Interactions on record — worth a quick check against your medications. Based on 2 of 5 ingredients. Check your meds →
Dietary supplement

Bio.Me Femme V Ingredients & Drug Interactions

by Invivo

Bio.Me Femme V label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Bio.Me Femme V against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Bio.Me Femme V is a dietary supplement by Invivo with 5 active ingredients. Its ingredients are commonly taken for digestive health, weight and belly fat management, vaginal and urinary health.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are SynBalance LG (L. gasseri - LMG P-29638), SynBalance LCr (L. crispatus - LMG P-31003). Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Bio.Me Femme V by Invivo

Ask about any prescription or over-the-counter medication and we check it for interactions with Bio.Me Femme V by Invivo — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Bio.Me Femme V by Invivo

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 5 active ingredients.
  • “SynBalance” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.

Bio.Me Femme V contains five active probiotic ingredients: four Lactobacillus species (L. plantarum, L. gasseri, L. crispatus, and L. rhamnosus) and one Bifidobacterium species (B. lactis), collectively branded as SynBalance. These are live, beneficial bacteria designed to support vaginal and digestive health.

The capsule also holds inactive ingredients — maltodextrin, corn starch, microcrystalline cellulose, and the capsule shell itself — that help deliver the probiotics.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Clinically researched probiotics for vaginal microbiome.
  • We looked for evidence on: Bacterial vaginosis, Urinary tract infections (UTIs), Vulvovaginal candidiasis, Recurrent yeast infections.
  • The strongest evidence on file: Lactobacillus Crispatus is rated "Possibly Effective" for Bacterial vaginosis (Natural Medicines).
  • Also on file: Lactobacillus Crispatus is rated "Insufficient Reliable Evidence To Rate" for Urinary tract infections (UTIs).
  • Also on file: Lactobacillus Gasseri is rated "Insufficient Reliable Evidence To Rate" for Bacterial vaginosis.

The evidence for this product's ingredients is mixed and mostly limited. L. crispatus shows possibly effective evidence for bacterial vaginosis, but the other four probiotics lack reliable evidence for the conditions they're marketed to address — including hay fever, asthma, common cold, diarrhea, UTIs, and preterm labor.

Because the data we hold doesn't establish effectiveness for most of these uses, talk with your doctor or pharmacist about whether this particular blend is the right fit for what you're hoping to treat.

The evidence, ingredient by ingredient Lactobacillus Gasseri Lactobacillus Crispatus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L. crispatus and L. gasseri are generally well tolerated in healthy adults, but the safety data is limited. A small number of people taking L. crispatus in clinical research reported nausea, gas, flatulence, or swelling of the tongue and epiglottis.

Since these products contain live microorganisms, there's a theoretical concern — though rare — that they could cause serious infections like bacteremia or endocarditis in people with certain underlying conditions. We don't have reliable pregnancy or breastfeeding safety data for any of these ingredients, so check with your doctor before using if you're pregnant or nursing.

Side effects, ingredient by ingredient Lactobacillus Gasseri Lactobacillus Crispatus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Lactobacillus Crispatus, Lactobacillus Gasseri.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take antibiotic drugs, check your exact medications before starting this product. The Lactobacillus crispatus and L. gasseri in the formula may lose effectiveness if dosed at the same time as antibiotics, so you'll want to space them out — ask your pharmacist how far apart to take them.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Bio.Me Femme V is a probiotic blend that may help with bacterial vaginosis (L. crispatus) and potentially other vaginal health concerns, but evidence for most uses is not yet established. If you take antibiotics, you'll need to separate them from this product to keep the probiotics effective.

Talk with your doctor or pharmacist before starting — especially if you have a compromised immune system, take regular antibiotics, or are pregnant or breastfeeding.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 23, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Bio.Me Femme V, straight from the product label.

Brand Invivo
Barcode (UPC) 7105353659868>
Net contents 30 Capsule(s)
Market status On market
Date entered into DSLD Apr 23, 2020
DSLD ID 217499
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Vegetarian, Adult Female (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Bio.Me Femme V by Invivo, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
UPC/BARCODE
7105353659868>
IngredientAmount% DV
SynBalance0 NP--
SynBalance LP (L. plantarum - DSM 24937)0 NP--
SynBalance BL (B. lactis - LMG P-29510)0 NP--
SynBalance LRh (L. rhamnosus - LMG P-295130 NP--
SynBalance LG (L. gasseri - LMG P-29638)0 NP--
SynBalance LCr (L. crispatus - LMG P-31003)0 NP--

Other ingredients: Maltodextrin, Corn Starch, Microcrystalline Cellulose, Capsule Shell

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

Food Supplement

Formulation

Clinically researched probiotics for the vaginal microbiome

No need to refrigerate, suitable for vegetarians

Storage

No need to refrigerate, suitable for vegetarians

Store in the original packaging, at room temperature, in a dry place.

Suggested/Recommended/Usage/Directions

Directions: Take 1 capsule per day. Do not exceed recommended dose, unless advised by your healthcare professional.

Precautions

Food supplements are not a substitute for a varied and balanced diet or lifestyle.

Keep out of reach of children.

Seals/Symbols

Certified B Corporation GMP certified Carbon neutral

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Bio.Me Femme V by Invivo label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Bio.Me Femme V label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Bio.Me Femme V by Invivo

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

SynBalance

0 NP per serving

Other (inactive) ingredients: Maltodextrin, Corn Starch, Microcrystalline Cellulose, Capsule Shell. These complete the product’s ingredient list but are not active constituents.

Interaction report

Bio.Me Femme V by Invivo Drug Interactions

Want to check YOUR meds against Bio.Me Femme V?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

SynBalance LG (L. gasseri - LMG P-29638) 182
SynBalance LCr (L. crispatus - LMG P-31003) 182

Individual Drug Interactions

The ingredients in Bio.Me Femme V interact with 182 drugs. Click any drug to see the details.

2 of the 5 ingredients in Bio.Me Femme V interact with drugs. Each result below shows which ingredient is responsible. SynBalance LG (L. gasseri - LMG P-29638) SynBalance LCr (L. crispatus - LMG P-31003)

Each ingredient & the kinds of drugs it affects

For each ingredient in Bio.Me Femme V with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

SynBalance LG (L. gasseri - LMG P-29638)1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus gasseri with antibiotic drugs might decrease the effectiveness of L. gasseri.
Lactobacillus gasseri preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. gasseri preparations by at least two hours.

Likelihood Probable Evidence D
SynBalance LG (L. gasseri - LMG P-29638) full monograph & interactions

SynBalance LCr (L. crispatus - LMG P-31003)1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus crispatus with antibiotic drugs might decrease the effectiveness of L. crispatus.
Lactobacillus crispatus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. crispatus preparations by at least two hours.

Likelihood Probable Evidence D
SynBalance LCr (L. crispatus - LMG P-31003) full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Bio.Me Femme V, from the product label.

Invivo

See all Invivo products
Name
Invivo Clinical
State
Gloucestershire
ZipCode
GL5 1RN
Web Address
invivohealthcare.com
Pharmacist Counseling Corner

Bio.Me Femme V by Invivo: Common Questions

Does Bio.Me Femme V by Invivo interact with any medications?
Yes. Based on its ingredients, Bio.Me Femme V has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Bio.Me Femme V contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while on antibiotics?
Yes, but not at the same time. The antibiotics can kill the live bacteria in the supplement before they work. Your pharmacist can tell you the right timing — usually a few hours apart — to get the benefit of both.
What are these Lactobacillus and Bifidobacterium strains for?
They're probiotics — live beneficial bacteria that naturally live in your vaginal and digestive tract. The blend is designed to support vaginal health and balance, and potentially help with things like bacterial vaginosis and UTI risk, though the evidence for most uses is still limited.
Are there any side effects?
Side effects are rare but possible. A small number of people reported nausea, gas, flatulence, or tongue swelling when taking L. crispatus. Because these are live microorganisms, there's a small theoretical risk of serious infection in people with weakened immune systems.
Is this safe to take while breastfeeding?
We don't have reliable safety data for breastfeeding, so check with your doctor before using. The same goes for pregnancy — there isn't enough information to know either way.
Does this actually help prevent UTIs or treat bacterial vaginosis?
L. crispatus shows some evidence for bacterial vaginosis, but for UTIs and other conditions the probiotics are marketed for, the evidence isn't established yet. Your doctor can help you decide if this is worth trying for your situation.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Bio.Me Femme V is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Bio.Me Femme V label
Go deeper

The Full Monographs Behind Bio.Me Femme V’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lactobacillus Gasseri

Interacts with 182 drugs

Lactobacillus gasseri is a 'friendly' probiotic bacterium found naturally in the human gut, mouth, and vaginal tract, and in some fermented foods. Early research suggests it may help with di...

Read the full Lactobacillus Gasseri monograph → Herb & supplement monograph

Lactobacillus Crispatus

Interacts with 182 drugs

Lactobacillus crispatus is a 'good' bacterium that naturally dominates a healthy vaginal microbiome and is sold as a probiotic, mainly for vaginal and urinary health. Early research is promi...

Read the full Lactobacillus Crispatus monograph →
Sources

Sources & How We Checked

Bio.Me Femme V's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 21 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lactobacillus Gasseri 12 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Ramachandran L, Dontaraju VS, Patel K. Lactobacillus-associated spontaneous bacterial peritonitis in a liver cirrhosis patient on probiotics. Cureus. 2020;12(12):e11896. PubMed
  3. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  4. Ranchal P, Gupta R, Goldberg R, A Lobo S, Pascual A, El Khoury MY. Penicillin-sensitive Lactobacillus jensenii bacteremia. Am J Ther 2021;28(2):e250-e252. PubMed
  5. Grazioli-Gauthier L, Rigamonti E, Leo LA, Martinetti Lucchini G, Lo Priore E, Bernasconi E. Lactobacillus jensenii mitral valve endocarditis: Case report, literature review and new perspectives. IDCases 2022;27:e01401. PubMed
  6. Toprak NU, Bozan T, Yilmaz S, Buyukbayrak EE, Tigen ET. Polymicrobial bacteremia due to Lactobacillus jensenii and Veillonella montpellierensis in a pregnant patient; case report and review of literature. Anaerobe 2022;75:102576. PubMed
  7. Chazan B, Raz R, Shental Y, Sprecher H, Colodner R. Bacteremia and pyelonephritis caused by Lactobacillus jensenii in a patient with urolithiasis. Isr Med Assoc J 2008;10(2):164-5.
  8. Ramos-Coria D, Canto-Losa J, Carrillo-Vázquez D, Carbajal-Morelos L, Estrada-León R, Corona-Rodarte E. Lactobacillus gasseri liver abscess and bacteremia: a case report. BMC Infect Dis 2021;21(1):518. PubMed
  9. Elikowski W, Malek-Elikowska M, Lisiecka M, Bodora A, Wisniewska K, Oko-Sarnowska Z. Lactobacillus gasseri endocarditis on the aortic valve bioprosthesis - a case report. Pol Merkur Lekarski 2017;43(257):220-223.
  10. Esquibel A, Dababneh AS, Palraj BR. Lactobacillus gasseri causing bilateral empyema. Case Rep Infect Dis 2017;2017:4895619.
  11. Tleyjeh IM, Routh J, Qutub MO, Lischer G, Liang KV, Baddour LM. Lactobacillus gasseri causing Fournier's gangrene. Scand J Infect Dis 2004;36(6-7):501-3. PubMed
  12. Dickgiesser U, Weiss N, Fritsche D. Lactobacillus gasseri as the cause of septic urinary infection. Infection 1984;12(1):14-6. PubMed

See these in context on the Lactobacillus Gasseri monograph →

Lactobacillus Crispatus 9 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  3. Ranchal P, Gupta R, Goldberg R, A Lobo S, Pascual A, El Khoury MY. Penicillin-sensitive Lactobacillus jensenii bacteremia. Am J Ther 2021;28(2):e250-e252. PubMed
  4. Grazioli-Gauthier L, Rigamonti E, Leo LA, Martinetti Lucchini G, Lo Priore E, Bernasconi E. Lactobacillus jensenii mitral valve endocarditis: Case report, literature review and new perspectives. IDCases 2022;27:e01401. PubMed
  5. Toprak NU, Bozan T, Yilmaz S, Buyukbayrak EE, Tigen ET. Polymicrobial bacteremia due to Lactobacillus jensenii and Veillonella montpellierensis in a pregnant patient; case report and review of literature. Anaerobe 2022;75:102576. PubMed
  6. Chazan B, Raz R, Shental Y, Sprecher H, Colodner R. Bacteremia and pyelonephritis caused by Lactobacillus jensenii in a patient with urolithiasis. Isr Med Assoc J 2008;10(2):164-5.
  7. DI Pierro F, Criscuolo AA, Dei Giudici A, et al. Oral administration of Lactobacillus crispatus M247 to papillomavirus-infected women: results of a preliminary, uncontrolled, open trial. Minerva Obstet Gynecol 2021;73(5):621-631. PubMed
  8. DE Leo V, Lazzeri E, Governini L, et al. Vaginal colonization of women after oral administration of Lactobacillus crispatus strain NTCVAG04 from the human microbiota. Minerva Obstet Gynecol 2022. PubMed
  9. Dellino M, Cascardi E, Laganà AS, et al. Lactobacillus crispatus M247 oral administration: Is it really an effective strategy in the management of papillomavirus-infected women?. Infect Agent Cancer 2022;17(1):53. PubMed

See these in context on the Lactobacillus Crispatus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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