Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Creatine Advance XR Unflavored Ingredients & Drug Interactions

by GNC Pro Performance

Creatine Advance XR Unflavored label
See full label image
Powder Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Creatine Advance XR Unflavored against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Creatine Advance XR Unflavored is a dietary supplement by GNC Pro Performance with 2 active ingredients. Its ingredients are commonly taken for improving high-intensity exercise performance, building muscle strength and size, sports and athletic training.Based on those ingredients, 403 medications have a known interaction with it, the most serious rated moderate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Creatine Advance XR Unflavored by GNC Pro Performance

Ask about any prescription or over-the-counter medication and we check it for interactions with Creatine Advance XR Unflavored by GNC Pro Performance — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Creatine Advance XR Unflavored by GNC Pro Performance

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 10 active ingredients.
  • “Creatine Blend” is a proprietary blend — the label gives one combined amount (5 Gram(s)) without saying how much of each component you get.
  • “Creatine Precursors” is listed as a grouped ingredient — the label gives one combined amount (100 mg) without saying how much of each component you get.

This product contains 10 ingredients, including several forms of creatine (creatine monohydrate, creatine HCl, creatine citrate, creatine AKG, creatine ethyl ester HCl, and OT2 creatine), plus L-arginine, L-methionine, guanidinoacetate, and alpha-ketoglutarate. The creatine forms are meant to support muscle strength and athletic performance.

L-arginine helps with nitric oxide production and blood vessel function. L-methionine is an amino acid, and the other compounds support creatine synthesis in your body.

The product also contains small amounts of natural flavor, hydrogenated vegetable oil, and monoglycerides as inactive ingredients.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: increases strength, power and athletic performance.
  • We looked for evidence on: Athletic performance, Muscle strength, Physical performance, Muscle breakdown, Postoperative recovery, Exercise performance — and 2 related terms.
  • The strongest evidence on file: Creatine is rated "Possibly Effective" for Athletic performance (Natural Medicines).
  • Also on file: Creatine is rated "Possibly Effective" for Muscle strength.
  • Also on file: Creatine is rated "Insufficient Reliable Evidence To Rate" for Muscle breakdown, Physical performance, Postoperative recovery.

The creatine forms in this product are possibly effective for muscle strength, athletic performance, sarcopenia (age-related muscle loss), and cerebral creatine deficiency syndromes. They appear possibly ineffective for Huntington disease and osteopenia.

L-methionine carries a rating of possibly effective for neural tube birth defects, but insufficient evidence exists for its use in hay fever, asthma, colorectal cancer, and acetaminophen poisoning. L-arginine has no effectiveness ratings in our data.

Effectiveness data for guanidinoacetate and alpha-ketoglutarate is not on file.

The evidence, ingredient by ingredient Creatine L-arginine Methionine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Creatine is generally well tolerated in healthy adults, though those with kidney problems should be cautious. Common side effects include dehydration, diarrhea, muscle cramps, water retention, and gastrointestinal upset.

Rare case reports mention kidney inflammation, kidney failure, muscle breakdown, and blood clots, though research hasn't confirmed a strong causal link. L-arginine is often well tolerated short-term but can lower blood pressure and isn't safe for everyone — it should be used only under medical supervision.

Common side effects of L-arginine include abdominal pain, bloating, nausea, diarrhea, headache, insomnia, and flushing. L-methionine is usually safe in food amounts but high-dose supplements may cause dizziness, drowsiness, low blood pressure, irritability, and vomiting.

Side effects, ingredient by ingredient Creatine L-arginine Methionine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 3 matched ingredients can interact with medications — L-arginine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 403 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your exact medications before taking this product. The most serious interactions are with blood pressure medications (antihypertensives), ACE inhibitors, and ARBs — L-arginine can lower blood pressure excessively and raise potassium levels.

Also check if you're on blood thinners or antiplatelet drugs (increased bleeding risk), diabetes medications (risk of low blood sugar), potassium-sparing diuretics (high potassium), sildenafil (Viagra), or isoproterenol. We couldn't check guanidinoacetate and alpha-ketoglutarate for interactions — data isn't on file.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product is designed for people looking to support muscle strength and athletic performance. However, if you take any blood pressure medication, blood thinners, diabetes drugs, or potassium-sparing diuretics, you need to check with your pharmacist first — L-arginine interacts with these and can cause serious complications.

Anyone with kidney disease should also talk to their doctor before starting. Those who are pregnant or nursing should avoid it, since safety hasn't been established for the creatine forms.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 8 of 10 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 23, 2017.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Creatine Advance XR Unflavored, straight from the product label.

Brand GNC Pro Performance
Barcode (UPC) 048107119577
Net contents 7.39 Oz(s); 210 Gram(s)
Market status On market
Date entered into DSLD Jun 23, 2017
DSLD ID 74586
Product type Other Combinations
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Creatine Advance XR Unflavored by GNC Pro Performance, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
7 Gram(s)
Maximum serving Sizes:
7 Gram(s)
Servings per container
30
UPC/BARCODE
048107119577
IngredientAmount% DV
Calories5 Calorie(s)--
Total Carbohydrates1 Gram(s)1%
L-Arginine0 NP--
L-Methionine0 NP--
Creatine HCl0 NP--
Creatine Citrate0 NP--
Guanidinoacetate0 NP--
Creatine AKG0 NP--
Alpha-Ketoglutarate0 NP--
micronized Creatine Monohydrate0 NP--
Creatine Ethyl Ester HCl0 NP--
Creatine Blend5 Gram(s)--
Creatine Precursors100 mg--
OT2 Creatine0 NP--

Other ingredients: Natural flavor, Hydrogenated Vegetable Oil, Monoglycerides

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

Keep out of reach of children.

Warning: Consult your physician prior to using this product if you are pregnant, nursing, taking medication, under 18 years of age or have a medical condition.

Warning: Consult your physician prior to using this product if you are pregnant, nursing, taking medication, under 18 years of age or have a medical condition.

Storage

Store in a cool, dry place.

FDA Statement of Identity

Dietary Supplement

Formula

5000mg, 6 form Creatine Blend fuels muscle energy & hydration

OT2 with immediate & sustained 6 hour extended release

General Statements

Increases strength & power and enhances athletic performance

30 servings

Strength

Discontinue use two weeks prior to surgery.

Notice: Significant product settling may occur.

Products bearing this logo have been tested for banned substances by LGC Science, Inc., a world-class anti-doping lab. Product was tested for over 145 banned substances on the 2014 World Anti-Doping Agency (WADA) Prohibited List via LGC skip lot testing protocol #ICP0307. See gnc.com for more information.

Creatine provides support for energy production during exercise and helps your muscles make and circulate ATP for quick, intense activity.

These breakthrough products are designed to deliver immediate and sustained release of ingredients to help maintain benefits throughout your workout, day or night.

These special activities may be seen in the product - now that's real technology you can see and feel! With the introduction of the unique, sustained-release technology, now muscle-fueling creatine is released for up to six hours!

The full muscle-building potential of a GNC product is based on its total nitrogen content-so the more nitrogen a product has, the stronger it will perform. Nitrogen needs increase during training, and if nitrogen levels are low, your body pulls from muscle stores which can result in catabolism, poor performance adn longer recovery.

Seals/Symbols

Banned substance free

Informed-Choice.org Trusted by sport

Brand IP Statement(s)

Nitro-factor 10g

OT2 Optimal timing technology

The benefits of Creatine Advance XR GNC's superior Pro Performance Creatine Advance XR product is a dual-release formula with technology-enhancement that extends the release of creatine, a key building block shown to support improved strength and performance. GNC's recently created Optimal Timing Technology-OT2- was designed for immediate and 6 hr sustained release creatine.

OT2-The GNC advantage OT2 is GNC's intelligent nutrient delivery system engineered to help release key ingredients during crucial times when you need them most!

OT2 ingredients are coated with a special technology that controls when they are released.

NItro-Factor - maximize muscle building

To fuel performance and anabolism, Pro Performance Creatine Advance XR is loaded with 10 grams of nitrogen-boosting ingredients.

Suggested/Recommended/Usage/Directions

Daily

Directions: As a dietary supplement, mix one scoop (7g) with 4-6 fl. oz. of water, your favorite beverage or protein and consume before, during or after training. Consume ample amounts of water while taking the product.

General

Code 386212 IOG

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Creatine Advance XR Unflavored by GNC Pro Performance label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Creatine Advance XR Unflavored label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Creatine Advance XR Unflavored by GNC Pro Performance

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size7 Gram(s) Dosage formPowder Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Creatine Blend

No known
interactions
5 Gram(s) per serving

Creatine is one of the most studied sports supplements, with solid evidence that it can boost strength and performance during short, high-intensity ac...

Creatine Blend monograph & interactions

Creatine Precursors

No known
interactions
100 mg per serving

Creatine is one of the most studied sports supplements, with solid evidence that it can boost strength and performance during short, high-intensity ac...

Creatine Precursors monograph & interactions

Other (inactive) ingredients: Natural flavor, Hydrogenated Vegetable Oil, Monoglycerides. These complete the product’s ingredient list but are not active constituents.

Interaction report

Creatine Advance XR Unflavored by GNC Pro Performance Drug Interactions

Want to check YOUR meds against Creatine Advance XR Unflavored?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
403Drugs
395 Moderate 8 Minor

Ingredients driving the most interactions

Individual Drug Interactions

The ingredients in Creatine Advance XR Unflavored interact with 403 drugs. Click any drug to see the details.

0 of the 2 ingredients in Creatine Advance XR Unflavored interact with drugs. Each result below shows which ingredient is responsible.

Each ingredient & the kinds of drugs it affects

For each ingredient in Creatine Advance XR Unflavored with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

The maker

Brand information

Manufacturer and brand details for Creatine Advance XR Unflavored, from the product label.

GNC Pro Performance

See all GNC Pro Performance products
Name
General Nutrition Corporation
City
Pittsburgh
State
PA
ZipCode
15222
Phone Number
1-888-462-2548
Web Address
gnc.com
Pharmacist Counseling Corner

Creatine Advance XR Unflavored by GNC Pro Performance: Common Questions

Does Creatine Advance XR Unflavored by GNC Pro Performance interact with any medications?
Yes. Based on its ingredients, Creatine Advance XR Unflavored has a known interaction with 403 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Creatine Advance XR Unflavored contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while pregnant?
The creatine forms should be avoided during pregnancy — safety hasn't been established. L-arginine is rated possibly safe in pregnancy, but L-methionine's safety at supplement doses while pregnant isn't proven. Talk with your doctor before using this product if you're pregnant or planning to be.
Can I take this while breastfeeding?
The creatine forms should be avoided — there isn't enough safety information for nursing mothers. L-methionine's safety at supplement doses while breastfeeding hasn't been well studied. Check with your pharmacist or doctor before using this product if you're nursing.
What is creatine, and does it really help with athletic performance?
Creatine is a compound that helps muscles produce energy during intense exercise. The various forms in this product are rated possibly effective for athletic performance and muscle strength, though individual results vary. It's most researched in short, high-intensity activities.
Will this cause water retention or bloating?
Yes, water retention is a common side effect of creatine. Some people also experience bloating, gastrointestinal upset, diarrhea, or muscle cramps. These effects are usually mild, but if you're sensitive to them, let your pharmacist know.
Is it safe if I have kidney disease?
No — the safety information advises caution if you have kidney problems. Talk with your doctor before starting, since creatine is processed by your kidneys and rare case reports have mentioned kidney issues in people taking it.
What are L-arginine and L-methionine in this product for?
L-arginine supports blood vessel function and nitric oxide production. L-methionine is an amino acid that helps your body synthesize creatine and may have other roles in metabolism. Together with the creatine forms, they're meant to optimize the product's effects on muscle.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Creatine Advance XR Unflavored is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Creatine Advance XR Unflavored label
Go deeper

The Full Monographs Behind Creatine Advance XR Unflavored’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Creatine

Creatine is one of the most studied sports supplements, with solid evidence that it can boost strength and performance during short, high-intensity activities like weightlifting and sprintin...

Read the full Creatine monograph → Herb & supplement monograph

L-arginine

Interacts with 403 drugs

L-arginine is an amino acid that the body uses to make nitric oxide, a substance that helps blood vessels relax and widen. It is popularly used for blood pressure, erectile dysfunction, and...

Read the full L-arginine monograph → Herb & supplement monograph

Methionine

Methionine is an essential amino acid that your body needs for protein building and many basic chemical reactions. Most people get enough from a normal diet, and supplements are generally no...

Read the full Methionine monograph →
Sources

Sources & How We Checked

Creatine Advance XR Unflavored's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 164 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

L-arginine 66 references
  1. Sapienza MA, Kharitonov SA, Horvath I, et al. Effect of inhaled L-arginine on exhaled nitric oxide in normal and asthmatic subjects. Thorax 1998;53:172-5.
  2. Clarkson P, Adams MR, Powe AJ, et al. Oral L-arginine improves endothelium-dependent dilation in hypercholesterolemic young adults. J Clin Invest 1996;97:1989-94. PubMed
  3. Tenenbaum A, Fisman EZ, Motro M. L-arginine: Rediscovery in progress. Cardiology 1998;90:153-9.
  4. Brittenden J, Park KGM, Heys SD, et al. L-Arginine stimulates host defenses in patients with breast cancer. Surgery 1994;115:205-12.
  5. Korting GE, Smith SD, Wheeler MA, et al. A randomized double-blind trial of oral L-arginine for treatment of interstitial cystitis. J Urol 1999;161:558-65. DOI
  6. Rector TS, Bank AJ, Mullen KA, et al. Randomized, double-blind, placebo-controlled study of supplemental oral L-arginine in patients with heart failure. Circulation 1996;93:2135-41.
  7. Siani A, Pagano E, Iacone R, et al. Blood pressure and metabolic changes during dietary L-arginine supplementation in humans. Am J Hypertens 2000;13:547-51. PubMed
  8. Cheng JW, Balwin SN. L-arginine in the management of cardiovascular diseases. Ann Pharmacother 2001;35:755-64. PubMed
  9. Wallace AW, Tom WL. Interaction of L-arginine and phosphodiesterase inhibitors in vasodilation of the porcine internal mammary artery. Anesth Analg 2000;90:840-6. DOI
  10. Huynh NT, Tayek JA. Oral arginine reduces systemic blood pressure in type 2 diabetes: its potential role in nitric oxide generation. J Am Coll Nutr 2002;21:422-7.. PubMed
  11. Staff AC, Berge L, Haugen G, et al. Dietary supplementation with L-arginine or placebo in women with pre-eclampsia. Acta Obstet Gynecol Scand 2004;83:103-7.
  12. Resnick DJ, Softness B, Murphy AR, et al. Case report of an anaphylactoid reaction to arginine. Ann Allergy Asthma Immunol 2002;88:67-8. PubMed
  13. Anon. Arginine hydrochloride injection (marketed as R-Gene 10). FDA Drug Safety Newsletter 2009;2(2):16-18. Available at: www.fda.gov/Drugs/DrugSafety/DrugSafetyNewsletter/default.htm.
  14. Higashi Y, Oshima T, Sasaki S, et. al. Angiotensin-converting enzyme inhibition, but not calcium antagonism, improves a response of the renal vasculature to L-arginine in patients with essential hypertension. Hypertension. 1998 Jul;32(1):16-24.
  15. Facchinetti, F., Longo, M., Piccinini, F., Neri, I., and Volpe, A. L-arginine infusion reduces blood pressure in preeclamptic women through nitric oxide release. J Soc Gynecol.Investig. 1999;6(4):202-207. DOI
  16. de Gouw, H. W., Verbruggen, M. B., Twiss, I. M., and Sterk, P. J. Effect of oral L-arginine on airway hyperresponsiveness to histamine in asthma. Thorax 1999;54(11):1033-1035. PubMed
  17. Komers, R., Komersova, K., Kazdova, L., Ruzickova, J., and Pelikanova, T. Effect of ACE inhibition and angiotensin AT1 receptor blockade on renal and blood pressure response to L-arginine in humans. J Hypertens. 2000;18(1):51-59. PubMed
  18. Cartledge, J. J., Davies, A. M., and Eardley, I. A randomized double-blind placebo-controlled crossover trial of the efficacy of L-arginine in the treatment of interstitial cystitis. BJU.Int. 2000;85(4):421-426.
  19. Sozykin, A. V., Noeva, E. A., Balakhonova, T. V., Pogorelova, O. A., and Men'shikov, M. I. [Effect of L-arginine on platelet aggregation, endothelial function adn exercise tolerance in patients with stable angina pectoris]. Ter.Arkh. 2000;72(8):24-27.
  20. Nagaya, N., Uematsu, M., Oya, H., Sato, N., Sakamaki, F., Kyotani, S., Ueno, K., Nakanishi, N., Yamagishi, M., and Miyatake, K. Short-term oral administration of L-arginine improves hemodynamics and exercise capacity in patients with precapillary pulmona
  21. Stokes, G. S., Barin, E. S., Gilfillan, K. L., and Kaesemeyer, W. H. Interactions of L-arginine, isosorbide mononitrate, and angiotensin II inhibitors on arterial pulse wave. Am J Hypertens. 2003;16(9 Pt 1):719-724.
  22. Park, K. G., Heys, S. D., Blessing, K., Kelly, P., McNurlan, M. A., Eremin, O., and Garlick, P. J. Stimulation of human breast cancers by dietary L-arginine. Clin.Sci.(Lond) 1992;82(4):413-417.
  23. Palloshi, A., Fragasso, G., Piatti, P., Monti, L. D., Setola, E., Valsecchi, G., Galluccio, E., Chierchia, S. L., and Margonato, A. Effect of oral L-arginine on blood pressure and symptoms and endothelial function in patients with systemic hypertension,
  24. Schlaich, M. P., Ahlers, B. A., Parnell, M. M., and Kaye, D. M. beta-Adrenoceptor-mediated, nitric-oxide-dependent vasodilatation is abnormal in early hypertension: restoration by L-arginine. J Hypertens. 2004;22(10):1917-1925. PubMed
  25. Neri, I., Blasi, I., and Facchinetti, F. Effects of acute L-arginine infusion on non-stress test in hypertensive pregnant women. J Matern.Fetal Neonatal Med. 2004;16(1):23-26. PubMed
  26. Rytlewski, K., Olszanecki, R., Korbut, R., and Zdebski, Z. Effects of prolonged oral supplementation with l-arginine on blood pressure and nitric oxide synthesis in preeclampsia. Eur.J Clin.Invest 2005;35(1):32-37.
  27. Mansoor, J. K., Morrissey, B. M., Walby, W. F., Yoneda, K. Y., Juarez, M., Kajekar, R., Severinghaus, J. W., Eldridge, M. W., and Schelegle, E. S. L-arginine supplementation enhances exhaled NO, breath condensate VEGF, and headache at 4,342 m. High Alt.M
  28. Neri, I., Jasonni, V. M., Gori, G. F., Blasi, I., and Facchinetti, F. Effect of L-arginine on blood pressure in pregnancy-induced hypertension: a randomized placebo-controlled trial. J Matern.Fetal Neonatal Med. 2006;19(5):277-281.
  29. Lucotti, P., Setola, E., Monti, L. D., Galluccio, E., Costa, S., Sandoli, E. P., Fermo, I., Rabaiotti, G., Gatti, R., and Piatti, P. Beneficial effects of a long-term oral L-arginine treatment added to a hypocaloric diet and exercise training program in
  30. Savoye, G., Jemaa, Y., Mosni, G., Savoye-Collet, C., Morcamp, P., Dechelotte, P., Bouin, M., Denis, P., and Ducrotte, P. Effects of intragastric L-arginine administration on proximal stomach tone under basal conditions and after an intragastric diet. Dig PubMed
  31. Facchinetti, F., Saade, G. R., Neri, I., Pizzi, C., Longo, M., and Volpe, A. L-arginine supplementation in patients with gestational hypertension: a pilot study. Hypertens.Pregnancy. 2007;26(1):121-130. PubMed
  32. Jovanovic, A., Gerrard, J., and Taylor, R. The second-meal phenomenon in type 2 diabetes. Diabetes Care 2009;32(7):1199-1201. PubMed
  33. Fontanive P, Saponati G, Iurato A, et al. Effects of L-arginine on the Minnesota Living with Heart Failure Questionnaire quality-of-life score in patients with chronic systolic heart failure. Med.Sci.Monit. 2009;15:CR606-11.
  34. Doutreleau, S., Rouyer, O., Di, Marco P., Lonsdorfer, E., Richard, R., Piquard, F., and Geny, B. L-arginine supplementation improves exercise capacity after a heart transplant. Am J Clin.Nutr. 2010;91(5):1261-1267. PubMed
  35. Ast, J., Jablecka, A., Bogdanski, P., Smolarek, I., Krauss, H., and Chmara, E. Evaluation of the antihypertensive effect of L-arginine supplementation in patients with mild hypertension assessed with ambulatory blood pressure monitoring. Med.Sci.Monit. 2
  36. Saleh, A. I., Abdel Maksoud, S. M., El-Maraghy, S. A., and Gad, M. Z. Protective effect of L-arginine in experimentally induced myocardial ischemia: comparison with aspirin. J Cardiovasc.Pharmacol.Ther 2011;16(1):53-62. PubMed
  37. Dong, J. Y., Qin, L. Q., Zhang, Z., Zhao, Y., Wang, J., Arigoni, F., and Zhang, W. Effect of oral L-arginine supplementation on blood pressure: a meta-analysis of randomized, double-blind, placebo-controlled trials. Am.Heart J 2011;162(6):959-965. PubMed
  38. Hertz, P. and Richardson, J. A. Arginine-induced hyperkalemia in renal failure patients. Arch.Intern.Med. 1972;130(5):778-780. DOI
  39. Bushinsky, D. A. and Gennari, F. J. Life-threatening hyperkalemia induced by arginine. Ann.Intern.Med. 1978;89(5 Pt 1):632-634. PubMed
  40. Adams, M. R., Forsyth, C. J., Jessup, W., Robinson, J., and Celermajer, D. S. Oral L-arginine inhibits platelet aggregation but does not enhance endothelium-dependent dilation in healthy young men. J Am Coll.Cardiol 1995;26(4):1054-1061. PubMed
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  42. Higashi, Y., Oshima, T., Ozono, R., Watanabe, M., Matsuura, H., and Kajiyama, G. Effects of L-arginine infusion on renal hemodynamics in patients with mild essential hypertension. Hypertension 1995;25(4 Pt 2):898-902.
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