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Dietary supplement

D-Ribose Powder Ingredients & Drug Interactions

by Solgar

D-Ribose Powder label
See full label image
Powder Category: Fiber And Other Nutrients
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking D-Ribose Powder against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

D-Ribose Powder is a dietary supplement by Solgar with 1 active ingredient. Its ingredients are commonly taken for energy and fatigue, athletic performance and recovery, fibromyalgia symptoms.Based on those ingredients, 86 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are D-Ribose. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against D-Ribose Powder by Solgar

Ask about any prescription or over-the-counter medication and we check it for interactions with D-Ribose Powder by Solgar — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of D-Ribose Powder by Solgar

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 23, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: D-Ribose, a naturally occurring five-carbon sugar. There are no other active ingredients or fillers listed.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Ribose's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: cellular nutrient for exercise recovery.
  • We looked for evidence on: Athletic performance, Muscle soreness, Chronic fatigue syndrome (CFS), Fibromyalgia, Energy, Stamina.
  • The closest evidence on file: Ribose is rated "Possibly Ineffective" for Athletic performance (Natural Medicines).
  • Also on file: Ribose is rated "Insufficient Reliable Evidence To Rate" for Chronic fatigue syndrome (CFS), Fibromyalgia, Muscle soreness.

The evidence we hold doesn't support D-Ribose for athletic performance or McArdle disease — both are rated possibly ineffective. For restless legs syndrome, muscle soreness, heart failure, and recovery after bypass surgery, there isn't enough reliable evidence in our data to rate whether it works.

If you're considering ribose for one of these uses, talk it over with your doctor or pharmacist about what the current research shows.

The evidence, ingredient by ingredient Ribose

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

D-Ribose is generally well tolerated for short-term use, but long-term safety hasn't been well studied. The most common side effects when taken by mouth are diarrhea, stomach upset, headache, nausea, and low blood sugar — and a smaller number of people report anxiety, lightheadedness, or increased appetite.

In studies, lowering the dose resolved nausea and anxiety in some people. There isn't enough safety information to use D-Ribose during pregnancy or while breastfeeding.

Talk with your doctor or pharmacist before taking it if you're pregnant, planning to become pregnant, or nursing.

Side effects, ingredient by ingredient Ribose

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Ribose.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist before taking this product if you're on insulin or any antidiabetes medication — ribose can lower blood sugar and may increase the risk of hypoglycemia when combined with these drugs.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

D-Ribose may be worth considering if you're looking to support muscle recovery or energy, but the evidence for most claimed uses isn't strong yet. The key caution is blood sugar — if you take insulin or antidiabetes medication, check your specific drugs before starting.

Talk with your doctor or pharmacist about whether it's right for you and whether you'll need monitoring.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Nov 21, 2019.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about D-Ribose Powder, straight from the product label.

Brand Solgar
Barcode (UPC) 033984009882
Net contents 5.3 oz.; 150 Gram(s)
Market status On market
Date entered into DSLD Nov 21, 2019
DSLD ID 201104
Product type Fiber And Other Nutrients
Supplement form Powder
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Kosher, Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for D-Ribose Powder by Solgar, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 tsp
Maximum serving Sizes:
1 tsp
Servings per container
68
UPC/BARCODE
033984009882
IngredientAmount% DV
Calories10 Calorie(s)--
Total Carbohydrates2 Gram(s)1%
D-Ribose2.2 Gram(s)--
Added Sugars2 Gram(s)4%
Total Sugars2 Gram(s)--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Ribose is an important component of cells, including muscle cells, and is traditionally used during and post-exercise.

Solgar’s KOF-K certification #K-1250

General Statements

This product is sold by weight, not by volume; therefore settling may occur.

Cellular nutrient

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Brand IP Statement(s)

2017 Solgar, Inc.

General

SOLGB70988 03C

Precautions

Since 1947

If you are pregnant, nursing, taking any medications or have any medical condition, please consult your healthcare practitioner before taking any dietary supplement.

Not intended for persons under the age of 18.

Discontinue use and consult your healthcare practitioner if any adverse reactions occur.

Keep out of reach of children.

Do not use if outer bottle seal is missing or damaged.

Formulation

Non-GMO Gluten, wheat & dairy free

Suitable for vegans

Free of: Gluten, Wheat, Dairy, Soy, Yeast, Sodium, Artificial Flavor, Sweetener, Preservatives and Color.

Seals/Symbols

K Parve

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested use: As a dietary supplement for adults, take one (1) teaspoon one to three times daily, with meals, or as directed by a healthcare practitioner. Mix with 8 oz. water.

Storage

Store at room temperature.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

D-Ribose Powder by Solgar label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

D-Ribose Powder label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in D-Ribose Powder by Solgar

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 tsp Dosage formPowder Servings per container68 Amounts shown are per serving.

D-Ribose

Interacts with
86 drugs
2.2 Gram(s) per serving

Ribose (D-ribose) is a simple sugar your body makes naturally and uses to build energy molecules like ATP. Some people take it for fatigue, fibromyalg...

D-Ribose monograph & interactions
Interaction report

D-Ribose Powder by Solgar Drug Interactions

Want to check YOUR meds against D-Ribose Powder?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
86Drugs
86 Moderate

Ingredients driving the most interactions

D-Ribose 86

Individual Drug Interactions

The ingredients in D-Ribose Powder interact with 86 drugs. Click any drug to see the details.

1 of the 1 ingredient in D-Ribose Powder interact with drugs. Each result below shows which ingredient is responsible. D-Ribose

Each ingredient & the kinds of drugs it affects

For each ingredient in D-Ribose Powder with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

D-Ribose2 drug types · 86 drugs

Antidiabetes Drugs

Theoretically, taking ribose in combination with antidiabetes drugs might increase the risk of hypoglycemia.
In clinical research, ribose decreases serum glucose levels in a dose-dependent manner.

Likelihood Probable Evidence B
Insulin

Theoretically, taking ribose with insulin could increase the hypoglycemic effect of insulin.
In clinical pharmacokinetic studies, oral administration of ribose modestly increased serum insulin levels.

Likelihood Possible Evidence B
D-Ribose full monograph & interactions
The maker

Brand information

Manufacturer and brand details for D-Ribose Powder, from the product label.

Solgar

See all Solgar products
Name
Solgar, Inc.
Street Address
500 Willow Tree Road
City
Leonia
State
NJ
ZipCode
07605
Phone Number
1-877-765-4274
Web Address
www.solgar.com
Pharmacist Counseling Corner

D-Ribose Powder by Solgar: Common Questions

Does D-Ribose Powder by Solgar interact with any medications?
Yes. Based on its ingredients, D-Ribose Powder has a known interaction with 86 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
D-Ribose Powder contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take D-Ribose if I have diabetes or take blood sugar medication?
Not without talking to your doctor or pharmacist first. Ribose lowers blood sugar on its own, and combining it with insulin or antidiabetes drugs raises the risk of low blood sugar (hypoglycemia). Your doctor or pharmacist can check whether it's safe for you and your specific medications.
What are the most common side effects?
When taken by mouth, the most common are diarrhea, stomach upset, headache, nausea, and low blood sugar. Some people also report anxiety, lightheadedness, or increased appetite. Lowering the dose resolved nausea and anxiety in some cases.
Is D-Ribose safe to use long-term?
It's generally well tolerated for up to a month, but long-term safety hasn't been well studied. If you're thinking about taking it regularly, talk with your doctor or pharmacist.
Can I take D-Ribose while pregnant or breastfeeding?
There isn't enough safety information, so it's best avoided in both cases. Talk with your doctor or pharmacist if you're pregnant, planning to become pregnant, or nursing.
Does D-Ribose really help with muscle soreness or athletic performance?
The evidence we hold doesn't support it for athletic performance, and for muscle soreness there simply isn't enough reliable evidence to say whether it works. If you're considering it for either use, check with your doctor about what current research shows.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if D-Ribose Powder is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

D-Ribose Powder label
Go deeper

The Full Monographs Behind D-Ribose Powder’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Ribose

Interacts with 86 drugs

Ribose (D-ribose) is a simple sugar your body makes naturally and uses to build energy molecules like ATP. Some people take it for fatigue, fibromyalgia, exercise recovery, or heart conditio...

Read the full Ribose monograph →
Sources

Sources & How We Checked

D-Ribose Powder's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 8 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Ribose 8 references
  1. Segal S, Foley J. The metabolism of D-ribose in man. J Clin Invest 1958;37:719-35. PubMed
  2. Perlmutter NS, Wilson RA, Angello DA, et al. Ribose facilitates thallium-201 redistribution in patients with coronary artery disease. J Nucl Med 1991;32:193-200.
  3. Hegewald MG, Palac RT, Angello DA, et al. Ribose infusion accelerates thallium redistribution with early imaging compared with late 24-hour imaging without ribose. J Am Coll Cardiol 1991;18:1671-81. PubMed
  4. Pliml W, von Arnim T, Stalein A, et al. Effects of ribose on excercise-induced ischaemia in stable coronary artery disease. Lancet 1992;340:507-10.
  5. Burke ER. D-Ribose What You Need To Know. Garden City Park, NY: Avery Publishing Group 1999;1-43.
  6. Gross M, Reiter S, Zollner N. Metabolism of D-ribose administered continuously to healthy persons and to patients with myoadenylate deaminase deficiency. Klin Wochenschr 1989;67:1205-13. PubMed
  7. Teitelbaum JE, Johnson C, St Cyr J. The use of D-ribose in chronic fatigue syndrome and fibromyalgia: a pilot study. J Altern Complement Med 2006;12:857-62. PubMed
  8. Thompson J, Neutel J, Homer K, Tempero K, Shah A, Khankari R. Evaluation of D-ribose pharmacokinetics, dose proportionality, food effect, and pharmacodynamics after oral solution administration in healthy male and female subjects. J Clin Pharmacol 2014;54 PubMed

See these in context on the Ribose monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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