Fenugreek Ingredients & Drug Interactions
by Genestra Brands
What is this page for?
First and foremost: checking Fenugreek against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Fenugreek is a dietary supplement by Genestra Brands with 1 active ingredient. Its ingredients are commonly taken for blood sugar control, boosting breast milk supply, high cholesterol.Based on those ingredients, 389 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Fenugreek (Trigonella foenum-graecum) seed extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Fenugreek by Genestra Brands
Ask about any prescription or over-the-counter medication and we check it for interactions with Fenugreek by Genestra Brands — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Fenugreek by Genestra Brands
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
Genestra Brands' Fenugreek is a single-ingredient capsule containing fenugreek (Trigonella foenum-graecum) seed extract. The capsule shell and tablet matrix also contain hypromellose, cellulose, and silica as inactive ingredients.
Does it work?
Moderate evidence
The evidence we hold shows fenugreek seed extract is possibly effective for sexual dysfunction and possibly effective for dysmenorrhea (painful menstrual cramps) and diabetes. These ratings mean some clinical research supports its use, but the evidence isn't yet conclusive or extensive.
How safe is it?
Well-documented data
Fenugreek seed is generally well tolerated at food amounts, but supplement doses may cause side effects. The most common ones are abdominal pain, bloating, diarrhea, indigestion, flatulence, low blood sugar (hypoglycemia), and nausea.
Rarely, severe allergic reactions—including throat swelling (angioedema), airway constriction (bronchospasm), and shock—have been reported. Fenugreek is likely unsafe during pregnancy; supplement amounts may affect the uterus.
If you're pregnant, avoid medicinal use. For breastfeeding, fenugreek is possibly safe and is often used to boost milk supply, but the evidence is limited—talk with your doctor or pharmacist first.
One rare note: if someone takes fenugreek during pregnancy or right before delivery, the newborn may develop an unusual body odor that could be mistaken for maple syrup urine disease, though this doesn't appear to cause long-term harm.
Meds to double-check
Moderate interaction found
Before starting fenugreek, double-check with your doctor or pharmacist if you take blood thinners (anticoagulants) or antiplatelet drugs, diabetes medications, theophylline, metoprolol, phenytoin, sildenafil, or clopidogrel—all documented as Moderate interactions. Use the medication search tool on this page to verify your specific drugs.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.
Fenugreek may help with sexual function, menstrual cramps, or blood sugar control, but it interacts with a wide range of medications—blood thinners, diabetes drugs, heart medications, seizure medications, and others. If you take any prescription or over-the-counter drugs, you'll need to clear it with your doctor or pharmacist first.
It's not safe in pregnancy but may be used during breastfeeding with professional guidance.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jan 25, 2016.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Fenugreek, straight from the product label.
| Brand | Genestra Brands |
|---|---|
| Barcode (UPC) | 88319614740 |
| Net contents | 120 Vegetable Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Jan 25, 2016 |
| DSLD ID | 55988 |
| Product type | Botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other |
| Intended target group(s) | Vegan, Vegetarian, Adult (18 - 50 Years), Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Fenugreek by Genestra Brands, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Fenugreek (Trigonella foenum-graecum) seed extract | 2000 mg | -- |
Other ingredients: Hypromellose, Cellulose, Silica
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions
Risk Information: If you are pregnant, breastfeeding or taking any medication; or if you have any health condition including diabetes, consult your healthcare practitioner prior to use.
Quality Assurance: Safety-sealed for your protection and for product freshness. Do not use if outer seal is missing or broken.
Keep out of reach of children.
Formulation
Guaranteed to contain no added wheat, starch, yeast, gluten, corn, soy, sugar, artificial coloring or flavoring, antimicrobial preservatives, dairy or animal products.
Ideal for vegans.
Storage
Store in a cool, dry place.
Seals/Symbols
Seroyal
FDA Statement of Identity
HERBAL SUPPLEMENT
General
V1.0 358
Suggested/Recommended/Usage/Directions
Recommended Adult Dose: Take four capsules daily or as recommended by your healthcare practitioner.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Fenugreek by Genestra Brands label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Fenugreek by Genestra Brands
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size4 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.
Fenugreek (Trigonella foenum-graecum) seed extract
Interacts with389 drugs
Fenugreek is a common kitchen spice that is also taken as a supplement, mainly for blood sugar, cholesterol, and to support breast milk production. So...
Fenugreek (Trigonella foenum-graecum) seed extract monograph & interactionsOther (inactive) ingredients: Hypromellose, Cellulose, Silica. These complete the product’s ingredient list but are not active constituents.
Fenugreek by Genestra Brands Drug Interactions
HelloPharmacist Interaction Report
Genestra Brands' Fenugreek contains one active ingredient—fenugreek seed extract—that interacts with a significant number of medications.
The most serious interactions are Moderate in severity and span multiple drug categories. Through its fenugreek seed extract content, this product may have additive effects with blood thinners (anticoagulants) and antiplatelet drugs, potentially increasing bleeding risk; it may also lower blood sugar (glucose) additively when combined with diabetes medications, raising the risk of low blood sugar (hypoglycemia).
Read the full breakdown — every affected drug type, severity by severity
Fenugreek may also reduce levels and effectiveness of theophylline (a respiratory medication), alter how your body activates clopidogrel (an antiplatelet drug), cause additive blood pressure lowering with metoprolol, decrease phenytoin levels (an anti-seizure drug), and reduce sildenafil levels and effects. All of these interactions are documented as Moderate in severity.
Altogether, these interactions span 389 individual medications.
Before you start fenugreek, check your exact medications with the search tool on this page, and talk with your doctor or pharmacist about whether it's safe to combine with anything you're taking.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Fenugreek?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Fenugreek interact with 389 drugs. Click any drug to see the details.
1 of the 1 ingredient in Fenugreek interact with drugs. Each result below shows which ingredient is responsible. Fenugreek (Trigonella foenum-graecum) seed extract
AbciximabReoPro
How Abciximab interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Fenugreek (trigonella Foenum-graecum) Seed ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek (trigonella Foenum-graecum) Seed Extract + Abciximab interactionAbrocitinibCibinqo
How Abrocitinib interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Fenugreek (trigonella Foenum-graecum) Seed ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek (trigonella Foenum-graecum) Seed Extract + Abrocitinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Fenugreek (trigonella Foenum-graecum) Seed ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, fenugreek seed might have additive hypoglycemic effects when used with antidiabetes drugs.
Read the full Fenugreek (trigonella Foenum-graecum) Seed Extract + Acarbose interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Fenugreek (trigonella Foenum-graecum) Seed ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek (trigonella Foenum-graecum) Seed Extract + Acenocoumarol interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Fenugreek (trigonella Foenum-graecum) Seed ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek (trigonella Foenum-graecum) Seed Extract + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Fenugreek (trigonella Foenum-graecum) Seed ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek (trigonella Foenum-graecum) Seed Extract + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, IbuprofenCombogesic
How Acetaminophen, Ibuprofen interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Fenugreek (trigonella Foenum-graecum) Seed ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek (trigonella Foenum-graecum) Seed Extract + Acetaminophen, Ibuprofen interactionAcetohexamideDymelor
How Acetohexamide interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Fenugreek (trigonella Foenum-graecum) Seed ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, fenugreek seed might have additive hypoglycemic effects when used with antidiabetes drugs.
Read the full Fenugreek (trigonella Foenum-graecum) Seed Extract + Acetohexamide interactionAcetylsalicylic AcidEntrophen
How Acetylsalicylic Acid interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Fenugreek (trigonella Foenum-graecum) Seed ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek (trigonella Foenum-graecum) Seed Extract + Acetylsalicylic Acid interactionAlbiglutideTanzeum
How Albiglutide interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Fenugreek (trigonella Foenum-graecum) Seed ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, fenugreek seed might have additive hypoglycemic effects when used with antidiabetes drugs.
Read the full Fenugreek (trigonella Foenum-graecum) Seed Extract + Albiglutide interactionAlogliptinNesina
How Alogliptin interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Fenugreek (trigonella Foenum-graecum) Seed ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, fenugreek seed might have additive hypoglycemic effects when used with antidiabetes drugs.
Read the full Fenugreek (trigonella Foenum-graecum) Seed Extract + Alogliptin interactionAlogliptin, MetforminKazano
How Alogliptin, Metformin interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Fenugreek (trigonella Foenum-graecum) Seed ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, fenugreek seed might have additive hypoglycemic effects when used with antidiabetes drugs.
Read the full Fenugreek (trigonella Foenum-graecum) Seed Extract + Alogliptin, Metformin interactionAlogliptin, PioglitazoneOseni
How Alogliptin, Pioglitazone interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Fenugreek (trigonella Foenum-graecum) Seed ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, fenugreek seed might have additive hypoglycemic effects when used with antidiabetes drugs.
Read the full Fenugreek (trigonella Foenum-graecum) Seed Extract + Alogliptin, Pioglitazone interactionAlteplase, TpaActilyse, Activase
How Alteplase, Tpa interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Fenugreek (trigonella Foenum-graecum) Seed ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek (trigonella Foenum-graecum) Seed Extract + Alteplase, Tpa interactionAluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #2
How Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Fenugreek (trigonella Foenum-graecum) Seed ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek (trigonella Foenum-graecum) Seed Extract + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionAluminum Hydroxide, Aspirin, Magnesium HydroxideAscriptin
How Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Fenugreek (trigonella Foenum-graecum) Seed ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek (trigonella Foenum-graecum) Seed Extract + Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interactionAnacaulase-bcdbNexoBrid
How Anacaulase-bcdb interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Fenugreek (trigonella Foenum-graecum) Seed ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek (trigonella Foenum-graecum) Seed Extract + Anacaulase-bcdb interactionAnagrelideAgrylin
How Anagrelide interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Fenugreek (trigonella Foenum-graecum) Seed ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek (trigonella Foenum-graecum) Seed Extract + Anagrelide interactionAnisindioneMiradon
How Anisindione interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Fenugreek (trigonella Foenum-graecum) Seed ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek (trigonella Foenum-graecum) Seed Extract + Anisindione interactionAntidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) InhibitorGlyxambi
How Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Fenugreek (trigonella Foenum-graecum) Seed ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, fenugreek seed might have additive hypoglycemic effects when used with antidiabetes drugs.
Read the full Fenugreek (trigonella Foenum-graecum) Seed Extract + Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interactionAntithrombin IiiThrombate III
How Antithrombin Iii interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Fenugreek (trigonella Foenum-graecum) Seed ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek (trigonella Foenum-graecum) Seed Extract + Antithrombin Iii interactionApixabanEliquis
How Apixaban interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Fenugreek (trigonella Foenum-graecum) Seed ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek (trigonella Foenum-graecum) Seed Extract + Apixaban interactionArgatrobanArgatroban
How Argatroban interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Fenugreek (trigonella Foenum-graecum) Seed ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek (trigonella Foenum-graecum) Seed Extract + Argatroban interactionAspirinAngettes 75, ASA, Asaphen, Aspirin, Caprin, Cartia +8 more
How Aspirin interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Fenugreek (trigonella Foenum-graecum) Seed ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek (trigonella Foenum-graecum) Seed Extract + Aspirin interactionAspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #3
How Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Fenugreek (trigonella Foenum-graecum) Seed ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek (trigonella Foenum-graecum) Seed Extract + Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide interactionAspirin, ButalbitalAxotal
How Aspirin, Butalbital interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Fenugreek (trigonella Foenum-graecum) Seed ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek (trigonella Foenum-graecum) Seed Extract + Aspirin, Butalbital interactionAspirin, Butalbital, CaffeineFiorinal
How Aspirin, Butalbital, Caffeine interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Fenugreek (trigonella Foenum-graecum) Seed ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek (trigonella Foenum-graecum) Seed Extract + Aspirin, Butalbital, Caffeine interactionAspirin, Butalbital, Caffeine, Codeine PhosphateFiorinal w/ Codeine
How Aspirin, Butalbital, Caffeine, Codeine Phosphate interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Fenugreek (trigonella Foenum-graecum) Seed ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek (trigonella Foenum-graecum) Seed Extract + Aspirin, Butalbital, Caffeine, Codeine Phosphate interactionAspirin, Butalbital, Caffeine, PhenacetinMarnal
How Aspirin, Butalbital, Caffeine, Phenacetin interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Fenugreek (trigonella Foenum-graecum) Seed ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek (trigonella Foenum-graecum) Seed Extract + Aspirin, Butalbital, Caffeine, Phenacetin interactionAspirin, CaffeineAnacin
How Aspirin, Caffeine interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Fenugreek (trigonella Foenum-graecum) Seed ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek (trigonella Foenum-graecum) Seed Extract + Aspirin, Caffeine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Fenugreek with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Fenugreek (Trigonella foenum-graecum) seed extract
Anticoagulant/Antiplatelet Drugs
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Some of the constituents in fenugreek have antiplatelet effects in animal and in vitro research. However, common fenugreek products might not contain sufficient concentrations of these constituents for clinical effects. A clinical study in patients with coronary artery disease or diabetes shows that taking fenugreek seed powder 2.5 grams twice daily for 3 months does not affect platelet aggregation, fibrinolytic activity, or fibrinogen levels .
Antidiabetes Drugs
Theoretically, fenugreek seed might have additive hypoglycemic effects when used with antidiabetes drugs.
Clinical research shows that fenugreek seed can reduce fasting blood glucose and 2-hour postprandial glucose levels in adults with type 2 diabetes.
Clopidogrel (Plavix)
Theoretically, fenugreek seed might alter the clinical effects of clopidogrel by inhibiting its conversion to the active form.
Animal research shows that fenugreek seed 200 mg/kg daily for 14 days increases the maximum serum concentration of clopidogrel by 21%. It is unclear how this affects the pharmacokinetics of the active metabolite of clopidogrel; however, this study found that concomitant use of fenugreek seed and clopidogrel prolonged bleeding time by an additional 11%.
Metoprolol (Toprol)
Theoretically, fenugreek seed might have additive hypotensive effects when used with metoprolol.
Animal research shows that fenugreek seed 300 mg/kg daily for 2 weeks decreases systolic and diastolic blood pressure by 9% and 11%, respectively, when administered alone, and by 15% and 22%, respectively, when given with metoprolol 10 mg/kg.
Phenytoin (Dilantin)
Theoretically, fenugreek might decrease plasma levels of phenytoin.
Animal research shows that taking fenugreek seeds for 1 week decreases maximum concentrations and the area under the curve of a single dose of phenytoin by 44% and 72%, respectively. This seems to be related to increased clearance. So far, this interaction has not been reported in humans.
Sildenafil (Viagra)
Theoretically, concurrent use of sildenafil and fenugreek might reduce levels and therapeutic effects of sildenafil.
Animal research shows that taking fenugreek seeds for 1 week reduces maximum concentrations and the area under the curve of a single dose of sildenafil by 27% and 48%, respectively. So far, this interaction has not been reported in humans.
Theophylline
Theoretically, fenugreek may reduce the levels and clinical effects of theophylline.
Animal research shows that fenugreek 50 grams daily for 7 days reduces the maximum serum concentration (Cmax) of theophylline by 28% and the area under the plasma drug concentration-time curve (AUC) by 22%.
Warfarin (Coumadin)
Theoretically, fenugreek might have additive effects with warfarin and increase the international normalized ratio (INR).
Some fenugreek constituents have antiplatelet effects, although these might not be present in concentrations that are clinically significant. In one case report, a patient taking warfarin experienced an increased INR when starting to take fenugreek in combination with boldo.
Antihypertensive Drugs
Fenugreek may also have an additive effect on blood pressure-lowering medications. Studies on animals have shown that fenugreek seed can decrease both systolic and diastolic blood pressure by up to 22% when combined with metoprolol. Therefore, it is essential to monitor your blood pressure regularly if you are taking fenugreek and metoprolol together or any other antihypertensive drugs.
Brand information
Manufacturer and brand details for Fenugreek, from the product label.
Genestra Brands
- Name
- Seroyal USA
- City
- Pittsburgh
- State
- PA
- ZipCode
- 15275
- Phone Number
- 1-888-737-6925
- Web Address
- seroyal.com
Fenugreek by Genestra Brands: Common Questions
Does Fenugreek by Genestra Brands interact with any medications?
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Fenugreek is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Fenugreek’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Fenugreek's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 30 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Fenugreek 30 references
- Madar Z, Thorne R. Dietary fiber. Prog Food Nutr Sci 1987;11:153-74.
- Sharma RD, Raghuram TC, Rao NS. Effect of fenugreek seeds on blood glucose and serum lipids in type I diabetes. Eur J Clin Nutr 1990;44:301-6.
- Patil SP, Niphadkar PV, Bapat MM. Allergy to fenugreek (Trigonella foenum graecum). Ann Allergy Asthma Immunol 1997;78:297-300. PubMed
- Lambert J, Cormier J. Potential interaction between warfarin and boldo-fenugreek. Pharmacotherapy 2001;21:509-12. PubMed
- Bordia A, Verma SK, Srivastava KC. Effect of ginger (Zingiber officinale Rosc.) and fenugreek (Trigonella foenumgraecum L.) on blood lipids, blood sugar and platelet aggregation in patients with coronary artery disease. Prostaglandins Leukot Essent Fatty PubMed
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