Cerefolin NAC By Alfasigma Overview & Drug Interactions
Check For Interactions With Cerefolin NAC
Supplement: Cerefolin NAC by Alfasigma
Cerefolin NAC Label Images
This product contains
Below is a list of the 'active' ingredients listed on the supplement label for this product.
For a list of 'other ingredients', such as fillers, please see the 'Label Information' section on this page.
L-Methylfolate Calcium
| Ingredient Group | Vitamin B9 (5-Methyltetrahydrofolate) |
|---|---|
| Category | vitamin |
Algae-S Powder
| Ingredient Group | Schizochytrium |
|---|---|
| Category | other |
Methylcobalamin
Vitamin B12, also known as cobalamin, is a water-soluble vitamin crucial for several bodily functions. It plays a pivotal role in the formation of red blood cells, aiding in the prevention of anemia. Vitamin B12 is essential for maintaining a healthy nervous system and proper brain function, as it is involved in the synthesis of myelin, the protective sheath around nerve fibers. This vitamin is primarily found in animal-based foods such as meat, fish, dairy products, and eggs, making it important for vegetarians and vegans to consider supplementation. A deficiency in vitamin B12 can lead to neurological issues, fatigue, and cognitive impairment.
See More Information Regarding Vitamin B12| Ingredient Group | Vitamin B12 |
|---|---|
| Category | vitamin |
N-Acetyl-L-Cysteine
N-acetyl cysteine (NAC) is derived from the amino acid cysteine. It is used as a prescription medication to treat acetaminophen overdose and to help thin mucus in people with certain respiratory conditions. It is also used as a dietary supplement. NAC has a number of potential health benefits. It is a source of the antioxidant enzyme glutathione, which is important for protecting cells from oxidative stress and supporting immune function. It also may have anti-inflammatory effects and studies show it may support healthy brain function. It is generally considered safe to take NAC supplements in recommended doses.
See More Information Regarding N-acetyl Cysteine (nac)| Ingredient Group | N-Acetyl Cysteine |
|---|---|
| Category | non-nutrient/non-botanical |
Drugs that interact with Cerefolin NAC by Alfasigma
Below is a list of drug interactions for each ingredient in this supplement product. Please note that a supplement product may contain more than one ingredient that has interactions.
Label Information
Supplement Facts:
| Daily Value (DV) Target Group(s): | Adults and children 4 or more years of age |
|---|---|
| Minimum serving Sizes: |
1 Caplet(s)
|
| Maximum serving Sizes: |
1 Caplet(s)
|
| Ingredient | Amount per Serving | Group | % DV, Adults & children 4+ years |
|---|---|---|---|
| L-Methylfolate Calcium |
6 mg
|
Vitamin B9 (5-Methyltetrahydrofolate) |
|
| Algae-S Powder |
90.314 mg
|
Schizochytrium |
|
| Methylcobalamin |
2 mg
|
Vitamin B12 |
|
| N-Acetyl-L-Cysteine |
600 mg
|
N-Acetyl Cysteine |
|
| Other Ingredients: |
silicified Microcrystalline Cellulose
Algae-S Powder
Forms
Polyvinyl Alcohol
Croscarmellose Sodium
Titanium Dioxide
Polyethylene Glycol 3350
Magnesium Stearate
Talc
Beet powder
Caramel
Carnauba wax
|
|---|
Label Statments:
| General Statements |
- Description
CerefolinNAC is a prescription medical food for use only under the supervision of a physician for the clinical dietary management of mild cognitive impairment and is specially formulated to meet the distinctive nutritional requirements for this condition.
- CAS# 151533-22-1
- This product is not an orange book product.
- CerefolinNAC bottle of 90 Product Code # 00525-0555-90.
- Each CerefolinNAC caplet is an oval coated beige colored caplet. Debossed with “PAL” on one side and “600” on the other.
- Alfasigma USA, Inc. does not represent these product codes to be National Drug Codes (NDC). Product codes are formatted according to standard industry practice, to meet the formatting requirements of pharmacy and health insurance computer systems.
|
|---|---|
| Formula |
- Contains milk and soy
- Indications and usage
CerefolinNAC is indicated for the distinct nutritional requirements of individuals with mild to moderate cognitive impairment who present with an increased risk for neurovascular oxidative stress and/or hyperhomocysteinemia; and/or suboptimal L-methylfolate and/or vitamin B12 levels in the cerebrospinal fluid, plasma, and/or red blood cells.
- Allergic reactions have been reported following the use of oral L-methylfolate Calcium. Mild transient diarrhea, itching, transitory exanthema and the feeling of swelling of the entire body has been associated with methylcobalamin. Nausea, vomiting, diarrhea, transient skin rash, flushing, epigastric pain, and constipation have been associated with N-acetyl-L-cysteine.
|
| Precautions |
- Contains milk and soy
- CerefolinNAC is a prescription medical food for use only under the supervision of a physician.
- Medical foods are intended for a patient who has a limited or impaired capacity to ingest, digest, absorb, or metabolize ordinary foodstuffs or certain nutrients, or who has other special medically determined nutrient requirements, the dietary management of which cannot be achieved by the modification of the normal diet alone.
- Contraindications
CerefolinNAC is contraindicated in patients with known hypersensitivity to any of the components contained in this product.
- Precautions
General
Folic acid, when administered in daily doses above 0.1mg, may obscure the detection of B12 deficiency (specifically, the administration of folic acid may reverse the hematological manifestations of B12 deficiency, including pernicious anemia, while not addressing the neurological manifestations). L-methylfolate Calcium may be less likely than folic acid to mask vitamin B12 deficiency. Folate therapy alone is inadequate for the treatment of a B12 deficiency.
- N-acetyl-L-cysteine should be avoided by nursing mothers.
- N-acetyl-L-cysteine clearance is reduced in those with chronic liver disease as well as in pre-term newborns.
- Headaches may be intensified in those taking N-acetyl-L-cysteine and nitrates for the treatment of angina.24 While the incidence of renal stones is low, those that do form renal stones, particularly cysteine stones should avoid CerefolinNAC. Do not administer CerefolinNAC to critically ill patients. N-acetyl-L-cysteine and its sulfhydryl metabolites could produce a false-positive result in the nitroprusside test for ketone bodies used in diabetes.24 N-acetyl-L-cysteine should be used with caution in those with a history of peptic ulcer disease since N-acetyl-L-cysteine may disrupt the gastric mucosal barrier.
- Adverse reactions
Allergic reactions have been reported following the use of oral L-methylfolate Calcium. Mild transient diarrhea, itching, transitory exanthema and the feeling of swelling of the entire body has been associated with methylcobalamin. Nausea, vomiting, diarrhea, transient skin rash, flushing, epigastric pain, and constipation have been associated with N-acetyl-L-cysteine.
- Use under medical supervision.
|
| Formulation |
- CerefolinNAC caplets do not contain lactose, yeast or gluten.
|
| Suggested/Recommended/Usage/Directions |
- Recommended use
The usual adult dose is one caplet daily or as directed under medical supervision.
|
| Storage |
- Storage
Store at controlled room temperature 15(0)C to 30(0)C (59(0)F to 86(0)F) (See USP). Protect from heat, light and moisture.
|
| Brand IP Statement(s) |
- Patents
Some or all of the following patents may apply:
U.S. Patent No. 5,997,915
U.S. Patent No. 6,008,221
U.S. Patent No. 6,011,040
U.S. Patent No. 6,127,370
U.S. Patent No. 6,254,904
U.S. Patent No. 6,441,168B1
U.S. Patent No. 7,172,778
U.S. Patent No. 7,674,490
U.S. Patent No. 7,709,460B2
- Metafolin is a registered trademark of Merck KGaA, Darmstadt, Germany.
|
Brand Information
See all products by this brand
| Manufactured and Distributed by | |
|---|---|
| Name | Alfasigma USA, Inc. |
| City | Covington |
| State | LA |
| ZipCode | 70433 |
| Phone Number | 1-844-639-9726 |
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Parts of this content are provided by the Therapeutic Research Center, LLC and the Dietary Supplement Label Database.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.