Fish Oil plus Joint Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Fish Oil plus Joint against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Fish Oil plus Joint is a dietary supplement by GNC Triple Strength with 4 active ingredients. Its ingredients are commonly taken for chronic pain, nerve (neuropathic) pain, inflammation.Based on those ingredients, 952 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are ApresFlex Boswellia serrata gum extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Fish Oil plus Joint by GNC Triple Strength
Ask about any prescription or over-the-counter medication and we check it for interactions with Fish Oil plus Joint by GNC Triple Strength — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Fish Oil plus Joint by GNC Triple Strength
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
GNC Triple Strength Fish Oil plus Joint contains 5 active ingredients. The main ones are omega-3 fatty acids—eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)—which are long-chain fats derived from fish oil and often used for heart and joint support.
The product also includes Boswellia serrata gum extract (under the brand name ApresFlex), a plant resin traditionally used for inflammation, and Palmitoylethanolamide (PEA, brand name Levagen), a fatty compound studied for joint and nerve discomfort. The remaining inactive ingredients are standard capsule materials and preservatives including gelatin, glycerin, silicon dioxide, and mixed tocopherols.
Does it work?
Moderate evidence
For the Boswellia serrata in this product, evidence suggests it may be effective for osteoarthritis—joint wear and tear. For other uses like allergies, Alzheimer disease, asthma, and cluster headaches, the evidence is insufficient to rate it.
Palmitoylethanolamide (PEA) is also possibly effective for osteoarthritis, but evidence is insufficient for carpal tunnel syndrome, migraines, autism spectrum disorder, and cannabis use disorder. For the omega-3 fatty acids (EPA and DHA), we hold no effectiveness data in our facts.
If you're considering this product for a specific condition, talk it over with your doctor or pharmacist to see if the evidence supports its use for your situation.
How safe is it?
Well-documented data
Both Boswellia serrata and Palmitoylethanolamide are generally well tolerated in short-term use, though long-term safety data are limited for both. The most common side effects of Boswellia taken by mouth are nausea, abdominal pain, diarrhea, headache, and heartburn; a small number of users report dizziness or vertigo.
PEA most commonly causes nausea when taken orally. Rarely, very large amounts of Boswellia gum resin can cause bezoar formation (a mass in the stomach).
Regarding pregnancy and breastfeeding: the safety data advise against Boswellia during both pregnancy and breastfeeding. Similarly, Palmitoylethanolamide should be avoided in pregnancy and while breastfeeding due to insufficient safety information.
We hold no pregnancy or breastfeeding data for the omega-3 ingredients.
Meds to double-check
Moderate interaction found
Before taking this product, double-check with your doctor or pharmacist if you're on any drugs processed through your liver—especially those that go through CYP2D6, CYP2C19, CYP1A2, CYP2C9, or CYP3A4 enzymes—or any immunosuppressant medications. The Boswellia extract can theoretically raise the levels of these drugs and change how they work.
We could not check the omega-3 ingredients against our medication database, so they may have interactions we haven't reviewed.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
GNC Triple Strength Fish Oil plus Joint may be worth considering if you're looking to support joint health, especially for osteoarthritis—both Boswellia and PEA have some evidence behind them. If you take any medications processed through your liver or any immunosuppressants, you'll want to check with your doctor or pharmacist before starting, since Boswellia can affect how those drugs work.
Avoid it if you're pregnant or breastfeeding. Talk with your own doctor or pharmacist about whether this product is right for you and your specific health situation.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 21, 2018.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Fish Oil plus Joint, straight from the product label.
| Brand | GNC Triple Strength |
|---|---|
| Net contents | 60 Softgel(s) |
| Market status | On market |
| Date entered into DSLD | Nov 21, 2018 |
| DSLD ID | 183171 |
| Product type | Other Combinations |
| Supplement form | Softgel Capsule |
| Dietary claims / uses | Nutrient, All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Fish Oil plus Joint by GNC Triple Strength, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Calories | 15 Calorie(s) | -- |
| Eicosapentaenoic Acid | 734 mg | -- |
| Docosahexaenoic Acid | 267 mg | -- |
| Total Fat | 1.5 Gram(s) | 2% |
| Total Omega-3 Fatty Acids | 1065 mg | -- |
| Other Omega-3 Fatty Acids | 65 mg | -- |
| Levagen Palmitic Acid Monoethanolamide | 300 mg | -- |
| Total EPA + DHA | 1000 mg | -- |
| ApresFlex Boswellia serrata gum extract | 100 mg | -- |
Other ingredients: Fish Oil, Gelatin, Glycerin, Beeswax, Enteric Coating, Silicon Dioxide, Soy Lecithin, Titanium Dioxide, Mixed Tocopherols, Chlorophyll
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)
ApresFlex is a registered trademark of Laila Nutraceuticals exclusively licensed to PL Thomas - Laila Nutra LLC. US Patent #8,551,496 and other patents pending. Levagen is a trademark of Gencor.
General Statements
Our quality commitment to you Since 1935, our mission as the industry leader has been to provide you with the highest-quality nutritional supplements. We continue to stand behind this mission. If you're not 100% satisfied with your purchase, return the unused portion of the product with your receipt within 30 days and we'll either refund your money or find you a replacement product that is right for you.
In a 30 day, randomized, double-blind, placebo-controlled study of 67 adults, subjects taking 50 mg of ApresFlex twice daily experienced a statistically significant difference in mean improvements from baseline for joint comfort, stiffness and function as measured by WOMAC that was 7.5 and 43 times greater in the ApresFlex group than placebo, respectively, after 30 days. Statistically significant improvements were seen as early as 5 days.
Improves joint comfort & stiffness in as few as 5 days
Certified purified
Potency verified by GNC procedure #5123. Conforms to USP <2091> for weight.
Enteric coated to help control fishy burps = guaranteed
Formulation
GNC Triple Strength Fish Oil Plus Joint combines premium ingredients that support joint health.
No Sugar, No Starch, No Artificial Flavors, No Wheat, Gluten Free, No Corn, No Dairy.
Free from detectable levels of mercury, lead, heavy metals and PCBs
Formula
Triple Strength Fish Oil Our Triple Strength Fish Oil is packed with Omega-3s, including EPA, which supports joint and health and the body's natural anti-inflammatory response. What's more, EPA supports heart and circulatory health, as well as normal, healthy triglyceride and cholesterol levels. Omega-3s also provide support for healthy vision, brain development and skin health. ApresFlex and Levagen ApresFlex is a potent boswellia serrata extract, which is clinically proven to support a 7 times greater improvement in joint comfort, as well as improvements in joint stiffness and function, in as few as 5 days. It is thought to work by targeting pathways related to your body's natural anti-inflammatory response. Levagen supports a healthy response to inflammation and may support comfort.
1000 mg of EPA/DHA Omega-3s & clinically proven joint support
Contains: Soybeans and Fish (Anchovy, Mackerel, Sardine, Smelt, Salmon, Tuna, Cod or a Combination thereof.)
From wild, deep ocean fish
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
FDA Statement of Identity
Omega-3 Supplement
General
CODE 736321 ESG
Suggested/Recommended/Usage/Directions
Directions: As a dietary supplement, take one softgel capsule twice daily with food.
Precautions
Contains: Soybeans and Fish (Anchovy, Mackerel, Sardine, Smelt, Salmon, Tuna, Cod or a Combination thereof.)
Seals/Symbols
Gf Gluten free
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Fish Oil plus Joint by GNC Triple Strength label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Fish Oil plus Joint by GNC Triple Strength
These are the 4 active ingredients this product is made of. Select any to open its full monograph.
Serving size2 Softgel Capsule(s) Dosage formSoftgel Capsule Servings per container30 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Total Omega-3 Fatty Acids
- › Other Omega-3 Fatty Acids
- › Total EPA + DHA
Levagen Palmitic Acid Monoethanolamide
No knowninteractions
Palmitoylethanolamide (PEA) is a fat-like molecule made naturally in the body and studied mainly for pain and inflammation. Some research suggests it...
Levagen Palmitic Acid Monoethanolamide monograph & interactionsApresFlex Boswellia serrata gum extract
Interacts with952 drugs
Boswellia serrata is a tree resin used in traditional medicine, mainly for joint pain and inflammation. Some studies suggest it may help with osteoart...
ApresFlex Boswellia serrata gum extract monograph & interactionsOther (inactive) ingredients: Fish Oil, Gelatin, Glycerin, Beeswax, Enteric Coating, Silicon Dioxide, Soy Lecithin, Titanium Dioxide, Mixed Tocopherols, Chlorophyll. These complete the product’s ingredient list but are not active constituents.
Fish Oil plus Joint by GNC Triple Strength Drug Interactions
HelloPharmacist Interaction Report
GNC Triple Strength Fish Oil plus Joint does interact with medications, primarily through its Boswellia serrata extract content.
Boswellia can increase the levels of drugs processed through several liver enzymes (CYP2D6, CYP2C19, CYP1A2, CYP2C9, and CYP3A4), which may change how those medications work in your body. It may also theoretically alter the effects of immunosuppressant drugs.
These are moderate-severity concerns based on laboratory research, though real-world clinical data are limited.
Read the full breakdown — every affected drug type, severity by severity
The omega-3 fatty acids in this product—eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and other omega-3s—we could not check; we hold no interaction data for them. That doesn't mean they don't interact; it means we haven't reviewed them against our medication database.
Additionally, the Palmitoylethanolamide (PEA) ingredient appears to have no known interactions documented in our data, though long-term safety is not well studied.
Before starting this product, check your exact medications with the search tool on this page, particularly if you take any drugs processed through your liver or any immunosuppressants.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Fish Oil plus Joint?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Fish Oil plus Joint interact with 952 drugs. Click any drug to see the details.
1 of the 4 ingredients in Fish Oil plus Joint interact with drugs. Each result below shows which ingredient is responsible. ApresFlex Boswellia serrata gum extract
6-mercaptopurinePurinethol
How 6-mercaptopurine interacts with Fish Oil plus Joint — through 1 ingredient. Tap an ingredient for the detail:
Apresflex Boswellia Serrata Gum ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, Boswellia serrata might alter the effects of immunosuppressive drugs.
Read the full Apresflex Boswellia Serrata Gum Extract + 6-mercaptopurine interactionAdo-trastuzumab EmtansineKadcyla
How Ado-trastuzumab Emtansine interacts with Fish Oil plus Joint — through 1 ingredient. Tap an ingredient for the detail:
Apresflex Boswellia Serrata Gum ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase or decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Apresflex Boswellia Serrata Gum Extract + Ado-trastuzumab Emtansine interactionAbemaciclibVerzenio
How Abemaciclib interacts with Fish Oil plus Joint — through 1 ingredient. Tap an ingredient for the detail:
Apresflex Boswellia Serrata Gum ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase or decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Apresflex Boswellia Serrata Gum Extract + Abemaciclib interactionAbiraterone
How Abiraterone interacts with Fish Oil plus Joint — through 1 ingredient. Tap an ingredient for the detail:
Apresflex Boswellia Serrata Gum ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase or decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Apresflex Boswellia Serrata Gum Extract + Abiraterone interactionAbiraterone AcetateYonsa, Zytiga
How Abiraterone Acetate interacts with Fish Oil plus Joint — through 1 ingredient. Tap an ingredient for the detail:
Apresflex Boswellia Serrata Gum ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase or decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Apresflex Boswellia Serrata Gum Extract + Abiraterone Acetate interactionAbrocitinibCibinqo
How Abrocitinib interacts with Fish Oil plus Joint — through 1 ingredient. Tap an ingredient for the detail:
Apresflex Boswellia Serrata Gum ExtractCytochrome P450 2c9 (cyp2c9) Substrates, Immunosuppressants +1 Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase the levels of CYP2C9 substrates.
Read the full Apresflex Boswellia Serrata Gum Extract + Abrocitinib interactionAcalabrutinibCalquence
How Acalabrutinib interacts with Fish Oil plus Joint — through 1 ingredient. Tap an ingredient for the detail:
Apresflex Boswellia Serrata Gum ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase or decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Apresflex Boswellia Serrata Gum Extract + Acalabrutinib interactionAcetaminophenChildren's Tylenol, Children's Tylenol Meltaways, Tylenol, Tylenol Ex Strength
How Acetaminophen interacts with Fish Oil plus Joint — through 1 ingredient. Tap an ingredient for the detail:
Apresflex Boswellia Serrata Gum ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase the levels of CYP1A2 substrates.
Read the full Apresflex Boswellia Serrata Gum Extract + Acetaminophen interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Fish Oil plus Joint — through 1 ingredient. Tap an ingredient for the detail:
Apresflex Boswellia Serrata Gum ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase the levels of CYP1A2 substrates.
Read the full Apresflex Boswellia Serrata Gum Extract + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Fish Oil plus Joint — through 1 ingredient. Tap an ingredient for the detail:
Apresflex Boswellia Serrata Gum ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase the levels of CYP1A2 substrates.
Read the full Apresflex Boswellia Serrata Gum Extract + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu
How Acetaminophen, Brompheniramine, Phenylpropanolamine interacts with Fish Oil plus Joint — through 1 ingredient. Tap an ingredient for the detail:
Apresflex Boswellia Serrata Gum ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase the levels of CYP1A2 substrates.
Read the full Apresflex Boswellia Serrata Gum Extract + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionAcetaminophen, ButalbitalAxocet, Bancap, Bucet, Butex Forte, Esgic CF, Orbivan CF +5 more
How Acetaminophen, Butalbital interacts with Fish Oil plus Joint — through 1 ingredient. Tap an ingredient for the detail:
Apresflex Boswellia Serrata Gum ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase the levels of CYP1A2 substrates.
Read the full Apresflex Boswellia Serrata Gum Extract + Acetaminophen, Butalbital interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with Fish Oil plus Joint — through 1 ingredient. Tap an ingredient for the detail:
Apresflex Boswellia Serrata Gum ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase the levels of CYP1A2 substrates.
Read the full Apresflex Boswellia Serrata Gum Extract + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Fish Oil plus Joint — through 1 ingredient. Tap an ingredient for the detail:
Apresflex Boswellia Serrata Gum ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +1 Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase or decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Apresflex Boswellia Serrata Gum Extract + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with Fish Oil plus Joint — through 1 ingredient. Tap an ingredient for the detail:
Apresflex Boswellia Serrata Gum ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase the levels of CYP1A2 substrates.
Read the full Apresflex Boswellia Serrata Gum Extract + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with Fish Oil plus Joint — through 1 ingredient. Tap an ingredient for the detail:
Apresflex Boswellia Serrata Gum ExtractCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase the levels of CYP2D6 substrates.
Read the full Apresflex Boswellia Serrata Gum Extract + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Fish Oil plus Joint — through 1 ingredient. Tap an ingredient for the detail:
Apresflex Boswellia Serrata Gum ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase the levels of CYP1A2 substrates.
Read the full Apresflex Boswellia Serrata Gum Extract + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Fish Oil plus Joint — through 1 ingredient. Tap an ingredient for the detail:
Apresflex Boswellia Serrata Gum ExtractCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase the levels of CYP2D6 substrates.
Read the full Apresflex Boswellia Serrata Gum Extract + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Fish Oil plus Joint — through 1 ingredient. Tap an ingredient for the detail:
Apresflex Boswellia Serrata Gum ExtractCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase the levels of CYP2D6 substrates.
Read the full Apresflex Boswellia Serrata Gum Extract + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Fish Oil plus Joint — through 1 ingredient. Tap an ingredient for the detail:
Apresflex Boswellia Serrata Gum ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +1 Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase the levels of CYP1A2 substrates.
Read the full Apresflex Boswellia Serrata Gum Extract + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with Fish Oil plus Joint — through 1 ingredient. Tap an ingredient for the detail:
Apresflex Boswellia Serrata Gum ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase or decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Apresflex Boswellia Serrata Gum Extract + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Fish Oil plus Joint — through 1 ingredient. Tap an ingredient for the detail:
Apresflex Boswellia Serrata Gum ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase the levels of CYP1A2 substrates.
Read the full Apresflex Boswellia Serrata Gum Extract + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Fish Oil plus Joint — through 1 ingredient. Tap an ingredient for the detail:
Apresflex Boswellia Serrata Gum ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +1 Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase the levels of CYP1A2 substrates.
Read the full Apresflex Boswellia Serrata Gum Extract + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Fish Oil plus Joint — through 1 ingredient. Tap an ingredient for the detail:
Apresflex Boswellia Serrata Gum ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase the levels of CYP1A2 substrates.
Read the full Apresflex Boswellia Serrata Gum Extract + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with Fish Oil plus Joint — through 1 ingredient. Tap an ingredient for the detail:
Apresflex Boswellia Serrata Gum ExtractCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase the levels of CYP2D6 substrates.
Read the full Apresflex Boswellia Serrata Gum Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAcetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with Fish Oil plus Joint — through 1 ingredient. Tap an ingredient for the detail:
Apresflex Boswellia Serrata Gum ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase or decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Apresflex Boswellia Serrata Gum Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interacts with Fish Oil plus Joint — through 1 ingredient. Tap an ingredient for the detail:
Apresflex Boswellia Serrata Gum ExtractCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase the levels of CYP2D6 substrates.
Read the full Apresflex Boswellia Serrata Gum Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interacts with Fish Oil plus Joint — through 1 ingredient. Tap an ingredient for the detail:
Apresflex Boswellia Serrata Gum ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +1 Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase or decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Apresflex Boswellia Serrata Gum Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interactionAcetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, SalicylamideRhinogesic GG
How Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interacts with Fish Oil plus Joint — through 1 ingredient. Tap an ingredient for the detail:
Apresflex Boswellia Serrata Gum ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase the levels of CYP1A2 substrates.
Read the full Apresflex Boswellia Serrata Gum Extract + Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylephrineAlka-Seltzer PLUS, Histex SR, Protid
How Acetaminophen, Chlorpheniramine, Phenylephrine interacts with Fish Oil plus Joint — through 1 ingredient. Tap an ingredient for the detail:
Apresflex Boswellia Serrata Gum ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase the levels of CYP1A2 substrates.
Read the full Apresflex Boswellia Serrata Gum Extract + Acetaminophen, Chlorpheniramine, Phenylephrine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Fish Oil plus Joint with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
ApresFlex Boswellia serrata gum extract
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, Boswellia serrata might increase the levels of CYP1A2 substrates.
In vitro research shows that Boswellia serrata gum resin inhibits CYP1A2 enzymes.
Cytochrome P450 2C19 (Cyp2C19) Substrates
Theoretically, Boswellia serrata might increase the levels of CYP2C19 substrates.
In vitro research shows that Boswellia serrata gum resin inhibits CYP2C19 enzymes.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, Boswellia serrata might increase the levels of CYP2C9 substrates.
In vitro research shows that Boswellia serrata gum resin inhibits CYP2C9 enzymes.
Cytochrome P450 2D6 (Cyp2D6) Substrates
Theoretically, Boswellia serrata might increase the levels of CYP2D6 substrates.
In vitro research shows that Boswellia serrata gum resin inhibits CYP2D6 enzymes.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, Boswellia serrata might increase or decrease the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that Boswellia serrata gum resin inhibits CYP3A4 enzymes. Other in vitro research shows that Boswellia serrata extract inhibits CYP3A4 enzymes at most concentrations, although it may modestly induce enzyme activity at low concentrations.
Immunosuppressants
Theoretically, Boswellia serrata might alter the effects of immunosuppressive drugs.
Some in vitro research suggests that Boswellia serrata extracts might inhibit mediators of autoimmune disorders such as leukotrienes and reduce production of antibodies and cell-mediated immunity. However, other in vitro research suggests that, when coupled with calcium ions, boswellic acids containing the keto group have immunostimulant properties within specific cell signaling pathways.
Brand information
Manufacturer and brand details for Fish Oil plus Joint, from the product label.
GNC Triple Strength
See all GNC Triple Strength products- Name
- General Nutrition Corporation
- City
- Pittsburgh
- State
- PA
- ZipCode
- 15222
- Phone Number
- 1-888-462-2548
- Web Address
- gnc.com
Fish Oil plus Joint by GNC Triple Strength: Common Questions
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What is Boswellia serrata used for in this product?
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Fish Oil plus Joint’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Palmitoylethanolamide (pea)
Palmitoylethanolamide (PEA) is a fat-like molecule made naturally in the body and studied mainly for pain and inflammation. Some research suggests it may help certain types of chronic and ne...
Read the full Palmitoylethanolamide (pea) monograph → Herb & supplement monographBoswellia Serrata
Interacts with 952 drugsBoswellia serrata is a tree resin used in traditional medicine, mainly for joint pain and inflammation. Some studies suggest it may help with osteoarthritis symptoms, but the overall evidenc...
Read the full Boswellia Serrata monograph →Sources & How We Checked
Fish Oil plus Joint's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 20 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Palmitoylethanolamide (pea) 4 references
- Indraccolo U, Barbieri F. Effect of palmitoylethanolamide-polydatin combination on chronic pelvic pain associated with endometriosis: preliminary observations. Eur J Obstet Gynecol Reprod Biol. 2010 May;150(1):76-9. PubMed
- Murina F, Graziottin A, Felice R, Radici G, Tognocchi C. Vestibulodynia: synergy between palmitoylethanolamide + transpolydatin and transcutaneous electrical nerve stimulation. J Low Genit Tract Dis. 2013 Apr;17(2):111-6.
- Papetti L, Sforza G, Tullo G, et al. Tolerability of palmitoylethanolamide in a pediatric population suffering from migraine: A pilot study. Pain Res Manag 2020;2020:3938640. PubMed
- Visse K, Blome C, Phan NQ, Augustin M, Ständer S. Efficacy of body lotion containing N-palmitoylethanolamine in subjects with chronic pruritus due to dry skin: A dermatocosmetic study. Acta Derm Venereol. 2017;97(5):639-641. PubMed
See these in context on the Palmitoylethanolamide (pea) monograph →
Boswellia Serrata 16 references
- Gupta I, Gupta V, Parihar A, et al. Effects of Boswellia serrata gum resin in patients with bronchial asthma: results of a double-blind, placebo-controlled, 6-week clinical study. Eur J Med Res 1998;3:511-4.
- Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
- Kimmatkar N, Thawani V, Hingorani L, et al. Efficacy and tolerability of Boswellia serrata extract in treatment of osteoarthritis of knee--a randomized double blind placebo controlled trial. Phytomedicine 2003;10:3-7. PubMed
- Liu JJ, Nilsson A, Oredsson S, et al. Boswellic acids trigger apoptosis via a pathway dependent on caspase-8 activation but independent on Fas/Fas ligand interaction in colon cancer HT-29 cells. Carcinogenesis 2002;23:2087-93. PubMed
- Wildfeuer A, Neu IS, Safayhi H, et al. Effects of boswellic acids extracted from a herbal medicine on the biosynthesis of leukotrienes and the course of experimental autoimmune encephalomyelitis. Arzneimittelforschung 1998;48:668-74.
- Gupta I, Parihar A, Malhotra P, et al. Effects of gum resin of Boswellia serrata in patients with chronic colitis. Planta Med 2001;67:391-5. PubMed
- Sengupta K, Alluri KV, Satish AR, et al. A double blind, randomized, placebo controlled study of the efficacy and safety of 5-Loxin. Arthritis Res Ther 2008;10:R85.
- Sengupta K, Krishnaraju AV, Vishal AA, et al. Comparative efficacy and tolerability of 5-Loxin and Aflapin against osteoarthritis of the knee: a double blind, randomized, placebo controlled clinical study. Int J Med Sci 2010;7:366-77.
- Ernst E. Frankincense: systematic review. BMJ 2008;337:a2813. PubMed
- Kirste S, Treier M, Wehrle SJ, et al. Boswellia serratea extract acts on cerebral edema in patients irradiated for brain tumors: a prospective, randomized, placebo-controlled, double-blind pilot trial. Cancer 2011;117:3788-95.
- Frank A, Unger M. Analysis of frankincense from various Boswellia species with inhibitory activity on human drug metabolising cytochrome P450 enzymes using liquid chromatography mass spectrometry after automated on-line extraction. J Chromatogr A 2006;111 PubMed
- Altmann A, Poeckel D, Fischer L, et al. Coupling of boswellic acid-incuded Ca2+ mobilisation and MAPK activation to lipid metabolism and peroxide formation in human leucocytes. Br J Pharmacol 2004;141:223-32.
- El Fortia, M., Badi, H., Elalem, Kh, Kadiki, O., and Topov, Y. Olibanum bezoar: complication of a traditional popular medicine. East Mediterr.Health J 2006;12(6):927-929.
- Meshkat S, Mahmoodi Baram S, Rajaei S, et al. Boswellia serrata extract shows cognitive benefits in a double-blind, randomized, placebo-controlled pilot clinical trial in individuals who suffered traumatic brain injury. Brain Inj 2022;36(4):553-559. PubMed
- Haron MH, Dale O, Martin K, et al. Evaluation of the Herb-Drug Interaction Potential of Commonly Used Botanicals on the US Market with Regard to PXR- and AhR-Mediated Influences on CYP3A4 and CYP1A2. J Diet Suppl 2022. PubMed
- Valente IVB, Garcia D, Abbott A, et al. The anti-proliferative effects of a frankincense extract in a window of opportunity phase ia clinical trial for patients with breast cancer. Breast Cancer Res Treat 2024;204(3):521-530. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC