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Dietary supplement

Isogen Forte Capsules Ingredients & Drug Interactions

by Genestra Brands

Isogen Forte Capsules label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Isogen Forte Capsules against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Isogen Forte Capsules is a dietary supplement by Genestra Brands with 2 active ingredients. Its ingredients are commonly taken for sleep quality and insomnia, relaxation, cognitive function.Based on those ingredients, 42 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Wild Yam (Dioscorea villosa) root extract, Soybean (Glycine max) Isoflavone extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Isogen Forte Capsules by Genestra Brands

Ask about any prescription or over-the-counter medication and we check it for interactions with Isogen Forte Capsules by Genestra Brands — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Isogen Forte Capsules by Genestra Brands

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 13, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • “Soybean (Glycine max) Isoflavone extract” is listed as a grouped ingredient — the label gives one combined amount (200 mg) without saying how much of each component you get.

Isogen Forte contains three active ingredients. The first is a soybean isoflavone extract — the product reports its components individually rather than as a single entry, but the overall extract and its isolated isoflavone parts (AIE Total Isoflavones and AIE Genistein/Genistin) make up the isoflavone content.

The second active ingredient is wild yam root extract, traditionally used for menopausal support. The capsules also contain inactive ingredients — hypromellose, cellulose, and stearic acid — which are fillers and binders that hold the capsule together.

Does it work?

Leans against
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Leans against

The strongest graded evidence we hold for the stated purpose leans against a benefit.

Why this rating?
  • The label markets this product for: Menopausal and menstrual symptom support.
  • We looked for evidence on: Menopausal symptoms, Dysmenorrhea, Premenstrual syndrome (PMS), Postmenopausal conditions, Hormone balance, Menstrual health.
  • The closest evidence on file: Wild Yam is rated "Possibly Ineffective" for Menopausal symptoms (Natural Medicines).
  • Also on file: Wild Yam is rated "Insufficient Reliable Evidence To Rate" for Postmenopausal conditions, Premenstrual syndrome (PMS), Dysmenorrhea.

For menopausal symptoms, wild yam is rated possibly ineffective based on current evidence. For gallbladder disease, sexual dysfunction, painful periods (dysmenorrhea), and infertility, we don't have enough reliable evidence to rate how well wild yam works.

We hold no effectiveness data for the soybean isoflavone components in this product.

The evidence, ingredient by ingredient Glycine Wild Yam

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Wild yam is generally well tolerated when taken by mouth short-term in healthy adults, though long-term safety hasn't been well studied. The most common side effects are fever, headache, upset stomach, and vomiting, especially at higher doses.

Serious side effects like anaphylaxis are rare. One case report described vision loss in someone taking a multi-ingredient phytoestrogen product that included wild yam, but it's unclear whether wild yam was the cause.

There isn't enough safety data during pregnancy or breastfeeding — the facts advise against use in both.

Side effects, ingredient by ingredient Glycine Wild Yam

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Wild Yam.
  • The most serious interaction on file is rated Moderate.
  • For scale: 41 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Isogen Forte, double-check if you're on any estrogen medications — including birth control pills and hormone replacement therapy. Wild yam root extract may theoretically increase or decrease their effects.

No other medication interactions are documented in our data for the ingredients we could check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with graded evidence leaning against its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Isogen Forte is designed for menopausal support, but wild yam is rated possibly ineffective for that purpose and long-term safety isn't well established. If you take any estrogen-based medication, check with your doctor or pharmacist first — wild yam may theoretically interfere with how those drugs work.

Pregnant or breastfeeding? Skip it until you've talked it over with your healthcare provider.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 25, 2016.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Isogen Forte Capsules, straight from the product label.

Brand Genestra Brands
Barcode (UPC) 88319613250
Net contents 90 Vegetable Capsule(s)
Market status On market
Date entered into DSLD Jan 25, 2016
DSLD ID 56058
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Isogen Forte Capsules by Genestra Brands, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
90
UPC/BARCODE
88319613250
IngredientAmount% DV
Soybean (Glycine max) Isoflavone extract200 mg--
AIE Total Isoflavones22 mg--
AIE Genistein/Genistin12 mg--
Wild Yam (Dioscorea villosa) root extract200 mg--

Other ingredients: Hypromellose, Cellulose, Stearic Acid

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Recommended Adult Dose: Take one capsule two to three times daily, a few hours before or after taking other medications or healthcare products, or as recommended by your healthcare practitioner.

Precautions

Risk Information: Ensure you are up-to-date on mammograms and gynecological evaluations prior to use.

If you are pregnant or breastfeeding; if you are taking blood thinners or have protein S deficiency; or if you have allergies to soy or to plants of the Dioscorea family, do not use.

If you are pregnant or breastfeeding; if you are taking blood thinners or have protein S deficiency; or if you have allergies to soy or to plants of the Dioscorea family, do not use.

If you currently have or previously had breast cancer or breast tumors; if you have a predisposition to breast cancer as indicated by an abnormal mammogram or biopsy, or a family member with breast cancer; or if you have a history of hormonal or gynecological disease, including uterine, endometrial, breast, or ovarian cancer, endometriosis or uterine fibroids, do not use. If you have a liver disorder or develop liver-related symptoms; or if you are taking hormone replacement therapy, including thyroid hormone replacement therapy, consult your healthcare practitioner prior to use. If you experience breast pain, discomfort or tenderness, or if you experience a recurrence of menstruation or uterine spotting, discontinue use and consult your healthcare practitioner. Warning: This product has come into contact with soy.

Do not use this product if you have a soy allergy.

Quality Assurance: Safety-sealed for your protection and for product freshness. Do not use if outer seal is missing or broken.

Contains: Soy

Formulation

Guaranteed to contain no added wheat, yeast, gluten, corn, sodium, sugar, artificial coloring or flavoring, antimicrobial preservatives, dairy or animal products.

Ideal for vegans.

The capsules are made from 100% pure vegetable sources, free of preservatives and additives.

Storage

Store in a cool, dry place.

FDA Statement of Identity

HERBAL SUPPLEMENT

Formula

Contains: Soy

General

V1.0 597

Seals/Symbols

Seroyal

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Isogen Forte Capsules by Genestra Brands label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Isogen Forte Capsules label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Isogen Forte Capsules by Genestra Brands

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Soybean (Glycine max) Isoflavone extract

Interacts with
1 drug
200 mg per serving

Glycine is a non-essential amino acid your body makes on its own and that also appears in protein-rich foods. It is most studied for improving sleep q...

Soybean (Glycine max) Isoflavone extract monograph & interactions
  • › AIE Total Isoflavones
  • › AIE Genistein/Genistin

Wild Yam (Dioscorea villosa) root extract

Interacts with
41 drugs
200 mg per serving Form: Diosgenin

Wild yam is a root traditionally used for menopausal symptoms, cramps, and as a so-called 'natural' hormone supplement, but solid human evidence for t...

Wild Yam (Dioscorea villosa) root extract monograph & interactions

Other (inactive) ingredients: Hypromellose, Cellulose, Stearic Acid. These complete the product’s ingredient list but are not active constituents.

Interaction report

Isogen Forte Capsules by Genestra Brands Drug Interactions

Want to check YOUR meds against Isogen Forte Capsules?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
42Drugs
42 Moderate

Ingredients driving the most interactions

Wild Yam (Dioscorea villosa) root extract 41
Soybean (Glycine max) Isoflavone extract 1

Individual Drug Interactions

The ingredients in Isogen Forte Capsules interact with 42 drugs. Click any drug to see the details.

2 of the 2 ingredients in Isogen Forte Capsules interact with drugs. Each result below shows which ingredient is responsible. Wild Yam (Dioscorea villosa) root extract Soybean (Glycine max) Isoflavone extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Isogen Forte Capsules with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Wild Yam (Dioscorea villosa) root extract1 drug type · 41 drugs

Estrogens

Theoretically, wild yam might increase or decrease the effects of estrogen.
Wild yam root shows estrogenic and anti-estrogenic effects in vitro. Theoretically, wild yam might interfere with hormone therapy.

Likelihood Possible Evidence D
Wild Yam (Dioscorea villosa) root extract full monograph & interactions

Soybean (Glycine max) Isoflavone extract1 drug type · 1 drug

Clozapine (Clozaril)

Theoretically, glycine might decrease the effectiveness of clozapine.
One small clinical study in patients with schizophrenia shows that adding glycine to clozapine therapy worsens symptoms of schizophrenia when compared with clozapine alone. The mechanism of this interaction is unclear.

Likelihood Probable Evidence B
Soybean (Glycine max) Isoflavone extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Isogen Forte Capsules, from the product label.

Genestra Brands

Name
Seroyal USA
City
Pittsburgh
State
PA
ZipCode
15275
Phone Number
1-888-737-6925
Web Address
seroyal.com
Pharmacist Counseling Corner

Isogen Forte Capsules by Genestra Brands: Common Questions

Does Isogen Forte Capsules by Genestra Brands interact with any medications?
Yes. Based on its ingredients, Isogen Forte Capsules has a known interaction with 42 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Isogen Forte Capsules contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help with hot flashes and night sweats?
Wild yam, the main botanical ingredient here, is rated possibly ineffective for menopausal symptoms based on current evidence. That doesn't mean it won't help you personally, but the research doesn't back it up as a reliable treatment for hot flashes or night sweats.
Is wild yam the same as natural progesterone?
No — wild yam contains compounds that act somewhat like estrogen in the body, not progesterone. It's often confused with progesterone cream because it was marketed that way years ago, but lab studies show it has both estrogenic and anti-estrogenic effects, which is why it could interfere with hormone therapy.
What are the most common side effects?
Fever, headache, upset stomach, and vomiting are the most common, and they tend to show up more at higher doses. Serious side effects like anaphylaxis are rare.
Can I take this if I'm pregnant?
There isn't enough safety data to know either way. The facts advise against it during pregnancy — talk with your doctor or pharmacist before taking it.
Can I take this if I'm breastfeeding?
There isn't enough safety data. The facts advise against it while breastfeeding — check with your doctor or pharmacist for personalized guidance.
How long has wild yam been studied for safety?
It's considered likely fine for short-term use in healthy adults, but long-term safety hasn't been well studied, so we don't know much about what happens if you take it for months or years.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Isogen Forte Capsules label
Go deeper

The Full Monographs Behind Isogen Forte Capsules’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Glycine

Interacts with 1 drug

Glycine is a non-essential amino acid your body makes on its own and that also appears in protein-rich foods. It is most studied for improving sleep quality, where early research is promisin...

Read the full Glycine monograph → Herb & supplement monograph

Wild Yam

Interacts with 41 drugs

Wild yam is a root traditionally used for menopausal symptoms, cramps, and as a so-called 'natural' hormone supplement, but solid human evidence for these uses is lacking. Despite popular cl...

Read the full Wild Yam monograph →
Sources

Sources & How We Checked

Isogen Forte Capsules's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 12 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Glycine 5 references
  1. Heresco-Levy U, Javitt DC, Ermilov M, et al. Efficacy of high-dose glycine in the treatment of enduring negative symptoms of schizophrenia. Arch Gen Psychiatry 1999;56:29-36.. PubMed
  2. Potkin SG, Jin Y, Bunney BG, Costa J, Gulasekaram B. Effect of clozapine and adjunctive high-dose glycine in treatment-resistant schizophrenia. Am J Psychiatry 1999;156:145-7.. PubMed
  3. Gusev EI, Skvortsova VI, Dambinova SA, et al. Neuroprotective effects of glycine for therapy of acute ischaemic stroke. Cerebrovasc Dis 2000;10:49-60. PubMed
  4. Inagawa K, Kawai N, Ono K, Sukegawa E, Tsubuku S, Takahashi M. Assessment of acute adverse effects of glycine ingestion at a high dose in human volunteers. Seikatsu Eisei. 2006; 50:27-32.
  5. Woods SW, Walsh BC, Hawkins KA, Miller TJ, Saksa JR, D'Souza DC, Pearlson GD, Javitt DC, McGlashan TH, Krystal JH. Glycine treatment of the risk syndrome for psychosis: report of two pilot studies. Eur Neuropsychopharmacol. 2013 Aug;23(8):931-40. PubMed

See these in context on the Glycine monograph →

Wild Yam 7 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Eagon PK, Elm MS, Hunter DS, et al. Medicinal herbs: modulation of estrogen action. Era of Hope Mtg, Dept Defense; Breast Cancer Res Prog, Atlanta, GA 2000;Jun 8-11.
  3. Cheong JL, Bucknall R. Retinal vein thrombosis associated with a herbal phytoestrogen preparation in a susceptible patient. Postgrad Med J 2005;81:266-7.. PubMed
  4. Rosenberg Zand, R. S., Jenkins, D. J., and Diamandis, E. P. Effects of natural products and nutraceuticals on steroid hormone-regulated gene expression. Clin Chim.Acta 2001;312(1-2):213-219. PubMed
  5. Araghiniknam M, Chung S, Nelson-White T, and et al. Antioxidant activity of Dioscorea and dehydroepiandrosterone (DHEA) in older humans. Life Sciences 1996;59:L147-L157.
  6. Zeng M, Zhang L, Li M, et al. Estrogenic effects of the extracts from the Chinese Yam (Dioscorea opposite Thunb.) and its effective compounds in vitro and in vivo. Molecules. 2018 Jan 23;23(2). Pii: E11. PubMed
  7. Lu J, Wong RN, Zhang L, et al. Comparative analysis of proteins with stimulating activity on ovarian estradiol biosynthesis from four different Dioscorea species in vitro using both phenotypic and target-based approaches: implication for treating menopaus

See these in context on the Wild Yam monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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