Epi-Integrity Powder By Pure Encapsulations Overview & Drug Interactions

Arabinogalactans are long, densely branched, high-molecular weight polysaccharides found in many plants, with the highest concentrations in larch trees. Larch arabinogalactan, specifically obtained from the western larch (Larix occidentalis) and eastern larch (Larix laricina), is approximately 98% arabinogalactan. This polysaccharide has a range of potential health benefits, including serving as a soluble, non-viscous fiber that ferments in the gut, potentially increasing beneficial gut bacteria like Lactobacillus. Additionally, larch arabinogalactan has been investigated for its possible role in drug delivery systems due to its water solubility and numerous hydroxyl groups, which may enhance the bioavailability of drugs like ibuprofen. Moreover, preliminary research suggests immunostimulatory effects, such as increased natural killer cell activity and enhanced immune response to certain vaccines.

L-glutamine is the most abundant free amino acid in the body, produced primarily in skeletal muscle and then released into circulation. It serves vital roles in various tissues, including the immune system, gastrointestinal tract, kidneys, and liver, where it supports essential functions such as maintaining intestinal integrity, immune response, and amino acid balance. Although traditionally classified as a non-essential amino acid, during periods of severe stress, glutamine becomes conditionally essential due to the body's increased demand. It acts as a critical nitrogen and carbon transporter between organs, and while the intestinal mucosa can synthesize glutamine, this production is insufficient during times of significant physiological stress. Dietary supplements generally contain L-glutamine as it is the biologically active form of the amino acid.

Perilla frutescens, an annual plant native to Asia, is valued for its diverse applications in cooking, manufacturing, and traditional medicine. Its leaves, stem, and seeds are utilized in traditional Chinese medicine for their rich content of flavones like apigenin, luteolin, shishonin, and vicenin-2, as well as beneficial compounds such as alpha-linolenic acid, rosmarinic acid, and policosanol. These components are purported to contribute to a range of health benefits, including potential anti-allergy properties that may alleviate symptoms like atopic dermatitis and airway inflammation, possibly by reducing inflammatory mediators and mast cell activity. Its anti-inflammatory effects, which may involve inhibiting cytokine production and modulating immune cell activity, align with its traditional uses for allergies, asthma, and gastrointestinal issues. Moreover, perilla is said to exhibit antimicrobial effects, with its seed extract, oil, and essential oil showing potential activity against bacteria and fungi. Laboratory research suggests potential nephroprotective effects, indicating that perilla may inhibit the proliferation of mesangial cells in kidney disorders.

Astragalus is a genus of plants native to Asia and Northern Africa, and is known for its small, yellow or purple flowers and its long, tapering root. In traditional medicine, astragalus has been used to boost the immune system and treat a variety of conditions, including colds, flu, and upper respiratory infections. It is commonly referred to as an 'adaptogen', which are theorized to help the body resist stress.

Licorice, also known as glycyrrhiza, is a plant native to parts of Europe, Asia, and the Mediterranean region. The root of the plant has been used for centuries in traditional medicine and is often consumed in the form of candy, tea, and supplements. Licorice has a number of purported health benefits, including the ability to soothe sore throats, reduce inflammation, and improve digestive problems. It may also have antiviral and antibacterial properties. Licorice naturally contains glycyrrhizin, or glycyrrhizic acid, which can have toxic effects if consumed in large amounts. However, licorice can be processed to remove glycyrrhizin, resulting in DGL (deglycyrrhizinated licorice). Many dietary supplements that contain deglycyrrhizinated licorice are often simply named 'DGL'.