Major interaction on record — check this product against your medications before combining. Check your meds →
Dietary supplement

AMP Pump XXX Fruit Punch Ingredients & Drug Interactions

by GNC Pro Performance

AMP Pump XXX Fruit Punch label
See full label image
Powder Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking AMP Pump XXX Fruit Punch against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

AMP Pump XXX Fruit Punch is a dietary supplement by GNC Pro Performance with 5 active ingredients. Its ingredients are commonly taken for preventing or treating low potassium (hypokalemia), supporting healthy blood pressure, muscle cramps.Based on those ingredients, 1,063 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Trans-Resveratrol, Cordiart Citrus fruit extract, L-Citrulline. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against AMP Pump XXX Fruit Punch by GNC Pro Performance

Ask about any prescription or over-the-counter medication and we check it for interactions with AMP Pump XXX Fruit Punch by GNC Pro Performance — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of AMP Pump XXX Fruit Punch by GNC Pro Performance

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 5 of its 5 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This powder contains five active ingredients. Potassium supports electrolyte balance.

L-citrulline is an amino acid that your body converts to another amino acid called L-arginine, which may help with blood flow and athletic performance. Creatine supports muscle energy and strength.

Cordiart Citrus fruit extract is a sweet orange extract. Trans-resveratrol is a plant compound found in grapes and berries.

The product also contains inactive ingredients — citric acid, natural and artificial flavors, sucralose, acesulfame potassium, potassium chloride, soy oil and lecithin blend, calcium silicate, and FD&C #40 (a food coloring) — which serve as fillers, binders, and flavoring.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: nitric oxide production and blood flow for muscle pumps.
  • We looked for evidence on: Athletic performance, Physical performance, Muscle strength, Erectile dysfunction (ED), Hypertension, Endothelial function — and 3 related terms.
  • The strongest evidence on file: Creatine is rated "Possibly Effective" for Athletic performance (Natural Medicines).
  • Also on file: Creatine is rated "Possibly Effective" for Muscle strength.
  • Also on file: L-citrulline is rated "Possibly Effective" for Athletic performance.

L-citrulline is possibly effective for athletic performance. Creatine is possibly effective for muscle strength, athletic performance, muscle loss (sarcopenia), and a rare condition called cerebral creatine deficiency syndromes.

Trans-resveratrol is possibly effective for obesity and allergic rhinitis (hay fever). The evidence for L-citrulline in cardiovascular disease, heart failure, and diabetes is insufficient to rate.

For trans-resveratrol in cardiovascular disease and high cholesterol, the evidence suggests it's possibly ineffective. Creatine appears possibly ineffective for Huntington disease and osteopenia.

The effectiveness data we hold doesn't cover potassium supplementation or Cordiart Citrus fruit extract for any condition.

The evidence, ingredient by ingredient Potassium L-citrulline Creatine Sweet Orange Resveratrol

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Potassium from a normal diet is fine, but supplements can cause dangerously high blood levels in some people, especially those with kidney disease — use supplements only under medical guidance. L-citrulline and creatine are generally well tolerated in healthy adults, though long-term safety of L-citrulline is not fully studied.

The most common side effects are gastrointestinal: with potassium, you may experience abdominal pain, nausea, diarrhea, or vomiting; with L-citrulline, heartburn or stomach discomfort; with creatine, dehydration, diarrhea, muscle cramps, or water retention. High potassium levels can rarely cause serious heart rhythm problems, low blood pressure, or confusion.

Sweet orange fruit is safe as food for most people, though concentrated extracts warrant caution. Resveratrol is generally well tolerated at typical doses, but may cause diarrhea or gastrointestinal discomfort at higher doses.

During pregnancy, dietary potassium is appropriate, but check with your doctor before using supplements. L-citrulline safety data is insufficient — it's best avoided during pregnancy.

Creatine safety during pregnancy has not been established, so avoid it. Trans-resveratrol is rated likely safe in pregnancy, and sweet orange fruit is likely safe; however, concentrated supplements of resveratrol lack safety data for pregnancy.

While breastfeeding, check with your doctor before using potassium supplements, and avoid L-citrulline and creatine — there isn't enough information to know they're safe.

Side effects, ingredient by ingredient Potassium L-citrulline Creatine Sweet Orange Resveratrol

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 4 of the 5 matched ingredients can interact with medications — Resveratrol, Potassium, Sweet Orange, L-citrulline.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 1,064 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your doctor or pharmacist if you take any of the following: blood pressure drugs (ACE inhibitors, ARBs, or potassium-sparing diuretics), pravastatin or other statins, blood thinners or antiplatelet drugs, phosphodiesterase-5 inhibitors (like sildenafil), antiparasitals like ivermectin, antihistamines like fexofenadine, beta-blockers like celiprolol, or quinolone antibiotics. These interactions range from Major to Moderate severity.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

If you're an athlete or looking to build muscle strength, the creatine and L-citrulline in this product may help, though the potassium and other ingredients are mainly present for taste and general support. Anyone taking blood pressure medications, statins, blood thinners, or drugs for parasitic infection should check their exact medications against the interaction tool before starting this product — the risks are real and sometimes serious.

If you have kidney disease or take potassium-sparing diuretics, talk with your doctor or pharmacist before using it, because extra potassium can be dangerous. Pregnant or breastfeeding women should discuss this product with their doctor or pharmacist before taking it.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 23, 2017.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about AMP Pump XXX Fruit Punch, straight from the product label.

Brand GNC Pro Performance
Barcode (UPC) 048107173463
Net contents 15.7 Oz(s); 444.6 Gram(s)
Market status On market
Date entered into DSLD Jun 23, 2017
DSLD ID 74583
Product type Other Combinations
Supplement form Powder
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for AMP Pump XXX Fruit Punch by GNC Pro Performance, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
14.82 Gram(s)
Maximum serving Sizes:
14.82 Gram(s)
Servings per container
30
UPC/BARCODE
048107173463
IngredientAmount% DV
Calories10 Calorie(s)--
Total Carbohydrates3 Gram(s)1%
Potassium60 mg1%
L-Citrulline3000 mg--
Total Sugars0 Gram(s)--
Creatine5000 mg--
Cordiart Citrus fruit extract500 mg--
Trans-Resveratrol30 mg--

Other ingredients: Citric Acid, Natural & Artificial flavors, Sucralose, Acesulfame Potassium, Potassium Chloride, Soy Oil & Lecithin Blend, Calcium Silicate, FD&C #40

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Pump XXX is a fully dosed, non-stimulant formula designed to fuel nitric oxide production and maximize blood flow for intense muscle pumps.

When used in conjunction with an exercise program.

Products bearing this logo have been tested for banned substances by LGC Science, Inc., a world-class anti-doping lab. Product was tested for over 145 banned substances on the 2017 World Anti-Doping Agency (WADA) Prohibited List via LGC skip lot testing protocol #ICP0307. See gnc.com for more information.

Fuels nitric oxide production for intense muscle pumps Enhances strength, performance & power output

Clinically researched

Natural + artificial flavors

30 servings

Notice: Significant produced settling may occur.

Formula

Includes: - Cordiart Citrus fruit extract is clinically researched to enhance power output. -L-Arginine and L-Citrulline fuel nitric oxide production, an important signaling molecule that regulates blood flow. -resVida Resveratrol is clinically shown to enhance blood vessel dilation for maximum blood flow. -Creatine helps fuel muscle energy for athletic power, strength and performance.

5g Creatine 500mg Cordiart 3g L-Citrulline

Contains: Soy.

Brand IP Statement(s)

In a randomized, double-blind, placebo-controlled, crossover study, 19 volunteers consumed 3 doses of resVida (30 mg, 90 mg, 270 mg) and a placebo at weekly intervals. Flow-mediated dilation (FMD) of the brachial artery was measured one hour after ingestion of each treatment and was significantly increased at all 3 doses relative to placebo. 30 mg of resVida demonstrated 2.5% greater increased in FMD relative to placebo.

Cordiart is a trademark of BioActor.

resVida is a trademark of DSM.

Seals/Symbols

Informed Choice.org Trusted by sport

Banned substance free

GF Gluten free

Formulation

Zero stimulants & zero sugar

GF Gluten free

FDA Statement of Identity

Dietary Supplement

General

Code 369896 HRG

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, mix one scoop (14.82 g) into 8-10 fl.oz. of cold water. Take prior to exercise. Use PUMP XXX in addition to your existing regimen. Consume ample amounts of water while taking this product.

Precautions

Contains: Soy.

Warning: Consult your physician prior to using this product if you are pregnant, nursing, taking medication, under 18 years or age or have a medical condition.

Warning: Consult your physician prior to using this product if you are pregnant, nursing, taking medication, under 18 years or age or have a medical condition.

Discontinue use two weeks prior to surgery.

Keep out of reach of children.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Storage

Store in a cool, dry place.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

AMP Pump XXX Fruit Punch by GNC Pro Performance label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

AMP Pump XXX Fruit Punch label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in AMP Pump XXX Fruit Punch by GNC Pro Performance

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size14.82 Gram(s) Dosage formPowder Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Potassium

Interacts with
62 drugs
60 mg per serving

Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanc...

Potassium monograph & interactions

L-Citrulline

Interacts with
178 drugs
3000 mg per serving

L-citrulline is an amino acid that the body turns into L-arginine to help make nitric oxide, which relaxes blood vessels and may improve blood flow. I...

L-Citrulline monograph & interactions

Creatine

No known
interactions
5000 mg per serving Form: Creatine Hydrochloride, Creatine Monohydrate

Creatine is one of the most studied sports supplements, with solid evidence that it can boost strength and performance during short, high-intensity ac...

Creatine monograph & interactions

Cordiart Citrus fruit extract

Interacts with
246 drugs
500 mg per serving Form: Rutinoside

Sweet orange is a common citrus fruit that is a good source of vitamin C, fiber, and antioxidants, and is enjoyed as a food worldwide. Its peel and es...

Cordiart Citrus fruit extract monograph & interactions

Trans-Resveratrol

Interacts with
822 drugs
30 mg per serving

Resveratrol is a plant compound found in red grapes, berries, and peanuts that is popular for heart health, anti-aging, and antioxidant support. While...

Trans-Resveratrol monograph & interactions

Other (inactive) ingredients: Citric Acid, Natural & Artificial flavors, Sucralose, Acesulfame Potassium, Potassium Chloride, Soy Oil & Lecithin Blend, Calcium Silicate, FD&C #40. These complete the product’s ingredient list but are not active constituents.

Interaction report

AMP Pump XXX Fruit Punch by GNC Pro Performance Drug Interactions

Want to check YOUR meds against AMP Pump XXX Fruit Punch?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,063Drugs
48 Major 1,015 Moderate

Ingredients driving the most interactions

Trans-Resveratrol 822
Cordiart Citrus fruit extract 246
L-Citrulline 178
Potassium 62

Individual Drug Interactions

The ingredients in AMP Pump XXX Fruit Punch interact with 1,063 drugs. Click any drug to see the details.

4 of the 5 ingredients in AMP Pump XXX Fruit Punch interact with drugs. Each result below shows which ingredient is responsible. Trans-Resveratrol Cordiart Citrus fruit extract L-Citrulline Potassium

Each ingredient & the kinds of drugs it affects

For each ingredient in AMP Pump XXX Fruit Punch with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Trans-Resveratrol5 drug types · 822 drugs

Anticoagulant/Antiplatelet Drugs

Resveratrol may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Resveratrol seems to have antiplatelet effects.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, resveratrol might increase levels of drugs metabolized by CYP1A2.
In vitro research shows that resveratrol can inhibit CYP1A2 enzymes. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, resveratrol might increase levels of drugs metabolized by CYP2C19.
In vitro research shows that resveratrol can inhibit CYP2C19 enzymes. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2E1 (Cyp2E1) Substrates

Resveratrol might increase levels of drugs metabolized by CYP2E1.
In vitro research suggests that resveratrol inhibits CYP2E1 isoenzyme. Also, a pharmacokinetic study shows that taking resveratrol 500 mg daily for 10 days prior to taking a single dose of chlorzoxazone 250 mg increases the maximum concentration of chlorzoxazone by about 54%, the area under the curve of chlorzoxazone by about 72%, and the half-life of chlorzoxazone by about 35%. Chlorzoxazone is used as a probe drug for CYP2E1.

Likelihood Probable Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, resveratrol might increase levels of drugs metabolized by CYP3A4.
In vitro research shows that resveratrol can inhibit the CYP3A4 enzyme. However, clinical research shows that taking resveratrol 3000 mg daily for 8 weeks does not necessitate dose adjustments to medications metabolized by CYP3A4.

Likelihood Possible Evidence D
Trans-Resveratrol full monograph & interactions

Cordiart Citrus fruit extract7 drug types · 246 drugs

Celiprolol (Celicard)

Consuming sweet orange with celiprolol can decrease oral absorption of celiprolol.
A pharmacokinetic study in healthy volunteers shows that celiprolol levels, after a single dose of 100 mg, are decreased by up to 90% in people who drink sweet orange juice 200 mL three times daily. It's not known if lower consumption of sweet orange juice will have the same effect. Theoretically, this occurs due to short-term inhibition of organic anion transporting polypeptide (OATP). Recommend separating drug administration and consumption of sweet orange by at least 4 hours.

Likelihood Likely Evidence B
Ivermectin (Stromectol, Others)

Consuming sweet orange juice with ivermectin can decrease the oral absorption of ivermectin.
A pharmacokinetic study in healthy volunteers shows that taking ivermectin orally with sweet orange juice 750 mL over 4 hours reduces the bioavailability of ivermectin. This effect does not seem to be related to effects on P-glycoprotein. The effect on ivermectin is more pronounced in males compared to females.

Likelihood Likely Evidence B
Organic Anion-Transporting Polypeptide Substrates (Oatp)

Consuming sweet orange juice can decrease oral absorption of OATP substrates. Separate administration by at least 4 hours.
Clinical research shows that consuming sweet orange juice inhibits OATP, which reduces bioavailability of oral drugs that are substrates of OATP. For example, sweet orange juice decreases bioavailability of fexofenadine, a substrate of OATP, by about 72% and of celiprolol, another OATP substrate, by up to 90%. Since sweet orange juice seems to affect OATP for a short time, recommend separating drug administration and consumption of sweet orange juice by at least 4 hours.

Likelihood Likely Evidence B
Pravastatin (Pravachol)

Consuming sweet orange juice with pravastatin can increase the absorption of pravastatin.
A small pharmacokinetic study in healthy volunteers shows that consuming sweet orange juice 800 mL over 3 hours, including before, during, and after taking pravastatin 10 mg, increases pravastatin levels by about 149%, without affecting pravastatin elimination. Theoretically this effect might be due to modulation of organic anion transporting polypeptides (OATPs) by sweet orange juice. Sweet orange juice does not seem to affect simvastatin levels, but it is not known if sweet orange affects any of the other statins.

Likelihood Likely Evidence B
Fexofenadine (Allegra)

Consuming sweet orange juice with fexofenadine can decrease oral absorption of fexofenadine.
Clinical research shows that coadministration of sweet orange juice 1200 mL decreases bioavailability of fexofenadine by about 72%. In an animal model, sweet orange juice decreased bioavailability of fexofenadine by 31%. Fexofenadine manufacturer data indicates that concomitant administration of sweet orange juice and fexofenadine results in larger wheal and flare sizes in research models. This suggests that sweet orange reduces the clinical response to fexofenadine. Theoretically, this occurs due to short-term inhibition of organic anion transporting polypeptide (OATP). Recommend separating drug administration and consumption of sweet orange by at least 4 hours.

Likelihood Likely Evidence B
P-Glycoprotein Substrates

Sweet orange juice seems to modulate P-glycoprotein (P-gp), which might affect the blood levels of P-gp substrates.
Animal and in vitro research suggest that orange juice extract inhibits drug efflux by P-gp, increasing absorption and levels of P-gp substrates. In contrast, pharmacokinetic research in humans shows that drinking large amounts of sweet orange juice decreases absorption and levels of the P-gp substrate celiprolol. This suggests that orange juice actually induces drug efflux by P-gp or affects drug levels by another mechanism such as inhibiting the gut drug transporter called organic anion transporting polypeptide (OATP). Until more is known, sweet orange juice should be used cautiously in people taking P-gp substrates.

Likelihood Possible Evidence B
Quinolone Antibiotics

Calcium-fortified sweet orange juice might reduce quinolone absorption.
Calcium binds to quinolones in the gut. Theoretically, the calcium in certain fortified orange juices can also bind to quinolone antibiotics and reduce their absorption and levels.

Likelihood Possible Evidence D
Cordiart Citrus fruit extract full monograph & interactions

L-Citrulline2 drug types · 178 drugs

Antihypertensive Drugs

Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
L-citrulline is converted to L-arginine, which can increase nitric oxide and cause vasodilation. However, a meta-analysis of 5 small clinical studies suggests that taking L-citrulline 3-6 grams daily for 1-8 weeks does not lower blood pressure when compared with control.

Likelihood Possible Evidence B
Phosphodiesterase-5 Inhibitors

Theoretically, concurrent use of phosphodiesterase-5 (PDE-5) inhibitors and L-citrulline might result in additive vasodilation.
L-citrulline is converted to L-arginine, which can increase nitric oxide and cause vasodilation. Theoretically, taking L-arginine with PDE-5 inhibitors might have additive vasodilatory and hypotensive effects. However, in studies evaluating the combined use of L-arginine and sildenafil for erectile dysfunction, hypotension was not reported.

Likelihood Possible Evidence D
L-Citrulline full monograph & interactions

Potassium3 drug types · 62 drugs

Ace Inhibitors (Aceis)

Using ACEIs with high doses of potassium increases the risk of hyperkalemia.
ACEIs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C
Angiotensin Receptor Blockers (Arbs)

Using ARBs with high doses of potassium increases the risk of hyperkalemia.
ARBs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C
Potassium-Sparing Diuretics

Concomitant use increases the risk of hyperkalemia.
Using potassium-sparing diuretics with potassium supplements increases the risk of hyperkalemia.

Likelihood Likely Evidence C
Potassium full monograph & interactions
The maker

Brand information

Manufacturer and brand details for AMP Pump XXX Fruit Punch, from the product label.

GNC Pro Performance

See all GNC Pro Performance products
Name
General Nutrition Corporation
City
Pittsburgh
State
PA
ZipCode
15222
Phone Number
1-888-462-2548
Web Address
gnc.com
Pharmacist Counseling Corner

AMP Pump XXX Fruit Punch by GNC Pro Performance: Common Questions

Does AMP Pump XXX Fruit Punch by GNC Pro Performance interact with any medications?
Yes. Based on its ingredients, AMP Pump XXX Fruit Punch has a known interaction with 1,063 medications, including 48 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
AMP Pump XXX Fruit Punch contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this product contain any fillers or other inactive ingredients?
Yes — it contains several inactive ingredients including citric acid, artificial and natural flavors, sucralose, acesulfame potassium, potassium chloride, soy oil and lecithin blend, calcium silicate, and FD&C #40 (a food coloring). These serve as sweeteners, binders, and flavoring agents.
Is potassium in this product safe if I have normal kidney function?
Potassium from a normal diet is fine, but supplements can raise blood levels dangerously in some people — especially those with kidney disease. If you have any kidney concerns or take blood pressure medications, check with your doctor or pharmacist before using this product.
Can I take this while pregnant or breastfeeding?
It depends on the ingredient. Trans-resveratrol and sweet orange fruit are rated likely safe during pregnancy, but potassium supplements should only be used under medical guidance during pregnancy. L-citrulline and creatine safety data is insufficient — the safety notes advise avoiding them. While breastfeeding, potassium supplements need doctor approval, and L-citrulline and creatine should be avoided. Talk with your doctor or pharmacist for personalized advice.
What are the most common side effects of this product?
The main ingredients can cause gastrointestinal symptoms: potassium may cause abdominal pain, nausea, diarrhea, or vomiting; L-citrulline and resveratrol may cause heartburn, stomach discomfort, or diarrhea; creatine may cause dehydration, diarrhea, muscle cramps, or water retention. These are generally mild and reported in a small number of users.
Does creatine interact with any medications?
No interactions are documented in our data for creatine. However, those with kidney disease should be cautious, as creatine is processed by the kidneys — talk with your doctor or pharmacist if you have any kidney concerns.
Is trans-resveratrol effective for heart health?
The evidence suggests trans-resveratrol is possibly ineffective for cardiovascular disease and high cholesterol. It is possibly effective for obesity and allergic rhinitis (hay fever), based on the data we hold.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if AMP Pump XXX Fruit Punch is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

AMP Pump XXX Fruit Punch label
Go deeper

The Full Monographs Behind AMP Pump XXX Fruit Punch’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Potassium

Interacts with 62 drugs

Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanced diet rich in fruits and vegetables. P...

Read the full Potassium monograph → Herb & supplement monograph

L-citrulline

Interacts with 178 drugs

L-citrulline is an amino acid that the body turns into L-arginine to help make nitric oxide, which relaxes blood vessels and may improve blood flow. It is popular for exercise performance an...

Read the full L-citrulline monograph → Herb & supplement monograph

Creatine

Creatine is one of the most studied sports supplements, with solid evidence that it can boost strength and performance during short, high-intensity activities like weightlifting and sprintin...

Read the full Creatine monograph → Herb & supplement monograph

Sweet Orange

Interacts with 246 drugs

Sweet orange is a common citrus fruit that is a good source of vitamin C, fiber, and antioxidants, and is enjoyed as a food worldwide. Its peel and essential oil are used in aromatherapy and...

Read the full Sweet Orange monograph → Herb & supplement monograph

Resveratrol

Interacts with 822 drugs

Resveratrol is a plant compound found in red grapes, berries, and peanuts that is popular for heart health, anti-aging, and antioxidant support. While lab and animal studies are promising, s...

Read the full Resveratrol monograph →
Sources

Sources & How We Checked

AMP Pump XXX Fruit Punch's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 147 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Potassium 12 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Gennaro A. Remington: The Science and Practice of Pharmacy. 19th ed. Lippincott: Williams & Wilkins, 1996.
  3. Whelton PK, He J, Cutler JA, et al. Effects of oral potassium on blood pressure. Meta-analysis of randomized controlled clinical trials. JAMA 1997;277:1624-32. PubMed
  4. Phillips, C. O., Kashani, A., Ko, D. K., Francis, G., and Krumholz, H. M. Adverse effects of combination angiotensin II receptor blockers plus angiotensin-converting enzyme inhibitors for left ventricular dysfunction: a quantitative review of data from ra DOI
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Creatine 86 references
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Sweet Orange 17 references
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  15. la, Porte C., Voduc, N., Zhang, G., Seguin, I., Tardiff, D., Singhal, N., and Cameron, D. W. Steady-State pharmacokinetics and tolerability of trans-resveratrol 2000 mg twice daily with food, quercetin and alcohol (ethanol) in healthy human subjects. Cli PubMed
  16. Brown, V. A., Patel, K. R., Viskaduraki, M., Crowell, J. A., Perloff, M., Booth, T. D., Vasilinin, G., Sen, A., Schinas, A. M., Piccirilli, G., Brown, K., Steward, W. P., Gescher, A. J., and Brenner, D. E. Repeat dose study of the cancer chemopreventive
  17. Pendurthi, U. R., Williams, J. T., and Rao, L. V. Resveratrol, a polyphenolic compound found in wine, inhibits tissue factor expression in vascular cells : A possible mechanism for the cardiovascular benefits associated with moderate consumption of wine. PubMed
  18. Chachay VS, Macdonald GA, Martin JH, Whitehead JP, O'Moore-Sullivan TM, Lee P, Franklin M, Klein K, Taylor PJ, Ferguson M, Coombes JS, Thomas GP, Cowin GJ, Kirkpatrick CM, Prins JB, Hickman IJ. Resveratrol does not benefit patients with nonalcoholic fatty
  19. Bedada SK, Neerati P. Resveratrol Pretreatment Affects CYP2E1 Activity of Chlorzoxazone in Healthy Human Volunteers. Phytother Res. 2016;30(3):463-8. PubMed
  20. Lin CT, Sun XY, Lin AX. Supplementation with high-dose trans-resveratrol improves ultrafiltration in peritoneal dialysis patients: a prospective, randomized, double-blind study. Ren Fail. 2016;38(2):214-21. PubMed
  21. Li Q, Yang G, Xu H, Tang S, Lee WY. Effects of resveratrol supplementation on bone quality: a systematic review and meta-analysis of randomized controlled trials. BMC Complement Med Ther 2021;21(1):214. PubMed
  22. McCreary MR, Schnell PM, Rhoda DA. Randomized double-blind placebo-controlled proof-of-concept trial of resveratrol for outpatient treatment of mild coronavirus disease (COVID-19). Sci Rep 2022;12(1):10978. PubMed
  23. Abdelhaleem IA, Brakat AM, Adayel HM, Asla MM, Rizk MA, Aboalfetoh AY. The effects of resveratrol on glycemic control and cardiometabolic parameters in patients with T2DM: A systematic review and meta-analysis. Med Clin (Barc) 2022;158(12):576-585. PubMed
  24. Badaoui A. Allergic contact dermatitis to resveratrol and Scutellaria baicalensis root extract in a cosmetic product. Contact Dermatitis 2022.

See these in context on the Resveratrol monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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