No known drug interactions for the matched ingredients — not a guarantee none exist. Check your meds →
Dietary supplement

Best Benfotiamine 80 mg Ingredients & Drug Interactions

by Doctor's Best

Capsule Category: Vitamin
No known interaction
The interaction bottom line No known interaction

Best Benfotiamine 80 mg is a dietary supplement by Doctor's Best with 1 active ingredient. Its ingredients are commonly taken for diabetic nerve pain (neuropathy), supporting healthy nerve function, thiamine deficiency.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.

HelloPharmacist Scorecard of Best Benfotiamine 80 mg by Doctor's Best

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: benfotiamine, a form of thiamine (vitamin B1) at 80 mg per capsule. Benfotiamine is a modified version of thiamine that may be absorbed differently in your body than regular B1.

The remaining ingredients are inactive — microcrystalline cellulose, modified cellulose, and silicon dioxide — which help form and fill the capsule.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: helps promote nerve health.
  • We looked for evidence on: Diabetic neuropathy, Peripheral neuropathy, neuropathic pain, nerve function.
  • The strongest evidence on file: Benfotiamine is rated "Possibly Effective" for Diabetic neuropathy (Natural Medicines).
  • Also on file: Benfotiamine is rated "Insufficient Reliable Evidence To Rate" for Peripheral neuropathy.

The evidence for benfotiamine is mixed and limited. It's rated possibly effective for diabetic neuropathy (nerve pain from diabetes).

For diabetic nephropathy (kidney damage from diabetes), the evidence suggests it's probably not effective. For other uses — alcohol use disorder, Alzheimer disease, and peripheral neuropathy — we don't have enough reliable evidence yet to say whether it works.

The evidence, ingredient by ingredient Benfotiamine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Benfotiamine is generally well tolerated in the studies we have, but long-term safety hasn't been fully studied, so we can't say much about what happens if you take it for years. In one trial of 98 people taking 300–600 mg daily for 6 weeks, a small number reported allergic skin reactions and mild stomach discomfort, at rates no different from placebo.

There isn't enough safety data on benfotiamine during breastfeeding, so caution is advised if you're nursing — talk with your doctor or pharmacist before starting. Pregnancy safety data also isn't on file, so discuss it with your healthcare provider if you're pregnant or planning to be.

Side effects, ingredient by ingredient Benfotiamine

Meds to double-check

No known interactions
Known Interaction Concern · database check
No known interactions

No medication interactions are currently documented for the matched ingredients — that isn't a guarantee none exist.

Why this rating?
  • None of the 1 matched ingredient has a documented medication interaction on file.

No interactions are documented in our data for benfotiamine. Use the search tool on this page to check your specific medications anyway — it's the safest step before you start.

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. No medication interactions are currently documented, and safety information is well characterized.

Best Benfotiamine is an option if you're looking at possibly effective support for diabetic nerve pain and want to try a B1 variant, but the evidence isn't strong and long-term safety is unclear. If you're pregnant, breastfeeding, or have any chronic condition, check with your doctor or pharmacist before starting.

No interactions are documented, but run your medications through the tool to be thorough.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 24, 2016.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Best Benfotiamine 80 mg, straight from the product label.

Brand Doctor's Best
Barcode (UPC) 753950001220
Net contents 120 Veggie Cap(s)
Market status On market
Date entered into DSLD Jun 24, 2016
DSLD ID 62231
Product type Vitamin
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Best Benfotiamine 80 mg by Doctor's Best, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
120
UPC/BARCODE
753950001220
IngredientAmount% DV
Benfotiamine80 mg--

Other ingredients: Microcrystalline Cellulose, Modified Cellulose, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Benfotiamine (S-benzoylthiamine-O-monophosphate) is a derivative of thiamin (Vitamin B1). Benfotiamine is fat-soluble and more bioavailable than thiamin. Benfotiamine raises the blood level of thiamin diphosphate (TDP), the most biologically active co-enzyme of thiamin, which is an essential cofactor for three enzymes involved in energy production* Helps maintain healthy glucose metabolism* Heps control formation of Advanced Glycation Endproducts (AGEs)* Helps support nerve integrity and function*

HELPS PROMOTE NERVE HEALTH

CONTAINS NOTHING OTHER THAN LISTED INGREDIENTS

Scan for more info

Brand IP Statement(s)

BenfoPure is a registered trademark of Hamari Chemicals Ltd., Japan.

Science-Based Nutrition

BenfoPure

FDA Disclaimer Statement

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Formula

Japanese Benfotiamine

Suggested/Recommended/Usage/Directions

Suggested Adult Use: Take 1 capsule twice daily, with or without food, or as recommended by a nutritionally-informed physician.

Formulation

Non-GMO / Gluten Free

Vegan

General

YDRB122-1

Seals/Symbols

Vegan

See for yourself

Best Benfotiamine 80 mg by Doctor's Best label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Best Benfotiamine 80 mg by Doctor's Best

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container120 Amounts shown are per serving.

Benfotiamine

No known
interactions
80 mg per serving

Benfotiamine is a man-made, fat-soluble form of vitamin B1 (thiamine) that the body may absorb more easily than regular thiamine. It is mostly studied...

Benfotiamine monograph & interactions

Other (inactive) ingredients: Microcrystalline Cellulose, Modified Cellulose, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Best Benfotiamine 80 mg by Doctor's Best Drug Interactions

We don’t currently list any known drug interactions for the mapped ingredients in Best Benfotiamine 80 mg. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.

The maker

Brand information

Manufacturer and brand details for Best Benfotiamine 80 mg, from the product label.

Doctor's Best

See all Doctor's Best products
Name
Doctor's Best, Inc.
City
San Clemente
State
CA
ZipCode
92673
Phone Number
(800) 777-2474
Web Address
www.drbvitamins.com
Pharmacist Counseling Corner

Best Benfotiamine 80 mg by Doctor's Best: Common Questions

Does Best Benfotiamine 80 mg by Doctor's Best interact with any medications?
We do not currently list a known interaction for the mapped ingredients in Best Benfotiamine 80 mg. This does not guarantee none exist, so confirm with your pharmacist.
How can one product interact with so many drugs?
Best Benfotiamine 80 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is benfotiamine and how is it different from regular B1?
Benfotiamine is a modified form of thiamine (vitamin B1) that may be absorbed differently by your body than standard thiamine supplements. This product contains 80 mg per capsule.
Does this supplement actually work for diabetic nerve pain?
Benfotiamine is rated possibly effective for diabetic neuropathy — meaning there's some evidence it may help, but the data isn't conclusive. Talk with your doctor about whether it makes sense for your situation.
What side effects did people report in studies?
In one trial, a small number of people reported allergic skin reactions and mild stomach discomfort, but these occurred at the same rate as in the placebo group. Overall, benfotiamine was well tolerated.
Is it safe to take while breastfeeding?
Safety data while breastfeeding hasn't been well studied, so caution is advised. Talk with your doctor or pharmacist before starting if you're nursing.
Can I take this long-term?
Long-term safety of benfotiamine is not fully known from the studies we have. Discuss with your doctor how long you plan to take it and whether it's right for your needs.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Best Benfotiamine 80 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Best Benfotiamine 80 mg label
Go deeper

The Full Monographs Behind Best Benfotiamine 80 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Sources

Sources & How We Checked

Best Benfotiamine 80 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 1 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Benfotiamine 1 reference
  1. Stracke H, Gaus W, Achenbach U, Federlin K, Bretzel RG. Benfotiamine in diabetic polyneuropathy (BENDIP): results of a randomised, double blind, placebo-controlled clinical study. Exp Clin Endocrinol Diabetes 2008;116(10):600-5. PubMed

See these in context on the Benfotiamine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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