Graviola Ingredients & Drug Interactions
by NusaPure
What is this page for?
First and foremost: checking Graviola against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Graviola is a dietary supplement by NusaPure with 2 active ingredients. Its ingredients are commonly taken for cancer support (unproven), infections, inflammation.Based on those ingredients, 1 medication has a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Graviola leaf extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Graviola by NusaPure
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AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Graviola by NusaPure
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
NusaPure Graviola contains 2 active ingredients: graviola leaf extract and graviola fruit extract. Both come from the graviola plant and are traditionally used in herbal medicine, though their effectiveness for specific conditions isn't well established in clinical trials.
The capsules also contain inactive ingredients—cellulose, silica, magnesium stearate, and rice flour—which are fillers and binders.
Does it work?
Couldn't assess
The evidence we hold doesn't establish that graviola works for any condition. For HPV infection, headache, use as an insect repellent, and male infertility, the data shows insufficient reliable evidence to rate it.
If you're considering graviola for one of these, talk with your doctor about whether there's a better-studied option available.
How safe is it?
Well-documented data
Regular graviola use raises some safety concerns. The most common side effects are stomach pain and nausea; in rare cases, people have reported movement disorders and nerve damage (myeloneuropathy) that resemble Parkinson disease symptoms.
One study found that even small amounts of graviola over time may worsen symptoms in people with Parkinson disease. Human safety data are limited, and lab studies suggest possible nerve toxicity with long-term use.
Graviola is rated possibly unsafe in pregnancy and should be avoided while breastfeeding. If you're pregnant, planning to become pregnant, or breastfeeding, don't take this product without talking to your doctor or pharmacist.
Meds to double-check
Moderate interaction found
If you take carbamazepine (Tegretol) for seizures, graviola may lower its blood levels and reduce how well it works. Check with your doctor or pharmacist before combining them.
The bottom line
Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
NusaPure Graviola is not well studied for any specific health condition, and regular use carries safety concerns—especially stomach upset, nausea, and rare nerve problems. If you take carbamazepine (Tegretol) for seizures, you'll need to check with your doctor before starting this product, as it may reduce the drug's effectiveness.
Pregnant and breastfeeding people should avoid it. Talk it over with your doctor or pharmacist before taking it.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 22, 2024.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Graviola, straight from the product label.
| Brand | NusaPure |
|---|---|
| Barcode (UPC) | X001O95VPV |
| Net contents | 180 Veg Cap(s) |
| Market status | On market |
| Date entered into DSLD | Mar 22, 2024 |
| DSLD ID | 307323 |
| Product type | Botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Vegan, Vegetarian, Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Graviola by NusaPure, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Graviola leaf extract | 250 mg | -- |
| Graviola Fruit Extract | 250 mg | -- |
Other ingredients: Cellulose, Silica, Magnesium Stearate, Rice Flour
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula
Graviola 5000 mg equivalent 10:1 standardized extracts
Graviola 5000 mg equivalent per capsule Graviola leaf & fruit complex
General Statements
New
Suggested/Recommended/Usage/Directions
Directions: Take one (1) capsule daily, preferably with a meal or as directed by a healthcare practitioner.
Precautions
Warning: For adults only. Keep out of reach of children. Not intended for use by persons under the age of 18.
Do not take this product if you have any neurodegenerative disorders or Parkinson's disease, or are taking any antihypertensive or MAO inhibitor medications. Not recommended for pregnant/nursing women. Consult physician if taking medication or have a medical condition.
Discontinue use and consult your doctor if any adverse reactions occur.
Allergen information: Not manufactured with yeast, wheat, gluten, soy, corn, milk, egg, fish, shellfish or tree nut ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.
Formulation
Natural color variation may occur in this product.
GMO free Made with Non-GMO ingredients Gluten free FDA Registered Facility
Assembled in USA Tested Supports normal nutritional supplementation Made under strict GMP guidelines Max strength
Suitable for vegetarians/vegans
Allergen information: Not manufactured with yeast, wheat, gluten, soy, corn, milk, egg, fish, shellfish or tree nut ingredients.
FDA Disclaimer Statement
This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Seals/Symbols
Premium quality Assembled in USA
Manufactured in a cGMP inspected facility
FDA Statement of Identity
Dietary Supplement
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Graviola by NusaPure label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Graviola by NusaPure
These are the 2 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Veg Capsule(s) Dosage formCapsule Servings per container180 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Graviola leaf extract
Interacts with1 drug
Graviola (soursop) is a tropical fruit tree whose leaves, fruit, and bark are used in traditional medicine, especially in parts of South America, Afri...
Graviola leaf extract monograph & interactionsGraviola Fruit Extract
Interacts with1 drug
Graviola (soursop) is a tropical fruit tree whose leaves, fruit, and bark are used in traditional medicine, especially in parts of South America, Afri...
Graviola Fruit Extract monograph & interactionsOther (inactive) ingredients: Cellulose, Silica, Magnesium Stearate, Rice Flour. These complete the product’s ingredient list but are not active constituents.
Graviola by NusaPure Drug Interactions
HelloPharmacist Interaction Report
NusaPure Graviola interacts with at least one medication through both its leaf and fruit extract content.
The most serious documented interaction is with carbamazepine (Tegretol), an anti-seizure drug. A rat study shows graviola extract can lower carbamazepine levels by 46% in area under the curve and 35% in peak concentration—meaning your body may clear the drug faster and it could become less effective at controlling seizures.
Read the full breakdown — every affected drug type, severity by severity
If you take carbamazepine, do not start graviola without talking to your doctor first. They may need to adjust your dose or monitor your seizure control more closely.
Altogether, these interactions span 1 individual medication.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Graviola?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Graviola interact with 1 drug. Click any drug to see the details.
1 of the 2 ingredients in Graviola interact with drugs. Each result below shows which ingredient is responsible. Graviola leaf extract
CarbamazepineCarbatrol, Carnexiv, Equetro, Tegretol, Tegretol XR
How Carbamazepine interacts with Graviola — through 1 ingredient. Tap an ingredient for the detail:
Graviola Fruit ExtractCarbamazepine (tegretol) Moderate
Interaction Summary
Theoretically, graviola might decrease concentrations of carbamazepine when used concomitantly.
Read the full Graviola Fruit Extract + Carbamazepine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Graviola with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Graviola leaf extract
Carbamazepine (Tegretol)
Theoretically, graviola might decrease concentrations of carbamazepine when used concomitantly.
A study in rats shows that graviola extract reduces the area under the curve of carbamazepine by 46% and maximum concentration by 35% when compared with carbamazepine alone.
Brand information
Manufacturer and brand details for Graviola, from the product label.
NusaPure
See all NusaPure products- Name
- Gmax Central, LLC
- Street Address
- 500 Westover Dr. #92909
- City
- Sanford
- State
- NC
- ZipCode
- 27330
Graviola by NusaPure: Common Questions
Does Graviola by NusaPure interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take this if I'm pregnant or breastfeeding?
What are the side effects?
Does graviola actually work for anything?
What's in each capsule?
Is this safe for long-term use?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Graviola is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Graviola’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Graviola's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 4 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Graviola 4 references
- Caparros-Lefebvre D, Elbaz A. Possible relation of atypical parkinsonism in the French West Indies with consumption of tropical plants: a case-control study. Caribbean Parkinsonism Study Group. Lancet 1999;354:281-6. PubMed
- Gavamukulya Y, Wamunyokoli F, El-Shemy HA. Annona muricata: Is the natural therapy to most disease conditions including cancer growing in our backyard? A systematic review of its research history and future prospects. Asian Pac J Trop Med. 2017;10(9):835- PubMed
- Abu Soukhon AA, Abu-Qatouseh L, Mansoor K, et al. Cytotoxicity Activity of Graviola Fruit Extract with Carbamazepine and Valproic Acid Show Antagonistic and Indifferent Effects. Asian Pac J Cancer Prev 2023;24(6):1869-1875. PubMed
- Cleret de Langavant L, Roze E, Petit A, et al. Annonaceae Consumption Worsens Disease Severity and Cognitive Deficits in Degenerative Parkinsonism. Mov Disord 2022;37(12):2355-2366. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC