose-dependent manner.

Likelihood Unlikely Evidence D
GABA full monograph & interactions

Velvet Bean extract8 drug types · 193 drugs

Levodopa

Concomitant use can increase the risk of levodopa-related adverse effects.
Cowhage contains levodopa. Some cowhage products have been standardized to contain 75-400 mg of levodopa per dose.

Likelihood Likely Evidence D
Methyldopa (Aldomet)

Theoretically, concomitant use of cowhage and methyldopa might increase the risk of hypotension.
Cowhage contains levodopa. Use of levodopa with methyldopa might cause additive hypotension. In addition, methyldopa may inhibit peripheral decarboxylation of levodopa and increase levodopa levels in the central nervous system; avoid using.

Likelihood Probable Evidence D
Monoamine Oxidase Inhibitors (Maois)

Theoretically, concomitant use of cowhage and non-selective MAOIs might increase the risk of hypertensive crisis.
Cowhage contains levodopa. Use of levodopa with non-selective MAOIs might cause hypertensive crisis. However, this interaction has not been reported with MAO-B selective inhibitors such as selegiline.

Likelihood Probable Evidence D
Anesthesia

Theoretically, concomitant use of cowhage and anesthesia might increase the risk of arrhythmias.
Cowhage contains levodopa. Use of levodopa with cyclopropane or halogenated hydrocarbon anesthesia has led to arrhythmias. Other anesthetics have not been implicated. Use other anesthetics in patients taking cowhage or tell patients to stop taking cowhage at least 2 weeks before surgery.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, concomitant use of cowhage and antidiabetes drugs might increase the risk of hypoglycemia.
Animal research shows that cowhage might have hypoglycemic effects.

Likelihood Possible Evidence D
Antipsychotic Drugs

Theoretically, use of cowhage might decrease the clinical effects of antipsychotic drugs.
Cowhage contains levodopa. Use of levodopa might counteract the antidopaminergic effects of antipsychotic medications.

Likelihood Possible Evidence D
Guanethidine (Ismelin)

Theoretically, concomitant use of cowhage and guanethidine might increase the risk of hypotension.
Cowhage contains levodopa. Use of levodopa with guanethidine might cause additive hypotension; avoid using.

Likelihood Probable Evidence D
Tricyclic Antidepressants (Tcas)

Theoretically, use of TCAs might reduce the levels and clinical effects of cowhage.
Cowhage contains levodopa. Use of TCAs might reduce the absorption of levodopa. Some case reports describe patients that developed hypertension and dyskinesia when taking both levodopa and TCAs.

Likelihood Possible Evidence D
Velvet Bean extract full monograph & interactions

L-Glutamine1 drug type · 50 drugs

Anticonvulsants

Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Glutamine is metabolized to the excitatory neurotransmitter glutamate. Glutamate might have antagonistic effects with anticonvulsant drugs. However, this interaction has not yet been reported in humans.

Likelihood Possible Evidence D
L-Glutamine full monograph & interactions

L-Tyrosine2 drug types · 21 drugs

Levodopa

Theoretically, tyrosine might decrease the effectiveness of levodopa.
Tyrosine and levodopa compete for absorption in the proximal duodenum by the large neutral amino acid (LNAA) transport system. Advise patients to separate doses of tyrosine and levodopa by at least 2 hours.

Likelihood Probable Evidence D
Thyroid Hormone

Theoretically, tyrosine might have additive effects with thyroid hormone medications.
Tyrosine is a precursor to thyroxine and might increase levels of thyroid hormones.

Likelihood Probable Evidence D
L-Tyrosine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for 2 Reduce Desire, from the product label.

Renew Life

Name
Renew Life Formulas
City
Palm Harbor
State
FL
ZipCode
34683
Phone Number
1-800-830-1800
Web Address
www.renewlife.com
Pharmacist Counseling Corner

2 Reduce Desire by Renew Life: Common Questions

Does 2 Reduce Desire by Renew Life interact with any medications?
Yes. Based on its ingredients, 2 Reduce Desire has a known interaction with 1,427 medications, including 17 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
2 Reduce Desire contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this product help me if I take blood pressure medication?
Both Ashwagandha and GABA in this product can theoretically lower blood pressure, so taking them with blood pressure medications raises the risk of hypotension (dangerously low blood pressure). Velvet Bean extract carries even more serious risks with certain blood pressure drugs like methyldopa and guanethidine. Talk to your pharmacist or doctor before adding this product if you take any blood pressure medication.
Can I take this if I'm on an antidepressant?
It depends on which one. Velvet Bean extract poses a Major risk with MAOIs (a class of older antidepressants) and could trigger a hypertensive crisis. It may also interact with tricyclic antidepressants. GABA and Ashwagandha can increase sedation with CNS depressants. Check your exact medication with your pharmacist before starting.
Is this safe if I have diabetes?
Both Ashwagandha and Velvet Bean extract may lower blood sugar, which could add to the effect of diabetes medications and increase your hypoglycemia (low blood sugar) risk. If you take diabetes medication, discuss this product with your pharmacist or doctor first.
Can I take this while pregnant or breastfeeding?
Ashwagandha is rated likely unsafe in pregnancy due to a traditional link to miscarriage risk, and should be avoided while breastfeeding. Velvet Bean extract should also be avoided in both cases—it contains levodopa, which can lower milk supply. L-Glutamine is rated likely safe in pregnancy but avoid supplemental doses while breastfeeding unless your doctor advises otherwise. Talk to your doctor or pharmacist before use if you're pregnant or nursing.
What are the most common side effects I might feel?
Across the ingredients, the most common side effects reported are gastrointestinal—nausea, diarrhea, bloating, flatulence, and vomiting. Ashwagandha and GABA may also cause drowsiness, and L-Tyrosine may cause headache or fatigue. Rare but serious cases of liver problems have been linked to Ashwagandha. Stop and contact your healthcare provider if you develop severe abdominal pain, yellowing of the skin or eyes, or persistent nausea and vomiting.
Does this product actually work for reducing desire?
The data we hold doesn't rate any ingredient in this product as effective or even possibly effective for reducing desire. Most are rated insufficient evidence. Before you buy, check the product label to see what clinical studies or claims the manufacturer cites.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if 2 Reduce Desire is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

2 Reduce Desire label
Go deeper

The Full Monographs Behind 2 Reduce Desire’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Glutamine

Interacts with 50 drugs

Glutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle cell disease complications, but for most...

Read the full Glutamine monograph → Herb & supplement monograph

Gamma-aminobutyric Acid (gaba)

Interacts with 419 drugs

GABA is a calming chemical messenger (neurotransmitter) that your body makes on its own, and it is sold as a supplement for stress, anxiety, and sleep. The science behind oral GABA supplemen...

Read the full Gamma-aminobutyric Acid (gaba) monograph → Herb & supplement monograph

Tyrosine

Interacts with 21 drugs

L-tyrosine is an amino acid your body uses to make brain chemicals like dopamine and norepinephrine. Some studies suggest it may help mental performance during short-term stress, sleep loss,...

Read the full Tyrosine monograph → Herb & supplement monograph

Ashwagandha

Interacts with 1,372 drugs

Ashwagandha is an Ayurvedic herb most often taken to help with stress, anxiety, and sleep, and some small studies suggest it may help, though the evidence is still limited. It is generally w...

Read the full Ashwagandha monograph → Herb & supplement monograph

Cowhage

Interacts with 193 drugs

Cowhage (Mucuna pruriens) is a tropical legume best known as a natural source of L-dopa, the compound the body turns into dopamine. It is most studied for Parkinson's disease symptoms and ma...

Read the full Cowhage monograph →
Sources

Sources & How We Checked

2 Reduce Desire's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 71 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Glutamine 11 references
  1. Miller AL. Therapeutic considerations of L-glutamine: a review of the literature. Altern Med Rev 1999;4:239-48..
  2. Bozzetti F, Biganzoli L, Gavazzi C, et al. Glutamine supplementation in cancer patients receiving chemotherapy: a double-blind randomized study. Nutrition 1997;13:748-51.. PubMed
  3. Mebane AH. L-Glutamine and mania. Am J Psychiatry 984;141:1302-3.
  4. Meldrum BS. Glutamate as a neurotransmitter in the brain: review of physiology and pathology. J Nutr 2000;130:1007S-15S.. PubMed
  5. Garlick PJ. Assessment of the safety of glutamine and other amino acids. J Nutr 2001;131:2556S-61S.. PubMed
  6. Chapman AG. Glutamate and epilepsy. J Nutr 2000;130:1043S-5S.. PubMed
  7. Ziegler TR. Glutamine supplementation in cancer patients receiving bone marrow transplantation and high dose chemotherapy. J Nutr 2001;131:2578S-84S.. PubMed
  8. Laviano A, Molfino A, Lacaria MT, Canelli A, De Leo S, Preziosa I, Rossi Fanelli F. Glutamine supplementation favors weight loss in nondieting obese female patients. A pilot study. Eur J Clin Nutr. 2014 Nov;68(11):1264-6. PubMed
  9. Endari (l-glutamine) [package insert]. Torrance, CA: Emmaus Medical,Inc; 2017.
  10. Niihara Y, Miller ST, Kanter J, et al. A Phase 3 Trial of l-Glutamine in Sickle Cell Disease. N Engl J Med 2018;379(3):226-35. doi: 10.1056/NEJMoa1715971.
  11. Ogden HB, Child RB, Fallowfield JL, et al. Gastrointestinal Tolerance of Low, Medium and High Dose Acute Oral l-Glutamine Supplementation in Healthy Adults: A Pilot Study. Nutrients. 2020;12(10):2953. PubMed

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Tyrosine 4 references
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Ashwagandha 32 references
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Cowhage 12 references
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