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Dietary supplement

Artemisinin SAP Ingredients & Drug Interactions

by NFH

Artemisinin SAP label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Artemisinin SAP against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Artemisinin SAP is a dietary supplement by NFH with 1 active ingredient. Its ingredients are commonly taken for malaria (traditional), fever, inflammation.Based on those ingredients, 889 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Sweet Wormwood Herb Top Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Artemisinin SAP by NFH

Ask about any prescription or over-the-counter medication and we check it for interactions with Artemisinin SAP by NFH — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Artemisinin SAP by NFH

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Artemisinin SAP is a single-ingredient product — just Sweet Wormwood Herb Top Extract, also called Sweet Annie. The extract comes in a vegetable capsule with a few inactive ingredients (magnesium stearate, silicon dioxide, hypromellose, and purified water) that help hold it together.

Sweet Annie contains artemisinin, a compound traditionally used in herbal medicine, though the extract itself is a mix of multiple plant constituents that may work differently than artemisinin alone.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

We hold no graded evidence for this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: gastrointestinal health, immunity and cellular health.
  • Our graded evidence for these ingredients doesn't cover that particular purpose.

The evidence for Sweet Annie is mixed and limited. It's possibly effective for allergic rhinitis (hay fever), though even that rating reflects modest data.

For nonalcoholic fatty liver disease (a form of liver disease without alcohol use), malaria, and osteoarthritis, there isn't enough reliable evidence to say whether it works. This product is not a proven treatment for any condition — talk with your doctor about whether it fits your health goals.

The evidence, ingredient by ingredient Sweet Annie

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Taken by mouth, Sweet Annie is generally well tolerated, though nausea and vomiting do occur in some people. More rarely, it can damage the liver (hepatotoxicity) — one documented case involved liver inflammation (hepatitis) after 10 days of use; symptoms resolved after stopping.

One mild allergic reaction (rash and cough) has been reported. The product should be used short-term only, and you should know that quality and dose vary widely between brands and batches.

The safety data advises against use during pregnancy because of possible harm to the developing baby. There isn't enough information to know whether it's safe while breastfeeding, so avoid it then as well.

Talk with your doctor or pharmacist if you're pregnant, planning pregnancy, or nursing and want to take this product.

Side effects, ingredient by ingredient Sweet Annie

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Sweet Annie.
  • The most serious interaction on file is rated Moderate.
  • For scale: 890 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this product, double-check your medications with your doctor or pharmacist if you take any drugs that can damage the liver (hepatotoxic drugs) or any medications processed by the liver enzymes CYP3A4 or CYP2B6 — a large group that includes many common prescriptions. Sweet Annie may raise or lower their levels unpredictably, which could reduce their effectiveness or cause side effects.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Artemisinin SAP may be worth considering if you have hay fever and want to explore herbal options, but the evidence is modest. Because this product affects how your liver processes many common medications and carries a small risk of liver damage itself, anyone on prescription drugs or with liver concerns should check with their doctor or pharmacist before starting it.

If you're pregnant, breastfeeding, or planning pregnancy, avoid it — the data advises against use in those situations.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Mar 22, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Artemisinin SAP, straight from the product label.

Brand NFH
Barcode (UPC) 856711111661
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Mar 22, 2023
DSLD ID 273581
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Artemisinin SAP by NFH, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
UPC/BARCODE
856711111661
IngredientAmount% DV
Sweet Wormwood Herb Top Extract500 mg--

Other ingredients: Vegetable Magnesium Stearate, Silicon Dioxide, Vegetable Hypromellose, Water, Purified

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Artemisinin SAP supports gastrointestinal health, promotes immunity and cellular health. Enhances antioxidant status. Antimicrobial.

All ingredients listed for this product lot number have been tested by a third-party laboratory for identity, potency, and purity.

Contains no: Gluten, soy, wheat, corn, eggs, dairy, yeast, citrus, preservatives, artificial flavor or color, starch, or sugar.

This product is non-GMO.

Color, size and smell may vary from one lot to another.

Cellular health and detox support

Made in Canada

Suggested/Recommended/Usage/Directions

Directions for use: Adults: Take 1 capsule one to two times daily or as directed by your healthcare practitioner. Consult a healthcare practitioner for use beyond 7 days. For occasional use only.

Precautions

Cautions and warnings: Consult a healthcare practitioner if symptoms persist or worsen.

Known adverse reactions: May cause gastric upset, dizziness, or headache, in which case discontinue use and consult a healthcare practitioner.

Hypersensitivity / allergy has been known to occur, in which case, discontinue use.

Do not use if seal is broken.

Keep out of reach of children.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is mot intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Artemisinin SAP by NFH label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Artemisinin SAP label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Artemisinin SAP by NFH

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Sweet Wormwood Herb Top Extract

Interacts with
889 drugs
500 mg per serving Form: Artemisinin

Sweet Annie (Artemisia annua) is the source of artemisinin, a compound used in prescription antimalarial drugs. While the purified drug is well studie...

Sweet Wormwood Herb Top Extract monograph & interactions

Other (inactive) ingredients: Vegetable Magnesium Stearate, Silicon Dioxide, Vegetable Hypromellose, Water, Purified. These complete the product’s ingredient list but are not active constituents.

Interaction report

Artemisinin SAP by NFH Drug Interactions

Want to check YOUR meds against Artemisinin SAP?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
889Drugs
889 Moderate

Ingredients driving the most interactions

Sweet Wormwood Herb Top Extract 889

Individual Drug Interactions

The ingredients in Artemisinin SAP interact with 889 drugs. Click any drug to see the details.

1 of the 1 ingredient in Artemisinin SAP interact with drugs. Each result below shows which ingredient is responsible. Sweet Wormwood Herb Top Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Artemisinin SAP with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Sweet Wormwood Herb Top Extract3 drug types · 889 drugs

Cytochrome P450 2B6 (Cyp2B6) Substrates

Sweet Annie may alter plasma levels and clinical effects of drugs metabolized by CYP2B6.
In vitro research shows that the Sweet Annie constituent artemisinin induces CYP2B6, possibly increasing CYP2B6 activity by 1.6-fold. However, Sweet Annie extract seems to inhibit the activity of CYP2B6 in vitro, suggesting that other constituents of Sweet Annie play a role in its effects on the overall activity of this enzyme. More information is needed to determine whether taking Sweet Annie extract affects the metabolism of CYP2B6 substrates.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Sweet Annie may alter plasma levels and clinical effects of drugs metabolized by CYP3A4.
In vitro research shows that the Sweet Annie constituent artemisinin induces CYP3A4, possibly increasing CYP3A4 activity by 1.9-fold. However, Sweet Annie extract seems to inhibit the activity of CYP3A4 in vitro, suggesting that other constituents of Sweet Annie play a role in its effects on the overall activity of this enzyme. More information is needed to determine whether taking Sweet Annie extract affects the metabolism of CYP3A4 substrates.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, concomitant use might have additive adverse hepatotoxic effects.
There is some concern that Sweet Annie can adversely affect the liver.

Likelihood Possible Evidence D
Sweet Wormwood Herb Top Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Artemisinin SAP, from the product label.

NFH

See all NFH products
Name
NFH - Nutritional Fundamentals for Health, Inc.
Street Address
351 Rue Joseph-Carrier
City
Vaudreuil
State
QC
ZipCode
J7V 5V5
Phone Number
1 866 510-3123
Web Address
nfh.ca
Pharmacist Counseling Corner

Artemisinin SAP by NFH: Common Questions

Does Artemisinin SAP by NFH interact with any medications?
Yes. Based on its ingredients, Artemisinin SAP has a known interaction with 889 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Artemisinin SAP contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does Sweet Annie actually work for anything?
The evidence is modest. It's possibly effective for hay fever (allergic rhinitis), meaning some research supports it but the data is limited. For liver disease, malaria, and arthritis, there isn't enough reliable evidence to say whether it works. This product shouldn't replace proven treatments your doctor has recommended.
Can I take this while I'm on other medications?
Probably not without checking first. This product interacts with a very large number of common medications — it affects how your liver processes them, which can make them stronger, weaker, or less predictable. Talk with your doctor or pharmacist about your specific drugs before starting.
Is Sweet Annie safe for my liver?
Generally yes, but it's not risk-free. Most people tolerate it well, but liver damage (hepatotoxicity) has been reported rarely, and one case of liver inflammation was documented after 10 days of use. You should definitely avoid this product if you're taking drugs that can damage the liver, and talk with your doctor if you have any liver disease.
What are the common side effects?
Nausea and vomiting are the most common. One mild allergic reaction (rash and cough) has been reported, and if you're allergic to Sweet Annie, numbness of the tongue or throat itching may occur. Stop and talk with your pharmacist if you experience any of these.
Can I take this if I'm pregnant or breastfeeding?
No — the safety data advises against use during pregnancy because of possible harm to the developing baby. There also isn't enough information to know whether it's safe while breastfeeding. If you're in either situation and interested in this product, talk with your doctor or pharmacist for personalized advice.
How long should I take this product?
It's generally used short-term only, not long-term. Quality and dose vary widely between brands, so you should also talk with your doctor about how long is appropriate for your situation and whether this is the right product for you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Artemisinin SAP label
Go deeper

The Full Monographs Behind Artemisinin SAP’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Sweet Annie

Interacts with 889 drugs

Sweet Annie (Artemisia annua) is the source of artemisinin, a compound used in prescription antimalarial drugs. While the purified drug is well studied for malaria, the herb itself as a supp...

Read the full Sweet Annie monograph →
Sources

Sources & How We Checked

Artemisinin SAP's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 11 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Sweet Annie 11 references
  1. Mueller MS, Karhagomba IB, Hirt HM, Wemakor E. The potential of Artemisia annua L. as a locally produced remedy for malaria in the tropics: agricultural, chemical and clinical aspects. J Ethnopharmacol 2000;73:487-93. PubMed
  2. Rath K, Taxis K, Walz G, et al. Pharmacokinetic study of artemisinin after oral intake of a traditional preparation of Artemisia annua L. (annual wormwood). Am J Trop Med Hyg 2004;70:128-32. DOI
  3. Centers for Disease Control and Prevention (CDC). Hepatitis temporally associated with an herbal supplement containing artemisinin-Washington, 2008. MMWR Morb Mortal Wkly Rep 2009;58:854-8.
  4. Xing J, Kirby BJ, Whittington D, et al. Evaluation of P450 inhibition and induction by artemisinin antimalarials in human liver microsomes and primary human hepatocytes. Drug Metabl Dispos 2012;40(9):1757-64. PubMed
  5. Savage RL, Hill GR, Barnes J, Kenyon SH, Tatley MV. Suspected hepatotoxicity with a supercritical carbon dioxide extract of Artemisia annua in grapeseed oil used in New Zealand. Front Pharmacol. 2019;10:1448. PubMed
  6. Ruperti-Repilado FJ, Haefliger S, Rehm S, et al. Danger of herbal tea: a case of acute cholestatic hepatitis due to Artemisia annua tea. Front Med (Lausanne). 2019;6:221. PubMed
  7. Yang J, Shen Z, Liu L, et al. Clinical efficacy and safety of Artesimia annua-Sublingual immunotherapy in seasonal allergic rhinitis patients based on different intervention time. Int Arch Allergy Immunol 2022;183(8):852-859.
  8. Kane NF, Kiani BH, Desrosiers MR, Towler MJ, Weathers PJ. Artemisia extracts differ from artemisinin effects on human hepatic CYP450s 2B6 and 3A4 in vitro. J Ethnopharmacol 2022. DOI
  9. Feng Y, Cao Y, Liu Y, et al. Clinical efficacy and safety of coseasonal initiation of Artemisia annua sublingual immunotherapy on patients with Artemisia-induced rhinoconjunctivitis. Am J Otolaryngol 2023;44(5):103942. PubMed
  10. Yang J, Wang W, Shen Z, et al. Efficacy and safety of Artemisia annua sublingual immunotherapy in patients with seasonal allergic rhinoconjunctivitis over two pollen seasons. Eur Arch Otorhinolaryngol. 2023;280(11):4939-4947. PubMed
  11. Shen Z, Zhang P, Kang W, et al. Clinical efficacy in one-year treatment with Artemisia annua-SLIT drops in monosensitized and polysensitized individuals. Am J Otolaryngol 2023;44(6):104002. PubMed

See these in context on the Sweet Annie monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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