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Dietary supplement

Ludent - Fluoride Chews 1.0 mg Ingredients & Drug Interactions

by Sancilio & Company

Ludent - Fluoride Chews 1.0 mg label
See full label image
Tablet Or Pill Category: Mineral
No known interaction
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Ludent - Fluoride Chews 1.0 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line No known interaction

Ludent - Fluoride Chews 1.0 mg is a dietary supplement by Sancilio & Company with 1 active ingredient. Its ingredients are commonly taken for preventing tooth decay (cavities), strengthening tooth enamel, dental care for children in low-fluoride areas.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.

Jump to a section

HelloPharmacist Scorecard of Ludent - Fluoride Chews 1.0 mg by Sancilio & Company

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 20, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Ludent contains one active ingredient: fluoride at 1.0 mg per chew. Fluoride is a mineral that helps prevent tooth decay by strengthening tooth enamel and reducing acid that causes cavities.

The chew also contains several inactive ingredients — xylitol, microcrystalline cellulose, malic acid, magnesium stearate, talc, citric acid, natural orange flavor, and sucralose — which give the tablet its form, taste, and shelf life.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: prevent tooth decay and strengthen enamel.
  • We looked for evidence on: Dental caries, Dental hypersensitivity, Dental plaque, Cavity prevention, Enamel remineralization.
  • The strongest evidence on file: Fluoride is rated "Effective" for Dental caries (Natural Medicines).
  • Also on file: Fluoride is rated "Possibly Effective" for Dental plaque.
  • Also on file: Fluoride is rated "Insufficient Reliable Evidence To Rate" for Dental hypersensitivity.

Fluoride is effective for preventing dental caries (cavities). It's possibly effective for osteoporosis, dental plaque buildup, and gingivitis, though the evidence for those uses isn't as strong.

The 1.0 mg dose in these chews is designed for dental protection; if you're considering them for bone health or gum health, talk with your doctor or dentist about whether they're the right choice for your situation.

The evidence, ingredient by ingredient Fluoride

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Fluoride at recommended dental doses is generally well tolerated. The main side effect people report when taking it by mouth is gastrointestinal upset — stomach or digestive discomfort.

Topical fluoride (like in toothpaste) can sometimes stain teeth. Rarely, allergic reactions occur, including rashes, swelling of the lips or mouth, or hives.

During pregnancy, normal dietary and water fluoride intake is considered fine, but routine fluoride supplements beyond that are not recommended. During breastfeeding, the safety data suggests caution — there isn't enough information to say either way.

Talk with your doctor or pharmacist about whether extra fluoride is right for you in either situation. High fluoride exposure in children has been studied for possible effects on brain development, but those findings are still exploratory and their real-world significance isn't yet clear.

Side effects, ingredient by ingredient Fluoride

Meds to double-check

No known interactions
Known Interaction Concern · database check
No known interactions

No medication interactions are currently documented for the matched ingredients — that isn't a guarantee none exist.

Why this rating?
  • None of the 1 matched ingredient has a documented medication interaction on file.

No interactions are documented in our data for the ingredients we could check. That said, absence of documented interactions isn't a guarantee none exist.

If you take any medications and want to be certain, ask your pharmacist or doctor before starting.

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. No medication interactions are currently documented, and safety information is well characterized.

Ludent fluoride chews are a straightforward way to support cavity prevention if your dentist recommends a fluoride supplement. They're generally well tolerated, though some people experience mild stomach upset.

If you're pregnant, breastfeeding, or have concerns about fluoride intake beyond normal diet and water, check with your doctor or dentist first — and never exceed the recommended dose.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Dec 18, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Ludent - Fluoride Chews 1.0 mg, straight from the product label.

Brand Sancilio & Company
Barcode (UPC) 344946101033
Net contents 120 Tablet(s)
Market status On market
Date entered into DSLD Dec 18, 2021
DSLD ID 264163
Product type Mineral
Supplement form Tablet Or Pill
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Ludent - Fluoride Chews 1.0 mg by Sancilio & Company, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
Servings per container
120
UPC/BARCODE
344946101033
IngredientAmount% DV
Fluoride1 mg--

Other ingredients: Xylitol, Microcrystalline Cellulose, Malic Acid, Magnesium Stearate, Talc, Citric Acid, natural Orange flavor, Sucralose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

SCI Developing Good Science into Great Medicine

Precautions

Rx Only

Warning: Keep this and all medications out of the reach of children. If overdosage is suspected, seek professional assistane or contact a poison control center immediately 1-800-222-1222. Tablet should be chewed. This product, as with all chewable tablets, is not recommended for children under age 4 due to risk of choking.

Do not use if foil seal under cap is broken or missing

Caution: Do not use this product if you are allergic to any of the ingredients.

Take this product at least 2 hours before or after taking any products containing calcium (including milk, yogurt, other dairy products) or aluminum/magnesium hydroxide (e.g., certain antacids/laxatives).

Prolonged daily ingestion of excessive fluoride may result in varying degrees of dental fluorosis. Account for all daily sources of fluoride intake.

Formula

Sodium fluoride chewable tablets

Contains Xylitol

Each 1.0 mg fluoride tablet contains 1.0 mg fluoride from 2.2 mg sodium fluoride (NaF).

Formulation

No dyes, artificial flavors or sugar Saccharin and gluten free

Made in U.S.A.

Description: White to off-white, orange flavor, round-shaped chewable tablet debossed "SCI" on one side and "4" on the other.

This medical food product is formulated to be administered orally, under the ongoing supervision of a physician and is intended for the dietary management of dental caries for which a distinctive nutritional requirement of fluoride, based on recognized scientific principles, has been established by medical evaluation.

Suggested/Recommended/Usage/Directions

Directions: Use as directed by your physician.

Storage

Store in a cool, dry place at room temperature 20 degrees - 25 degrees C (68 degrees - 77 degrees F) away from heat and sunlight. Store in original container.

General Statements

The numeric identifier on this product's labeling is an assigned product code for use with pharmacy-level, health-insurance and state level reimbursement programs and is not intended to denote registration with the FDA.

44946-1010-3

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Ludent - Fluoride Chews 1.0 mg by Sancilio & Company label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Ludent - Fluoride Chews 1.0 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Ludent - Fluoride Chews 1.0 mg by Sancilio & Company

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container120 Amounts shown are per serving.

Fluoride

No known
interactions
1 mg per serving Form: Sodium Fluoride

Fluoride is a mineral best known for preventing cavities and strengthening tooth enamel, and it is widely used in toothpaste, mouth rinses, and commun...

Fluoride monograph & interactions

Other (inactive) ingredients: Xylitol, Microcrystalline Cellulose, Malic Acid, Magnesium Stearate, Talc, Citric Acid, Natural Orange flavor, Sucralose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Ludent - Fluoride Chews 1.0 mg by Sancilio & Company Drug Interactions

We don’t currently list any known drug interactions for the mapped ingredients in Ludent - Fluoride Chews 1.0 mg. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.

The maker

Brand information

Manufacturer and brand details for Ludent - Fluoride Chews 1.0 mg, from the product label.

Sancilio & Company

See all Sancilio & Company products
Name
Sancilio & Co., Inc.
City
Rivera Beach
State
FL
ZipCode
33404
Pharmacist Counseling Corner

Ludent - Fluoride Chews 1.0 mg by Sancilio & Company: Common Questions

Does Ludent - Fluoride Chews 1.0 mg by Sancilio & Company interact with any medications?
We do not currently list a known interaction for the mapped ingredients in Ludent - Fluoride Chews 1.0 mg. This does not guarantee none exist, so confirm with your pharmacist.
How can one product interact with so many drugs?
Ludent - Fluoride Chews 1.0 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will fluoride chews give me fluorosis or stain my teeth?
Staining happens mainly with topical fluoride (like toothpaste left on teeth), not typically with swallowed chews. Fluorosis — white spots or streaking on teeth — can happen if you get too much fluoride, especially during childhood when teeth are forming. That's why it's important to stick to the recommended dose and not combine this supplement with other fluoride sources (like high-fluoride toothpaste or excess tap water) without your dentist's say-so.
Can I take these while I'm pregnant?
Normal fluoride from diet and water is considered fine in pregnancy. But routine fluoride supplements beyond that aren't recommended. The safety data says to be cautious; there isn't enough information to know if extra fluoride supplements are safe in pregnancy. Talk with your doctor or dentist about what makes sense for you.
Is fluoride safe for kids?
Fluoride at recommended doses supports healthy teeth. However, too much fluoride — especially during childhood when teeth are developing — can cause fluorosis. Some research is exploring whether very high fluoride exposure might affect brain development in children, but those findings are still preliminary. Your dentist can recommend the right fluoride dose for your child's age and local water supply.
What if I have a sensitive stomach?
Gastrointestinal symptoms like stomach upset are the most common side effect when fluoride is taken by mouth. If that happens to you, stop and talk with your doctor or pharmacist — they may suggest taking it with food, adjusting the dose, or trying a different form of fluoride.
Can I use these if I'm already using fluoride toothpaste?
Yes, but be careful not to overdo it. Fluoride adds up from all sources — water, toothpaste, and supplements. Too much fluoride can cause fluorosis or other problems. Your dentist can tell you whether you need a supplement on top of what you're already getting from toothpaste and water.
Are there any rare but serious side effects I should know about?
Allergic reactions to fluoride are rare but possible — they include rashes, hives, swollen lips, mouth sores, and in very rare cases, breathing trouble. If you notice any of these after taking a chew, stop and get medical attention right away.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Ludent - Fluoride Chews 1.0 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Ludent - Fluoride Chews 1.0 mg label
Go deeper

The Full Monographs Behind Ludent - Fluoride Chews 1.0 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Fluoride

Fluoride is a mineral best known for preventing cavities and strengthening tooth enamel, and it is widely used in toothpaste, mouth rinses, and community water. Supplements (drops or tablets...

Read the full Fluoride monograph →
Sources

Sources & How We Checked

Ludent - Fluoride Chews 1.0 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 39 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Fluoride 39 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Calcium, Phosphorus, Magnesium, Vitamin D, and Fluoride. Washington, DC: National Academy Press, 1999. Available at: http://books.nap.edu/books/0309063507/html/index.html.
  3. Position of the American Dietetic Association: the impact of fluoride on health. J Am Diet Assoc 2001;101:126-32.. PubMed
  4. Brown JP, Josse RG, et al. 2002 clinical practice guidelines for the diagnosis and management of osteoporosis in Canada. CMAJ 2002;167:S1-S34..
  5. Haguenauer D, Welch V, Shea B, et al. Fluoride for treating postmenopausal osteoporosis.(Cochrane Review). Cochrane Database Syst Rev 2002;(4):CD002825.. PubMed
  6. Choi AL, Sun G, Zhang Y, Grandjean P. Developmental fluoride neurotoxicity: a systematic review and meta-analysis. Environ Health Perspect. 2012 Oct;120(10):1362-8. PubMed
  7. Enamandram M, Das S, Chaney KS. Cheilitis and urticaria associated with stannous fluoride in toothpaste. J Am Acad Dermatol. 2014 Sep;71(3):e75-6. PubMed
  8. Foti C, Romita P, Ficco D, Bonamonte D, Angelini G. Allergic contact cheilitis to amine fluoride in a toothpaste. Dermatitis. 2014 Jul-Aug;25(4):209. PubMed
  9. Grey A, Garg S, Dray M, Purvis L, Horne A, Callon K, Gamble G, Bolland M, Reid IR, Cundy T. Low-dose fluoride in postmenopausal women: a randomized controlled trial. J Clin Endocrinol Metab. 2013 Jun;98(6):2301-7. PubMed
  10. Peters P, Drummond C. Perioral dermatitis from high fluoride dentifrice: a case report and review of literature. Aust Dent J. 2013 Sep;58(3):371-2. PubMed
  11. Sälzer S, Slot DE, Dörfer CE, Van der Weijden GA. Comparison of triclosan and stannous fluoride dentifrices on parameters of gingival inflammation and plaque scores: a systematic review and meta-analysis. Int J Dent Hyg. 2015 Feb;13(1):1-17.
  12. Till C, Green R, Flora D, et al. Fluoride exposure from infant formula and child IQ in a Canadian birth cohort. Environ Int. 2020;134:105315. PubMed
  13. Seddek AL, Ghallab A. Fluoride: No evidence of developmental neurotoxicity due to current exposure levels in Europe. Arch Toxicol. 2020;94(7):2543-2544. PubMed
  14. Green R, Lanphear B, Hornung R, et al. Association between maternal fluoride exposure during pregnancy and IQ scores in offspring in Canada. JAMA Pediatr. 2019;173(10):940-8. PubMed
  15. Guth S, Hüser S, Roth A, et al. Toxicity of fluoride: critical evaluation of evidence for human developmental neurotoxicity in epidemiological studies, animal experiments and in vitro analyses. Arch Toxicol. 2020;94(5):1375-1415. PubMed
  16. Canadian Dental Association. CDA position on use of fluorides in caries prevention. March 2012. Available at: https://www.cda-adc.ca/_files/position_statements/fluoride.pdf. Accessed December 9, 2020.
  17. Bellinger DC. Is fluoride potentially neurotoxic? JAMA Pediatr. 2019. PubMed
  18. Till C, Green R, Lanphear B. Association between maternal fluoride exposure and child IQ-reply. JAMA Pediatr. 2020;174(2):216-217. PubMed
  19. Bledsoe J, Breiger D, McKeever J. Association between maternal fluoride exposure and child IQ. JAMA Pediatr. 2020;174(2):213. PubMed
  20. Gong CX, James NE. Association between maternal fluoride exposure and child IQ. JAMA Pediatr. 2020;174(2):212-213. PubMed
  21. Bashash M, Marchand M, Hu H, et al. Prenatal fluoride exposure and attention deficit hyperactivity disorder (ADHD) symptoms in children at 6-12?years of age in Mexico City. Environ Int. 2018;121(Pt 1):658-666. PubMed
  22. Riddell JK, Malin AJ, Flora D, McCague H, Till C. Association of water fluoride and urinary fluoride concentrations with attention deficit hyperactivity disorder in Canadian youth. Environ Int. 2019;133(Pt B):105190. PubMed
  23. Wei Y, Zhu J, Wetzstein SA. Plasma and water fluoride levels and hyperuricemia among adolescents: A cross-sectional study of a nationally representative sample of the United States for 2013-2016. Ecotoxicol Environ Saf 2021;208:111670. PubMed
  24. Davoudi M, Barjasteh-Askari F, Sarmadi M, et al. Relationship of fluoride in drinking water with blood pressure and essential hypertension prevalence: a systematic review and meta-analysis. Int Arch Occup Environ Health 2021;94(6):1137-1146. PubMed
  25. Veneri F, Vinceti M, Generali L, et al. Fluoride exposure and cognitive neurodevelopment: Systematic review and dose-response meta-analysis. Environ Res 2023;221:115239. PubMed
  26. Iamandii I, De Pasquale L, Giannone ME, et al. Does fluoride exposure affect thyroid function? A systematic review and dose-response meta-analysis. Environ Res 2024;242:117759. PubMed
  27. Mou Y, Qu T, Wang R, Zhang Y, He Z, Gu S. The association of high-fluoride and high-iodine combined exposure with dental fluorosis and goiter: a meta-analysis. Environ Geochem Health 2023;45(6):3143-3153. PubMed
  28. Hall M, Lanphear B, Chevrier J, Hornung R, Green R, Goodman C, et al. Fluoride exposure and hypothyroidism in a Canadian pregnancy cohort. Sci Total Environ 2023;869:161149. PubMed
  29. Malin AJ, Riddell J, McCague H, Till C. Fluoride exposure and thyroid function among adults living in Canada: Effect modification by iodine status. Environ Int 2018;121(Pt 1):667-674. PubMed
  30. Do LG, Sawyer A, John Spencer A, et al. Early Childhood Exposures to Fluorides and Cognitive Neurodevelopment: A Population-Based Longitudinal Study. J Dent Res 2024; Dec. PubMed
  31. Do LG, Spencer AJ, Sawyer A, et al. Early Childhood Exposures to Fluorides and Child Behavioral Development and Executive Function: A Population-Based Longitudinal Study. J Dent Res 2023;102(1):28-36. PubMed
  32. Farmus L, Till C, Green R, et al. Critical windows of fluoride neurotoxicity in Canadian children. Environ Res 2021;200:111315. PubMed
  33. Grandjean P, Meddis A, Nielsen F, et al. Dose dependence of prenatal fluoride exposure associations with cognitive performance at school age in three prospective studies. Eur J Public Health 2024;34(1):143-149. PubMed
  34. Griebel-Thompson AK, Sands S, Chollet-Hinton L, et al. A Scoping Review of Iodine and Fluoride in Pregnancy in Relation to Maternal Thyroid Function and Offspring Neurodevelopment. Adv Nutr 2023;14(2):317-338. PubMed
  35. Kumar JV, Moss ME, Liu H, Fisher-Owens S. Association between low fluoride exposure and children's intelligence: a meta-analysis relevant to community water fluoridation. Public Health 2023;219:73-84. PubMed
  36. Levy SM. Caution Needed in Interpreting the Evidence Base on Fluoride and IQ. JAMA Pediatr 2025. PubMed
  37. Taylor KW, Eftim SE, Sibrizzi CA, et al. Fluoride Exposure and Children's IQ Scores: A Systematic Review and Meta-Analysis. JAMA Pediatr 2025. PubMed
  38. Goodman CV, Hall M, Green R, et al. Iodine Status Modifies the Association between Fluoride Exposure in Pregnancy and Preschool Boys' Intelligence. Nutrients 2022;14(14):2920. PubMed
  39. Castiblanco-Rubio GA, Muñoz-Rocha TV, Téllez-Rojo MM, et al. Dietary Influences on Urinary Fluoride over the Course of Pregnancy and at One-Year Postpartum. Biol Trace Elem Res 2022;200(4):1568-1579. PubMed

See these in context on the Fluoride monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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