Ludent - Fluoride Chews 0.25 mg Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Ludent - Fluoride Chews 0.25 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Ludent - Fluoride Chews 0.25 mg is a dietary supplement by Sancilio & Company with 1 active ingredient. Its ingredients are commonly taken for preventing tooth decay (cavities), strengthening tooth enamel, dental care for children in low-fluoride areas.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.
HelloPharmacist Scorecard of Ludent - Fluoride Chews 0.25 mg by Sancilio & Company
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
Ludent contains one active ingredient: fluoride at 0.25 mg per chew. Fluoride is a mineral that helps protect tooth enamel and may support bone strength.
The product also contains several inactive ingredients (xylitol, microcrystalline cellulose, malic acid, magnesium stearate, talc, citric acid, natural orange flavor, and sucralose) that serve as sweeteners, binders, and flavorings.
Does it work?
Strong evidence
Fluoride is effective for preventing dental cavities. There is also possibly effective evidence for fluoride in helping with osteoporosis, reducing dental plaque, and easing gingivitis—though the strongest data supports its use for cavity prevention.
The dose in these chews (0.25 mg) is a typical supplemental amount.
How safe is it?
Well-documented data
Fluoride at recommended doses is generally well tolerated. The most common side effect from oral fluoride is gastrointestinal upset.
Rare allergic reactions can occur and may include rash, inflamed lips, mouth sores, or respiratory symptoms. Excess fluoride exposure—beyond normal dietary intake and recommended supplements—can cause dental fluorosis (discoloration of tooth enamel) and other harm.
Some early research has explored a possible link between very high fluoride exposure during pregnancy or childhood and neurodevelopment, but these findings are still exploratory and more research is needed. Talk with your doctor or pharmacist before giving these chews to a child or taking them during pregnancy or breastfeeding.
Meds to double-check
No known interactions
No interactions are documented in our data for the fluoride in Ludent. That doesn't rule out the possibility of interactions with your specific medications—use the search tool on this page to check your exact drugs, or confirm with your doctor or pharmacist before starting.
The bottom line
Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. No medication interactions are currently documented, and safety information is well characterized.
Ludent is a straightforward fluoride supplement for cavity prevention and possibly for bone health support. It's generally well tolerated at the recommended dose.
Because fluoride can cause harm if overused, avoid combining this product with other fluoride supplements (toothpaste, mouthwash, or drinking water with added fluoride) without checking the total daily amount—ask your dentist or pharmacist to confirm your child's or your own fluoride intake is on target.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Dec 18, 2021.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Ludent - Fluoride Chews 0.25 mg, straight from the product label.
| Brand | Sancilio & Company |
|---|---|
| Barcode (UPC) | 344946100838 |
| Net contents | 120 Tablet(s) |
| Market status | On market |
| Date entered into DSLD | Dec 18, 2021 |
| DSLD ID | 264133 |
| Product type | Mineral |
| Supplement form | Tablet Or Pill |
| Dietary claims / uses | Nutrient, All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Ludent - Fluoride Chews 0.25 mg by Sancilio & Company, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Fluoride | 0.25 mg | -- |
Other ingredients: Xylitol, Microcrystalline Cellulose, Malic Acid, Magnesium Stearate, Talc, Citric Acid, natural Orange flavor, Sucralose
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)
SCI Developing Good Science into Great Medicine
Formula
Sodium fluoride chewable tablets Contains Xylitol
Formulation
No dyes, artificial flavors or sugar Saccharin and gluten free
Description: White to off-white, orange flavor, round-shaped chewable tablet debossed "SCI" on one side and "6" on the other.
FDA Statement of Identity
Dietary Supplement
Precautions
Dispense under a physician's order
Tamper Evident Feature: Do not use if inner-seal beneath cap is missing or broken.
Warning: Keep this product out of the reach of children.
If overdosage is suspected, seek professional assistane or contact a poison control center immediately 1-800-222-1222.
This product, as with all chewable tablets, is not recommended for children under age 4 due to risk of choking.
Caution: Do not use this product if you are allergic to any of the ingredients.
Take this product at least 2 hours before or after taking any products containing calcium (including milk, yogurt, other dairy products) or aluminum/magnesium hydroxide (e.g., certain antacids/laxatives).
Prolonged daily ingestion of excessive fluoride may result in varying degrees of dental fluorosis. Account for all daily sources of fluoride intake.
Other Information: You may report serious side effects to 1-800-SCI-8711.
The manufacturer of this product requires that it be dispensed only under the order of a physician or licensed medical practitioner.
General Statements
Adds a negligible amount of sugar
See inside panel for additional information.
The numeric identifier on this product's labeling is an assigned product code for use with pharmacy-level, health-insurance and state level reimbursement programs and is not intended to denote registration with the FDA.
44946-1008-3
Suggested/Recommended/Usage/Directions
Directions: Use as directed by your physician.
Tablet should be chewed.
Seals/Symbols
Made in the USA
Storage
Store in a cool, dry place at room temperature 20 degrees - 25 degrees C (68 degrees - 77 degrees F) away from heat and sunlight. Store in original container.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Ludent - Fluoride Chews 0.25 mg by Sancilio & Company label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Ludent - Fluoride Chews 0.25 mg by Sancilio & Company
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container120 Amounts shown are per serving.
Fluoride
No knowninteractions
Fluoride is a mineral best known for preventing cavities and strengthening tooth enamel, and it is widely used in toothpaste, mouth rinses, and commun...
Fluoride monograph & interactionsOther (inactive) ingredients: Xylitol, Microcrystalline Cellulose, Malic Acid, Magnesium Stearate, Talc, Citric Acid, Natural Orange flavor, Sucralose. These complete the product’s ingredient list but are not active constituents.
Ludent - Fluoride Chews 0.25 mg by Sancilio & Company Drug Interactions
We don’t currently list any known drug interactions for the mapped ingredients in Ludent - Fluoride Chews 0.25 mg. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.
Brand information
Manufacturer and brand details for Ludent - Fluoride Chews 0.25 mg, from the product label.
Sancilio & Company
See all Sancilio & Company products- Name
- Sancilio & Company, Inc.
- Street Address
- 3874 Fiscal Court
- City
- Riviera Beach
- State
- FL
- ZipCode
- 33404
- Phone Number
- (800) 724-8711
Ludent - Fluoride Chews 0.25 mg by Sancilio & Company: Common Questions
Does Ludent - Fluoride Chews 0.25 mg by Sancilio & Company interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Is fluoride safe for kids?
Can I take these if I'm pregnant or breastfeeding?
What's xylitol doing in these chews?
Can fluoride cause allergic reactions?
What happens if I take too much?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Ludent - Fluoride Chews 0.25 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Ludent - Fluoride Chews 0.25 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Ludent - Fluoride Chews 0.25 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 39 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Fluoride 39 references
- McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
- Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Calcium, Phosphorus, Magnesium, Vitamin D, and Fluoride. Washington, DC: National Academy Press, 1999. Available at: http://books.nap.edu/books/0309063507/html/index.html.
- Position of the American Dietetic Association: the impact of fluoride on health. J Am Diet Assoc 2001;101:126-32.. PubMed
- Brown JP, Josse RG, et al. 2002 clinical practice guidelines for the diagnosis and management of osteoporosis in Canada. CMAJ 2002;167:S1-S34..
- Haguenauer D, Welch V, Shea B, et al. Fluoride for treating postmenopausal osteoporosis.(Cochrane Review). Cochrane Database Syst Rev 2002;(4):CD002825.. PubMed
- Choi AL, Sun G, Zhang Y, Grandjean P. Developmental fluoride neurotoxicity: a systematic review and meta-analysis. Environ Health Perspect. 2012 Oct;120(10):1362-8. PubMed
- Enamandram M, Das S, Chaney KS. Cheilitis and urticaria associated with stannous fluoride in toothpaste. J Am Acad Dermatol. 2014 Sep;71(3):e75-6. PubMed
- Foti C, Romita P, Ficco D, Bonamonte D, Angelini G. Allergic contact cheilitis to amine fluoride in a toothpaste. Dermatitis. 2014 Jul-Aug;25(4):209. PubMed
- Grey A, Garg S, Dray M, Purvis L, Horne A, Callon K, Gamble G, Bolland M, Reid IR, Cundy T. Low-dose fluoride in postmenopausal women: a randomized controlled trial. J Clin Endocrinol Metab. 2013 Jun;98(6):2301-7. PubMed
- Peters P, Drummond C. Perioral dermatitis from high fluoride dentifrice: a case report and review of literature. Aust Dent J. 2013 Sep;58(3):371-2. PubMed
- Sälzer S, Slot DE, Dörfer CE, Van der Weijden GA. Comparison of triclosan and stannous fluoride dentifrices on parameters of gingival inflammation and plaque scores: a systematic review and meta-analysis. Int J Dent Hyg. 2015 Feb;13(1):1-17.
- Till C, Green R, Flora D, et al. Fluoride exposure from infant formula and child IQ in a Canadian birth cohort. Environ Int. 2020;134:105315. PubMed
- Seddek AL, Ghallab A. Fluoride: No evidence of developmental neurotoxicity due to current exposure levels in Europe. Arch Toxicol. 2020;94(7):2543-2544. PubMed
- Green R, Lanphear B, Hornung R, et al. Association between maternal fluoride exposure during pregnancy and IQ scores in offspring in Canada. JAMA Pediatr. 2019;173(10):940-8. PubMed
- Guth S, Hüser S, Roth A, et al. Toxicity of fluoride: critical evaluation of evidence for human developmental neurotoxicity in epidemiological studies, animal experiments and in vitro analyses. Arch Toxicol. 2020;94(5):1375-1415. PubMed
- Canadian Dental Association. CDA position on use of fluorides in caries prevention. March 2012. Available at: https://www.cda-adc.ca/_files/position_statements/fluoride.pdf. Accessed December 9, 2020.
- Bellinger DC. Is fluoride potentially neurotoxic? JAMA Pediatr. 2019. PubMed
- Till C, Green R, Lanphear B. Association between maternal fluoride exposure and child IQ-reply. JAMA Pediatr. 2020;174(2):216-217. PubMed
- Bledsoe J, Breiger D, McKeever J. Association between maternal fluoride exposure and child IQ. JAMA Pediatr. 2020;174(2):213. PubMed
- Gong CX, James NE. Association between maternal fluoride exposure and child IQ. JAMA Pediatr. 2020;174(2):212-213. PubMed
- Bashash M, Marchand M, Hu H, et al. Prenatal fluoride exposure and attention deficit hyperactivity disorder (ADHD) symptoms in children at 6-12?years of age in Mexico City. Environ Int. 2018;121(Pt 1):658-666. PubMed
- Riddell JK, Malin AJ, Flora D, McCague H, Till C. Association of water fluoride and urinary fluoride concentrations with attention deficit hyperactivity disorder in Canadian youth. Environ Int. 2019;133(Pt B):105190. PubMed
- Wei Y, Zhu J, Wetzstein SA. Plasma and water fluoride levels and hyperuricemia among adolescents: A cross-sectional study of a nationally representative sample of the United States for 2013-2016. Ecotoxicol Environ Saf 2021;208:111670. PubMed
- Davoudi M, Barjasteh-Askari F, Sarmadi M, et al. Relationship of fluoride in drinking water with blood pressure and essential hypertension prevalence: a systematic review and meta-analysis. Int Arch Occup Environ Health 2021;94(6):1137-1146. PubMed
- Veneri F, Vinceti M, Generali L, et al. Fluoride exposure and cognitive neurodevelopment: Systematic review and dose-response meta-analysis. Environ Res 2023;221:115239. PubMed
- Iamandii I, De Pasquale L, Giannone ME, et al. Does fluoride exposure affect thyroid function? A systematic review and dose-response meta-analysis. Environ Res 2024;242:117759. PubMed
- Mou Y, Qu T, Wang R, Zhang Y, He Z, Gu S. The association of high-fluoride and high-iodine combined exposure with dental fluorosis and goiter: a meta-analysis. Environ Geochem Health 2023;45(6):3143-3153. PubMed
- Hall M, Lanphear B, Chevrier J, Hornung R, Green R, Goodman C, et al. Fluoride exposure and hypothyroidism in a Canadian pregnancy cohort. Sci Total Environ 2023;869:161149. PubMed
- Malin AJ, Riddell J, McCague H, Till C. Fluoride exposure and thyroid function among adults living in Canada: Effect modification by iodine status. Environ Int 2018;121(Pt 1):667-674. PubMed
- Do LG, Sawyer A, John Spencer A, et al. Early Childhood Exposures to Fluorides and Cognitive Neurodevelopment: A Population-Based Longitudinal Study. J Dent Res 2024; Dec. PubMed
- Do LG, Spencer AJ, Sawyer A, et al. Early Childhood Exposures to Fluorides and Child Behavioral Development and Executive Function: A Population-Based Longitudinal Study. J Dent Res 2023;102(1):28-36. PubMed
- Farmus L, Till C, Green R, et al. Critical windows of fluoride neurotoxicity in Canadian children. Environ Res 2021;200:111315. PubMed
- Grandjean P, Meddis A, Nielsen F, et al. Dose dependence of prenatal fluoride exposure associations with cognitive performance at school age in three prospective studies. Eur J Public Health 2024;34(1):143-149. PubMed
- Griebel-Thompson AK, Sands S, Chollet-Hinton L, et al. A Scoping Review of Iodine and Fluoride in Pregnancy in Relation to Maternal Thyroid Function and Offspring Neurodevelopment. Adv Nutr 2023;14(2):317-338. PubMed
- Kumar JV, Moss ME, Liu H, Fisher-Owens S. Association between low fluoride exposure and children's intelligence: a meta-analysis relevant to community water fluoridation. Public Health 2023;219:73-84. PubMed
- Levy SM. Caution Needed in Interpreting the Evidence Base on Fluoride and IQ. JAMA Pediatr 2025. PubMed
- Taylor KW, Eftim SE, Sibrizzi CA, et al. Fluoride Exposure and Children's IQ Scores: A Systematic Review and Meta-Analysis. JAMA Pediatr 2025. PubMed
- Goodman CV, Hall M, Green R, et al. Iodine Status Modifies the Association between Fluoride Exposure in Pregnancy and Preschool Boys' Intelligence. Nutrients 2022;14(14):2920. PubMed
- Castiblanco-Rubio GA, Muñoz-Rocha TV, Téllez-Rojo MM, et al. Dietary Influences on Urinary Fluoride over the Course of Pregnancy and at One-Year Postpartum. Biol Trace Elem Res 2022;200(4):1568-1579. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC