iFerex 150 Ingredients & Drug Interactions
by ZIKS
What is this page for?
First and foremost: checking iFerex 150 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
iFerex 150 is a dietary supplement by ZIKS with 1 active ingredient. Its ingredients are commonly taken for iron-deficiency anemia, low iron stores during pregnancy, fatigue from iron deficiency.Based on those ingredients, 80 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Iron. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
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HelloPharmacist Scorecard of iFerex 150 by ZIKS
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
iFerex 150 is a single-ingredient supplement: polysaccharide iron complex, an iron compound designed to help your body absorb iron more gently than some other iron forms. The capsule itself contains several inactive ingredients — gelatin, microcrystalline cellulose, magnesium stearate, titanium dioxide, and various FDA-approved colorants (iron oxides and FD&C dyes) — that hold it together and give it color.
Does it work?
Strong evidence
Iron in iFerex 150 is effective for iron deficiency anemia and anemia of chronic disease — two conditions where your body either isn't getting enough iron or can't hold on to it properly. There's also evidence it may be helpful for heart failure, though the data there is less established (rated Possibly Effective).
For pregnancy-related iron deficiency, iron is also rated Effective.
How safe is it?
Well-documented data
Taken at recommended doses, iron is generally well tolerated — but excess iron can be toxic, so this supplement is meant to be used when you actually have a real iron need, not as a routine preventive. The most common side effects are stomach-related: abdominal pain, constipation, diarrhea, nausea, and vomiting.
Rare serious concerns include stomach or gastric ulcers from oral iron. Iron is often recommended in pregnancy and is considered acceptable while breastfeeding at appropriate doses, but in both cases you should have your prenatal care provider or your doctor guide your dosing.
Meds to double-check
Moderate interaction found
Before taking iFerex 150, check with your doctor or pharmacist if you're on any of these: levodopa, quinolone or tetracycline antibiotics, bisphosphonates, methyldopa, levothyroxine, mycophenolate mofetil, or penicillamine. All carry Moderate-severity interactions — iron will reduce how much of these drugs your body absorbs, so doses need to be separated by at least 2 hours (and up to 6 hours for some).
The bottom line
Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
iFerex 150 works well for iron deficiency and chronic anemia, but it's a supplement that demands attention to timing if you take other medications — particularly antibiotics, thyroid drugs, and blood pressure meds. If you're on any prescription medication, check it against the interaction search on this page before starting, and talk with your doctor or pharmacist about spacing doses.
Iron also works best when there's a real need for it, not as a general supplement.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jan 22, 2022.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about iFerex 150, straight from the product label.
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for iFerex 150 by ZIKS, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Iron | 150 mg | 833% |
| Polysaccharide Iron Complex | 326.1 mg | -- |
Other ingredients: Gelatin, Microcrystalline Cellulose, Magnesium Stearate, Titanium Dioxide, FDA/E172 Red Iron Oxide, FD&C Yellow #10, FDA/E172 Black Iron Oxide, FD&C Red #28, FD&C Red #40, FD&C Blue #1
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
Description: iFerex 150 capsules is a brown and orange capsule with marking "ziks 0203". It is a product of ferric iron complexed to a low molecular weight polysaccharide.
Indications and Usage: iFerex 150 is indicated for the prevention and treatment of iron deficiency anemia and/or nutritional megaloblastic anemias.
Precautions
Contraindications: iFerex 150 is contraindicated in patients with a known hypersensitivity to any of the components of this product. Hemochromatosis and hemosiderosis are contraindications to iron therapy.
Adverse Events: You should call your doctor for medical advice about adverse events. To report a serious adverse event contact Nnodum Pharmaceuticals. 483 Northland Blvd., Cincinnati, OH, 45240.
Warning: Accidental overdose of iron-containing products is a leading cause of fatal poisoning in children under 6. Keep this product out of reach of children. In case of accidental overdose, call a doctor or poison control immediately. Keep this product and all drugs out of reach of children.
Dispense in a tight, light-resistant container with a child resistant closure.
Suggested/Recommended/Usage/Directions
Dosage and Administration: Adults: 1 capsule daily or as directed by your physician.
FDA Statement of Identity
Iron Supplement
Storage
Storage: Store at 20 degrees C - 25 degrees C (58 degrees - 77 degrees F): excursions permitted to 15 degrees C - 30 degrees C (59 degrees - 86 degrees F).
General Statements
63044-0203-01
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
iFerex 150 by ZIKS label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in iFerex 150 by ZIKS
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container100 Amounts shown are per serving.
Iron
Interacts with80 drugs
Iron is an essential mineral your body needs to make hemoglobin and carry oxygen in the blood. Supplements are mainly useful for treating or preventin...
Iron monograph & interactionsOther (inactive) ingredients: Gelatin, Microcrystalline Cellulose, Magnesium Stearate, Titanium Dioxide, FDA/E172 Red Iron Oxide, FD&C Yellow #10, FDA/E172 Black Iron Oxide, FD&C Red #28, FD&C Red #40, FD&C Blue #1. These complete the product’s ingredient list but are not active constituents.
iFerex 150 by ZIKS Drug Interactions
HelloPharmacist Interaction Report
iFerex 150 by ZIKS contains polysaccharide iron complex, which interacts with a number of medications by reducing how well your body absorbs them.
The most serious interactions are Moderate in severity and involve antibiotics, blood pressure medications, thyroid drugs, and others. Iron binds to these drugs in your stomach and intestines, forming complexes that your body can't absorb — which means the drug doesn't work as well as it should.
Read the full breakdown — every affected drug type, severity by severity
The affected drug types include levodopa (used for Parkinson's disease), quinolone antibiotics (like ciprofloxacin), bisphosphonates (bone-strengthening drugs), methyldopa (a blood pressure medication), tetracycline antibiotics, levothyroxine (thyroid hormone), mycophenolate mofetil (an immunosuppressant), and penicillamine (used for Wilson's disease and rheumatoid arthritis). All of these carry a Moderate severity rating.
Altogether, these interactions span 80 individual medications.
The key strategy for all of them is timing: separate iron doses from these medications by at least 2 hours — and in some cases (tetracyclines, mycophenolate mofetil) you'll need to space them out even further. Before you start iFerex 150, run your current medications through the search tool on this page, and talk with your doctor or pharmacist about whether you need to adjust your dosing schedule.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against iFerex 150?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in iFerex 150 interact with 80 drugs. Click any drug to see the details.
1 of the 1 ingredient in iFerex 150 interact with drugs. Each result below shows which ingredient is responsible. Iron
AlendronateBinosto, Fosamax
How Alendronate interacts with iFerex 150 — through 1 ingredient. Tap an ingredient for the detail:
Polysaccharide Iron ComplexBisphosphonates Moderate
Interaction Summary
Iron reduces the absorption of bisphosphonates.
Read the full Polysaccharide Iron Complex + Alendronate interactionAlendronate Sodium
How Alendronate Sodium interacts with iFerex 150 — through 1 ingredient. Tap an ingredient for the detail:
Polysaccharide Iron ComplexBisphosphonates Moderate
Interaction Summary
Iron reduces the absorption of bisphosphonates.
Read the full Polysaccharide Iron Complex + Alendronate Sodium interactionAlendronate Sodium, CholecalciferolFosamax Plus D
How Alendronate Sodium, Cholecalciferol interacts with iFerex 150 — through 1 ingredient. Tap an ingredient for the detail:
Polysaccharide Iron ComplexBisphosphonates Moderate
Interaction Summary
Iron reduces the absorption of bisphosphonates.
Read the full Polysaccharide Iron Complex + Alendronate Sodium, Cholecalciferol interactionAmphotericin, TetracyclineMysteclin-F
How Amphotericin, Tetracycline interacts with iFerex 150 — through 1 ingredient. Tap an ingredient for the detail:
Polysaccharide Iron ComplexTetracycline Antibiotics Moderate
Interaction Summary
Iron might decrease levels of tetracycline antibiotics by reducing their absorption.
Read the full Polysaccharide Iron Complex + Amphotericin, Tetracycline interactionBenserazide, LevodopaMadopar, Prolopa
How Benserazide, Levodopa interacts with iFerex 150 — through 1 ingredient. Tap an ingredient for the detail:
Polysaccharide Iron ComplexLevodopa Moderate
Interaction Summary
Iron might decrease levodopa levels by reducing its absorption.
Read the full Polysaccharide Iron Complex + Benserazide, Levodopa interactionBictegravir, Emtricitabine, Tenofovir AlafenamideBiktarvy
How Bictegravir, Emtricitabine, Tenofovir Alafenamide interacts with iFerex 150 — through 1 ingredient. Tap an ingredient for the detail:
Polysaccharide Iron ComplexBictegravir/emtricitabine/tenofovir Alafenamide (biktarvy) Moderate
Interaction Summary
Iron might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption when taken in a fasting state.
Read the full Polysaccharide Iron Complex + Bictegravir, Emtricitabine, Tenofovir Alafenamide interactionBismuth Subsalicylate, Metronidazole, TetracyclineHelidac
How Bismuth Subsalicylate, Metronidazole, Tetracycline interacts with iFerex 150 — through 1 ingredient. Tap an ingredient for the detail:
Polysaccharide Iron ComplexTetracycline Antibiotics Moderate
Interaction Summary
Iron might decrease levels of tetracycline antibiotics by reducing their absorption.
Read the full Polysaccharide Iron Complex + Bismuth Subsalicylate, Metronidazole, Tetracycline interactionCarbidopa, LevodopaDhivy, Rytary, Sinemet, Sinemet CR
How Carbidopa, Levodopa interacts with iFerex 150 — through 1 ingredient. Tap an ingredient for the detail:
Polysaccharide Iron ComplexLevodopa Moderate
Interaction Summary
Iron might decrease levodopa levels by reducing its absorption.
Read the full Polysaccharide Iron Complex + Carbidopa, Levodopa interactionCarbidopa, Levodopa, EntacaponeStalevo
How Carbidopa, Levodopa, Entacapone interacts with iFerex 150 — through 1 ingredient. Tap an ingredient for the detail:
Polysaccharide Iron ComplexLevodopa Moderate
Interaction Summary
Iron might decrease levodopa levels by reducing its absorption.
Read the full Polysaccharide Iron Complex + Carbidopa, Levodopa, Entacapone interactionChlorothiazide, MethyldopaAldochlor, Aldoclor 150, Aldoclor 250
How Chlorothiazide, Methyldopa interacts with iFerex 150 — through 1 ingredient. Tap an ingredient for the detail:
Polysaccharide Iron ComplexMethyldopa (aldomet) Moderate
Interaction Summary
Iron might decrease methyldopa levels by reducing its absorption.
Read the full Polysaccharide Iron Complex + Chlorothiazide, Methyldopa interactionChlortetracyclineAureomycin
How Chlortetracycline interacts with iFerex 150 — through 1 ingredient. Tap an ingredient for the detail:
Polysaccharide Iron ComplexTetracycline Antibiotics Moderate
Interaction Summary
Iron might decrease levels of tetracycline antibiotics by reducing their absorption.
Read the full Polysaccharide Iron Complex + Chlortetracycline interactionCinoxacinCinobac
How Cinoxacin interacts with iFerex 150 — through 1 ingredient. Tap an ingredient for the detail:
Polysaccharide Iron ComplexQuinolone Antibiotics Moderate
Interaction Summary
Iron might decrease levels of quinolone antibiotics by reducing their absorption.
Read the full Polysaccharide Iron Complex + Cinoxacin interactionCiprofloxacinCiloxan, Cipro, Cipro IV, Cipro XR, Ciprobay, Otiprio
How Ciprofloxacin interacts with iFerex 150 — through 1 ingredient. Tap an ingredient for the detail:
Polysaccharide Iron ComplexQuinolone Antibiotics Moderate
Interaction Summary
Iron might decrease levels of quinolone antibiotics by reducing their absorption.
Read the full Polysaccharide Iron Complex + Ciprofloxacin interactionClinafloxacinClinafloxacin
How Clinafloxacin interacts with iFerex 150 — through 1 ingredient. Tap an ingredient for the detail:
Polysaccharide Iron ComplexQuinolone Antibiotics Moderate
Interaction Summary
Iron might decrease levels of quinolone antibiotics by reducing their absorption.
Read the full Polysaccharide Iron Complex + Clinafloxacin interactionCobicistat, Elvitegravir, Emtricitabine, Tenofovir Alafenamide FumarateGenvoya
How Cobicistat, Elvitegravir, Emtricitabine, Tenofovir Alafenamide Fumarate interacts with iFerex 150 — through 1 ingredient. Tap an ingredient for the detail:
Polysaccharide Iron ComplexBictegravir/emtricitabine/tenofovir Alafenamide (biktarvy) Moderate
Interaction Summary
Iron might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption when taken in a fasting state.
Read the full Polysaccharide Iron Complex + Cobicistat, Elvitegravir, Emtricitabine, Tenofovir Alafenamide Fumarate interactionDarunavir, Cobicistat, Emtricitabine, Tenofovir AlafenamideSymtuza
How Darunavir, Cobicistat, Emtricitabine, Tenofovir Alafenamide interacts with iFerex 150 — through 1 ingredient. Tap an ingredient for the detail:
Polysaccharide Iron ComplexBictegravir/emtricitabine/tenofovir Alafenamide (biktarvy) Moderate
Interaction Summary
Iron might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption when taken in a fasting state.
Read the full Polysaccharide Iron Complex + Darunavir, Cobicistat, Emtricitabine, Tenofovir Alafenamide interactionDemeclocyclineDeclomycin
How Demeclocycline interacts with iFerex 150 — through 1 ingredient. Tap an ingredient for the detail:
Polysaccharide Iron ComplexTetracycline Antibiotics Moderate
Interaction Summary
Iron might decrease levels of tetracycline antibiotics by reducing their absorption.
Read the full Polysaccharide Iron Complex + Demeclocycline interactionDenosumabProlia, XGEVA
How Denosumab interacts with iFerex 150 — through 1 ingredient. Tap an ingredient for the detail:
Polysaccharide Iron ComplexDenosumab (prolia, Others) Moderate
Interaction Summary
Administration of intravenous iron within one month of denosumab administration might increase the risk of severe hypophosphatemia and hypocalcemia.
Read the full Polysaccharide Iron Complex + Denosumab interactionDolutegravirTivicay
How Dolutegravir interacts with iFerex 150 — through 1 ingredient. Tap an ingredient for the detail:
Polysaccharide Iron ComplexDolutegravir (tivicay) Moderate
Interaction Summary
Iron might decrease dolutegravir levels by reducing its absorption.
Read the full Polysaccharide Iron Complex + Dolutegravir interactionDolutegravir, Emtricitabine, Tenofovir AlafenamideDolutegravir, Emtricitabine, Tenofovir Alafenamide
How Dolutegravir, Emtricitabine, Tenofovir Alafenamide interacts with iFerex 150 — through 1 ingredient. Tap an ingredient for the detail:
Polysaccharide Iron ComplexDolutegravir (tivicay), Bictegravir/emtricitabine/tenofovir Alafenamide (biktarvy) Moderate
Interaction Summary
Iron might decrease dolutegravir levels by reducing its absorption.
Read the full Polysaccharide Iron Complex + Dolutegravir, Emtricitabine, Tenofovir Alafenamide interactionDolutegravir, RilpivirineJuluca
How Dolutegravir, Rilpivirine interacts with iFerex 150 — through 1 ingredient. Tap an ingredient for the detail:
Polysaccharide Iron ComplexDolutegravir (tivicay) Moderate
Interaction Summary
Iron might decrease dolutegravir levels by reducing its absorption.
Read the full Polysaccharide Iron Complex + Dolutegravir, Rilpivirine interactionDoripenemDoribax
How Doripenem interacts with iFerex 150 — through 1 ingredient. Tap an ingredient for the detail:
Polysaccharide Iron ComplexQuinolone Antibiotics, Tetracycline Antibiotics Moderate
Interaction Summary
Iron might decrease levels of quinolone antibiotics by reducing their absorption.
Read the full Polysaccharide Iron Complex + Doripenem interactionDoxycyclineDoryx, Doxy, Doxy-D, Doxycin, Doxycycline Injection, Doxylin +6 more
How Doxycycline interacts with iFerex 150 — through 1 ingredient. Tap an ingredient for the detail:
Polysaccharide Iron ComplexTetracycline Antibiotics Moderate
Interaction Summary
Iron might decrease levels of tetracycline antibiotics by reducing their absorption.
Read the full Polysaccharide Iron Complex + Doxycycline interactionDoxycycline HyclateActiclate, Acticlate Cap, Lymepak
How Doxycycline Hyclate interacts with iFerex 150 — through 1 ingredient. Tap an ingredient for the detail:
Polysaccharide Iron ComplexTetracycline Antibiotics Moderate
Interaction Summary
Iron might decrease levels of tetracycline antibiotics by reducing their absorption.
Read the full Polysaccharide Iron Complex + Doxycycline Hyclate interactionDoxycycline MonohydrateErfacea
How Doxycycline Monohydrate interacts with iFerex 150 — through 1 ingredient. Tap an ingredient for the detail:
Polysaccharide Iron ComplexTetracycline Antibiotics Moderate
Interaction Summary
Iron might decrease levels of tetracycline antibiotics by reducing their absorption.
Read the full Polysaccharide Iron Complex + Doxycycline Monohydrate interactionDoxycylineDoxychel
How Doxycyline interacts with iFerex 150 — through 1 ingredient. Tap an ingredient for the detail:
Polysaccharide Iron ComplexTetracycline Antibiotics Moderate
Interaction Summary
Iron might decrease levels of tetracycline antibiotics by reducing their absorption.
Read the full Polysaccharide Iron Complex + Doxycyline interactionElvitegravir, Cobicistat, Emtricitabine, Tenofovir Disoproxil FumarateStribild
How Elvitegravir, Cobicistat, Emtricitabine, Tenofovir Disoproxil Fumarate interacts with iFerex 150 — through 1 ingredient. Tap an ingredient for the detail:
Polysaccharide Iron ComplexBictegravir/emtricitabine/tenofovir Alafenamide (biktarvy) Moderate
Interaction Summary
Iron might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption when taken in a fasting state.
Read the full Polysaccharide Iron Complex + Elvitegravir, Cobicistat, Emtricitabine, Tenofovir Disoproxil Fumarate interactionEmtricitabineEmtriva
How Emtricitabine interacts with iFerex 150 — through 1 ingredient. Tap an ingredient for the detail:
Polysaccharide Iron ComplexBictegravir/emtricitabine/tenofovir Alafenamide (biktarvy) Moderate
Interaction Summary
Iron might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption when taken in a fasting state.
Read the full Polysaccharide Iron Complex + Emtricitabine interactionEmtricitabine, Rilpivirine, TenofovirComplera
How Emtricitabine, Rilpivirine, Tenofovir interacts with iFerex 150 — through 1 ingredient. Tap an ingredient for the detail:
Polysaccharide Iron ComplexBictegravir/emtricitabine/tenofovir Alafenamide (biktarvy) Moderate
Interaction Summary
Iron might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption when taken in a fasting state.
Read the full Polysaccharide Iron Complex + Emtricitabine, Rilpivirine, Tenofovir interactionEmtricitabine, Rilpivirine, Tenofovir AlafenamideOdefsey
How Emtricitabine, Rilpivirine, Tenofovir Alafenamide interacts with iFerex 150 — through 1 ingredient. Tap an ingredient for the detail:
Polysaccharide Iron ComplexBictegravir/emtricitabine/tenofovir Alafenamide (biktarvy) Moderate
Interaction Summary
Iron might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption when taken in a fasting state.
Read the full Polysaccharide Iron Complex + Emtricitabine, Rilpivirine, Tenofovir Alafenamide interactionEach ingredient & the kinds of drugs it affects
For each ingredient in iFerex 150 with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Iron
Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy)
Iron might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption when taken in a fasting state.
Advise patients that bictegravir/emtricitabine/tenofovir alafenamide and iron can be taken together if taken with food. However, if taken on an empty stomach, bictegravir/emtricitabine/tenofovir alafenamide should not be taken with, or 2 hours after, iron containing products.
Bisphosphonates
Iron reduces the absorption of bisphosphonates.
Advise patients that doses of bisphosphonates should be separated by at least two hours from doses of all other medications, including supplements such as iron. Divalent cations, including iron, can decrease absorption of bisphosphonates by forming insoluble complexes in the gastrointestinal tract.
Denosumab (Prolia, Others)
Administration of intravenous iron within one month of denosumab administration might increase the risk of severe hypophosphatemia and hypocalcemia.
A case of severe hypocalcemia (albumin corrected calcium 6.88 mg/dL, ionized calcium 3.68 mg/dL) and hypophosphatemia (<0.5 mg/dL) with respiratory acidosis, QT interval prolongation, and nonsustained ventricular tachycardia was reported in a 76-year-old male who had received an iron polymaltose infusion within 2 weeks of a subcutaneous injection of denosumab. Serum parathyroid hormone was also elevated (348 pg/mL). Subsequent iron infusions with iron polymaltose and ferric carboxymaltose were followed by transient hypophosphatemia, but without hypocalcemia. Additionally, a literature review describes 6 additional cases of hypophosphatemia and hypocalcemia in patients 52-92 years of age who had been administered intravenous iron as either ferric carboxymaltose or iron polymaltose and subcutaneous denosumab within 1-4 weeks of each other.
Dolutegravir (Tivicay)
Iron might decrease dolutegravir levels by reducing its absorption.
Advise patients to take dolutegravir at least 2 hours before or 6 hours after taking iron. Pharmacokinetic research shows that iron can decrease the absorption of dolutegravir from the gastrointestinal tract through chelation. When taken under fasting conditions, a single dose of ferrous fumarate 324 mg orally along with dolutegravir 50 mg reduces overall exposure to dolutegravir by 54%.
Integrase Inhibitors
Theoretically, taking iron along with integrase inhibitors might decrease the levels and clinical effects of these drugs.
Iron is a divalent cation. There is concern that iron may decrease the absorption of integrase inhibitors from the gastrointestinal tract through chelation. One pharmacokinetic study shows that iron can decrease blood levels of the specific integrase inhibitor dolutegravir through chelation. Also, other pharmacokinetic research shows that other divalent cations such as calcium can decrease the absorption and levels of some integrase inhibitors through chelation.
Levodopa
Iron might decrease levodopa levels by reducing its absorption.
Advise patients to separate doses of levodopa and iron as much as possible. There is some evidence in healthy people that iron forms chelates with levodopa, reducing the amount of levodopa absorbed by around 50%. The clinical significance of this hasn't been determined.
Levothyroxine (Synthroid, Others)
Iron might decrease levothyroxine levels by reducing its absorption.
Advise patients to separate levothyroxine and iron doses by at least 2 hours. Iron can decrease the absorption and efficacy of levothyroxine by forming insoluble complexes in the gastrointestinal tract.
Methyldopa (Aldomet)
Iron might decrease methyldopa levels by reducing its absorption.
Advise patients to separate methyldopa and iron doses by at least 2 hours. Iron can decrease the absorption of methyldopa from the gastrointestinal tract through chelation, resulting in increases in blood pressure.
Mycophenolate Mofetil (Cellcept)
Theoretically, iron might decrease mycophenolate mofetil levels by reducing its absorption.
Advise patients to take iron 4-6 hours before, or 2 hours after, mycophenolate mofetil. It has been suggested that a decrease of absorption is possible, probably by forming nonabsorbable chelates. However, mycophenolate pharmacokinetics are not affected by iron supplementation in available clinical research.
Penicillamine (Cuprimine, Depen)
Iron might decrease penicillamine levels by reducing its absorption.
Advise patients to separate penicillamine and iron doses by at least 2 hours. Oral iron supplements can reduce absorption of penicillamine by 30% to 70%, probably due to chelate formation. In people with Wilson's disease, this interaction has led to reduced efficacy of penicillamine.
Quinolone Antibiotics
Iron might decrease levels of quinolone antibiotics by reducing their absorption.
Advise patients to separate quinolone antibiotics and iron doses by at least 2 hours. Iron decreases the absorption of quinolones due to formation of insoluble complexes in the gastrointestinal tract.
Tetracycline Antibiotics
Iron might decrease levels of tetracycline antibiotics by reducing their absorption.
Advise patients to take iron at least 2 hours before or 4 hours after tetracycline antibiotics. Concomitant use can decrease absorption of tetracycline antibiotics from the gastrointestinal tract by 50% to 90%.
Chloramphenicol
Theoretically, taking chloramphenicol with iron might reduce the response to iron therapy in iron deficiency anemia.
Chloramphenicol interferes with erythrocyte maturation. However, since chloramphenicol isn't usually taken for prolonged periods, this isn't likely to be clinically significant.
Brand information
Manufacturer and brand details for iFerex 150, from the product label.
iFerex 150 by ZIKS: Common Questions
Does iFerex 150 by ZIKS interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Is iron safe to take during pregnancy?
Can I take iFerex 150 while breastfeeding?
What side effects should I expect from iron?
Does iron actually work for anemia?
Why do I need to separate iron from other medications?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if iFerex 150 is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind iFerex 150’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
iFerex 150's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 72 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Iron 72 references
- McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
- Bruner AB, Joffe A, Duggan AK, et al. Randomized study of cognitive effects of iron supplementation in non- anaemic iron-deficient adolescent girls. Lancet 1996;348:992-6.
- Ullen H, Augustsson K, Gustavsson C, Steineck G. Supplementary iron intake and risk of cancer: reversed causality? Cancer Lett 1997;114:215-6.
- Reunanen A, Takkunen H, Knekt P, et al. Body iron stores, dietary iron intake and coronary heart disease mortality. J Intern Med 1995;238:223-30. PubMed
- Lund EK, Wharf SG, Fairweather-Tait SJ, Johnson IT. Oral ferrous sulfate supplements increase the free radical-generating capacity of feces from healthy volunteers. Am J Clin Nutr 1999;69:250-5.
- Rehman A, Collis CS, Yang M, et al. The effects of iron and vitamin C co-supplementation on oxidative damage to DNA in healthy volunteers. Biochem Biophys Res Comm 1998;246:293-8. PubMed
- Klipstein-Grobusch K, Grobbee DE, den Breeijen JH, et al. Dietary iron and risk of myocardial infarction in the Rotterdam Study. Am J Epidemiol 1999;149:421-8. PubMed
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