Major interaction on record — check this product against your medications before combining. Based on 2 of 4 ingredients. Check your meds →
Dietary supplement

Cerefolin NAC Ingredients & Drug Interactions

by Alfasigma

Cerefolin NAC label
See full label image
Other (e.g. Tea Bag) Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Cerefolin NAC against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Cerefolin NAC is a dietary supplement by Alfasigma with 4 active ingredients. Its ingredients are commonly taken for thinning mucus in lung conditions, acetaminophen (tylenol) overdose treatment, antioxidant and glutathione support.Based on those ingredients, 314 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are N-Acetyl-L-Cysteine, Methylcobalamin. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Cerefolin NAC by Alfasigma

Ask about any prescription or over-the-counter medication and we check it for interactions with Cerefolin NAC by Alfasigma — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Cerefolin NAC by Alfasigma

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 4 of its 4 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Cerefolin NAC contains four active ingredients. N-acetyl cysteine is an amino acid that supports the body's antioxidant defenses and has established roles in treating acetaminophen poisoning and certain respiratory conditions.

Methylcobalamin is a form of vitamin B12 needed for nerve function and red blood cell formation. L-methylfolate calcium is a form of folate (vitamin B9).

Algae-S Powder rounds out the formula. The product also contains several inactive ingredients including cellulose, polyvinyl alcohol, silicon dioxide compounds, and food colorants.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Clinical dietary management of mild cognitive impairment.
  • We looked for evidence on: Age-related cognitive decline, Cognitive impairment, Cognitive function, Alzheimer disease, Dementia, Hyperhomocysteinemia — and 3 related terms.
  • The strongest evidence on file: Vitamin B12 is rated "Possibly Effective" for Hyperhomocysteinemia (Natural Medicines).
  • Also on file: N-acetyl Cysteine (nac) is rated "Possibly Effective" for Hyperhomocysteinemia.
  • Also on file: Vitamin B12 is rated "Possibly Ineffective" for Age-related cognitive decline, Alzheimer disease, Cognitive impairment.

N-acetyl cysteine is established as effective for acetaminophen poisoning, atelectasis (lung collapse), and bronchial diagnostic procedures, and tracheostomy care. It's possibly effective for bronchitis.

Methylcobalamin (B12) is effective for vitamin B12 deficiency and Imerslund-Grasbeck disease, and likely effective for cyanide poisoning. It's possibly effective for canker sores and postherpetic neuralgia (nerve pain after shingles).

We don't hold effectiveness data for L-methylfolate calcium or Algae-S Powder in our monographs.

The evidence, ingredient by ingredient N-acetyl Cysteine (nac) Vitamin B12

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

N-acetyl cysteine is generally well tolerated at typical doses, though most adverse effects appear when you take more than 9 grams in a single dose or exceed 30 grams daily. Common side effects from oral use include diarrhea, dry mouth, nausea, vomiting, heartburn, and loss of appetite.

Some people report joint pain. Methylcobalamin (B12) is very well tolerated and safe; excess is removed in urine so there's no established upper limit.

The product's safety during pregnancy and breastfeeding hasn't been well studied—talk with your doctor or pharmacist before use if you're pregnant, planning pregnancy, or nursing.

Side effects, ingredient by ingredient N-acetyl Cysteine (nac) Vitamin B12

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Vitamin B12, N-acetyl Cysteine (nac).
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 314 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Cerefolin NAC, check with your pharmacist if you take nitroglycerin (Major interaction risk), blood pressure medications, blood thinners or antiplatelet drugs, chloroquine, metformin, or activated charcoal. We have no interaction data for two of the four ingredients, so mentioning all your medications is especially important.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

Cerefolin NAC is worth discussing with your pharmacist if you need support with acetaminophen poisoning, certain lung conditions, or B12 deficiency—but definitely check it against your medications first, especially if you take heart medications, blood pressure drugs, or blood thinners. Pregnant or nursing?

Ask your pharmacist before starting, as safety data is limited. It's generally well tolerated at standard doses.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2019.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Cerefolin NAC, straight from the product label.

Brand Alfasigma
Net contents 90 Caplet(s)
Market status On market
Date entered into DSLD Aug 23, 2019
DSLD ID 206099
Product type Other Combinations
Supplement form Other (e.g. Tea Bag)
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Cerefolin NAC by Alfasigma, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Caplet(s)
Maximum serving Sizes:
1 Caplet(s)
IngredientAmount% DV
N-Acetyl-L-Cysteine600 mg--
Methylcobalamin2 mg--
L-Methylfolate Calcium6 mg--
Algae-S Powder90.314 mg--

Other ingredients: silicified Microcrystalline Cellulose, Algae-S Powder, Polyvinyl Alcohol, Croscarmellose Sodium, Titanium Dioxide, Polyethylene Glycol 3350, Magnesium Stearate, Talc, Beet powder, Caramel, Carnauba wax

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Description CerefolinNAC is a prescription medical food for use only under the supervision of a physician for the clinical dietary management of mild cognitive impairment and is specially formulated to meet the distinctive nutritional requirements for this condition.

CAS# 151533-22-1

This product is not an orange book product.

CerefolinNAC bottle of 90 Product Code # 00525-0555-90.

Each CerefolinNAC caplet is an oval coated beige colored caplet. Debossed with “PAL” on one side and “600” on the other.

Alfasigma USA, Inc. does not represent these product codes to be National Drug Codes (NDC). Product codes are formatted according to standard industry practice, to meet the formatting requirements of pharmacy and health insurance computer systems.

Formula

Contains milk and soy

Indications and usage CerefolinNAC is indicated for the distinct nutritional requirements of individuals with mild to moderate cognitive impairment who present with an increased risk for neurovascular oxidative stress and/or hyperhomocysteinemia; and/or suboptimal L-methylfolate and/or vitamin B12 levels in the cerebrospinal fluid, plasma, and/or red blood cells.

Allergic reactions have been reported following the use of oral L-methylfolate Calcium. Mild transient diarrhea, itching, transitory exanthema and the feeling of swelling of the entire body has been associated with methylcobalamin. Nausea, vomiting, diarrhea, transient skin rash, flushing, epigastric pain, and constipation have been associated with N-acetyl-L-cysteine.

Precautions

Contains milk and soy

CerefolinNAC is a prescription medical food for use only under the supervision of a physician.

Medical foods are intended for a patient who has a limited or impaired capacity to ingest, digest, absorb, or metabolize ordinary foodstuffs or certain nutrients, or who has other special medically determined nutrient requirements, the dietary management of which cannot be achieved by the modification of the normal diet alone.

Contraindications CerefolinNAC is contraindicated in patients with known hypersensitivity to any of the components contained in this product.

Precautions General Folic acid, when administered in daily doses above 0.1mg, may obscure the detection of B12 deficiency (specifically, the administration of folic acid may reverse the hematological manifestations of B12 deficiency, including pernicious anemia, while not addressing the neurological manifestations). L-methylfolate Calcium may be less likely than folic acid to mask vitamin B12 deficiency. Folate therapy alone is inadequate for the treatment of a B12 deficiency.

N-acetyl-L-cysteine should be avoided by nursing mothers.

N-acetyl-L-cysteine clearance is reduced in those with chronic liver disease as well as in pre-term newborns.

Headaches may be intensified in those taking N-acetyl-L-cysteine and nitrates for the treatment of angina.24 While the incidence of renal stones is low, those that do form renal stones, particularly cysteine stones should avoid CerefolinNAC. Do not administer CerefolinNAC to critically ill patients. N-acetyl-L-cysteine and its sulfhydryl metabolites could produce a false-positive result in the nitroprusside test for ketone bodies used in diabetes.24 N-acetyl-L-cysteine should be used with caution in those with a history of peptic ulcer disease since N-acetyl-L-cysteine may disrupt the gastric mucosal barrier.

Adverse reactions Allergic reactions have been reported following the use of oral L-methylfolate Calcium. Mild transient diarrhea, itching, transitory exanthema and the feeling of swelling of the entire body has been associated with methylcobalamin. Nausea, vomiting, diarrhea, transient skin rash, flushing, epigastric pain, and constipation have been associated with N-acetyl-L-cysteine.

Use under medical supervision.

Formulation

CerefolinNAC caplets do not contain lactose, yeast or gluten.

Suggested/Recommended/Usage/Directions

Recommended use The usual adult dose is one caplet daily or as directed under medical supervision.

Storage

Storage Store at controlled room temperature 15(0)C to 30(0)C (59(0)F to 86(0)F) (See USP). Protect from heat, light and moisture.

Brand IP Statement(s)

Patents Some or all of the following patents may apply: U.S. Patent No. 5,997,915 U.S. Patent No. 6,008,221 U.S. Patent No. 6,011,040 U.S. Patent No. 6,127,370 U.S. Patent No. 6,254,904 U.S. Patent No. 6,441,168B1 U.S. Patent No. 7,172,778 U.S. Patent No. 7,674,490 U.S. Patent No. 7,709,460B2

Metafolin is a registered trademark of Merck KGaA, Darmstadt, Germany.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Cerefolin NAC by Alfasigma label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Cerefolin NAC label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Cerefolin NAC by Alfasigma

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Caplet(s) Dosage formOther (e.g. Tea Bag) Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

N-Acetyl-L-Cysteine

Interacts with
294 drugs
600 mg per serving

N-acetyl cysteine (NAC) is a supplement form of the amino acid cysteine and a building block for the antioxidant glutathione. It has well-established...

N-Acetyl-L-Cysteine monograph & interactions

Methylcobalamin

Interacts with
20 drugs
2 mg per serving

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very h...

Methylcobalamin monograph & interactions

L-Methylfolate Calcium

6 mg per serving

Algae-S Powder

90.314 mg per serving

Other (inactive) ingredients: Silicified Microcrystalline Cellulose, Algae-S Powder, Polyvinyl Alcohol, Croscarmellose Sodium, Titanium Dioxide, Polyethylene Glycol 3350, Magnesium Stearate, Talc, Beet powder, Caramel, Carnauba wax. These complete the product’s ingredient list but are not active constituents.

Interaction report

Cerefolin NAC by Alfasigma Drug Interactions

Want to check YOUR meds against Cerefolin NAC?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
314Drugs
1 Major 293 Moderate 20 Minor

Ingredients driving the most interactions

N-Acetyl-L-Cysteine 294
Methylcobalamin 20

Individual Drug Interactions

The ingredients in Cerefolin NAC interact with 314 drugs. Click any drug to see the details.

2 of the 4 ingredients in Cerefolin NAC interact with drugs. Each result below shows which ingredient is responsible. N-Acetyl-L-Cysteine Methylcobalamin

Each ingredient & the kinds of drugs it affects

For each ingredient in Cerefolin NAC with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

N-Acetyl-L-Cysteine5 drug types · 294 drugs

Nitroglycerin

N-acetyl cysteine can increase the risk for hypotension and headaches when taken with intravenous or transdermal nitroglycerin.
Clinical research shows that concomitant administration of N-acetyl cysteine and intravenous or transdermal nitroglycerin can cause severe hypotension and intolerable headaches. Furthermore, in vitro research suggests that N-acetyl cysteine increases the anticoagulant activity of nitroglycerin.

Likelihood Probable Evidence B
Activated Charcoal

N-acetyl cysteine might reduce the effects of activated charcoal, while activated charcoal might reduce the absorption of N-acetyl cysteine.
N-acetyl cysteine appears to reduce the capacity of activated charcoal to adsorb acetaminophen and salicylic acid. Conversely, although clinical research suggests that although activated charcoal can reduce the absorption of N-acetyl cysteine by up to 40%, it does not seem to reduce its clinical effects. Other clinical evidence suggests that activated charcoal does not affect the absorption of N-acetyl cysteine.

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, N-acetyl cysteine might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Clinical research suggests that intravenous N-acetyl cysteine decreases prothrombin time, prolongs coagulation time, decreases platelet aggregation, and increases blood loss in surgical patients. Furthermore, in vitro research suggests that N-acetyl cysteine increases the anticoagulant activity of nitroglycerin.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, N-acetyl cysteine might increase the risk of hypotension when taken with antihypertensive drugs.
Animal research suggests that N-acetyl cysteine potentiates the hypotensive effects of the angiotensin-converting enzyme inhibitors (ACEIs) captopril and enalaprilat. Theoretically, combining N-acetyl cysteine with other antihypertensive drugs might increase the risk of hypotension.

Likelihood Possible Evidence D
Chloroquine (Aralen)

Theoretically, N-acetyl cysteine might interfere with the antimalarial effects of chloroquine.
Animal research suggests that N-acetyl cysteine might reduce the antimalarial effects of chloroquine by increasing cellular levels of glutathione.

Likelihood Possible Evidence D
N-Acetyl-L-Cysteine full monograph & interactions

Methylcobalamin1 drug type · 20 drugs

Metformin (Glucophage)

Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals. Prolonged use of metformin can interfere with the absorption of B12 in the digestive system, potentially leading to a deficiency in this essential vitamin.

Likelihood Possible Evidence A
Methylcobalamin full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Cerefolin NAC, from the product label.

Alfasigma

See all Alfasigma products
Name
Alfasigma USA, Inc.
City
Covington
State
LA
ZipCode
70433
Phone Number
1-844-639-9726
Pharmacist Counseling Corner

Cerefolin NAC by Alfasigma: Common Questions

Does Cerefolin NAC by Alfasigma interact with any medications?
Yes. Based on its ingredients, Cerefolin NAC has a known interaction with 314 medications, including 1 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Cerefolin NAC contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is N-acetyl cysteine, and what is it used for?
N-acetyl cysteine, or NAC, is an amino acid that boosts your body's antioxidant defenses. It's established as effective for treating acetaminophen poisoning, helping with certain lung conditions like bronchitis, and aiding in respiratory care and diagnostic procedures.
I take metformin for my blood sugar. Is this product safe with it?
Metformin can lower your B12 levels over time, and this product contains methylcobalamin (B12). While the interaction is Minor, it's a good reason to mention this product to your pharmacist so they can monitor your B12 status and adjust if needed.
What side effects might I have from N-acetyl cysteine?
Most people tolerate it well at normal doses. The most common side effects are diarrhea, dry mouth, nausea, vomiting, heartburn, and loss of appetite. Some people report joint pain. Serious side effects are rare and mostly tied to very high doses.
Is this product safe during pregnancy or while breastfeeding?
Safety during pregnancy and breastfeeding hasn't been well studied for this product. Talk with your doctor or pharmacist about whether it's right for you in those situations—they can weigh the benefits and risks based on your individual health.
What is methylcobalamin, and why is it in this product?
Methylcobalamin is a form of vitamin B12, which your body needs for nerve function and healthy red blood cells. It's effective for treating B12 deficiency and possibly helpful for nerve pain and mouth sores.
Can I take this if I'm on blood thinners?
N-acetyl cysteine may increase the risk of bleeding when combined with blood thinners or antiplatelet drugs. You'll want to check with your pharmacist before starting to make sure it's safe alongside your specific medication.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Cerefolin NAC is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Cerefolin NAC label
Go deeper

The Full Monographs Behind Cerefolin NAC’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

N-acetyl Cysteine (nac)

Interacts with 294 drugs

N-acetyl cysteine (NAC) is a supplement form of the amino acid cysteine and a building block for the antioxidant glutathione. It has well-established prescription uses for acetaminophen over...

Read the full N-acetyl Cysteine (nac) monograph → Herb & supplement monograph

Vitamin B12

Interacts with 20 drugs

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very helpful for people who are deficient — su...

Read the full Vitamin B12 monograph →
Sources

Sources & How We Checked

Cerefolin NAC's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 116 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

N-acetyl Cysteine (nac) 86 references
  1. Ellenhorn MJ, et al. Ellenhorn's Medical Toxicology: Diagnoses and Treatment of Human Poisoning. 2nd ed. Baltimore, MD: Williams & Wilkins, 1997.
  2. Jepsen S, Hansen AB. The influence of N-acetylcysteine on the measurement of prothrombin time and activated partial thromboplastin time in healthy subjects. Scand J Clin Lab Invest 1994;54:543-7. PubMed
  3. van Zandwijk N, Dalesio O, Pastorino U, et al. EUROSCAN, a randomized trial of vitamin A and N-acetylcysteine in patients with head and neck cancer or lung cancer. For the European Organization for Research and Treatment of Cancer Head and Neck and Lung C DOI
  4. Horowitz RS, Dart RC, Jarvie DR, et al. Placental transfer of N-acetylcysteine following human maternal acetaminophen toxicity. J Toxicol Clin Toxicol 1997;35:447-51.
  5. Bailey B, McGuigan MA. Management of anaphylactoid reactions to intravenous N-acetylcysteine. Ann Emerg Med 1998;31:710-5. PubMed
  6. Spiller HA, Krenzelok EP, Grande GA, et al. A prospective evaluation of the effect of activated charcoal before oral N-acetylcysteine in acetaminophen overdose. Ann Emerg Med 1994;23:519-23. PubMed
  7. Ardissino D, Merlini PA, Savonitto S, et al. Effect of transdermal nitroglycerin or N-acetylcysteine, or both, in the long-term treatment of unstable angina pectoris. J Am Coll Cardiol 1997;29:941-7. PubMed
  8. Horowitz JD, Henry CA, Syrjanen ML, et al. Nitroglycerine/N-acetylcysteine in the management of unstable angina pectoris. Eur Heart J 1988;9:95-100. PubMed
  9. Louwerse ES, Weverling GJ, Bossuyt PM, et al. Randomized, double-blind, controlled trial of acetylcysteine in amyotrophic lateral sclerosis. Arch Neurol 1995;52:559-64. PubMed
  10. Wiklund O, Fager G, Andersson A, et al. N-acetylcysteine treatment lowers plasma homocysteine but not serum lipoprotein(a) levels. Atherosclerosis 1996;119:99-106. PubMed
  11. De Flora S, Grassi C, Carati L. Attenuation of influenza-like symptomatology and improvement of cell-mediated immunity with long-term N-acetylcysteine treatment. Eur Respir J 1997;10:1535-41. PubMed
  12. Iversen HK. N-acetylcysteine enhances nitroglycerin-induced headache and cranial arterial responses. Clin Pharmacol Ther 1992;52:125-33. PubMed
  13. Behr J, Maier K, Degenkolb B, et al. Antioxidative and clinical effects of high-dose N-acetylcysteine in fibrosing alveolitis. Adjunctive therapy to maintenance immunosuppression. Am J Respir Crit Care Med 1997;156:1897-901.
  14. Tenenbein PK, Sitar DS, Tenenbein M. Interaction between N-acetylcysteine and activated charcoal: implications for the treatment of acetaminophen poisoning. Pharmacotherapy 2001;21:1331-6.
  15. Arstall MA, Yang J, Stafford I, et al. N-acetylcysteine in combination with nitroglycerin and streptokinase for the treatment of evolving acute myocardial infarction. Safety and biochemical effects. Circulation 1995;92:2855-62.
  16. Estensen RD, Levy M, Klopp SJ, et al. N-acetylcysteine suppression of the proliferative index in the colon of patients with previous adenomatous colonic polyps. Cancer Lett 1999;147:109-14. PubMed
  17. Pela R, Calcagni AM, Subiaco S, et al. N-acetylcysteine reduces the exacerbation rate in patients with moderate to severe COPD. Respiration 1999;66:495-500.. PubMed
  18. Oldemeyer JB, Biddle WP, Wurdeman RL, et al. Acetylcysteine in the prevention of contrast-induced nephropathy after coronary angiography. Am Heart J 2003;146:E23. . PubMed
  19. Ekins BR, Ford DC, Thompson MI, et al. The effect of activated charcoal on N-acetylcysteine absorption in normal subjects. Am J Emerg Med. 1987;5(6):483-7. PubMed
  20. Chamberlain JM, Gorman RL, Oderda GM, Klein-Schwartz W, Klein BL. Use of activated charcoal in a simulated poisoning with acetaminophen: a new loading dose for N-acetylcysteine? Ann Emerg Med. 1993;22(9):1398-402. PubMed
  21. Renzi FP, Donovan JW, Martin TG, Morgan L, Harrison EF. Concomitant use of activated charcoal and N-acetylcysteine. Ann Emerg Med. 1985;14(6):568-72. DOI
  22. North DS, Peterson RG, Krenzelok EP. Effect of activated charcoal administration on acetylcysteine serum levels in humans. Am J Hosp Pharm. 1981;38(7):1022-4. DOI
  23. Loscalzo J. N-Acetylcysteine potentiates inhibition of platelet aggregation by nitroglycerin. J Clin Invest. 1985;76(2):703-8. PubMed
  24. Ruiz FJ, Salom MG, Inglés AC, et al. N-acetyl-L-cysteine potentiates depressor response to captopril and enalaprilat in SHRs. Am J Physiol. 1994;267(3 Pt 2):R767-72. PubMed
  25. Deharo E, Barkan D, Krugliak M, Golenser J, Ginsburg H. Potentiation of the antimalarial action of chloroquine in rodent malaria by drugs known to reduce cellular glutathione levels. Biochem Pharmacol. 2003;66(5):809-17. PubMed
  26. Buckley, N. A., Whyte, I. M., O'Connell, D. L., and Dawson, A. H. Oral or intravenous N-acetylcysteine: which is the treatment of choice for acetaminophen (paracetamol) poisoning? J Toxicol.Clin Toxicol. 1999;37(6):759-767.
  27. Sunman, W., Hughes, A. D., and Sever, P. S. Anaphylactoid response to intravenous acetylcysteine. Lancet 5-16-1992;339(8803):1231-1232. PubMed
  28. Reynard, K., Riley, A., and Walker, B. E. Respiratory arrest after N-acetylcysteine for paracetamol overdose. Lancet 9-12-1992;340(8820):675. PubMed
  29. BERNSTEIN, I. L. and AUSDENMOORE, R. W. IATROGENIC BRONCHOSPASM OCCURRING DURING CLINICAL TRIALS OF A NEW MUCOLYTIC AGENT, ACETYLCYSTEINE. Dis.Chest 1964;46:469-473. PubMed
  30. REAS, H. W. THE USE OF N-ACETYLCYSTEINE IN THE TREATMENT OF CYSTIC FIBROSIS. J Pediatr 1964;65:542-557. PubMed
  31. Bibi, H., Seifert, B., Oullette, M., and Belik, J. Intratracheal N-acetylcysteine use in infants with chronic lung disease. Acta Paediatr. 1992;81(4):335-339. PubMed
  32. Jepsen, S., Herlevsen, P., Knudsen, P., Bud, M. I., and Klausen, N. O. Antioxidant treatment with N-acetylcysteine during adult respiratory distress syndrome: a prospective, randomized, placebo-controlled study. Crit Care Med 1992;20(7):918-923. PubMed
  33. Roes, E. M., Raijmakers, M. T., Boo, T. M., Zusterzeel, P. L., Merkus, H. M., Peters, W. H., and Steegers, E. A. Oral N-acetylcysteine administration does not stabilise the process of established severe preeclampsia. Eur.J Obstet.Gynecol.Reprod.Biol 2006
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  35. Tirouvanziam, R., Conrad, C. K., Bottiglieri, T., Herzenberg, L. A., Moss, R. B., and Herzenberg, L. A. High-dose oral N-acetylcysteine, a glutathione prodrug, modulates inflammation in cystic fibrosis. Proc Natl.Acad.Sci U.S.A 3-21-2006;103(12):4628-463
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See these in context on the N-acetyl Cysteine (nac) monograph →

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