Major interaction on record — check this product against your medications before combining. Check your meds →
Dietary supplement

Complete Tissue & Bone Syrup Ingredients & Drug Interactions

by Christopher's Original Formulas

Complete Tissue & Bone Syrup label
See full label image
Liquid Category: Botanical
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Complete Tissue & Bone Syrup against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Complete Tissue & Bone Syrup is a dietary supplement by Christopher's Original Formulas with 12 active ingredients. Its ingredients are commonly taken for anxiety and stress, trouble sleeping, nervous tension.Based on those ingredients, 2,097 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Marshmallow, Plantain, Slippery Elm. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Complete Tissue & Bone Syrup by Christopher's Original Formulas

Ask about any prescription or over-the-counter medication and we check it for interactions with Complete Tissue & Bone Syrup by Christopher's Original Formulas — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Complete Tissue & Bone Syrup by Christopher's Original Formulas

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 12 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label doesn't break down how much of each component you get.

Complete Tissue & Bone Syrup contains 12 active herbal ingredients in a liquid base. The formula combines scullcap, slippery elm, marshmallow, mullein, lobelia, plantain (black psyllium), black walnut, wormwood, white oak, gravel root, lungwort, and aloe vera.

Most are traditional botanicals chosen for their long history of use; plantain and aloe vera have some clinical evidence for their intended purposes. The exact proportions are proprietary and not disclosed on the label.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

We hold no graded evidence for this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: tissue and bone support.
  • We looked for evidence on: bone health, connective tissue health, structural integrity.
  • Our graded evidence for these ingredients doesn't cover that particular purpose.

The evidence for most ingredients in this formula is incomplete. Plantain (black psyllium) shows the strongest support — it's Likely Effective for coronary heart disease and Effective for constipation.

Aloe vera is Possibly Effective for several conditions including constipation, diabetes, burns, and psoriasis. For the remaining ingredients — scullcap, slippery elm, marshmallow, mullein, lobelia, black walnut, wormwood, white oak, gravel root, and lungwort — the data we hold does not establish reliable evidence for their intended effects.

Lobelia, in fact, is rated Possibly Ineffective for smoking cessation.

The evidence, ingredient by ingredient Skullcap Slippery Elm Marshmallow Mullein Lobelia Black Psyllium Black Walnut Wormwood

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 9 of the 12 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 12 of 12.
  • General safety write-ups exist for 12 of 12.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Most ingredients are generally well tolerated for short-term use, though safety data are limited for many. The main concerns are dose-dependent: scullcap can cause sedation and cognitive impairment at higher doses; lobelia can be toxic, causing nausea, vomiting, diarrhea, tremors, and at 600 mg or higher, serious effects like rapid heart rate, low blood pressure, and even death.

Aloe latex (if present in this syrup) can cause abdominal pain, cramps, and diarrhea, and long-term overuse may deplete potassium. Gravel root carries a hepatotoxicity risk due to pyrrolizidine alkaloid content and should be used only short-term.

Black walnut's leaf, bark, and hull contain tannins that may upset your stomach. Wormwood contains thujone, a neurotoxin, and overuse can cause kidney damage, muscle breakdown, and seizures.

For pregnancy and breastfeeding, the data advise against scullcap, marshmallow, mullein, wormwood, gravel root, and lungwort, and strongly against lobelia and aloe vera. Black walnut and slippery elm have insufficient or conflicting safety data in pregnancy — discuss with your doctor or pharmacist before use.

Side effects, ingredient by ingredient Skullcap Slippery Elm Marshmallow Mullein Lobelia Black Psyllium Black Walnut Wormwood

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 9 of the 12 matched ingredients can interact with medications — Black Psyllium, Lobelia, Mullein, Aloe, Gravel Root, among others.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; seizure medications; diabetes medications; heart-rhythm medications; lithium.
  • For scale: 2,098 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your pharmacist or doctor if you take any of these: digoxin or other heart medications (Major interaction with aloe vera); blood thinners or antiplatelet drugs like warfarin, aspirin, or clopidogrel (aloe vera, mullein, marshmallow); lithium (marshmallow, lobelia, plantain, gravel root); metformin or other diabetes drugs (plantain, aloe vera); carbamazepine or other anticonvulsants (plantain, wormwood); water pills or diuretics (aloe vera); birth control pills containing ethinyl estradiol (plantain); olanzapine (plantain); or sedating medications such as benzodiazepines or sleep aids (scullcap). Slippery elm may slow absorption of many oral medications — space it 30–60 minutes away from other drugs.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no assessable stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This is a traditional herbal formula best suited for short-term use under the guidance of a practitioner familiar with herbal medicine. If you take digoxin, any blood thinner, lithium, metformin, carbamazepine, olanzapine, birth control pills, or a diuretic, you must check your medications with the tool below before starting.

If you are pregnant or breastfeeding, talk to your pharmacist or doctor first — several ingredients are not considered safe in these situations.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 12 of 12 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 25, 2019.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Complete Tissue & Bone Syrup, straight from the product label.

Brand Christopher's Original Formulas
Barcode (UPC) 084783885283
Net contents 16 fl. Oz.; 423 mL
Market status On market
Date entered into DSLD Feb 25, 2019
DSLD ID 200164
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Complete Tissue & Bone Syrup by Christopher's Original Formulas, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablespoon(s)
Maximum serving Sizes:
1 Tablespoon(s)
Servings per container
32
UPC/BARCODE
084783885283
IngredientAmount% DV
Scullcap0 NP--
Slippery Elm0 NP--
Marshmallow0 NP--
Proprietary Blend0 NP--
Mullein0 NP--
Lobelia0 NP--
Plantain0 NP--
Black Walnut0 NP--
Wormwood0 NP--
White Oak0 NP--
Gravel Root0 NP--
Lungwort0 NP--
Aloe vera0 NP--

Other ingredients: A base of

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, take 1 tablespoon a day as a tonic, or 1 tablespoon every hour as needed, or as directed by your health care professional.

Storage

Refrigerate after opening.

Precautions

Warning: Do not use during pregnancy, or while nursing, except as directed by your health care professional.

Brand IP Statement(s)

2010 Wholistic Botanicals L.L.C. All Rights Reserved

John R. Christopher

FDA Statement of Identity

Dietary Supplement

General Statements

BF&C Reformulated for Internal Consumption

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Complete Tissue & Bone Syrup by Christopher's Original Formulas label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Complete Tissue & Bone Syrup label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Complete Tissue & Bone Syrup by Christopher's Original Formulas

These are the 12 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Tablespoon(s) Dosage formLiquid Servings per container32 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Blend

0 NP per serving

Other (inactive) ingredients: A base of. These complete the product’s ingredient list but are not active constituents.

Interaction report

Complete Tissue & Bone Syrup by Christopher's Original Formulas Drug Interactions

Want to check YOUR meds against Complete Tissue & Bone Syrup?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2,097Drugs
1 Major 2,089 Moderate 7 Minor

Ingredients driving the most interactions

Marshmallow 2,040
Plantain 2,025
Slippery Elm 2,022
Aloe vera 461
Scullcap 248

Individual Drug Interactions

The ingredients in Complete Tissue & Bone Syrup interact with 2,097 drugs. Click any drug to see the details.

9 of the 12 ingredients in Complete Tissue & Bone Syrup interact with drugs. Each result below shows which ingredient is responsible. Marshmallow Plantain Slippery Elm Aloe vera Scullcap Mullein Gravel Root Wormwood Lobelia

Each ingredient & the kinds of drugs it affects

For each ingredient in Complete Tissue & Bone Syrup with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Marshmallow3 drug types · 2,040 drugs

Lithium

Theoretically, due to potential diuretic effects, marshmallow might reduce excretion and increase levels of lithium.
Marshmallow is thought to have diuretic properties. To avoid lithium toxicity, the dose of lithium might need to be decreased when used with marshmallow.

Likelihood Probable Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, marshmallow flower might have antiplatelet effects.
Animal research suggests that marshmallow flower extract has antiplatelet effects. However, the root and leaf of marshmallow, not the flower, are the plant parts most commonly found in dietary supplements. Theoretically, use of marshmallow flower with anticoagulant/antiplatelet drugs can have additive effects, and might increase the risk for bleeding in some patients.

Likelihood Unlikely Evidence D
Oral Drugs

Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Marshmallow contains mucilage which can affect oral drug absorption. To avoid changes in absorption, take marshmallow 30-60 minutes after oral medications.

Likelihood Possible Evidence D
Marshmallow full monograph & interactions

Plantain7 drug types · 2,025 drugs

Carbamazepine (Tegretol)

Theoretically, black psyllium might reduce the effects of carbamazepine and increase the risk for convulsions.
Theoretically, black psyllium might reduce carbamazepine absorption. A preliminary study using blond psyllium reported decreased carbamazepine bioavailability due to binding of the drug to psyllium, as well as reduction of available fluid in the gut for dissolution of the drug. This interaction may also occur with black psyllium.

Likelihood Probable Evidence D
Lithium

Theoretically, taking black psyllium at the same time as lithium might reduce lithium absorption.
The fiber in black psyllium might reduce lithium absorption and plasma levels. Some case reports describe a reduction in plasma lithium levels with concomitant administration of blond psyllium. This was reversed when psyllium was stopped. This interaction may also occur with black psyllium.

Likelihood Probable Evidence D
Metformin (Glucophage)

Theoretically, black psyllium might increase the therapeutic and adverse effects of metformin.
Animal research shows that concurrent consumption of blond psyllium with metformin slows and increases the absorption of metformin. This interaction may also occur with black psyllium. To avoid changes in absorption, take psyllium 30-60 minutes after metformin.

Likelihood Possible Evidence D
Olanzapine (Zyprexa)

Theoretically, taking black psyllium at the same time as olanzapine might reduce olanzapine absorption.
The fiber in black psyllium might decrease the absorption of olanzapine. A single case report describes a reduction in the effectiveness of olanzapine when it was concomitantly administered with an unspecified type of psyllium 3 grams orally twice daily. This effect was reversed when psyllium was stopped.

Likelihood Possible Evidence D
Digoxin (Lanoxin)

Theoretically, taking black psyllium at the same time as digoxin might reduce digoxin absorption and decrease digoxin levels.
Psyllium might bind digoxin in the gut. However, some clinical evidence suggests that psyllium does not impact digoxin absorption.

Likelihood Unlikely Evidence B
Ethinyl Estradiol

Theoretically, taking black psyllium at the same time as ethinyl estradiol might alter levels of estradiol.
Concurrent use of blond psyllium with ethinyl estradiol results in a slight increase in the extent of ethinyl estradiol absorption and a slower rate of absorption. This is unlikely to be clinically significant.

Likelihood Unlikely Evidence D
Oral Drugs

Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Psyllium seems to have variable effects on drug absorption. To avoid changes in absorption, take psyllium 30-60 minutes after oral medications. Animal research shows that blond psyllium delays and increases the absorption of metformin and ethinyl estradiol. Case reports and animal research suggest that blond psyllium might reduce absorption of lithium, digoxin, olanzapine, and carbamazepine. Finally, some pharmacokinetic studies show that psyllium does not affect the absorption of levothyroxine or warfarin. Although many of these studies evaluated blond psyllium, the fiber content in black psyllium may have similar effects.

Likelihood Possible Evidence B
Plantain full monograph & interactions

Slippery Elm1 drug type · 2,022 drugs

Oral Drugs

Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Slippery elm inner bark contains mucilage, which may interfere with the absorption of orally administered drugs.

Likelihood Possible Evidence D
Slippery Elm full monograph & interactions

Aloe vera7 drug types · 461 drugs

Digoxin (Lanoxin)

Theoretically, aloe latex might increase the risk of adverse effects when taken with cardiac glycosides.
Overuse of aloe latex can increase the risk of adverse effects from cardiac glycoside drugs, such as digoxin, due to potassium depletion. Overuse of aloe, along with cardiac glycoside drugs, can increase the risk of toxicity.

Likelihood Probable Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, aloe gel might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
In vitro research shows that aloe gel can inhibit platelet aggregation. This inhibition was greater than that seen with celecoxib, but less than that seen with aspirin.

Likelihood Possible Evidence D
Antidiabetes Drugs

Aloe might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Preliminary clinical research suggests aloe gel might lower blood glucose levels and have additive effects when used with antidiabetes drugs. Monitor blood glucose levels closely.

Likelihood Possible Evidence D
Diuretic Drugs

Theoretically, aloe latex might increase the risk of hypokalemia when taken with diuretic drugs.
Overuse of aloe latex might compound diuretic-induced potassium loss, increasing the risk of hypokalemia.

Likelihood Possible Evidence D
Stimulant Laxatives

Theoretically, aloe latex might increase the risk for fluid and electrolyte loss when taken with stimulant laxatives.
Due to cathartic laxative effects of aloe latex, concomitant use with other stimulant laxatives might compound fluid and electrolyte loss.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, aloe latex might increase the risk of bleeding when taken with warfarin.
Aloe latex has stimulant laxative effects. In some people aloe latex can cause diarrhea. Diarrhea can increase the effects of warfarin, increase international normalized ratio (INR), and increase the risk of bleeding. Advise patients who take warfarin not to take excessive amounts of aloe vera.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, aloe might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that aloe extract induces CYP1A2 enzymes.

Likelihood Possible Evidence D
Aloe vera full monograph & interactions

Scullcap1 drug type · 248 drugs

Cns Depressants

Theoretically, skullcap can have additive effects when used with other CNS depressants.
Animal and clinical research suggests that skullcap can cause sedation and cognitive impairment.

Likelihood Possible Evidence D
Scullcap full monograph & interactions

Mullein1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Lab tests on extracts from different parts of common and dense-flowered mullein plants show that they do have some blood-thinning effects, as they increase the time it takes for blood to clot. This is likely due to at least one of the known constituents of muellein, triterpenoid saponins. However, the effects appear to be mild and results have been inconsistent. Extracts from different plant parts have been show to have varying anticoagulant strengths, with water-based ones being more potent than alcohol-based extracts.

Likelihood Unlikely Evidence A
Mullein full monograph & interactions

Gravel Root2 drug types · 88 drugs

Cytochrome P450 3A4 (Cyp3A4) Inducers

Hepatotoxic pyrrolizidine alkaloids (PA) are substrates of cytochrome P450 3A4 (CYP3A4). Theoretically, drugs that induce CYP3A4 might increase the conversion of PAs to toxic metabolites. Some drugs that induce CYP3A4 include carbamazepine (Tegretol), phenobarbital, phenytoin (Dilantin), rifampin, rifabutin (Mycobutin), and others.

Likelihood Possible Evidence D
Lithium

Gravel root is thought to have diuretic properties. Theoretically, due to these potential diuretic effects, gravel root might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
Gravel Root full monograph & interactions

Wormwood1 drug type · 50 drugs

Anticonvulsants

Theoretically, taking wormwood might interfere with the effects of anticonvulsant drugs.
Thujone, a constituent of wormwood, has convulsant effects.

Likelihood Possible Evidence D
Wormwood full monograph & interactions

Lobelia1 drug type · 1 drug

Lithium

Lobelia is thought to have diuretic properties. Theoretically, due to these potential diuretic effects, lobelia might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
Lobelia full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Complete Tissue & Bone Syrup, from the product label.

Christopher's Original Formulas

See all Christopher's Original Formulas products
Name
Wholistic Botanicals L.L.C.
City
Spanish Fork
State
UT
ZipCode
84660
Phone Number
1-800-453-1406
Web Address
www.drchristopher.com
Pharmacist Counseling Corner

Complete Tissue & Bone Syrup by Christopher's Original Formulas: Common Questions

Does Complete Tissue & Bone Syrup by Christopher's Original Formulas interact with any medications?
Yes. Based on its ingredients, Complete Tissue & Bone Syrup has a known interaction with 2,097 medications, including 1 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Complete Tissue & Bone Syrup contains 12 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
Several ingredients — including scullcap, marshmallow, mullein, wormwood, gravel root, and lungwort — are not considered safe during pregnancy or breastfeeding. Lobelia and aloe vera are specifically advised against. Black walnut and slippery elm have insufficient or conflicting safety data. Talk with your doctor or pharmacist for personalized guidance before use.
Will this interact with my blood pressure or heart medications?
Yes — aloe vera can interact with digoxin (a heart medication) and increase toxicity risk. Marshmallow and lobelia may affect lithium levels. Your pharmacist can check your specific medications using the tool on this page.
What does plantain (black psyllium) do in this formula?
Plantain is a soluble fiber that has solid evidence for helping constipation and supporting heart health. It's Effective for constipation and Likely Effective for coronary heart disease. The downside is it can slow the absorption of other oral medications, so space it 30–60 minutes away from your prescriptions.
What are the most common side effects I should expect?
With short-term use, most people tolerate this formula well. Plantain commonly causes bloating and gas, especially when first starting — you can reduce this by increasing the dose gradually. Scullcap may cause sedation or digestive upset at higher doses. Aloe can cause abdominal cramping and diarrhea. Lobelia carries a higher risk of nausea, vomiting, and diarrhea even at modest doses.
Can I take this long-term?
The data we hold recommend short-term use for most ingredients in this formula. Gravel root and lobelia especially should be used only briefly due to toxicity and liver concerns. If you're considering longer-term use, talk with your herbalist or pharmacist first.
How should I space this syrup away from my other medications?
Slippery elm and plantain both contain mucilage that can slow oral drug absorption, so take them at least 30–60 minutes after your other medications. If you're taking multiple prescriptions, check with your pharmacist for the best timing, as interactions vary by drug.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Complete Tissue & Bone Syrup label
Go deeper

The Full Monographs Behind Complete Tissue & Bone Syrup’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Skullcap

Interacts with 248 drugs

American skullcap is an herb traditionally used to calm anxiety and promote relaxation, but solid human evidence is very limited. It is generally considered relatively safe for short-term us...

Read the full Skullcap monograph → Herb & supplement monograph

Slippery Elm

Interacts with 2,022 drugs

Slippery elm is a traditional herbal remedy made from the inner bark of a North American elm tree, used mainly to soothe sore throats and irritated digestive tracts. Its mucilage can coat an...

Read the full Slippery Elm monograph → Herb & supplement monograph

Marshmallow

Interacts with 2,040 drugs

Marshmallow root is a traditional herb rich in soothing, gel-like fibers called mucilage, which is why it has long been used for coughs, sore throats, and stomach irritation. Evidence for th...

Read the full Marshmallow monograph → Herb & supplement monograph

Mullein

Interacts with 122 drugs

Mullein is a traditional herbal remedy most often used as a tea or syrup to soothe coughs, sore throats, and respiratory irritation. High-quality human studies are lacking, so its benefits a...

Read the full Mullein monograph → Herb & supplement monograph

Lobelia

Interacts with 1 drug

Lobelia is a traditional herb once used for breathing problems and to help people quit smoking, but reliable evidence supporting these uses is lacking. It can be toxic in higher amounts, cau...

Read the full Lobelia monograph → Herb & supplement monograph

Black Psyllium

Interacts with 2,025 drugs

Black psyllium is a soluble-fiber supplement made from the seeds of a Plantago plant, used mostly to ease constipation and support digestive health. It is best known and most studied for rel...

Read the full Black Psyllium monograph → Herb & supplement monograph

Black Walnut

Black walnut is a tree whose green hulls are traditionally used as a natural antiparasitic and digestive remedy, but solid human evidence for these uses is lacking. It contains a compound ca...

Read the full Black Walnut monograph → Herb & supplement monograph

Wormwood

Interacts with 50 drugs

Wormwood is a very bitter herb traditionally used to stimulate appetite and ease digestion, and it has early research interest in Crohn's disease. It contains thujone, which can be toxic in...

Read the full Wormwood monograph → Herb & supplement monograph

White Oak

White oak bark is a traditional herbal remedy rich in tannins, used mostly as a tea or skin wash for diarrhea, sore throat, and minor skin problems. Solid human evidence is very limited, and...

Read the full White Oak monograph → Herb & supplement monograph

Gravel Root

Interacts with 88 drugs

Gravel Root is a traditional North American herb long used by herbalists for kidney stones and urinary problems, but there is very little modern scientific evidence to support these uses. Be...

Read the full Gravel Root monograph → Herb & supplement monograph

Lungwort

Lungwort (Pulmonaria officinalis) is a traditional European herb long used as a tea for coughs and minor breathing complaints, named for its lung-shaped, spotted leaves. There is very little...

Read the full Lungwort monograph → Herb & supplement monograph

Aloe

Interacts with 461 drugs

Aloe vera gel is widely used on the skin for minor burns and irritation, and some research suggests it may help. Aloe latex (the yellow part) is a strong laxative that can cause cramping and...

Read the full Aloe monograph →
Sources

Sources & How We Checked

Complete Tissue & Bone Syrup's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 99 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Skullcap 3 references
  1. Wolfson P, Hoffmann DL. An investigation into the efficacy of Scutellaria lateriflora in healthy volunteers. Altern Ther Health Med 2003;9:74-8.
  2. Awad, R., Arnason, J. T., Trudeau, V., Bergeron, C., Budzinski, J. W., Foster, B. C., and Merali, Z. Phytochemical and biological analysis of skullcap (Scutellaria lateriflora L.): a medicinal plant with anxiolytic properties. Phytomedicine. 2003;10(8):6 PubMed
  3. Brock C, Whitehouse J, Tewfik I, Towell T. American skullcap (Scutellaria lateriflora): a randomised, double-blind placebo-controlled crossover study of its effects on mood in healthy volunteers. Phytother Res 2014;28(5):692-8.

See these in context on the Skullcap monograph →

Slippery Elm 3 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  3. Czarnecki D, Nixon R, Bekhor P, and et al. Delayed prolonged contact urticaria from the elm tree. Contact Dermatitis 1993;28:196-197. PubMed

See these in context on the Slippery Elm monograph →

Marshmallow 5 references
  1. Monographs on the medicinal uses of plant drugs. Exeter, UK: European Scientific Co-op Phytother, 1997.
  2. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  3. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
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Mullein 2 references
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Lobelia 6 references
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Black Walnut 3 references
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Wormwood 10 references
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White Oak 2 references
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Gravel Root 5 references
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See these in context on the Gravel Root monograph →

Lungwort 1 reference
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See these in context on the Lungwort monograph →

Aloe 41 references
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  37. Hoogenboom TCH, Patel N, Cook NA, Williams R, Taylor-Robinson SD, Lim AKP. The effect of Aloe vera juice on liver enzymes and hepatic structure in a healthy population. Integr Med (Encinitas) 2020;19(3):30-4.
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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