Interactions on record — worth a quick check against your medications. Based on 1 of 3 ingredients. Check your meds →
Dietary supplement

Flush Ingredients & Drug Interactions

by Reaction Nutrition

Flush label
See full label image
Capsule Category: Botanical With Nutrients
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Flush against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Flush is a dietary supplement by Reaction Nutrition with 3 active ingredients. Its ingredients are commonly taken for preventing or treating low potassium (hypokalemia), supporting healthy blood pressure, muscle cramps.Based on those ingredients, 62 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Potassium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Flush by Reaction Nutrition

Ask about any prescription or over-the-counter medication and we check it for interactions with Flush by Reaction Nutrition — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Flush by Reaction Nutrition

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Flush contains 3 active ingredients: potassium, a Water Release System, and an Anti-Bloating System. Potassium is a mineral your body needs for nerve and muscle function, heart rhythm, and fluid balance.

The product also contains several inactive ingredients — maltodextrin, magnesium stearate, gelatin, FD&C Blue #1, and titanium dioxide — that serve as binders and capsule material.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

We hold no graded evidence for this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: water release and anti-bloating.
  • Our graded evidence for these ingredients doesn't cover that particular purpose.

We hold no effectiveness ratings for the ingredients in Flush in our data. That means the evidence for what this product claims to do isn't established in the monographs we have on file.

The evidence, ingredient by ingredient Potassium

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Potassium from food is safe and necessary, but supplements are a different story — they can cause dangerously high blood levels, especially if you have kidney problems. The most common side effects from potassium taken by mouth are stomach upset: abdominal pain, nausea, vomiting, diarrhea, and gas.

Rare but serious effects of very high potassium levels include irregular heartbeat, low blood pressure, and confusion. For pregnancy and breastfeeding: dietary potassium is appropriate, but if you're pregnant or nursing and considering a potassium supplement, talk with your doctor or pharmacist first — they can weigh whether it's right for you individually.

We don't have safety data on file for the other two active ingredients.

Side effects, ingredient by ingredient Potassium

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Potassium.
  • The most serious interaction on file is rated Moderate.
  • For scale: 62 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take Flush, double-check any potassium-sparing diuretics, ACE inhibitors, or ARBs you're on — they all raise the risk of dangerously high potassium when combined with this supplement. The drug-checker tool on this page will show you exactly which medications are affected.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Flush may be worth a look if you're interested in potassium and digestive support, but potassium supplements are not something to start on your own — you need to check with your doctor first, especially if you take blood pressure or heart medications. If you have kidney disease or any kidney concerns, skip this until you've talked with your pharmacist or doctor.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 25, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Flush, straight from the product label.

Brand Reaction Nutrition
Barcode (UPC) 283333900128
Net contents 60 Capsule(s); 1165 mg
Market status On market
Date entered into DSLD Mar 25, 2013
DSLD ID 19606
Product type Botanical With Nutrients
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Flush by Reaction Nutrition, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
UPC/BARCODE
283333900128
IngredientAmount% DV
Potassium40 mg1%
Water Release System1025 mg--
Anti-Bloating System100 mg--

Other ingredients: Maltodextrin, Magnesium Stearate, Gelatin, FD&C Blue #1, Titanium Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

KEEP OUT OF REACH OF CHILDREN.

WARNING: If you are pregnant, nursing, taking any medications or planning any medical procedure, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur.

Not intended for use by children.

Tamper Resistant: Do not use if seal under cap is broken or missing.

General

LBRNCFlush-60_20130111 Rev.C

General Statements

CLINICAL

Water Release & Anti-Bloating System MADE IN THE USA OF DOMESTIC & IMPORTED INGREDIENTS

Seals/Symbols

Rx(R)

INSPECTED cGMP FACILITY Good Manufacturing Practice GLUTEN-FREE

FDA Statement of Identity

DIETARY SUPPLEMENT

Suggested/Recommended/Usage/Directions

SUGGESTED USE: As a dietary supplement, take 2 capsules prior to breakfast with 8 ounces of water. For best results, drink 4 - 6 glasses (32 - 48 oz.) of water daily.

Brand IP Statement(s)

The ingredients in FLUSH(TM) help control uncomfortable bloating and keep the body from storing excess water. FLUSH(TM), when taken as a supplement daily, may help shed extract water weight giving you a leaner and dryer physique.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Storage

Keep this bottle tightly closed in a cool, dry place away from direct sunlight and moisture.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Flush by Reaction Nutrition label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Flush label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Flush by Reaction Nutrition

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Potassium

Interacts with
62 drugs
40 mg per serving Form: Potassium Chloride

Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanc...

Potassium monograph & interactions

Water Release System

1025 mg per serving Form: Agathosma Betulina, Cranberry Extract, Dandelion, Evodiamine, Juniperus Communis extract

Anti-Bloating System

100 mg per serving Form: Angelica, Anise, Ginger

Other (inactive) ingredients: Maltodextrin, Magnesium Stearate, Gelatin, FD&C Blue #1, Titanium Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Flush by Reaction Nutrition Drug Interactions

Want to check YOUR meds against Flush?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
62Drugs
62 Moderate

Ingredients driving the most interactions

Potassium 62

Individual Drug Interactions

The ingredients in Flush interact with 62 drugs. Click any drug to see the details.

1 of the 3 ingredients in Flush interact with drugs. Each result below shows which ingredient is responsible. Potassium

Each ingredient & the kinds of drugs it affects

For each ingredient in Flush with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Potassium3 drug types · 62 drugs

Ace Inhibitors (Aceis)

Using ACEIs with high doses of potassium increases the risk of hyperkalemia.
ACEIs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C
Angiotensin Receptor Blockers (Arbs)

Using ARBs with high doses of potassium increases the risk of hyperkalemia.
ARBs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C
Potassium-Sparing Diuretics

Concomitant use increases the risk of hyperkalemia.
Using potassium-sparing diuretics with potassium supplements increases the risk of hyperkalemia.

Likelihood Likely Evidence C
Potassium full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Flush, from the product label.

Reaction Nutrition

See all Reaction Nutrition products
Name
REACTION NUTRITION, LLC.
City
CARNEGIE
State
PA
ZipCode
15106
Phone Number
877.REACT.77
Pharmacist Counseling Corner

Flush by Reaction Nutrition: Common Questions

Does Flush by Reaction Nutrition interact with any medications?
Yes. Based on its ingredients, Flush has a known interaction with 62 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Flush contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is potassium in this product supposed to do?
Potassium is a mineral your body needs for nerve and muscle function, heart rhythm, and keeping your fluid balance right. It's one of the three active ingredients in Flush.
What are the most common side effects I might feel if I take Flush?
The most common side effects from potassium taken by mouth are stomach issues: belly pain, nausea, vomiting, diarrhea, and gas. Most people tolerate it well, but your stomach may let you know if you don't.
Is it safe to take this if I'm pregnant?
Dietary potassium is fine during pregnancy, but supplements are different. The safety data says it's likely safe, but because this is an individual decision, check with your doctor or pharmacist before you start — they know your full health picture.
Can I take Flush while I'm breastfeeding?
Dietary potassium is appropriate while breastfeeding, but potassium supplements need a conversation with your doctor or pharmacist first. They can help you decide if it's right for you and your baby.
What do the 'Water Release System' and 'Anti-Bloating System' do?
Those are two of the three active ingredients in Flush, but we don't have data on file for what they do or how they work. Your best bet is to check the brand's website or ask us directly.
Is potassium from food different from this supplement?
Yes — potassium from a normal diet is safe and your body handles it well. Supplements are more concentrated and can push your blood potassium too high, especially if you have kidney disease, so they need medical supervision.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Flush is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Flush label
Go deeper

The Full Monographs Behind Flush’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Potassium

Interacts with 62 drugs

Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanced diet rich in fruits and vegetables. P...

Read the full Potassium monograph →
Sources

Sources & How We Checked

Flush's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 12 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Potassium 12 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Gennaro A. Remington: The Science and Practice of Pharmacy. 19th ed. Lippincott: Williams & Wilkins, 1996.
  3. Whelton PK, He J, Cutler JA, et al. Effects of oral potassium on blood pressure. Meta-analysis of randomized controlled clinical trials. JAMA 1997;277:1624-32. PubMed
  4. Phillips, C. O., Kashani, A., Ko, D. K., Francis, G., and Krumholz, H. M. Adverse effects of combination angiotensin II receptor blockers plus angiotensin-converting enzyme inhibitors for left ventricular dysfunction: a quantitative review of data from ra DOI
  5. Altieri, P. I., Herrero, C., Suero, R., and Ortiz, A. Bleeding duodenal ulcer in a patient taking slow-releasing potassium tablets. Bol.Asoc.Med P.R. 1977;69(8):276.
  6. Raf, L. E. Enteric-coated potassium chloride tablets and ulcer of the small intestine. Acta Chir Scand Suppl 1967;(374):1-87.
  7. Potassium chloride oral solution [package insert]. Allentown, PA: Lehigh Valley Technologies, Inc.; 2014.
  8. Potassium chloride injection [package insert]. Lake Forest, IL: Hospira Inc.; 2009.
  9. Patel RB, Tannenbaum S, Viana-Tejedor A, et al. Serum potassium levels, cardiac arrhythmias, and mortality following non-ST-elevation myocardial infarction or unstable angina: insights from MERLIN-TIMI 36. Eur Heart J Acute Cardiovasc Care 2017 Feb;6(1):1 PubMed
  10. Malta D, Arcand J, Ravindran A, Floras V, Allard JP, Newton GE. Adequate intake of potassium does not cause hyperkalemia in hypertensive individuals taking medications that antagonize the renin angiotensin aldosterone system. Am J Clin Nutr 2016 Oct;104(4 PubMed
  11. Keskin M, Kaya A, Tatlisu MA, et al. The effect of serum potassium level on in-hospital and long-term mortality in ST elevation myocardial infarction. Int J cardiol. 2016 Oct 15;221:505-10.
  12. Stallings VA, Harrison M, Oria M; Committee to Review the Dietary Reference Intakes for Sodium and Potassium, Food and Nutrition Board, Health and Medicine Division, National Academies of Sciences, Engineering, and Medicine. Washington (DC): National Acad

See these in context on the Potassium monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team