Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Echinacea Combination #2 Ingredients & Drug Interactions

by Genestra Brands

Echinacea Combination #2 label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Echinacea Combination #2 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Echinacea Combination #2 is a dietary supplement by Genestra Brands with 5 active ingredients. Its ingredients are commonly taken for common cold, flu and respiratory infections, immune support.Based on those ingredients, 995 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Echinacea (Echinacea purpurea) root extract, Cayenne (Capsicum annuum) fuit extract, Yarrow (Achillea millefolium) aerial parts extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Echinacea Combination #2 by Genestra Brands

Ask about any prescription or over-the-counter medication and we check it for interactions with Echinacea Combination #2 by Genestra Brands — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Echinacea Combination #2 by Genestra Brands

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 23, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 5 of its 5 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Echinacea Combination #2 contains 5 active ingredients. Echinacea purpurea root extract is the primary ingredient; the others are purple loosestrife aerial parts, osha root, yarrow aerial parts, and cayenne fruit extract.

The product is a liquid formulation in a base of purified water and ethanol.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Strong

Strong clinical evidence supports its ingredients for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Diabetic neuropathy — rated "Likely Effective" (Capsicum) (Natural Medicines).
  • On file: Postherpetic neuralgia — rated "Likely Effective" (Capsicum) (Natural Medicines).
  • On file: Back pain — rated "Possibly Effective" (Capsicum) (Natural Medicines).
  • On file: Cluster headache — rated "Possibly Effective" (Capsicum) (Natural Medicines).
  • On file: Postoperative nausea and vomiting (PONV) — rated "Possibly Effective" (Capsicum) (Natural Medicines).

The product facts we hold do not establish effectiveness ratings for echinacea in the specific conditions listed — all are rated insufficient reliable evidence. Yarrow and osha are also insufficient evidence for their listed uses.

Cayenne (capsicum) does have established ratings: likely effective for postherpetic neuralgia and diabetic neuropathy, and possibly effective for cluster headache, back pain, and postoperative nausea. However, this product combines multiple herbs, and the clinical evidence for the combination as a whole is not on file.

The evidence, ingredient by ingredient Echinacea Purple Loosestrife Osha Yarrow Capsicum

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Echinacea is generally well tolerated short-term but may cause allergic reactions, especially in people sensitive to ragweed and related plants. Common side effects include abdominal pain, constipation, diarrhea, heartburn, nausea, rashes, and stomach upset.

Rare serious effects include severe allergic reactions and hepatitis. Yarrow is traditionally avoided in pregnancy because it may affect the uterus and should not be used.

Osha is also likely unsafe in pregnancy and should be avoided. Purple loosestrife has limited safety data and is best avoided while breastfeeding.

Cayenne is likely safe in pregnancy but concentrated supplements are not well studied — food amounts are fine, but medicinal doses need doctor approval.

Side effects, ingredient by ingredient Echinacea Purple Loosestrife Osha Yarrow Capsicum

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 5 matched ingredients can interact with medications — Yarrow, Capsicum, Echinacea.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications; lithium.
  • For scale: 996 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your pharmacist or doctor if you take blood thinners (warfarin or antiplatelet drugs), diabetes medications, caffeine supplements, immunosuppressants, lithium, theophylline, or any drug metabolized by the liver's CYP1A2 or CYP3A4 pathways — the echinacea and cayenne in this formula affect many common medications. Also flag ACE inhibitors (blood pressure drugs) and ciprofloxacin (an antibiotic) if you take them.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with strong clinical evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

This is a multi-ingredient herbal liquid with significant medication interactions, especially through echinacea's effects on drug metabolism and the potential for immune stimulation. If you take any prescription medications — particularly blood thinners, diabetes drugs, immunosuppressants, or anything metabolized by the liver — check with your doctor or pharmacist before starting it.

Yarrow and osha carry pregnancy cautions; if you're pregnant, breastfeeding, or planning to be, discuss this product with your healthcare provider.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 23, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Echinacea Combination #2, straight from the product label.

Brand Genestra Brands
Barcode (UPC) 883196140305
Net contents 2 Fluid Ounce(s); 60 mL
Market status On market
Date entered into DSLD Apr 23, 2020
DSLD ID 217992
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Echinacea Combination #2 by Genestra Brands, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.75 mL
Maximum serving Sizes:
0.75 mL
Servings per container
80
UPC/BARCODE
883196140305
IngredientAmount% DV
Echinacea (Echinacea purpurea) root extract0.34 mL--
Purple Loosestrife (Lythrum salicaria) aerial parts extract0.17 mL--
Osha (Ligusticum porteri) root extract0.11 mL--
Yarrow (Achillea millefolium) aerial parts extract0.11 mL--
Cayenne (Capsicum annuum) fuit extract0.02 mL--

Other ingredients: purified Water, Ethanol

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Recommended Dose: Take 15 drops 3 to 5 times daily, 30 minutes before meals, or as recommended by your health professional.

Precautions

Warning: If you are pregnant or lactating, or are allergic to plants of the Asteraceae/Compositae/Daisy family, have heart disease, high or low blood pressure, a kidney or liver disorder, diabetes or edema, or are taking products containing diuretics do not use. If you have any health condition or are taking any medication, consult your health professional before use.

If you experience dizziness, confusion, muscle weakness or pain, abnormal heart beat or difficulty breathing, discontinue use and seek medical attention immediately. If hypersensitivity occurs, discontinue use.

Keep out of reach of children.

Use only if safety seal is intact.

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

General Statements

Contents may not fill package in order to accommodate required labeling. Please rely on stated quantity.

Scan to learn about our quality excellence

FDA Statement of Identity

Dietary Supplement

Formulation

Traditional support to promote healthy immune function

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Echinacea Combination #2 by Genestra Brands label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Echinacea Combination #2 label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Echinacea Combination #2 by Genestra Brands

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size0.75 mL Dosage formLiquid Servings per container80 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Echinacea (Echinacea purpurea) root extract

Interacts with
816 drugs
0.34 mL per serving

Echinacea is a popular herb taken to help prevent or shorten the common cold, but study results are mixed and the overall benefit appears small at bes...

Echinacea (Echinacea purpurea) root extract monograph & interactions

Purple Loosestrife (Lythrum salicaria) aerial parts extract

No known
interactions
0.17 mL per serving

Purple Loosestrife is a flowering wetland plant traditionally used for diarrhea and minor digestive or skin complaints, largely because of its astring...

Purple Loosestrife (Lythrum salicaria) aerial parts extract monograph & interactions

Osha (Ligusticum porteri) root extract

No known
interactions
0.11 mL per serving

Osha is a root from a wild mountain plant native to the western United States and Mexico, traditionally used by Native American and Hispanic communiti...

Osha (Ligusticum porteri) root extract monograph & interactions

Yarrow (Achillea millefolium) aerial parts extract

Interacts with
1 drug
0.11 mL per serving

Yarrow is a traditional herb long used for wounds, digestive complaints, and colds, but high-quality human studies are very limited, so its benefits a...

Yarrow (Achillea millefolium) aerial parts extract monograph & interactions

Cayenne (Capsicum annuum) fuit extract

Interacts with
239 drugs
0.02 mL per serving

Capsicum (chili pepper) contains capsaicin, which is best known and best studied as a topical treatment for certain types of pain. Topical capsaicin p...

Cayenne (Capsicum annuum) fuit extract monograph & interactions

Other (inactive) ingredients: Purified Water, Ethanol. These complete the product’s ingredient list but are not active constituents.

Interaction report

Echinacea Combination #2 by Genestra Brands Drug Interactions

Want to check YOUR meds against Echinacea Combination #2?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
995Drugs
975 Moderate 20 Minor

Ingredients driving the most interactions

Echinacea (Echinacea purpurea) root extract 816
Cayenne (Capsicum annuum) fuit extract 239
Yarrow (Achillea millefolium) aerial parts extract 1

Individual Drug Interactions

The ingredients in Echinacea Combination #2 interact with 995 drugs. Click any drug to see the details.

3 of the 5 ingredients in Echinacea Combination #2 interact with drugs. Each result below shows which ingredient is responsible. Echinacea (Echinacea purpurea) root extract Cayenne (Capsicum annuum) fuit extract Yarrow (Achillea millefolium) aerial parts extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Echinacea Combination #2 with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Echinacea (Echinacea purpurea) root extract12 drug types · 816 drugs

Caffeine

Echinacea can increase plasma levels of caffeine by inhibiting its metabolism.
Echinacea seems to increase plasma concentrations of caffeine by around 30%. This is likely due to inhibition of cytochrome P450 1A2 (CYP1A2) by echinacea.

Likelihood Probable Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Echinacea might inhibit the metabolism of CYP1A2 and increase plasma levels of some drugs.
Echinacea appears to inhibit CYP1A2 enzymes in humans. Additionally, echinacea seems to increase plasma concentrations of caffeine, a CYP1A2 substrate, by around 30%. Theoretically, echinacea might increase levels of other drugs metabolized by CYP1A2.

Likelihood Possible Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Echinacea may induce hepatic CYP3A4 and inhibit intestinal CYP3A4. This may increase or decrease levels of drugs metabolized by CYP3A4.
Several clinical trials have shown that taking echinacea for up to one month does not significantly affect the metabolism of various CYP3A4 substrates, including midazolam, docetaxel, etravirine, lopinavir-ritonavir, and darunavir-ritonavir. However, other clinical research shows that echinacea may increase the clearance of midazolam, suggesting that echinacea might induce CYP3A4. The discrepancy is thought to be due to differing effects of echinacea on intestinal versus hepatic CYP3A4 enzymes. Echinacea appears to induce hepatic CYP3A4 but inhibit intestinal CYP3A4. In some cases, these effects might cancel each other out, but in others, drug levels may be increased or decreased depending on the level of effect at hepatic and intestinal sites. The effect of echinacea on CYP3A4 activity may differ depending on the CYP3A4 substrate.

Likelihood Possible Evidence B
Etoposide (Vepesid)

Echinacea may increase levels of etoposide.
In one report, concomitant use of etoposide and echinacea was associated with more severe thrombocytopenia than the use of etoposide alone, suggesting inhibition of etoposide metabolism. Etoposide is a cytochrome P450 3A4 (CYP3A4) substrate. Echinacea has variable effects on CYP3A4, but some studies have reported inhibition of the enzyme.

Likelihood Possible Evidence D
Immunosuppressants

Echinacea has immunostimulant activity which may interfere with immunosuppressant therapy.
Theoretically, echinacea may interfere with immunosuppressant therapy because of its immunostimulant activity.

Likelihood Possible Evidence B
Darunavir (Prezista)

Theoretically, echinacea may interfere with the metabolism of darunavir; however, a small clinical study found no effect.
Darunavir is metabolized by cytochrome P450 3A4 (CYP3A4) and is administered with the CYP3A4 inhibitor ritonavir to increase its plasma concentrations. Echinacea has variable effects on CYP3A4, but administration of an E. purpurea root extract (Arkocapsulas Echinacea, Arkopharma) 500 mg four times daily for 14 days did not affect darunavir/ritonavir pharmacokinetics in 15 HIV-infected patients.

Likelihood Unlikely Evidence B
Dayquil Severe

Echinacea is reported to have varying effects on a number of Cytochrome P450 metabolizing enzymes in the liver, including CYP1A2 and CYP3A4, which play a role in acetaminophen and dextromethorphan metabolism (both contained in DayQuil Severe), respectively. Studies have reported both enzyme inhibition and induction, making it difficult to predict clinically significant drug interactions with reliability. Specific drug interaction studies reporting definitive results are rare, and potential drug interactions involving echinacea should likely be taken on a case-by-case basis. Based on what we know about how acetaminophen and dextromethorphan are metabolized, the risk of a clinically significant interaction between echinacea and DayQuil Severe is low.

Likelihood Unlikely Evidence A
Docetaxel (Taxotere)

Theoretically, echinacea may interfere with the metabolism of docetaxel; however, a small clinical study found no effect.
Docetaxel is metabolized by cytochrome P450 3A4 (CYP3A4). Echinacea has variable effects on CYP3A4, but taking E. purpurea whole plant extract (Echinaforce, A. Vogel Biopharma AG) 20 drops three times daily for 2 weeks did not alter the pharmacokinetics of docetaxel in one clinical study.

Likelihood Unlikely Evidence B
Etravirine (Intelence)

Theoretically, echinacea may interfere with the metabolism of etravirine; however, a small clinical study found no effect.
Etravirine is metabolized by cytochrome P450 3A4 (CYP3A4). Echinacea has variable effects on CYP3A4, but taking E. purpurea root extract (Arkocapsulas Echinacea, Arkopharma) 500 mg three times daily for 14 days did not alter the pharmacokinetics of etravirine in HIV-infected patients.

Likelihood Unlikely Evidence B
Lopinavir/Ritonavir (Kaletra)

Theoretically, echinacea may interfere with the metabolism of lopinavir; however, a small clinical study found no effect.
Lopinavir is metabolized by cytochrome P450 3A4 (CYP3A4) and is administered with the CYP3A4 inhibitor ritonavir to increase its plasma concentrations. Echinacea has variable effects on CYP3A4, but taking E. purpurea (Echinamide, Natural Factors Nutritional Products, Inc.) 500 mg three times daily for 14 days did not alter the pharmacokinetics of lopinavir/ritonavir in healthy volunteers.

Likelihood Unlikely Evidence B
Midazolam (Versed)

Theoretically, echinacea may increase the metabolism of intravenous midazolam.
Echinacea induces hepatic CYP3A4 and might decrease plasma levels of midazolam by about 20%, reducing the effectiveness of intravenous midazolam. Echinacea also appears to inhibit intestinal CYP3A4, which could theoretically increase the bioavailability of oral midazolam. This may cancel out the decrease in availability caused by induction of hepatic CYP3A4, such that overall plasma levels after oral administration of midazolam are not affected by echinacea.

Likelihood Possible Evidence B
Warfarin (Coumadin)

Echinacea seems to increase the clearance of warfarin, although the effect may not be clinically significant.
Preliminary clinical research in healthy male volunteers suggests that taking echinacea increases the clearance of the active S-isomer of warfarin after a single dose of warfarin, but there was not a clinically significant effect on the INR.

Likelihood Possible Evidence B
Echinacea (Echinacea purpurea) root extract full monograph & interactions

Cayenne (Capsicum annuum) fuit extract6 drug types · 239 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, capsicum may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro research shows that capsicum might increase the effects of antiplatelet drugs. Also, population research shows that capsicum is associated with an increased risk of self-reported bleeding in patients taking warfarin. However, clinical research shows that taking a single dose of capsaicin (Asian Herbex Ltd.), the active ingredient in capsicum, 400-800 mcg orally in combination with aspirin 500 mg does not decrease platelet aggregation when compared with taking aspirin 500 mg alone. Also, there was no notable effect on measures of platelet aggregation with capsaicin. It is unclear whether capsaicin must be used in more than a single dose to affect platelet aggregation.

Likelihood Possible Evidence B
Antidiabetes Drugs

Theoretically, taking capsicum with antidiabetes drugs might increase the risk of hypoglycemia.
Preliminary clinical research shows that consuming capsicum 5 grams along with a glucose drink attenuates the rise in plasma glucose after 30 minutes by 21%, decreases the 2-hour postprandial area under the curve of plasma glucose by 11%, and increases the 2-hour postprandial area under the curve of plasma insulin by 58% in healthy individuals when compared with placebo. Other clinical research shows that taking capsicum 5 mg daily for 28 days significantly reduces postprandial blood glucose and insulin levels, but not fasting blood glucose and insulin levels, in patients with gestational diabetes.

Likelihood Possible Evidence B
Aspirin

Theoretically, taking capsicum with aspirin might reduce the bioavailability of aspirin.
Animal research shows that acute or chronic intake of capsicum pepper reduces oral aspirin bioavailability. This has not been shown in humans.

Likelihood Possible Evidence D
Theophylline

Theoretically, taking capsicum with theophylline might increase the levels and adverse effects of theophylline.
In animal research, oral administration of capsicum reduced excretion of theophylline. However, capsicum does not seem to affect the pharmacokinetics of theophylline when administered intravenously.

Likelihood Possible Evidence D
Ace Inhibitors (Aceis)

Theoretically, using topical capsaicin may increase the risk of ACE inhibitor-induced cough.
There is one case report of a topically applied capsaicin cream contributing to the cough reflex in a patient using an ACEI. However, it is unclear if this interaction is clinically significant.

Likelihood Unlikely Evidence D
Ciprofloxacin (Cipro)

Theoretically, taking capsicum with ciprofloxacin might increase levels and adverse effects of ciprofloxacin.
Animal research shows that concomitant use of capsaicin, the active constituent of capsicum, and ciprofloxacin increases the bioavailability of ciprofloxacin by up to 70%.

Likelihood Possible Evidence D
Cayenne (Capsicum annuum) fuit extract full monograph & interactions

Yarrow (Achillea millefolium) aerial parts extract1 drug type · 1 drug

Lithium

Theoretically, taking yarrow with lithium might increase the levels and adverse effects of lithium.
Animal research shows that yarrow has diuretic activity. Theoretically, due to these potential diuretic effects, yarrow might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
Yarrow (Achillea millefolium) aerial parts extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Echinacea Combination #2, from the product label.

Genestra Brands

Name
Seroyal USA
City
Pittsburgh
State
PA
ZipCode
15275
Phone Number
1-888-737-6925
Web Address
seroyal.com
Pharmacist Counseling Corner

Echinacea Combination #2 by Genestra Brands: Common Questions

Does Echinacea Combination #2 by Genestra Brands interact with any medications?
Yes. Based on its ingredients, Echinacea Combination #2 has a known interaction with 995 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Echinacea Combination #2 contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while I'm pregnant?
Yarrow and osha are traditionally avoided or likely unsafe in pregnancy and the safety data advise against them. Echinacea is rated possibly safe, and cayenne likely safe, but because this is a combination product with ingredients that carry cautions, talk with your doctor or pharmacist before use — they can weigh the specifics for you.
What's echinacea actually for in this formula?
The facts on file don't establish an effectiveness rating for echinacea for any specific condition — the evidence is rated insufficient. It's commonly used in immune-support supplements, but whether it works for a particular reason is not established in the data we hold.
I'm allergic to ragweed — is this safe for me?
No. Echinacea can trigger allergic reactions, especially in people sensitive to ragweed and related plants in the same family. If you have a ragweed allergy, avoid this product or check with your doctor first.
What are the most common side effects?
Echinacea can cause abdominal pain, constipation, diarrhea, heartburn, nausea, rashes, and stomach upset. Cayenne commonly causes belching, bloating, burning, diarrhea, gas, headache, nausea, and flushing. Most people tolerate it, but GI upset is not uncommon.
Will this work for anxiety or ADHD?
The facts we hold rate echinacea as insufficient evidence for anxiety and ADHD, so we don't have proof it works for either. Talk with your doctor about whether this product is right for your needs.
Can I take this if I'm on blood thinners?
No — not without checking with your doctor first. Both echinacea and cayenne in this formula interact with blood thinners like warfarin. Your doctor may need to monitor you or adjust your dose. Do not start this product without their approval.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Echinacea Combination #2 label
Go deeper

The Full Monographs Behind Echinacea Combination #2’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Echinacea

Interacts with 816 drugs

Echinacea is a popular herb taken to help prevent or shorten the common cold, but study results are mixed and the overall benefit appears small at best. It is generally well tolerated for sh...

Read the full Echinacea monograph → Herb & supplement monograph

Purple Loosestrife

Purple Loosestrife is a flowering wetland plant traditionally used for diarrhea and minor digestive or skin complaints, largely because of its astringent tannin content. Modern human studies...

Read the full Purple Loosestrife monograph → Herb & supplement monograph

Osha

Osha is a root from a wild mountain plant native to the western United States and Mexico, traditionally used by Native American and Hispanic communities for coughs, colds, and sore throats....

Read the full Osha monograph → Herb & supplement monograph

Yarrow

Interacts with 1 drug

Yarrow is a traditional herb long used for wounds, digestive complaints, and colds, but high-quality human studies are very limited, so its benefits are not well proven. It is generally used...

Read the full Yarrow monograph → Herb & supplement monograph

Capsicum

Interacts with 239 drugs

Capsicum (chili pepper) contains capsaicin, which is best known and best studied as a topical treatment for certain types of pain. Topical capsaicin products are supported by reasonable evid...

Read the full Capsicum monograph →
Sources

Sources & How We Checked

Echinacea Combination #2's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 150 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Echinacea 51 references
  1. Mullins RJ. Echinacea-associated anaphylaxis. Med J Aust 1998;168:170-1. PubMed
  2. Mullins RJ. Allergic reactions to Echinacea. J Allergy Clin Immunol 2000;104:S340-341 (Abstract 1003).
  3. Chavez ML, Chavez PI. Echinacea. Hosp Pharm 1998;33:180-8.
  4. Grimm W, Muller HH. A randomized controlled trial of the effect of fluid extract of Echinacea purpurea on the incidence and severity of colds and respiratory infections. Am J Med 1999;106:138-43. PubMed
  5. Taylor JA, Weber W, Standish L, et al. Efficacy and safety of echinacea in treating upper respiratory tract infections in children: a randomized controlled trial. JAMA 2003;290:2824-30.. PubMed
  6. Luettig B, Steinmuller C, Gifford GE, et al. Macrophage activation by the polysaccharide arabinogalactan isolated from plant cell cultures of Echinacea purpurea. J Natl Cancer Inst 1989;81:669-75. PubMed
  7. Stimpel M, Proksch A, Wagner H, et al. Macrophage activation and induction of macrophage cytotoxicity by purified polysaccharide fractions from the plant Echinacea purpurea. Infect Immun 1984;46:845-9. PubMed
  8. Budzinski JW, Foster BC, Vandenhoek S, Arnason JT. An in vitro evaluation of human cytochrome P450 3A4 inhibition by selected commercial herbal extracts and tinctures. Phytomedicine 2000;7:273-82. PubMed
  9. Gallo M, Sarkar M, Au W, et al. Pregnancy outcome following gestational exposure to echinacea: A prospective controlled study. Arch Intern Med 2000;160:3141-3. PubMed
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  85. Kocak AO, Dogruyol S, Akbas I, et al. Comparison of topical capsaicin and topical piroxicam in the treatment of acute trauma-induced pain: A randomized double-blind trial. Am J Emerg Med. 2020;38(9):1767-1771. PubMed
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  87. Predel HG, Ebel-Bitoun C, Peil B, Weiser TW, Lange R. Efficacy and safety of diclofenac?+?capsaicin gel in patients with acute back/neck pain: A multicenter randomized controlled study. Pain Ther. 2020;9(1):279-296. PubMed
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See these in context on the Capsicum monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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