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L-tyrosine is a non-essential amino acid produced within the body through the conversion of the essential amino acid, phenylalanine. It is often used as a dietary supplement to support cognitive function, enhance focus, and mitigate stress by serving as a precursor for neurotransmitters like dopamine and norepinephrine.

Alpha-GPC (alpha-glycerylphosphorylcholine) is a natural compound found in small amounts in foods such as soy lecithin, and is also available as a dietary supplement. It is a source of choline, a nutrient that is important for brain health and function. Alpha-GPC is particularly known for its potential to improve cognitive function, particularly in the areas of memory and learning. It is also being studied for its potential to improve symptoms of Alzheimer's disease and other forms of dementia. Alpha-GPC is likely better absorbed and utilized in the body than other sources of choline as it is known to cross the blood-brain barrier. The choline provided from Alpha-GPC is also a precursor to acetylcholine, an important neurotransmitter for cognitive functions such as attention, memory, and learning.

Theanine, often referred to as L-theanine as that is the predominant isomer of theanine, is an amino acid commonly found in tea leaves, particularly in green tea. It is purported to increase levels of GABA, serotonin, and dopamine in the brain, which can help to reduce stress and anxiety. L-theanine may also promote a sense of calm and improve overall well-being. Some studies have also suggested that it may improve cognitive function, although more research is needed. Most reported drug interactions with theanine are due to its sedative effects.