Interactions on record — worth a quick check against your medications. Based on 1 of 3 ingredients. Check your meds →
Dietary supplement

Biothin With Irvingia And Fucoxanthin Ingredients & Drug Interactions

by Dr. Mercola Premium Supplements

Biothin With Irvingia And Fucoxanthin label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Biothin With Irvingia And Fucoxanthin against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Biothin With Irvingia And Fucoxanthin is a dietary supplement by Dr. Mercola Premium Supplements with 3 active ingredients. Its ingredients are commonly taken for weight loss, appetite control, cholesterol support.Based on those ingredients, 94 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Certified Irvingia(TM) Irvingia gabonensis proprietary extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Biothin With Irvingia And Fucoxanthin by Dr. Mercola Premium Supplements

Ask about any prescription or over-the-counter medication and we check it for interactions with Biothin With Irvingia And Fucoxanthin by Dr. Mercola Premium Supplements — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Biothin With Irvingia And Fucoxanthin by Dr. Mercola Premium Supplements

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • “Fucoxanthin extract” is listed as a grouped ingredient — the label gives one combined amount (300 mg) without saying how much of each component you get.

This product has three active ingredients. Irvingia gabonensis is a proprietary extract from the seeds of the African mango tree, traditionally used in weight management formulas.

Fucoxanthin extract and 30 mg of fucoxanthin (a compound from brown seaweed) are also included. The capsule also contains cellulose and silica as inactive ingredients.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Irvingia Gabonensis's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Helps support healthy weight loss.
  • We looked for evidence on: Obesity, Metabolic syndrome, Hypercholesterolemia, Diabetes.
  • The closest evidence on file: Irvingia Gabonensis is rated "Insufficient Reliable Evidence To Rate" for Diabetes (Natural Medicines).
  • Also on file: Irvingia Gabonensis is rated "Insufficient Reliable Evidence To Rate" for Hypercholesterolemia, Obesity, Metabolic syndrome.

The evidence for what this product actually does is not established. Irvingia gabonensis has been studied for diabetes, high cholesterol, obesity, and metabolic syndrome, but the data we hold shows insufficient reliable evidence to rate it for any of these purposes.

Fucoxanthin's effectiveness is not rated in our data. If you're thinking about this supplement for a specific health goal, that's worth discussing with your doctor or pharmacist, since the research backing is limited.

The evidence, ingredient by ingredient Irvingia Gabonensis

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Irvingia gabonensis is generally well tolerated in short-term studies, but long-term safety and product quality are not well established. The most common side effects reported in trials are flatulence, headache, insomnia, and nausea.

One case of acute liver inflammation (hepatitis) has been reported, occurring a few days after someone started taking Irvingia gabonensis at high doses for fat loss—this is rare but worth knowing about. The product is not recommended during pregnancy or while breastfeeding; there isn't enough safety data to know either way, so talk with your doctor or pharmacist if you're pregnant, planning pregnancy, or nursing.

Side effects, ingredient by ingredient Irvingia Gabonensis

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Irvingia Gabonensis.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 94 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you take antidiabetes drugs (Moderate risk of low blood sugar) or testosterone products (Moderate risk of additive effects). We could not check two of the three active ingredients, so confirm your complete medication list with your own pharmacist.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This supplement may be worth considering if you're exploring weight management or blood sugar support, but the research is limited and long-term safety isn't clear. If you take antidiabetes drugs or testosterone products, or take any prescription medication at all, check with your doctor or pharmacist before starting.

Your provider can help you decide if this product makes sense for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Biothin With Irvingia And Fucoxanthin, straight from the product label.

Brand Dr. Mercola Premium Supplements
Barcode (UPC) 813006012492
Net contents 60 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Aug 23, 2013
DSLD ID 24873
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Biothin With Irvingia And Fucoxanthin by Dr. Mercola Premium Supplements, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Vegetarian Capsule(s)
Maximum serving Sizes:
2 Vegetarian Capsule(s)
Servings per container
30
UPC/BARCODE
813006012492
IngredientAmount% DV
Fucoxanthin extract300 mg--
30 mg of fucoxanthin30 mg--
Certified Irvingia(TM) Irvingia gabonensis proprietary extract300 mg--
Proprietary Blend300 mg--

Other ingredients: Cellulose, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

Contains Tree Nuts

KEEP OUT OF REACH OF CHILDREN.

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, adults take 2 vegetarian capsules daily or as directed by your healthcare professional.

General Statements

Helps Support Healthy Weight Loss!

FDA Statement of Identity

A Dietary Supplement

Storage

For optimal storage conditions, store in a cool, dry place. (59(0)-77(0)F/15(0)-25(0)C) (35-65% relative humidity). Tamper resistant package. Do not use if outer seal is missing.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Brand IP Statement(s)

Certified Irvingia(TM) Irvingia is protected by U.S. Patent 7,537,790. Other patents pending

Formulation

This product contains NO yeast, wheat gluten, soy protein, milk/dairy, corn, sodium, sugar, starch or preservatives.

General

10057-v402 Formula #200868/#2169951

Seals/Symbols

CERTIFIED AUTHENTIC IRVINGIA

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Biothin With Irvingia And Fucoxanthin by Dr. Mercola Premium Supplements label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Biothin With Irvingia And Fucoxanthin label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Biothin With Irvingia And Fucoxanthin by Dr. Mercola Premium Supplements

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Vegetarian Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Fucoxanthin extract

300 mg per serving
  • › 30 mg of fucoxanthin

Certified Irvingia(TM) Irvingia gabonensis proprietary extract

Interacts with
94 drugs
300 mg per serving

Irvingia gabonensis (African mango) is a seed extract marketed mainly for weight loss and metabolic health. A few small studies suggest possible benef...

Certified Irvingia(TM) Irvingia gabonensis proprietary extract monograph & interactions

Proprietary Blend

300 mg per serving Form: Apple Cider Vinegar, Cayenne, Garcinia cambogia, Ginger, Hoodia gordonii, Pomegranate extract

Other (inactive) ingredients: Cellulose, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Biothin With Irvingia And Fucoxanthin by Dr. Mercola Premium Supplements Drug Interactions

Want to check YOUR meds against Biothin With Irvingia And Fucoxanthin?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
94Drugs
94 Moderate

Ingredients driving the most interactions

Certified Irvingia(TM) Irvingia gabonensis proprietary extract 94

Individual Drug Interactions

The ingredients in Biothin With Irvingia And Fucoxanthin interact with 94 drugs. Click any drug to see the details.

1 of the 3 ingredients in Biothin With Irvingia And Fucoxanthin interact with drugs. Each result below shows which ingredient is responsible. Certified Irvingia(TM) Irvingia gabonensis proprietary extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Biothin With Irvingia And Fucoxanthin with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Certified Irvingia(TM) Irvingia gabonensis proprietary extract2 drug types · 94 drugs

Antidiabetes Drugs

Theoretically, taking Irvingia gabonensis with antidiabetes drugs might increase the risk of hypoglycemia in some patients.
Human research shows that Irvingia gabonensis decreases blood sugar in diabetic patients being treated with antidiabetes agents. Monitor blood glucose levels closely. Dose adjustments might be necessary.

Likelihood Possible Evidence B
Testosterone

Theoretically, taking Irvingia gabonensis with testosterone products drugs might cause additive effects in some patients.
Animal research suggests that Irvingia gabonensis increases testosterone levels. The mechanism of action is unclear. Until more is known, advise patients taking testosterone to avoid using or use Irvingia gabonensis cautiously.

Likelihood Possible Evidence D
Certified Irvingia(TM) Irvingia gabonensis proprietary extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Biothin With Irvingia And Fucoxanthin, from the product label.

Dr. Mercola Premium Supplements

See all Dr. Mercola Premium Supplements products
Name
Mercola Health Resources, LLC.
Street Address
3200 W. Higgins Road
City
Hoffman Estates
State
IL
ZipCode
60169
Phone Number
(847) 252-4355
Web Address
www.mercola.com
Pharmacist Counseling Corner

Biothin With Irvingia And Fucoxanthin by Dr. Mercola Premium Supplements: Common Questions

Does Biothin With Irvingia And Fucoxanthin by Dr. Mercola Premium Supplements interact with any medications?
Yes. Based on its ingredients, Biothin With Irvingia And Fucoxanthin has a known interaction with 94 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Biothin With Irvingia And Fucoxanthin contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is Irvingia gabonensis?
It's an extract from the seed of the African mango tree, included in weight management and metabolic support formulas. The research on what it actually does is limited—there's not enough reliable evidence yet to confirm it works for obesity, cholesterol, blood sugar, or metabolic syndrome.
Can I take this if I'm diabetic or on diabetes medication?
Talk with your doctor or pharmacist first. Irvingia gabonensis can lower blood sugar, which means your blood glucose levels and medication dose may need to be adjusted if you take antidiabetes drugs. Your provider needs to monitor you closely.
What are the most common side effects?
The most frequently reported side effects in studies are flatulence, headache, insomnia, and nausea. These are usually mild, though long-term safety and quality of products aren't well established.
Is this safe to take during pregnancy or while breastfeeding?
The safety data isn't there, so it's not recommended during pregnancy or while nursing. If you're pregnant, planning pregnancy, or breastfeeding, talk with your doctor or pharmacist about whether this product is right for you.
Does this product have any fillers?
The formula includes cellulose and silica as inactive ingredients—those are standard capsule materials and binders.
What does fucoxanthin do?
Fucoxanthin is a compound from brown seaweed often included in weight management supplements. We don't have effectiveness data on file for it in this product, so we can't confirm what it does.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Biothin With Irvingia And Fucoxanthin is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Biothin With Irvingia And Fucoxanthin label
Go deeper

The Full Monographs Behind Biothin With Irvingia And Fucoxanthin’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Irvingia Gabonensis

Interacts with 94 drugs

Irvingia gabonensis (African mango) is a seed extract marketed mainly for weight loss and metabolic health. A few small studies suggest possible benefits, but the research is limited and low...

Read the full Irvingia Gabonensis monograph →
Sources

Sources & How We Checked

Biothin With Irvingia And Fucoxanthin's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 7 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Irvingia Gabonensis 7 references
  1. Oben JE, Ngondi JL, Momo CN, et al. The use of Cissus quadrangularis/Irvingia gabonensis combination in the management of weight loss: a double-blind placebo-controlled study. Lipids Health Dis 2008;7:12.
  2. Ngondi JL, Etoundi BC, Nyangono CB, et al. IGOB131, a novel seed extract of the West African plant Irvingia gabonensis, significantly reduces body weight and improves metabolic parameters in overweight humans in a randomized double-blind placebo controll
  3. Adamson, I., Okafor, C., and Abu-Bakare, A. A supplement of Dikanut (Irvingia gabonesis) improves treatment of type II diabetics. West Afr.J.Med. 1990;9(2):108-115.
  4. Adamson, I., Okafor, C., and Abu-Bakare, A. Erythrocyte membrane ATPases in diabetes: effect of dikanut (Irvingia gabonensis). Enzyme 1986;36(3):212-215. PubMed
  5. Wolfe OA, Ijeoma UF. Effects of aqueous extracts of Irvingia gabonensis seeds on the hormonal parameters of male guinea pigs. Asian Pacific Journal of Tropical Medicine. 2010;3(3):200-204. DOI
  6. Kilinçalp S, Basar O, Coban S, Yüksel I. Irvingia gabonensis (African mango): innocent magic formula? Acta Gastroenterol Belg 2014;77(1):75-6.
  7. Nonsa-Ard R, Aneknan P, Tong-Un T, Honsawek S, Leelayuwat N. Effects of Irvingia gabonensis Extract on Metabolism, Antioxidants, Adipocytokines, Telomere Length, and Aerobic Capacity in Overweight/Obese Individuals. Nutrients 2022;14(21):4646. PubMed

See these in context on the Irvingia Gabonensis monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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