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Dietary supplement

LactoSpore Probiotic Ingredients & Drug Interactions

by AFI America's Finest

LactoSpore Probiotic label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking LactoSpore Probiotic against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

LactoSpore Probiotic is a dietary supplement by AFI America's Finest with 1 active ingredient. Its ingredients are commonly taken for constipation, irritable bowel syndrome (ibs), diarrhea.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Lactospore Bacillus Coagulans MTCC5856. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against LactoSpore Probiotic by AFI America's Finest

Ask about any prescription or over-the-counter medication and we check it for interactions with LactoSpore Probiotic by AFI America's Finest — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of LactoSpore Probiotic by AFI America's Finest

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 13, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 1 active ingredient.

LactoSpore Probiotic contains one active ingredient: Bacillus Coagulans MTCC5856, a probiotic strain that supplies live, active organisms meant to support digestive health. The capsule also contains two inactive ingredients — rice flour and hypromellose — that are fillers and the capsule material itself.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: maintain healthy intestinal flora.
  • We looked for evidence on: Antibiotic-associated diarrhea, Clostridioides difficile infection, Constipation, Diarrhea, Dyspepsia, Flatulence — and 4 related terms.
  • The strongest evidence on file: Bacillus Coagulans is rated "Possibly Effective" for Constipation (Natural Medicines).
  • Also on file: Bacillus Coagulans is rated "Possibly Effective" for Irritable bowel syndrome (IBS).
  • Also on file: Bacillus Coagulans is rated "Insufficient Reliable Evidence To Rate" for Antibiotic-associated diarrhea, Inflammatory bowel disease (IBD), Diarrhea, Dyspepsia, and more.

The evidence here is mixed. Bacillus Coagulans is possibly effective for constipation and irritable bowel syndrome (IBS) — meaning there's some research support, but more data would help confirm it.

For antibiotic-associated diarrhea, athletic performance, cancer, and fatty liver disease, we don't have enough reliable evidence yet to rate whether it works. Talk to your doctor about whether it's right for your particular situation.

The evidence, ingredient by ingredient Bacillus Coagulans

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Bacillus Coagulans is generally well tolerated in healthy adults, but the evidence and quality of probiotic products vary, so there's no guarantee. One concern: because it's a live organism, there's a theoretical risk it could cause infection in people with central lines (catheters), severely weakened immune systems, or premature infants — though infections in otherwise healthy people with intact immunity appear rare.

If you have a weakened immune system, are critically ill, or have an indwelling catheter, talk to your doctor or pharmacist before using this product. Safety data overall are limited, so check with your doctor or pharmacist first if you have any health concerns.

Side effects, ingredient by ingredient Bacillus Coagulans

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Bacillus Coagulans.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this product, check with your doctor or pharmacist if you're on antibiotics. Antibiotics can reduce how well this probiotic works by killing its active organisms, so timing matters — you'll want to space them out.

No other medication interactions are documented for the ingredient we checked.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This probiotic may help with constipation or IBS if you're generally healthy. The main thing to watch: if you're on antibiotics, time them apart so the antibiotics don't kill off the live organisms in the supplement.

If you have a weak immune system, a central line, or are very ill, check with your doctor or pharmacist before starting it.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Oct 24, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about LactoSpore Probiotic, straight from the product label.

Brand AFI America's Finest
Barcode (UPC) 767382030338
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Oct 24, 2022
DSLD ID 275493
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for LactoSpore Probiotic by AFI America's Finest, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
UPC/BARCODE
767382030338
IngredientAmount% DV
Lactospore Bacillus Coagulans MTCC58560 NP--

Other ingredients: Rice Flour, Hypromellose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

LactoSpore is a probiotic which helps maintain a healthy intestinal flora.

Suggested/Recommended/Usage/Directions

Suggested Use: Take 1 capsule daily with meal, or as directed by a healthcare professional.

Precautions

Precaution/Warning: Do not use if bottle seal is missing, torn or damaged.

If you are pregnant, nursing, taking any medication or have a medical condition, consult your healthcare practitioner before taking any dietary supplement.

Keep out of reach of children.

Storage

Store in a cool place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Brand IP Statement(s)

Patent numbers: US 10,668,115; US 10,609,935; US 9,579,352; US 10,166,261; US 10,260,112; US 10,806,760; US 10,293,008; US 10,792,295; AU2015308650; EA034017; EP3185877; EP3240553; HK1233174; IDP000066793; JP6630723; JP6629875; KR10-2157043; KR10-2089566; MX376004; MY-174855-A; MY-182658-A; SG11201700006U; ZL201580042813.X

LactoSpore Stable Probiotic LactoSpore is a registered trademark of Sabinsa Corporation.

FDA Statement of Identity

Probiotic Dietary Supplement

Formulation

This product does not contain: Milk, eggs, fish, shellfish, tree nuts, peanuts, wheat, or soybeans.

General Statements

1 CFU = One Colony Forming Unit

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

LactoSpore Probiotic by AFI America's Finest label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

LactoSpore Probiotic label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in LactoSpore Probiotic by AFI America's Finest

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Lactospore Bacillus Coagulans MTCC5856

Interacts with
182 drugs
0 NP per serving

Bacillus coagulans is a spore-forming probiotic that survives stomach acid well and may help with some digestive problems such as IBS, constipation, a...

Lactospore Bacillus Coagulans MTCC5856 monograph & interactions

Other (inactive) ingredients: Rice Flour, Hypromellose. These complete the product’s ingredient list but are not active constituents.

Interaction report

LactoSpore Probiotic by AFI America's Finest Drug Interactions

Want to check YOUR meds against LactoSpore Probiotic?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Lactospore Bacillus Coagulans MTCC5856 182

Individual Drug Interactions

The ingredients in LactoSpore Probiotic interact with 182 drugs. Click any drug to see the details.

1 of the 1 ingredient in LactoSpore Probiotic interact with drugs. Each result below shows which ingredient is responsible. Lactospore Bacillus Coagulans MTCC5856

Each ingredient & the kinds of drugs it affects

For each ingredient in LactoSpore Probiotic with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Lactospore Bacillus Coagulans MTCC58561 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking antibiotics with Bacillus coagulans might decrease the effectiveness of B. coagulans.
B. coagulans preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. coagulans preparations by at least two hours.

Likelihood Probable Evidence D
Lactospore Bacillus Coagulans MTCC5856 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for LactoSpore Probiotic, from the product label.

AFI America's Finest

See all AFI America's Finest products
Name
America's Finest, Inc. (AFI)
Street Address
20 Lake Dr, Ste B
City
East Windsor
State
NJ
ZipCode
08520
Phone Number
800-350-3305
Web Address
afisupplements.com
Pharmacist Counseling Corner

LactoSpore Probiotic by AFI America's Finest: Common Questions

Does LactoSpore Probiotic by AFI America's Finest interact with any medications?
Yes. Based on its ingredients, LactoSpore Probiotic has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
LactoSpore Probiotic contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this probiotic while I'm on an antibiotic?
Not at the same time. Antibiotics will kill the live organisms in this supplement and make it less effective. Talk with your doctor or pharmacist about separating the two — they can recommend a schedule that works for your treatment.
Will this help my IBS?
It's possibly effective for IBS based on available research, but the evidence isn't airtight yet. Whether it'll help you specifically is something to discuss with your doctor.
Is this safe if I have a weak immune system?
The data here are limited. Because this is a live organism, there's concern it might cause infection in people with very weak immunity or central catheters, though it's rare in otherwise healthy people. Check with your doctor or pharmacist first if your immune system is compromised.
What's in this supplement besides the probiotic?
Just rice flour and hypromellose — both inactive ingredients that fill out the capsule. Nothing fancy, just the probiotic and basic capsule material.
Is this probiotic strain tested and standardized?
This one uses Bacillus Coagulans MTCC5856, which is a specific strain with an identifier. That said, probiotic product quality varies across brands, so you're choosing based on the strain name here.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if LactoSpore Probiotic is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

LactoSpore Probiotic label
Go deeper

The Full Monographs Behind LactoSpore Probiotic’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Bacillus Coagulans

Interacts with 182 drugs

Bacillus coagulans is a spore-forming probiotic that survives stomach acid well and may help with some digestive problems such as IBS, constipation, and certain types of diarrhea. The eviden...

Read the full Bacillus Coagulans monograph →
Sources

Sources & How We Checked

LactoSpore Probiotic's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 20 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bacillus Coagulans 20 references
  1. Saxelin M, Chuang NH, Chassy B, et al. Lactobacilli and bacteremia in southern Finland 1989-1992. Clin Infect Dis 1996;22:564-6. PubMed
  2. Tynkkynen S, Singh KV, Varmanen P. Vancomycin resistance factor of Lactobacillus rhamnosus GG in relation to enterococcal vancomycin resistance (van) genes. Int J Food Microbiol 1998;41:195-204. PubMed
  3. Klein G, Zill E, Schindler R, et al. Peritonitis associated with vancomycin-resistant Lactobacillus rhamnosus in a continuous ambulatory peritoneal dialysis patient; organism identification, antibiotic therapy, and case report. J Clin Microbiol 1998;36:
  4. Kalima P, Masterton RG, Roddie PH, et al. Lactobacillus rhamnosus infection in a child following bone marrow transplant. J Infect 1996;32:165-7. PubMed
  5. Goldin BR. Health Benefits of probiotics. Br J Nutr 1998;80:S203-7. DOI
  6. Rautio M, Jousimies-Somer H, Kauma H, et al. Liver abscess due to Lactobacillus rhamnosus strain indistinguishable from L. rhamnosus strain GG. Clin Infect Dis 1999;28:1159-60.
  7. MacGregor G, Smith AJ, Thakker B, Kinsella J. Yoghurt biotherapy: contraindicated in immunosuppressed patients? Postgrad Med J 2002;78:366-7. PubMed
  8. Land MH, Rouster-Stevens K, Woods CR, et al. Lactobacillus sepsis associated with probiotic therapy. Pediatrics 2005;115:178-81.
  9. De Groote MA, Frank DN, Dowell E, et al. Lactobacillus rhamnosus GG bacteremia associated with probiotic use in a child with short gut syndrome. Pediatr Infect Dis J 2005;24:278-80. PubMed
  10. Vahabnezhad E, Mochon AB, Wozniak LJ, Ziring DA. Lactobacillus bacteremia associated with probiotic use in a pediatric patient with ulcerative colitis. J Clin Gastroenterol. 2013;47(5):437-9. PubMed
  11. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  12. Sendil S, Shrimanker I, Mansoora Q, Goldman J, Nookala VK. Lactobacillus rhamnosus bacteremia in an immunocompromised renal transplant patient. Cureus. 2020;12(2):e6887. PubMed
  13. Albarillo FS, Shah U, Joyce C, Slade D. Lactobacillus rhamnosus Infection: A single-center 4-year descriptive analysis. J Glob Infect Dis. 2020;12(3):119-123. PubMed
  14. Pasala S, Singer L, Arshad T, Roach K. Lactobacillus endocarditis in a healthy patient with probiotic use. IDCases. 2020;22:e00915. PubMed
  15. Agrawal S, Tuchman ES, Bruce MJ, Theodorou ME. Fatal Lactobacillus endocarditis in a patient with transcatheter aortic valve replacement. BMJ Case Rep. 2020;13(11):e236835.
  16. Antoun M, Hattab Y, Akhrass FA, Hamilton LD. Uncommon pathogen, Lactobacillus, causing infective endocarditis: Case report and review. Case Rep Infect Dis. 2020;2020:8833948. PubMed
  17. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  18. Franko B, Vaillant M, Recule C, Vautrin E, et al. Lactobacillus paracasei endocarditis in a consumer of probiotics. Med Mal Infect. 2013;43(4):171-3. PubMed
  19. Campbell RE, Miller A, Afroze A. Native valve endocarditis secondary to Lactobacillus paracasei bacteremia. Consultant. 2020;60(9):27-8. DOI
  20. Kato K, Funabashi N, Takaoka H, et al. Lactobacillus paracasei endocarditis in a consumer of probiotics with advanced and severe bicuspid aortic valve stenosis complicated with diffuse left ventricular mid-layer fibrosis. Int J Cardiol. 2016;224:157-161. PubMed

See these in context on the Bacillus Coagulans monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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