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Dietary supplement

Hoodia Force Oral Spray Ingredients & Drug Interactions

by NewtonEverett

Hoodia Force Oral Spray label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Hoodia Force Oral Spray against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Hoodia Force Oral Spray is a dietary supplement by NewtonEverett with 1 active ingredient. Its ingredients are commonly taken for appetite suppression, weight loss, reducing food cravings.Based on those ingredients, 262 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Hoodia Gordonii 20:1 extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Hoodia Force Oral Spray by NewtonEverett

Ask about any prescription or over-the-counter medication and we check it for interactions with Hoodia Force Oral Spray by NewtonEverett — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Hoodia Force Oral Spray by NewtonEverett

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • “Hoodia Gordonii 20:1 extract” is listed as a grouped ingredient — the label gives one combined amount (53 mg) without saying how much of each component you get.

Hoodia Force contains a single active ingredient: 1,065 mg of hoodia gordonii powder, delivered as an oral spray. Hoodia is a plant extract traditionally used in appetite support products.

The spray also contains inactive ingredients — glycerin, organic alcohol, and purified water — that make up the liquid base.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Hoodia's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: appetite control and weight management support.
  • We looked for evidence on: Obesity, overweight, weight loss, satiety.
  • The closest evidence on file: Hoodia is rated "Insufficient Reliable Evidence To Rate" for Obesity (Natural Medicines).

The evidence for hoodia in supporting weight management is insufficient to make a reliable claim. While the ingredient has been studied, the data we hold does not establish that it works for obesity or weight loss.

If you're considering it for appetite support, talk with your doctor or pharmacist about what the research actually shows and whether it's the right choice for you.

The evidence, ingredient by ingredient Hoodia

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Limited safety data exist for hoodia, and product quality concerns have been reported. Some people have reported minor side effects including headache, dizziness, nausea, and skin sensation changes.

There is also concern that hoodia may increase blood pressure and heart rate. Hoodia should not be used during pregnancy or while breastfeeding — there is not enough safety information to know either way, and the data advises against it.

If you are pregnant, nursing, or planning to become pregnant, talk with your doctor or pharmacist before taking this product.

Side effects, ingredient by ingredient Hoodia

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Hoodia.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 262 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Hoodia Force, double-check with your doctor or pharmacist if you take blood pressure medications (like captopril, enalapril, losartan, or valsartan), beta-blockers (like atenolol or metoprolol), diabetes drugs, or insulin. Hoodia may raise blood pressure and heart rate and may enhance blood glucose-lowering effects, which could affect how well your medications work or raise the risk of low blood sugar.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Hoodia Force is intended for appetite support, but the evidence for its effectiveness is not established in the data we hold. Its main concern is with people taking blood pressure medications, heart rate drugs, diabetes medications, or insulin — hoodia may interfere with how these work.

If you take any prescription medications, check with your doctor or pharmacist before starting this spray.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 25, 2014.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Hoodia Force Oral Spray, straight from the product label.

Brand NewtonEverett
Barcode (UPC) 689076015134
Net contents 180 Total Spray(s)
Market status On market
Date entered into DSLD Jul 25, 2014
DSLD ID 35302
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Hoodia Force Oral Spray by NewtonEverett, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Spray(s)
Maximum serving Sizes:
2 Spray(s)
UPC/BARCODE
689076015134
IngredientAmount% DV
Hoodia Gordonii 20:1 extract53 mg--
1065mg of Hoodia Gordonii powder1065 mg--

Other ingredients: Glycerin, organic Alcohol, purified Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

DIRECTIONS: Adults: Spray twice under the tongue three times a day, 15 minutes before breakfast, lunch and dinner. This product should be used in conjunction with a sensible diet and exercise program.

Precautions

CAUTION: This product is not recommended for pregnant or nursing mothers, children under 18 years of age or persons with a known medical condition including diabetes or hypoglycemia.

CAUTION: This product is not recommended for pregnant or nursing mothers, children under 18 years of age or persons with a known medical condition including diabetes or hypoglycemia.

If you have questions about the advisability of taking this product, consult your physician prior to use.

KEEP OUT OF REACH OF CHILDREN.

DO NOT USE IF OUTER SEAL IS DAMAGED OR MISSING.

General Statements

Made in USA

~ APPETITE CONTROL ~ WORKS QUICKLY ~ 100% NATURAL

20:1 Extract

FDA Statement of Identity

DIETARY SUPPLEMENT

FDA Disclaimer Statement

These statements have not been reviewed by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Hoodia Force Oral Spray by NewtonEverett label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Hoodia Force Oral Spray label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Hoodia Force Oral Spray by NewtonEverett

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Spray(s) Dosage formLiquid Amounts shown are per serving.

Hoodia Gordonii 20:1 extract

Interacts with
262 drugs
53 mg per serving

Hoodia is a succulent plant from southern Africa that is marketed as an appetite suppressant for weight loss, but solid human evidence that it actuall...

Hoodia Gordonii 20:1 extract monograph & interactions

Other (inactive) ingredients: Glycerin, Organic Alcohol, Purified Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

Hoodia Force Oral Spray by NewtonEverett Drug Interactions

Want to check YOUR meds against Hoodia Force Oral Spray?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
262Drugs
262 Moderate

Ingredients driving the most interactions

Hoodia Gordonii 20:1 extract 262

Individual Drug Interactions

The ingredients in Hoodia Force Oral Spray interact with 262 drugs. Click any drug to see the details.

1 of the 1 ingredient in Hoodia Force Oral Spray interact with drugs. Each result below shows which ingredient is responsible. Hoodia Gordonii 20:1 extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Hoodia Force Oral Spray with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Hoodia Gordonii 20:1 extract4 drug types · 262 drugs

Antidiabetes Drugs

Animal research shows that a steroid glycoside of hoodia, gordonoside F, increases glucose-stimulated insulin secretion by activating GPR119. This effect enhances glucose disposal. Theoretically, concomitant use of hoodia with antidiabetes medications may enhance blood glucose-lowering effects and increase the risk of hypoglycemia. Some antidiabetes medications include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), chlorpropamide (Diabinese), glipizide (Glucotrol), tolbutamide (Orinase), and others.

Likelihood Possible Evidence D
Antihypertensive Drugs

Clinical research shows that hoodia can increase blood pressure. Theoretically, concomitant use of hoodia with antihypertensive drugs might decrease the effectiveness of the antihypertensive drugs and increase the risk of hypertension. Some antihypertensive drugs include captopril (Capoten), enalapril (Vasotec), losartan (Cozaar), valsartan (Diovan), diltiazem (Cardizem), Amlodipine (Norvasc), hydrochlorothiazide (HydroDiuril), furosemide (Lasix), and many others.

Likelihood Possible Evidence D
Beta-Blockers

Evidence from in vitro research shows that hoodia may stimulate beta-adrenergic receptors. Also, clinical research shows that hoodia can increase blood pressure and heart rate. Theoretically, using hoodia with beta-blockers might decrease the effects of these medications. Some beta-blocker drugs include atenolol (Tenormin), metoprolol (Lopressor, Toprol XL), nadolol (Corgard), and propranolol (Inderal).

Likelihood Possible Evidence D
Insulin

Animal research shows that a steroid glycoside of hoodia, gordonoside F, increases glucose-stimulated insulin secretion by activating GPR119. Theoretically, concomitant use of hoodia with insulin may enhance the blood glucose-lowering effects of insulin. Blood glucose levels should be monitored.

Likelihood Possible Evidence D
Hoodia Gordonii 20:1 extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Hoodia Force Oral Spray, from the product label.

NewtonEverett

See all NewtonEverett products
Name
Newton-Everett Biotech
Web Address
www.newton-everett.com
Pharmacist Counseling Corner

Hoodia Force Oral Spray by NewtonEverett: Common Questions

Does Hoodia Force Oral Spray by NewtonEverett interact with any medications?
Yes. Based on its ingredients, Hoodia Force Oral Spray has a known interaction with 262 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Hoodia Force Oral Spray contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is hoodia gordonii, and what is it used for?
Hoodia gordonii is a plant extract that has been used in appetite support products. This spray delivers it as a liquid for ease of use. The theory is that it may help with appetite, though the evidence for its effectiveness is not established in our data.
Can I take Hoodia Force if I'm pregnant or breastfeeding?
No — there is not enough safety information, so hoodia should be avoided during pregnancy and while breastfeeding. If you're pregnant, nursing, or planning to become pregnant, talk with your doctor or pharmacist before taking this product.
What side effects has hoodia reported?
Minor side effects have included headache, dizziness, nausea, and disturbances of skin sensation. There is also concern that hoodia may increase blood pressure and heart rate. Limited safety data exist overall, and product quality concerns have been reported.
Does Hoodia Force contain anything other than the active ingredient?
Yes, the spray also contains inactive ingredients — glycerin, organic alcohol, and purified water — that make up the liquid base and help deliver the hoodia powder.
I take a blood pressure medication. Is it safe to use this product?
Hoodia may raise blood pressure and potentially reduce how well your medication works. Before starting this spray, check with your doctor or pharmacist to make sure it won't interfere with your treatment.
I take insulin for diabetes. Can I use Hoodia Force?
Hoodia may enhance the blood glucose-lowering effects of insulin, which could raise the risk of low blood sugar. Talk with your doctor or pharmacist before starting this product so your blood sugar can be monitored if needed.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Hoodia Force Oral Spray label
Go deeper

The Full Monographs Behind Hoodia Force Oral Spray’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Hoodia

Interacts with 262 drugs

Hoodia is a succulent plant from southern Africa that is marketed as an appetite suppressant for weight loss, but solid human evidence that it actually works is lacking. The few quality stud...

Read the full Hoodia monograph →
Sources

Sources & How We Checked

Hoodia Force Oral Spray's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 3 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Hoodia 3 references
  1. Blom WAM, Abrahamse SL, Bradford R, et al. Effects of 15-d repeated consumption of Hoodia gordonii purified extract on safety, ad libitum energy intake, and body weight in healthy, overweight women: a randomized controlled trial. Am J Clin Nutr 2011;94(5) PubMed
  2. Roza O, Lovász N, Zupkó I, Hohmann J, Csupor D. Sympathomimetic activity of a Hoodia gordonii product: a possible mechanism of cardiovascular side effects. Biomed Res Int. 2013;2013:171059.
  3. Zhang S, Ma Y, Li J, et al. Molecular matchmaking between the popular weight-loss herb Hoodia gordonii and GPR119, a potential drug target for metabolic disorder. Proc Natl Acad Sci U S A. 2014;111(40):14571-6.

See these in context on the Hoodia monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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