No known drug interactions for the matched ingredients — not a guarantee none exist. Check your meds →
Dietary supplement

Betaine Anhydrous Ingredients & Drug Interactions

by NutraBio

Betaine Anhydrous label
See full label image
Capsule Category: Non-nutrient/non-botanical
No known interaction
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Betaine Anhydrous against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line No known interaction

Betaine Anhydrous is a dietary supplement by NutraBio with 1 active ingredient. Its ingredients are commonly taken for high homocysteine levels, liver health (fatty liver), exercise performance and strength.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.

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HelloPharmacist Scorecard of Betaine Anhydrous by NutraBio

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: betaine anhydrous, a compound your body naturally produces that plays a role in regulating homocysteine (an amino acid your body makes). The capsule itself is made from hypromellose and water, which are inactive ingredients that help deliver the active component.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Betaine Anhydrous's overall clinical evidence instead.

Strong

Strong clinical evidence supports Betaine Anhydrous for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Homocystinuria — rated "Effective" (Natural Medicines).
  • On file: Hyperhomocysteinemia — rated "Possibly Effective" (Natural Medicines).

Betaine anhydrous is effective for homocystinuria (a rare genetic disorder that raises homocysteine levels dangerously high). It's possibly effective for hyperhomocysteinemia (high homocysteine in the blood).

For other uses listed on this product — fatty liver disease (nonalcoholic steatohepatitis or NASH), colorectal adenoma prevention, depression, and acid reflux (GERD) — we don't have enough reliable evidence to rate how well it works.

The evidence, ingredient by ingredient Betaine Anhydrous

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Betaine anhydrous is generally well tolerated at studied doses, but there isn't enough reliable safety data overall, so the best approach is to check with your doctor before starting it. The most common side effects are body odor, diarrhea, elevated cholesterol, stomach upset, nausea, and vomiting.

Cerebral edema (brain swelling) is a rare serious effect. Safety during breastfeeding is not well established, so caution is advised if you're nursing — talk with your doctor or pharmacist for personalized guidance.

Side effects, ingredient by ingredient Betaine Anhydrous

Meds to double-check

No known interactions
Known Interaction Concern · database check
No known interactions

No medication interactions are currently documented for the matched ingredients — that isn't a guarantee none exist.

Why this rating?
  • None of the 1 matched ingredient has a documented medication interaction on file.

No interactions are documented in our data for the medications we checked. Still, run your exact prescriptions through the search tool on this page to be sure.

The bottom line

Scorecard at a glanceFully disclosed formula with strong clinical evidence behind its ingredients' uses. No medication interactions are currently documented, and safety information is well characterized.

Betaine anhydrous is established as effective for homocystinuria and possibly helpful for high homocysteine levels. If you have one of those conditions or are considering this for another reason, start by talking with your doctor or pharmacist — especially before use, since the overall safety data is limited.

No drug interactions are documented for this ingredient.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Dec 13, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Betaine Anhydrous, straight from the product label.

Brand NutraBio
Barcode (UPC) 649908521974
Net contents 90 Capsule(s)
Market status On market
Date entered into DSLD Dec 13, 2022
DSLD ID 278721
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Kosher, Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Betaine Anhydrous by NutraBio, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Vegetarian Capsule(s)
Maximum serving Sizes:
2 Vegetarian Capsule(s)
Servings per container
45
UPC/BARCODE
649908521974
IngredientAmount% DV
Betaine Anhydrous1000 mg--

Other ingredients: Hypromellose, Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Use: Take 2 capsules, 1 to 3 times daily, as needed, preferably with meals.

Formulation

Vegetarian

Gluten free Non-GMO Lactose free

Precautions

Warning: Not intended for use by persons under the age of 18. Keep out of reach of children.

If you are pregnant, breast feeding, have known medical conditions. (including kidney or liver disease) or are taking prescription or OTC medication(s) consult with your health care practitioner before using this product.

Discontinue use two weeks prior to surgery.

WARNING: Consuming this product can expose you to chemicals including lead, which are known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov/food.

Seals/Symbols

Check. Verify. Trust. View Independent Lab Results CHECKMYSUPPS.COM

Manufactured in our GMP & FDA inspected facility FDA Registration: 16906175560 Made in USA -with ingredients- sourced worldwide

OU (Kosher)

Brand IP Statement(s)

Nutrabio since 1996

FDA Statement of Identity

Amino Acid Supplement

Formula

OU (Kosher)

Storage

Store in a cool dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Betaine Anhydrous by NutraBio label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Betaine Anhydrous label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Betaine Anhydrous by NutraBio

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Vegetarian Capsule(s) Dosage formCapsule Servings per container45 Amounts shown are per serving.

Betaine Anhydrous

No known
interactions
1000 mg per serving Form: Trimethylglycine

Betaine anhydrous (also called trimethylglycine) is a compound found in foods like beets, spinach, and whole grains, and is sold as a supplement and a...

Betaine Anhydrous monograph & interactions

Other (inactive) ingredients: Hypromellose, Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

Betaine Anhydrous by NutraBio Drug Interactions

We don’t currently list any known drug interactions for the mapped ingredients in Betaine Anhydrous. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.

The maker

Brand information

Manufacturer and brand details for Betaine Anhydrous, from the product label.

NutraBio

See all NutraBio products
Name
NutraBio Labs, Inc.
Street Address
564 Lincoln Blvd.
City
Middlesex
State
NJ
ZipCode
08846
Phone Number
732-748-8606
Web Address
www.nutrabio.com
Pharmacist Counseling Corner

Betaine Anhydrous by NutraBio: Common Questions

Does Betaine Anhydrous by NutraBio interact with any medications?
We do not currently list a known interaction for the mapped ingredients in Betaine Anhydrous. This does not guarantee none exist, so confirm with your pharmacist.
How can one product interact with so many drugs?
Betaine Anhydrous contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is betaine anhydrous supposed to do?
Betaine anhydrous is a compound that helps regulate homocysteine, an amino acid in your body. It's established as effective for homocystinuria, a rare genetic condition that causes dangerously high homocysteine. It's also possibly helpful for hyperhomocysteinemia, which is when your homocysteine levels are elevated but not at the extreme seen in homocystinuria.
Does betaine anhydrous actually work?
For homocystinuria, yes — it's proven effective. For high homocysteine in general (hyperhomocysteinemia), it's possibly effective based on the data we have. For other uses like fatty liver disease, depression, or acid reflux, we don't have enough reliable evidence to say how well it works.
What side effects should I expect?
Most people who take betaine anhydrous tolerate it well. The most common side effects are body odor, diarrhea, stomach upset, nausea, and vomiting. Some people also experience elevated cholesterol. Rarely, cerebral edema (brain swelling) has been reported — if you develop severe headache or confusion, seek medical attention right away.
Is it safe to take while breastfeeding?
Safety while breastfeeding isn't well established, so caution is advised. Talk with your doctor or pharmacist before using this product if you're nursing — they can give you personalized guidance based on your situation.
Is betaine anhydrous safe in general?
It's generally well tolerated at studied doses, but there isn't enough reliable safety data overall. Before you start, check with a healthcare provider to make sure it's right for you and your health history.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Betaine Anhydrous is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Betaine Anhydrous label
Go deeper

The Full Monographs Behind Betaine Anhydrous’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Betaine Anhydrous

Betaine anhydrous (also called trimethylglycine) is a compound found in foods like beets, spinach, and whole grains, and is sold as a supplement and as a prescription medicine for a rare gen...

Read the full Betaine Anhydrous monograph →
Sources

Sources & How We Checked

Betaine Anhydrous's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 11 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Betaine Anhydrous 11 references
  1. Cystadane (betaine anhydrous for oral solution) Package insert. Orphan Medical, Inc. Minnetonka, MN. November 2005.
  2. Abdelmalek MF, Angulo P, Jorgensen RA, et al. Betaine, a promising new agent for patients with nonalcoholic steatohepatitis: results of a pilot study. Am J Gastroenterol 2001;96:2711-7.. PubMed
  3. Schwab U, Torronen A, Toppinen L, et al. Betaine supplementation decreases plasma homocysteine concentrations but does not affect body weight, body composition, or resting energy expenditure in human subjects. Am J Clin Nutr 2002;76:961-7. PubMed
  4. McGregor DO, Dellow WJ, Robson RA, et al. Betaine supplementation decreases post-methionine hyperhomocysteinemia in chronic renal failure. Kidney Int 2002;61:1040-6. PubMed
  5. Olthof MR, van Vliet T, Verhoef P, et al. Effect of homocysteine-lowering nutrients on blood lipids: results from four randomised, placebo-controlled studies in healthy humans. PloS Med 2005;2:e135. PubMed
  6. Knopman, D. and Patterson, M. An open-label, 24-week pilot study of the methyl donor betaine in Alzheimer disease patients. Alzheimer Dis.Assoc.Disord. 2001;15(3):162-165. PubMed
  7. Moat, S. J., Madhavan, A., Taylor, S. Y., Payne, N., Allen, R. H., Stabler, S. P., Goodfellow, J., McDowell, I. F., Lewis, M. J., and Lang, D. High- but not low-dose folic acid improves endothelial function in coronary artery disease. Eur J Clin Invest 2 PubMed
  8. Abdelmalek, M. F., Sanderson, S. O., Angulo, P., Soldevila-Pico, C., Liu, C., Peter, J., Keach, J., Cave, M., Chen, T., McClain, C. J., and Lindor, K. D. Betaine for nonalcoholic fatty liver disease: results of a randomized placebo-controlled trial. Hepa PubMed
  9. Ashtary-Larky D, Bagheri R, Ghanavati M, et al. Effects of betaine supplementation on cardiovascular markers: a systematic review and meta-analysis. Crit Rev Food Sci Nutr. 2021 Mar 25:1-18. PubMed
  10. Zawieja EE, Zawieja B, Chmurzynska A. Betaine supplementation moderately increases total cholesterol levels: a systematic review and meta-analysis. J Diet Suppl. 2021;18(1):105-117. PubMed
  11. Imbard A, Toumazi A, Magréault S, et al. Efficacy and pharmacokinetics of betaine in CBS and cblC deficiencies: a cross-over randomized controlled trial. Orphanet J Rare Dis 2022;17(1):417. PubMed

See these in context on the Betaine Anhydrous monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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