Interactions on record — worth a quick check against your medications. Based on 2 of 4 ingredients. Check your meds →
Dietary supplement

Fish Oil plus Joint Ingredients & Drug Interactions

by GNC Triple Strength

Softgel Capsule Category: Other Combinations
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Fish Oil plus Joint is a dietary supplement by GNC Triple Strength with 4 active ingredients. Its ingredients are commonly taken for chronic pain, nerve (neuropathic) pain, inflammation.Based on those ingredients, 952 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are ApresFlex Boswellia serrata gum extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Fish Oil plus Joint by GNC Triple Strength

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 5 of its 5 active ingredients.
  • “Total Omega-3 Fatty Acids” is listed as a grouped ingredient — the label gives one combined amount (1,065 mg) without saying how much of each component you get.
  • “Total EPA + DHA” is listed as a grouped ingredient — the label gives one combined amount (1,000 mg) without saying how much of each component you get.

GNC Triple Strength Fish Oil plus Joint contains 5 active ingredients. The main ones are omega-3 fatty acids—eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)—which are long-chain fats derived from fish oil and often used for heart and joint support.

The product also includes Boswellia serrata gum extract (under the brand name ApresFlex), a plant resin traditionally used for inflammation, and Palmitoylethanolamide (PEA, brand name Levagen), a fatty compound studied for joint and nerve discomfort. The remaining inactive ingredients are standard capsule materials and preservatives including gelatin, glycerin, silicon dioxide, and mixed tocopherols.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: joint health and comfort support.
  • We looked for evidence on: Osteoarthritis, Rheumatoid arthritis (RA), Knee pain, Joint stiffness, Cartilage health.
  • The strongest evidence on file: Boswellia Serrata is rated "Possibly Effective" for Osteoarthritis (Natural Medicines).
  • Also on file: Palmitoylethanolamide (pea) is rated "Possibly Effective" for Osteoarthritis.
  • Also on file: Boswellia Serrata is rated "Insufficient Reliable Evidence To Rate" for Rheumatoid arthritis (RA), Knee pain.

For the Boswellia serrata in this product, evidence suggests it may be effective for osteoarthritis—joint wear and tear. For other uses like allergies, Alzheimer disease, asthma, and cluster headaches, the evidence is insufficient to rate it.

Palmitoylethanolamide (PEA) is also possibly effective for osteoarthritis, but evidence is insufficient for carpal tunnel syndrome, migraines, autism spectrum disorder, and cannabis use disorder. For the omega-3 fatty acids (EPA and DHA), we hold no effectiveness data in our facts.

If you're considering this product for a specific condition, talk it over with your doctor or pharmacist to see if the evidence supports its use for your situation.

The evidence, ingredient by ingredient Palmitoylethanolamide (pea) Boswellia Serrata

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Both Boswellia serrata and Palmitoylethanolamide are generally well tolerated in short-term use, though long-term safety data are limited for both. The most common side effects of Boswellia taken by mouth are nausea, abdominal pain, diarrhea, headache, and heartburn; a small number of users report dizziness or vertigo.

PEA most commonly causes nausea when taken orally. Rarely, very large amounts of Boswellia gum resin can cause bezoar formation (a mass in the stomach).

Regarding pregnancy and breastfeeding: the safety data advise against Boswellia during both pregnancy and breastfeeding. Similarly, Palmitoylethanolamide should be avoided in pregnancy and while breastfeeding due to insufficient safety information.

We hold no pregnancy or breastfeeding data for the omega-3 ingredients.

Side effects, ingredient by ingredient Palmitoylethanolamide (pea) Boswellia Serrata

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Boswellia Serrata.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: immunosuppressants / transplant drugs.
  • For scale: 953 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your doctor or pharmacist if you're on any drugs processed through your liver—especially those that go through CYP2D6, CYP2C19, CYP1A2, CYP2C9, or CYP3A4 enzymes—or any immunosuppressant medications. The Boswellia extract can theoretically raise the levels of these drugs and change how they work.

We could not check the omega-3 ingredients against our medication database, so they may have interactions we haven't reviewed.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

GNC Triple Strength Fish Oil plus Joint may be worth considering if you're looking to support joint health, especially for osteoarthritis—both Boswellia and PEA have some evidence behind them. If you take any medications processed through your liver or any immunosuppressants, you'll want to check with your doctor or pharmacist before starting, since Boswellia can affect how those drugs work.

Avoid it if you're pregnant or breastfeeding. Talk with your own doctor or pharmacist about whether this product is right for you and your specific health situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 21, 2018.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Fish Oil plus Joint, straight from the product label.

Brand GNC Triple Strength
Net contents 60 Softgel(s)
Market status On market
Date entered into DSLD Nov 21, 2018
DSLD ID 183171
Product type Other Combinations
Supplement form Softgel Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Fish Oil plus Joint by GNC Triple Strength, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Softgel Capsule(s)
Maximum serving Sizes:
2 Softgel Capsule(s)
Servings per container
30
IngredientAmount% DV
Calories15 Calorie(s)--
Eicosapentaenoic Acid734 mg--
Docosahexaenoic Acid267 mg--
Total Fat1.5 Gram(s)2%
Total Omega-3 Fatty Acids1065 mg--
Other Omega-3 Fatty Acids65 mg--
Levagen Palmitic Acid Monoethanolamide300 mg--
Total EPA + DHA1000 mg--
ApresFlex Boswellia serrata gum extract100 mg--

Other ingredients: Fish Oil, Gelatin, Glycerin, Beeswax, Enteric Coating, Silicon Dioxide, Soy Lecithin, Titanium Dioxide, Mixed Tocopherols, Chlorophyll

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

ApresFlex is a registered trademark of Laila Nutraceuticals exclusively licensed to PL Thomas - Laila Nutra LLC. US Patent #8,551,496 and other patents pending. Levagen is a trademark of Gencor.

General Statements

Our quality commitment to you Since 1935, our mission as the industry leader has been to provide you with the highest-quality nutritional supplements. We continue to stand behind this mission. If you're not 100% satisfied with your purchase, return the unused portion of the product with your receipt within 30 days and we'll either refund your money or find you a replacement product that is right for you.

In a 30 day, randomized, double-blind, placebo-controlled study of 67 adults, subjects taking 50 mg of ApresFlex twice daily experienced a statistically significant difference in mean improvements from baseline for joint comfort, stiffness and function as measured by WOMAC that was 7.5 and 43 times greater in the ApresFlex group than placebo, respectively, after 30 days. Statistically significant improvements were seen as early as 5 days.

Improves joint comfort & stiffness in as few as 5 days

Certified purified

Potency verified by GNC procedure #5123. Conforms to USP <2091> for weight.

Enteric coated to help control fishy burps = guaranteed

Formulation

GNC Triple Strength Fish Oil Plus Joint combines premium ingredients that support joint health.

No Sugar, No Starch, No Artificial Flavors, No Wheat, Gluten Free, No Corn, No Dairy.

Free from detectable levels of mercury, lead, heavy metals and PCBs

Formula

Triple Strength Fish Oil Our Triple Strength Fish Oil is packed with Omega-3s, including EPA, which supports joint and health and the body's natural anti-inflammatory response. What's more, EPA supports heart and circulatory health, as well as normal, healthy triglyceride and cholesterol levels. Omega-3s also provide support for healthy vision, brain development and skin health. ApresFlex and Levagen ApresFlex is a potent boswellia serrata extract, which is clinically proven to support a 7 times greater improvement in joint comfort, as well as improvements in joint stiffness and function, in as few as 5 days. It is thought to work by targeting pathways related to your body's natural anti-inflammatory response. Levagen supports a healthy response to inflammation and may support comfort.

1000 mg of EPA/DHA Omega-3s & clinically proven joint support

Contains: Soybeans and Fish (Anchovy, Mackerel, Sardine, Smelt, Salmon, Tuna, Cod or a Combination thereof.)

From wild, deep ocean fish

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Omega-3 Supplement

General

CODE 736321 ESG

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, take one softgel capsule twice daily with food.

Precautions

Contains: Soybeans and Fish (Anchovy, Mackerel, Sardine, Smelt, Salmon, Tuna, Cod or a Combination thereof.)

Seals/Symbols

Gf Gluten free

See for yourself

Fish Oil plus Joint by GNC Triple Strength label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Fish Oil plus Joint by GNC Triple Strength

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Softgel Capsule(s) Dosage formSoftgel Capsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Total Omega-3 Fatty Acids

1065 mg per serving
  • › Other Omega-3 Fatty Acids
  • › Total EPA + DHA
300 mg per serving

Palmitoylethanolamide (PEA) is a fat-like molecule made naturally in the body and studied mainly for pain and inflammation. Some research suggests it...

Levagen Palmitic Acid Monoethanolamide monograph & interactions

ApresFlex Boswellia serrata gum extract

Interacts with
952 drugs
100 mg per serving Form: 3-0-Acetyl-11-Keto Beta Boswellic Acid

Boswellia serrata is a tree resin used in traditional medicine, mainly for joint pain and inflammation. Some studies suggest it may help with osteoart...

ApresFlex Boswellia serrata gum extract monograph & interactions

Other (inactive) ingredients: Fish Oil, Gelatin, Glycerin, Beeswax, Enteric Coating, Silicon Dioxide, Soy Lecithin, Titanium Dioxide, Mixed Tocopherols, Chlorophyll. These complete the product’s ingredient list but are not active constituents.

Interaction report

Fish Oil plus Joint by GNC Triple Strength Drug Interactions

Want to check YOUR meds against Fish Oil plus Joint?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
952Drugs
952 Moderate

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in Fish Oil plus Joint with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

ApresFlex Boswellia serrata gum extract6 drug types · 952 drugs

Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, Boswellia serrata might increase the levels of CYP1A2 substrates.
In vitro research shows that Boswellia serrata gum resin inhibits CYP1A2 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, Boswellia serrata might increase the levels of CYP2C19 substrates.
In vitro research shows that Boswellia serrata gum resin inhibits CYP2C19 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, Boswellia serrata might increase the levels of CYP2C9 substrates.
In vitro research shows that Boswellia serrata gum resin inhibits CYP2C9 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, Boswellia serrata might increase the levels of CYP2D6 substrates.
In vitro research shows that Boswellia serrata gum resin inhibits CYP2D6 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, Boswellia serrata might increase or decrease the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that Boswellia serrata gum resin inhibits CYP3A4 enzymes. Other in vitro research shows that Boswellia serrata extract inhibits CYP3A4 enzymes at most concentrations, although it may modestly induce enzyme activity at low concentrations.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, Boswellia serrata might alter the effects of immunosuppressive drugs.
Some in vitro research suggests that Boswellia serrata extracts might inhibit mediators of autoimmune disorders such as leukotrienes and reduce production of antibodies and cell-mediated immunity. However, other in vitro research suggests that, when coupled with calcium ions, boswellic acids containing the keto group have immunostimulant properties within specific cell signaling pathways.

Likelihood Possible Evidence D
The maker

Brand information

Manufacturer and brand details for Fish Oil plus Joint, from the product label.

GNC Triple Strength

See all GNC Triple Strength products
Name
General Nutrition Corporation
City
Pittsburgh
State
PA
ZipCode
15222
Phone Number
1-888-462-2548
Web Address
gnc.com
Pharmacist Counseling Corner

Fish Oil plus Joint by GNC Triple Strength: Common Questions

Does Fish Oil plus Joint by GNC Triple Strength interact with any medications?
Yes. Based on its ingredients, Fish Oil plus Joint has a known interaction with 952 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Fish Oil plus Joint contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this product if I'm pregnant or breastfeeding?
The safety data advise against both Boswellia serrata and Palmitoylethanolamide during pregnancy and while breastfeeding. We don't hold safety information for the omega-3 fatty acids in this formula. Talk with your doctor or pharmacist about whether this product is appropriate for you during these times.
What are the most common side effects?
From Boswellia serrata, the most common side effects are nausea, abdominal pain, diarrhea, headache, and heartburn. Palmitoylethanolamide most commonly causes nausea. Both ingredients are generally well tolerated overall, though long-term safety data are limited.
Is this product good for osteoarthritis?
Yes—both the Boswellia serrata and Palmitoylethanolamide in this product are possibly effective for osteoarthritis based on the evidence we hold. If you have osteoarthritis, talk with your doctor about whether this product might help your situation.
What is Boswellia serrata used for in this product?
Boswellia serrata is a plant resin traditionally used to support joint comfort and manage inflammation. In this product, it's included under the brand name ApresFlex.
Why can't you check the omega-3 ingredients for drug interactions?
We don't hold interaction data for eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), or the other omega-3 fatty acids in our database yet. That doesn't mean they don't interact with medications—it means we haven't reviewed them. Use the search tool on this page to check your specific medications, or ask your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Fish Oil plus Joint is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Fish Oil plus Joint label
Sources

Sources & How We Checked

Fish Oil plus Joint's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 20 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Palmitoylethanolamide (pea) 4 references
  1. Indraccolo U, Barbieri F. Effect of palmitoylethanolamide-polydatin combination on chronic pelvic pain associated with endometriosis: preliminary observations. Eur J Obstet Gynecol Reprod Biol. 2010 May;150(1):76-9. PubMed
  2. Murina F, Graziottin A, Felice R, Radici G, Tognocchi C. Vestibulodynia: synergy between palmitoylethanolamide + transpolydatin and transcutaneous electrical nerve stimulation. J Low Genit Tract Dis. 2013 Apr;17(2):111-6.
  3. Papetti L, Sforza G, Tullo G, et al. Tolerability of palmitoylethanolamide in a pediatric population suffering from migraine: A pilot study. Pain Res Manag 2020;2020:3938640. PubMed
  4. Visse K, Blome C, Phan NQ, Augustin M, Ständer S. Efficacy of body lotion containing N-palmitoylethanolamine in subjects with chronic pruritus due to dry skin: A dermatocosmetic study. Acta Derm Venereol. 2017;97(5):639-641. PubMed

See these in context on the Palmitoylethanolamide (pea) monograph →

Boswellia Serrata 16 references
  1. Gupta I, Gupta V, Parihar A, et al. Effects of Boswellia serrata gum resin in patients with bronchial asthma: results of a double-blind, placebo-controlled, 6-week clinical study. Eur J Med Res 1998;3:511-4.
  2. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
  3. Kimmatkar N, Thawani V, Hingorani L, et al. Efficacy and tolerability of Boswellia serrata extract in treatment of osteoarthritis of knee--a randomized double blind placebo controlled trial. Phytomedicine 2003;10:3-7. PubMed
  4. Liu JJ, Nilsson A, Oredsson S, et al. Boswellic acids trigger apoptosis via a pathway dependent on caspase-8 activation but independent on Fas/Fas ligand interaction in colon cancer HT-29 cells. Carcinogenesis 2002;23:2087-93. PubMed
  5. Wildfeuer A, Neu IS, Safayhi H, et al. Effects of boswellic acids extracted from a herbal medicine on the biosynthesis of leukotrienes and the course of experimental autoimmune encephalomyelitis. Arzneimittelforschung 1998;48:668-74.
  6. Gupta I, Parihar A, Malhotra P, et al. Effects of gum resin of Boswellia serrata in patients with chronic colitis. Planta Med 2001;67:391-5. PubMed
  7. Sengupta K, Alluri KV, Satish AR, et al. A double blind, randomized, placebo controlled study of the efficacy and safety of 5-Loxin. Arthritis Res Ther 2008;10:R85.
  8. Sengupta K, Krishnaraju AV, Vishal AA, et al. Comparative efficacy and tolerability of 5-Loxin and Aflapin against osteoarthritis of the knee: a double blind, randomized, placebo controlled clinical study. Int J Med Sci 2010;7:366-77.
  9. Ernst E. Frankincense: systematic review. BMJ 2008;337:a2813. PubMed
  10. Kirste S, Treier M, Wehrle SJ, et al. Boswellia serratea extract acts on cerebral edema in patients irradiated for brain tumors: a prospective, randomized, placebo-controlled, double-blind pilot trial. Cancer 2011;117:3788-95.
  11. Frank A, Unger M. Analysis of frankincense from various Boswellia species with inhibitory activity on human drug metabolising cytochrome P450 enzymes using liquid chromatography mass spectrometry after automated on-line extraction. J Chromatogr A 2006;111 PubMed
  12. Altmann A, Poeckel D, Fischer L, et al. Coupling of boswellic acid-incuded Ca2+ mobilisation and MAPK activation to lipid metabolism and peroxide formation in human leucocytes. Br J Pharmacol 2004;141:223-32.
  13. El Fortia, M., Badi, H., Elalem, Kh, Kadiki, O., and Topov, Y. Olibanum bezoar: complication of a traditional popular medicine. East Mediterr.Health J 2006;12(6):927-929.
  14. Meshkat S, Mahmoodi Baram S, Rajaei S, et al. Boswellia serrata extract shows cognitive benefits in a double-blind, randomized, placebo-controlled pilot clinical trial in individuals who suffered traumatic brain injury. Brain Inj 2022;36(4):553-559. PubMed
  15. Haron MH, Dale O, Martin K, et al. Evaluation of the Herb-Drug Interaction Potential of Commonly Used Botanicals on the US Market with Regard to PXR- and AhR-Mediated Influences on CYP3A4 and CYP1A2. J Diet Suppl 2022. PubMed
  16. Valente IVB, Garcia D, Abbott A, et al. The anti-proliferative effects of a frankincense extract in a window of opportunity phase ia clinical trial for patients with breast cancer. Breast Cancer Res Treat 2024;204(3):521-530. PubMed

See these in context on the Boswellia Serrata monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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