Lymphatic System 2 Capsules Ingredients & Drug Interactions
by Dr. Morse's Cellular Botanicals
What is this page for?
First and foremost: checking Lymphatic System 2 Capsules against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Lymphatic System 2 Capsules is a dietary supplement by Dr. Morse's Cellular Botanicals with 7 active ingredients. Its ingredients are commonly taken for blood sugar control, boosting breast milk supply, high cholesterol.Based on those ingredients, 1,250 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Echinacea angustifolia, Fenugreek, Chaparral. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Lymphatic System 2 Capsules by Dr. Morse's Cellular Botanicals
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AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Lymphatic System 2 Capsules by Dr. Morse's Cellular Botanicals
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
This product contains 7 ingredients, including a proprietary blend. The active botanical components are cleavers, fenugreek seed, echinacea angustifolia root, white oak bark, yarrow, bayberry, and chaparral.
The capsule itself is an inactive ingredient. Each ingredient is meant to support lymphatic function, though the blend's specific proportions aren't disclosed on the label.
Does it work?
Moderate evidence
The evidence for this product's ingredients is mixed. Fenugreek has possibly effective ratings for sexual dysfunction, sexual arousal, dysmenorrhea (painful periods), and diabetes.
Echinacea and yarrow, however, are listed as having insufficient reliable evidence for the conditions they're traditionally used for—including anxiety, athletic performance, ADHD, burns, chronic fatigue, migraines, wound healing, eczema, and other uses. White oak, bayberry, and chaparral have no established effectiveness ratings in our data.
How safe is it?
Well-documented data
Fenugreek is generally well tolerated in food amounts, but supplement doses can cause abdominal pain, bloating, diarrhea, indigestion, gas, nausea, and in rare cases severe allergic reactions. Echinacea is well tolerated short-term but may trigger allergic reactions, especially in people sensitive to ragweed and related plants; rare cases of hepatitis have been reported.
Yarrow is generally well tolerated when taken orally or used vaginally, though topical use can cause dermatitis and allergic reactions. White oak and bayberry have limited safety data; bayberry can cause stomach irritation and vomiting.
Chaparral is a major concern—it has been linked to serious liver and kidney toxicity and is not recommended for use. During pregnancy, fenugreek and yarrow are likely unsafe, while echinacea is possibly safe.
Chaparral, white oak, and bayberry should be avoided in pregnancy due to insufficient safety data or toxicity concerns. For breastfeeding, echinacea is possibly safe, but yarrow and white oak should be avoided; fenugreek is often used to boost milk supply but evidence is limited and should be discussed with your provider first.
Data on bayberry and chaparral during lactation are insufficient.
Meds to double-check
Moderate interaction found
Before taking this product, check with your own doctor or pharmacist about any medications you're on. The most serious concern is chaparral's potential to harm the liver when combined with drugs that also stress the liver.
Fenugreek can affect blood thinners (including warfarin), diabetes medications, blood pressure drugs, theophylline, and several others. Echinacea may interfere with how your liver clears a large range of medications, and it can counteract immunosuppressants.
Yarrow may increase lithium levels. If you take any of these, confirmation from your pharmacist is important before you start.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.
This product combines several plant botanicals—some with possibly useful evidence (fenugreek for sexual function and diabetes) and others with insufficient evidence. The biggest red flag is chaparral, which carries serious liver and kidney toxicity risks and isn't recommended.
If you take blood thinners, diabetes drugs, lithium, immunosuppressants, or any hepatotoxic medication, talk with your own doctor or pharmacist before starting. The same goes if you're pregnant, breastfeeding, or have liver or kidney concerns.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 6 of 7 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2023.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Lymphatic System 2 Capsules, straight from the product label.
| Brand | Dr. Morse's Cellular Botanicals |
|---|---|
| Net contents | 90 Veggiecap(s) |
| Market status | On market |
| Date entered into DSLD | Nov 22, 2023 |
| DSLD ID | 302960 |
| Product type | Botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Lymphatic System 2 Capsules by Dr. Morse's Cellular Botanicals, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Proprietary Blend | 900 mg | -- |
| Cleavers | 0 NP | -- |
| Fenugreek | 0 NP | -- |
| Echinacea angustifolia | 0 NP | -- |
| White Oak | 0 NP | -- |
| Yarrow | 0 NP | -- |
| Bayberry | 0 NP | -- |
| Chaparral | 0 NP | -- |
Other ingredients: Capsule
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
Support cellular regeneration with our tissue specific formulas! Created with over 45 years of experience and the highest quality ingredients available. Experience health and vitality like never before!
Our formulas are made with organic, wildcrafted or consciously cultivated herbs
Suggested/Recommended/Usage/Directions
Suggested Use 2 capsules, 3 times a day.
Precautions
See our website for any precautions.
Keep out of reach of children.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Made in the USA with global ingredients
FDA Statement of Identity
Dietary Supplement
Formula
Lymphatic System 2 Capsules (450 mg each)
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Lymphatic System 2 Capsules by Dr. Morse's Cellular Botanicals label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Lymphatic System 2 Capsules by Dr. Morse's Cellular Botanicals
These are the 7 active ingredients this product is made of. Select any to open its full monograph.
Serving size2 Capsule(s) Dosage formCapsule Servings per container45 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Other (inactive) ingredients: Capsule. These complete the product’s ingredient list but are not active constituents.
Lymphatic System 2 Capsules by Dr. Morse's Cellular Botanicals Drug Interactions
HelloPharmacist Interaction Report
Lymphatic System 2 Capsules by Dr.
Morse's Cellular Botanicals contains several ingredients with documented interactions with medications. The most serious concern is chaparral, which can have additive toxic effects on the liver when combined with hepatotoxic drugs (Moderate severity).
Beyond that, fenugreek interacts with anticoagulant and antiplatelet drugs, diabetes medications, blood pressure drugs, and several others; echinacea affects how your body metabolizes certain drugs through liver enzymes and can interfere with immunosuppressants; and yarrow may increase lithium levels.
Read the full breakdown — every affected drug type, severity by severity
Fenugreek's interactions span anticoagulants and antiplatelet agents (including warfarin and clopidogrel), diabetes drugs, theophylline, metoprolol, phenytoin, and sildenafil—all Moderate severity. Echinacea can inhibit or induce liver enzymes that clear many common medications (CYP1A2 and CYP3A4 substrates), interfere with immunosuppressants, increase etoposide levels, and raise caffeine concentrations; most are Moderate, with warfarin, lopinavir/ritonavir, and midazolam rated Minor.
Yarrow's documented interaction is with lithium (Moderate severity).
We could not check cleavers for interactions. White oak and bayberry have no interactions documented in our data.
Altogether, these interactions span 1,251 individual medications.
Before you start this product, use the medication checker below to look up any prescriptions or over-the-counter drugs you're taking—especially if you take blood thinners, diabetes medications, immunosuppressants, or lithium.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Lymphatic System 2 Capsules?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Lymphatic System 2 Capsules interact with 1,250 drugs. Click any drug to see the details.
4 of the 7 ingredients in Lymphatic System 2 Capsules interact with drugs. Each result below shows which ingredient is responsible. Echinacea angustifolia Fenugreek Chaparral Yarrow
6-mercaptopurinePurinethol
How 6-mercaptopurine interacts with Lymphatic System 2 Capsules — through 2 ingredients. Tap an ingredient for the detail:
Echinacea AngustifoliaImmunosuppressants Moderate
Interaction Summary
Echinacea has immunostimulant activity which may interfere with immunosuppressant therapy.
Read the full Echinacea Angustifolia + 6-mercaptopurine interactionChaparralHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, chaparral might have additive adverse effects on the liver when used with hepatotoxic drugs.
Read the full Chaparral + 6-mercaptopurine interactionAdo-trastuzumab EmtansineKadcyla
How Ado-trastuzumab Emtansine interacts with Lymphatic System 2 Capsules — through 1 ingredient. Tap an ingredient for the detail:
Echinacea AngustifoliaCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Echinacea may induce hepatic CYP3A4 and inhibit intestinal CYP3A4.
Read the full Echinacea Angustifolia + Ado-trastuzumab Emtansine interactionAbacavir Sulfate, Dolutegravir, LamivudineTriumeq
How Abacavir Sulfate, Dolutegravir, Lamivudine interacts with Lymphatic System 2 Capsules — through 1 ingredient. Tap an ingredient for the detail:
ChaparralHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, chaparral might have additive adverse effects on the liver when used with hepatotoxic drugs.
Read the full Chaparral + Abacavir Sulfate, Dolutegravir, Lamivudine interactionAbacavir, LamivudineEpzicom
How Abacavir, Lamivudine interacts with Lymphatic System 2 Capsules — through 1 ingredient. Tap an ingredient for the detail:
ChaparralHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, chaparral might have additive adverse effects on the liver when used with hepatotoxic drugs.
Read the full Chaparral + Abacavir, Lamivudine interactionAbciximabReoPro
How Abciximab interacts with Lymphatic System 2 Capsules — through 1 ingredient. Tap an ingredient for the detail:
FenugreekAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek + Abciximab interactionAbemaciclibVerzenio
How Abemaciclib interacts with Lymphatic System 2 Capsules — through 1 ingredient. Tap an ingredient for the detail:
Echinacea AngustifoliaCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Echinacea may induce hepatic CYP3A4 and inhibit intestinal CYP3A4.
Read the full Echinacea Angustifolia + Abemaciclib interactionAbiraterone
How Abiraterone interacts with Lymphatic System 2 Capsules — through 2 ingredients. Tap an ingredient for the detail:
ChaparralHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, chaparral might have additive adverse effects on the liver when used with hepatotoxic drugs.
Read the full Chaparral + Abiraterone interactionEchinacea AngustifoliaCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Echinacea may induce hepatic CYP3A4 and inhibit intestinal CYP3A4.
Read the full Echinacea Angustifolia + Abiraterone interactionAbiraterone AcetateYonsa, Zytiga
How Abiraterone Acetate interacts with Lymphatic System 2 Capsules — through 2 ingredients. Tap an ingredient for the detail:
Echinacea AngustifoliaCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Echinacea may induce hepatic CYP3A4 and inhibit intestinal CYP3A4.
Read the full Echinacea Angustifolia + Abiraterone Acetate interactionChaparralHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, chaparral might have additive adverse effects on the liver when used with hepatotoxic drugs.
Read the full Chaparral + Abiraterone Acetate interactionAbrocitinibCibinqo
How Abrocitinib interacts with Lymphatic System 2 Capsules — through 2 ingredients. Tap an ingredient for the detail:
Echinacea AngustifoliaImmunosuppressants Moderate
Interaction Summary
Echinacea has immunostimulant activity which may interfere with immunosuppressant therapy.
Read the full Echinacea Angustifolia + Abrocitinib interactionFenugreekAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek + Abrocitinib interactionAcalabrutinibCalquence
How Acalabrutinib interacts with Lymphatic System 2 Capsules — through 1 ingredient. Tap an ingredient for the detail:
Echinacea AngustifoliaCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Echinacea may induce hepatic CYP3A4 and inhibit intestinal CYP3A4.
Read the full Echinacea Angustifolia + Acalabrutinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Lymphatic System 2 Capsules — through 2 ingredients. Tap an ingredient for the detail:
ChaparralHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, chaparral might have additive adverse effects on the liver when used with hepatotoxic drugs.
Read the full Chaparral + Acarbose interactionFenugreekAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, fenugreek seed might have additive hypoglycemic effects when used with antidiabetes drugs.
Read the full Fenugreek + Acarbose interactionAcebutololRhotral, Sectral
How Acebutolol interacts with Lymphatic System 2 Capsules — through 2 ingredients. Tap an ingredient for the detail:
ChaparralHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, chaparral might have additive adverse effects on the liver when used with hepatotoxic drugs.
Read the full Chaparral + Acebutolol interactionFenugreekAntihypertensive Drugs Minor
Interaction Summary
Fenugreek may also have an additive effect on blood pressure-lowering medications.
Read the full Fenugreek + Acebutolol interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Lymphatic System 2 Capsules — through 1 ingredient. Tap an ingredient for the detail:
FenugreekAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek + Acenocoumarol interactionAcetaminophenChildren's Tylenol, Children's Tylenol Meltaways, Tylenol, Tylenol Ex Strength
How Acetaminophen interacts with Lymphatic System 2 Capsules — through 2 ingredients. Tap an ingredient for the detail:
Echinacea AngustifoliaCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Echinacea might inhibit the metabolism of CYP1A2 and increase plasma levels of some drugs.
Read the full Echinacea Angustifolia + Acetaminophen interactionChaparralHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, chaparral might have additive adverse effects on the liver when used with hepatotoxic drugs.
Read the full Chaparral + Acetaminophen interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Lymphatic System 2 Capsules — through 3 ingredients. Tap an ingredient for the detail:
FenugreekAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek + Acetaminophen, Aspirin interactionChaparralHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, chaparral might have additive adverse effects on the liver when used with hepatotoxic drugs.
Read the full Chaparral + Acetaminophen, Aspirin interactionEchinacea AngustifoliaCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Echinacea might inhibit the metabolism of CYP1A2 and increase plasma levels of some drugs.
Read the full Echinacea Angustifolia + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Lymphatic System 2 Capsules — through 3 ingredients. Tap an ingredient for the detail:
Echinacea AngustifoliaCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Echinacea might inhibit the metabolism of CYP1A2 and increase plasma levels of some drugs.
Read the full Echinacea Angustifolia + Acetaminophen, Aspirin, Caffeine interactionFenugreekAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek + Acetaminophen, Aspirin, Caffeine interactionChaparralHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, chaparral might have additive adverse effects on the liver when used with hepatotoxic drugs.
Read the full Chaparral + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu
How Acetaminophen, Brompheniramine, Phenylpropanolamine interacts with Lymphatic System 2 Capsules — through 2 ingredients. Tap an ingredient for the detail:
ChaparralHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, chaparral might have additive adverse effects on the liver when used with hepatotoxic drugs.
Read the full Chaparral + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionEchinacea AngustifoliaCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Echinacea might inhibit the metabolism of CYP1A2 and increase plasma levels of some drugs.
Read the full Echinacea Angustifolia + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionAcetaminophen, ButalbitalAxocet, Bancap, Bucet, Butex Forte, Esgic CF, Orbivan CF +5 more
How Acetaminophen, Butalbital interacts with Lymphatic System 2 Capsules — through 2 ingredients. Tap an ingredient for the detail:
Echinacea AngustifoliaCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Echinacea might inhibit the metabolism of CYP1A2 and increase plasma levels of some drugs.
Read the full Echinacea Angustifolia + Acetaminophen, Butalbital interactionChaparralHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, chaparral might have additive adverse effects on the liver when used with hepatotoxic drugs.
Read the full Chaparral + Acetaminophen, Butalbital interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with Lymphatic System 2 Capsules — through 2 ingredients. Tap an ingredient for the detail:
ChaparralHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, chaparral might have additive adverse effects on the liver when used with hepatotoxic drugs.
Read the full Chaparral + Acetaminophen, Butalbital, Caffeine interactionEchinacea AngustifoliaCytochrome P450 1a2 (cyp1a2) Substrates, Caffeine +1 Moderate
Interaction Summary
Echinacea might inhibit the metabolism of CYP1A2 and increase plasma levels of some drugs.
Read the full Echinacea Angustifolia + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Lymphatic System 2 Capsules — through 2 ingredients. Tap an ingredient for the detail:
Echinacea AngustifoliaCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Echinacea may induce hepatic CYP3A4 and inhibit intestinal CYP3A4.
Read the full Echinacea Angustifolia + Acetaminophen, Butalbital, Caffeine, Codeine interactionChaparralHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, chaparral might have additive adverse effects on the liver when used with hepatotoxic drugs.
Read the full Chaparral + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with Lymphatic System 2 Capsules — through 2 ingredients. Tap an ingredient for the detail:
ChaparralHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, chaparral might have additive adverse effects on the liver when used with hepatotoxic drugs.
Read the full Chaparral + Acetaminophen, Butalbital, Codeine interactionEchinacea AngustifoliaCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Echinacea might inhibit the metabolism of CYP1A2 and increase plasma levels of some drugs.
Read the full Echinacea Angustifolia + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with Lymphatic System 2 Capsules — through 2 ingredients. Tap an ingredient for the detail:
Echinacea AngustifoliaCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Echinacea might inhibit the metabolism of CYP1A2 and increase plasma levels of some drugs.
Read the full Echinacea Angustifolia + Acetaminophen, Butalbital, Codeine Phosphate interactionChaparralHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, chaparral might have additive adverse effects on the liver when used with hepatotoxic drugs.
Read the full Chaparral + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Lymphatic System 2 Capsules — through 2 ingredients. Tap an ingredient for the detail:
Echinacea AngustifoliaCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Echinacea might inhibit the metabolism of CYP1A2 and increase plasma levels of some drugs.
Read the full Echinacea Angustifolia + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionChaparralHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, chaparral might have additive adverse effects on the liver when used with hepatotoxic drugs.
Read the full Chaparral + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Lymphatic System 2 Capsules — through 2 ingredients. Tap an ingredient for the detail:
Echinacea AngustifoliaCaffeine, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Echinacea can increase plasma levels of caffeine by inhibiting its metabolism.
Read the full Echinacea Angustifolia + Acetaminophen, Caffeine, Codeine interactionChaparralHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, chaparral might have additive adverse effects on the liver when used with hepatotoxic drugs.
Read the full Chaparral + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Lymphatic System 2 Capsules — through 2 ingredients. Tap an ingredient for the detail:
Echinacea AngustifoliaCytochrome P450 3a4 (cyp3a4) Substrates, Caffeine +1 Moderate
Interaction Summary
Echinacea may induce hepatic CYP3A4 and inhibit intestinal CYP3A4.
Read the full Echinacea Angustifolia + Acetaminophen, Caffeine, Codeine, Salicylamide interactionChaparralHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, chaparral might have additive adverse effects on the liver when used with hepatotoxic drugs.
Read the full Chaparral + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Lymphatic System 2 Capsules — through 2 ingredients. Tap an ingredient for the detail:
Echinacea AngustifoliaCytochrome P450 1a2 (cyp1a2) Substrates, Caffeine +1 Moderate
Interaction Summary
Echinacea might inhibit the metabolism of CYP1A2 and increase plasma levels of some drugs.
Read the full Echinacea Angustifolia + Acetaminophen, Caffeine, Dihydrocodeine interactionChaparralHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, chaparral might have additive adverse effects on the liver when used with hepatotoxic drugs.
Read the full Chaparral + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with Lymphatic System 2 Capsules — through 2 ingredients. Tap an ingredient for the detail:
ChaparralHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, chaparral might have additive adverse effects on the liver when used with hepatotoxic drugs.
Read the full Chaparral + Acetaminophen, Caffeine, Isometheptene interactionEchinacea AngustifoliaCaffeine, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Echinacea can increase plasma levels of caffeine by inhibiting its metabolism.
Read the full Echinacea Angustifolia + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Lymphatic System 2 Capsules — through 2 ingredients. Tap an ingredient for the detail:
Echinacea AngustifoliaCytochrome P450 3a4 (cyp3a4) Substrates, Caffeine +1 Moderate
Interaction Summary
Echinacea may induce hepatic CYP3A4 and inhibit intestinal CYP3A4.
Read the full Echinacea Angustifolia + Acetaminophen, Caffeine, Pyrilamine interactionChaparralHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, chaparral might have additive adverse effects on the liver when used with hepatotoxic drugs.
Read the full Chaparral + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Lymphatic System 2 Capsules — through 2 ingredients. Tap an ingredient for the detail:
Echinacea AngustifoliaCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Echinacea might inhibit the metabolism of CYP1A2 and increase plasma levels of some drugs.
Read the full Echinacea Angustifolia + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionChaparralHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, chaparral might have additive adverse effects on the liver when used with hepatotoxic drugs.
Read the full Chaparral + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Lymphatic System 2 Capsules — through 2 ingredients. Tap an ingredient for the detail:
Echinacea AngustifoliaCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Echinacea might inhibit the metabolism of CYP1A2 and increase plasma levels of some drugs.
Read the full Echinacea Angustifolia + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionChaparralHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, chaparral might have additive adverse effects on the liver when used with hepatotoxic drugs.
Read the full Chaparral + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Lymphatic System 2 Capsules with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Echinacea angustifolia
Caffeine
Echinacea can increase plasma levels of caffeine by inhibiting its metabolism.
Echinacea seems to increase plasma concentrations of caffeine by around 30%. This is likely due to inhibition of cytochrome P450 1A2 (CYP1A2) by echinacea.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Echinacea might inhibit the metabolism of CYP1A2 and increase plasma levels of some drugs.
Echinacea appears to inhibit CYP1A2 enzymes in humans. Additionally, echinacea seems to increase plasma concentrations of caffeine, a CYP1A2 substrate, by around 30%. Theoretically, echinacea might increase levels of other drugs metabolized by CYP1A2.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Echinacea may induce hepatic CYP3A4 and inhibit intestinal CYP3A4. This may increase or decrease levels of drugs metabolized by CYP3A4.
Several clinical trials have shown that taking echinacea for up to one month does not significantly affect the metabolism of various CYP3A4 substrates, including midazolam, docetaxel, etravirine, lopinavir-ritonavir, and darunavir-ritonavir. However, other clinical research shows that echinacea may increase the clearance of midazolam, suggesting that echinacea might induce CYP3A4. The discrepancy is thought to be due to differing effects of echinacea on intestinal versus hepatic CYP3A4 enzymes. Echinacea appears to induce hepatic CYP3A4 but inhibit intestinal CYP3A4. In some cases, these effects might cancel each other out, but in others, drug levels may be increased or decreased depending on the level of effect at hepatic and intestinal sites. The effect of echinacea on CYP3A4 activity may differ depending on the CYP3A4 substrate.
Etoposide (Vepesid)
Echinacea may increase levels of etoposide.
In one report, concomitant use of etoposide and echinacea was associated with more severe thrombocytopenia than the use of etoposide alone, suggesting inhibition of etoposide metabolism. Etoposide is a cytochrome P450 3A4 (CYP3A4) substrate. Echinacea has variable effects on CYP3A4, but some studies have reported inhibition of the enzyme.
Immunosuppressants
Echinacea has immunostimulant activity which may interfere with immunosuppressant therapy.
Theoretically, echinacea may interfere with immunosuppressant therapy because of its immunostimulant activity.
Darunavir (Prezista)
Theoretically, echinacea may interfere with the metabolism of darunavir; however, a small clinical study found no effect.
Darunavir is metabolized by cytochrome P450 3A4 (CYP3A4) and is administered with the CYP3A4 inhibitor ritonavir to increase its plasma concentrations. Echinacea has variable effects on CYP3A4, but administration of an E. purpurea root extract (Arkocapsulas Echinacea, Arkopharma) 500 mg four times daily for 14 days did not affect darunavir/ritonavir pharmacokinetics in 15 HIV-infected patients.
Dayquil Severe
Echinacea is reported to have varying effects on a number of Cytochrome P450 metabolizing enzymes in the liver, including CYP1A2 and CYP3A4, which play a role in acetaminophen and dextromethorphan metabolism (both contained in DayQuil Severe), respectively. Studies have reported both enzyme inhibition and induction, making it difficult to predict clinically significant drug interactions with reliability. Specific drug interaction studies reporting definitive results are rare, and potential drug interactions involving echinacea should likely be taken on a case-by-case basis. Based on what we know about how acetaminophen and dextromethorphan are metabolized, the risk of a clinically significant interaction between echinacea and DayQuil Severe is low.
Docetaxel (Taxotere)
Theoretically, echinacea may interfere with the metabolism of docetaxel; however, a small clinical study found no effect.
Docetaxel is metabolized by cytochrome P450 3A4 (CYP3A4). Echinacea has variable effects on CYP3A4, but taking E. purpurea whole plant extract (Echinaforce, A. Vogel Biopharma AG) 20 drops three times daily for 2 weeks did not alter the pharmacokinetics of docetaxel in one clinical study.
Etravirine (Intelence)
Theoretically, echinacea may interfere with the metabolism of etravirine; however, a small clinical study found no effect.
Etravirine is metabolized by cytochrome P450 3A4 (CYP3A4). Echinacea has variable effects on CYP3A4, but taking E. purpurea root extract (Arkocapsulas Echinacea, Arkopharma) 500 mg three times daily for 14 days did not alter the pharmacokinetics of etravirine in HIV-infected patients.
Lopinavir/Ritonavir (Kaletra)
Theoretically, echinacea may interfere with the metabolism of lopinavir; however, a small clinical study found no effect.
Lopinavir is metabolized by cytochrome P450 3A4 (CYP3A4) and is administered with the CYP3A4 inhibitor ritonavir to increase its plasma concentrations. Echinacea has variable effects on CYP3A4, but taking E. purpurea (Echinamide, Natural Factors Nutritional Products, Inc.) 500 mg three times daily for 14 days did not alter the pharmacokinetics of lopinavir/ritonavir in healthy volunteers.
Midazolam (Versed)
Theoretically, echinacea may increase the metabolism of intravenous midazolam.
Echinacea induces hepatic CYP3A4 and might decrease plasma levels of midazolam by about 20%, reducing the effectiveness of intravenous midazolam. Echinacea also appears to inhibit intestinal CYP3A4, which could theoretically increase the bioavailability of oral midazolam. This may cancel out the decrease in availability caused by induction of hepatic CYP3A4, such that overall plasma levels after oral administration of midazolam are not affected by echinacea.
Warfarin (Coumadin)
Echinacea seems to increase the clearance of warfarin, although the effect may not be clinically significant.
Preliminary clinical research in healthy male volunteers suggests that taking echinacea increases the clearance of the active S-isomer of warfarin after a single dose of warfarin, but there was not a clinically significant effect on the INR.
Fenugreek
Anticoagulant/Antiplatelet Drugs
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Some of the constituents in fenugreek have antiplatelet effects in animal and in vitro research. However, common fenugreek products might not contain sufficient concentrations of these constituents for clinical effects. A clinical study in patients with coronary artery disease or diabetes shows that taking fenugreek seed powder 2.5 grams twice daily for 3 months does not affect platelet aggregation, fibrinolytic activity, or fibrinogen levels .
Antidiabetes Drugs
Theoretically, fenugreek seed might have additive hypoglycemic effects when used with antidiabetes drugs.
Clinical research shows that fenugreek seed can reduce fasting blood glucose and 2-hour postprandial glucose levels in adults with type 2 diabetes.
Clopidogrel (Plavix)
Theoretically, fenugreek seed might alter the clinical effects of clopidogrel by inhibiting its conversion to the active form.
Animal research shows that fenugreek seed 200 mg/kg daily for 14 days increases the maximum serum concentration of clopidogrel by 21%. It is unclear how this affects the pharmacokinetics of the active metabolite of clopidogrel; however, this study found that concomitant use of fenugreek seed and clopidogrel prolonged bleeding time by an additional 11%.
Metoprolol (Toprol)
Theoretically, fenugreek seed might have additive hypotensive effects when used with metoprolol.
Animal research shows that fenugreek seed 300 mg/kg daily for 2 weeks decreases systolic and diastolic blood pressure by 9% and 11%, respectively, when administered alone, and by 15% and 22%, respectively, when given with metoprolol 10 mg/kg.
Phenytoin (Dilantin)
Theoretically, fenugreek might decrease plasma levels of phenytoin.
Animal research shows that taking fenugreek seeds for 1 week decreases maximum concentrations and the area under the curve of a single dose of phenytoin by 44% and 72%, respectively. This seems to be related to increased clearance. So far, this interaction has not been reported in humans.
Sildenafil (Viagra)
Theoretically, concurrent use of sildenafil and fenugreek might reduce levels and therapeutic effects of sildenafil.
Animal research shows that taking fenugreek seeds for 1 week reduces maximum concentrations and the area under the curve of a single dose of sildenafil by 27% and 48%, respectively. So far, this interaction has not been reported in humans.
Theophylline
Theoretically, fenugreek may reduce the levels and clinical effects of theophylline.
Animal research shows that fenugreek 50 grams daily for 7 days reduces the maximum serum concentration (Cmax) of theophylline by 28% and the area under the plasma drug concentration-time curve (AUC) by 22%.
Warfarin (Coumadin)
Theoretically, fenugreek might have additive effects with warfarin and increase the international normalized ratio (INR).
Some fenugreek constituents have antiplatelet effects, although these might not be present in concentrations that are clinically significant. In one case report, a patient taking warfarin experienced an increased INR when starting to take fenugreek in combination with boldo.
Antihypertensive Drugs
Fenugreek may also have an additive effect on blood pressure-lowering medications. Studies on animals have shown that fenugreek seed can decrease both systolic and diastolic blood pressure by up to 22% when combined with metoprolol. Therefore, it is essential to monitor your blood pressure regularly if you are taking fenugreek and metoprolol together or any other antihypertensive drugs.
Chaparral
Hepatotoxic Drugs
Theoretically, chaparral might have additive adverse effects on the liver when used with hepatotoxic drugs.
Yarrow
Lithium
Theoretically, taking yarrow with lithium might increase the levels and adverse effects of lithium.
Animal research shows that yarrow has diuretic activity. Theoretically, due to these potential diuretic effects, yarrow might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.
Brand information
Manufacturer and brand details for Lymphatic System 2 Capsules, from the product label.
Dr. Morse's Cellular Botanicals
See all Dr. Morse's Cellular Botanicals products- Name
- Western Botanicals FL, LLC
- City
- Spanish Fork
- State
- UT
- ZipCode
- 84660
- Web Address
- DMHHC.com
Lymphatic System 2 Capsules by Dr. Morse's Cellular Botanicals: Common Questions
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The Full Monographs Behind Lymphatic System 2 Capsules’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Fenugreek
Interacts with 389 drugsFenugreek is a common kitchen spice that is also taken as a supplement, mainly for blood sugar, cholesterol, and to support breast milk production. Some early research is encouraging for blo...
Read the full Fenugreek monograph → Herb & supplement monographEchinacea
Interacts with 816 drugsEchinacea is a popular herb taken to help prevent or shorten the common cold, but study results are mixed and the overall benefit appears small at best. It is generally well tolerated for sh...
Read the full Echinacea monograph → Herb & supplement monographWhite Oak
White oak bark is a traditional herbal remedy rich in tannins, used mostly as a tea or skin wash for diarrhea, sore throat, and minor skin problems. Solid human evidence is very limited, and...
Read the full White Oak monograph → Herb & supplement monographYarrow
Interacts with 1 drugYarrow is a traditional herb long used for wounds, digestive complaints, and colds, but high-quality human studies are very limited, so its benefits are not well proven. It is generally used...
Read the full Yarrow monograph → Herb & supplement monographBayberry
Bayberry is a traditional herb used mainly as an astringent for diarrhea, sore throats, and minor skin or gum problems, but there is very little modern human research to confirm it works. It...
Read the full Bayberry monograph → Herb & supplement monographChaparral
Interacts with 370 drugsChaparral is a desert shrub long used in traditional medicine, but there is no reliable proof it treats any condition. It has been linked to serious and sometimes irreversible liver and kidn...
Read the full Chaparral monograph →Sources & How We Checked
Lymphatic System 2 Capsules's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 110 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Fenugreek 30 references
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- Sharma RD, Raghuram TC, Rao NS. Effect of fenugreek seeds on blood glucose and serum lipids in type I diabetes. Eur J Clin Nutr 1990;44:301-6.
- Patil SP, Niphadkar PV, Bapat MM. Allergy to fenugreek (Trigonella foenum graecum). Ann Allergy Asthma Immunol 1997;78:297-300. PubMed
- Lambert J, Cormier J. Potential interaction between warfarin and boldo-fenugreek. Pharmacotherapy 2001;21:509-12. PubMed
- Bordia A, Verma SK, Srivastava KC. Effect of ginger (Zingiber officinale Rosc.) and fenugreek (Trigonella foenumgraecum L.) on blood lipids, blood sugar and platelet aggregation in patients with coronary artery disease. Prostaglandins Leukot Essent Fatty PubMed
- Yalcin SS, Tekinalp G, Ozalp I. Peculiar odor of traditional food and maple syrup urine disease. Pediatr Int 1999;41:108-9. PubMed
- Sewell AC, Mosandl A, Bohles H. False diagnosis of maple syrup urine disease owing to ingestion of herbal tea. N Engl J Med 1999;341:769.. PubMed
- Abdo MS, al-Kafawi AA. Experimental studies on the effect of Trigonella foenum-graecum (abstract). Planta Med 1969;17:14-8.
- Gupta A, Gupta R, Lal B. Effect of Trigonella foenum-graecum (fenugreek) seeds on glycaemic control and insulin resistance in type 2 diabetes mellitus: a double blind placebo controlled study. J Assoc Physicians India 2001;49:1057-61.
- Gabay MP. Galactogogues: medications that induce lactation. J Hum Lact 2002;18:274-9. PubMed
- Chevassus H, Gaillard JB, Farret A, et al. A fenugreek seed extract selectively reduces spontaneous fat intake in overweight subjects. Eur J Clin Pharmacol 2010;66(5):449-55. PubMed
- Turkyilmaz C, Onal E, Hirfanoglu IM, et al. The effect of galactagogue herbal tea on breast milk production and short-term catch-up of birth weight in the first week of life. J Altern Complement Med 2011;17(2):139-42. PubMed
- Swafford S, Berens P. Effect of fenugreek on breast milk volume. Abstract presented at: 5th International Meeting of the Academy of Breastfeeding Medicine; September 11-13,2000, Tucson, Arizona.
- Abdel-Barry, J. A., Abdel-Hassan, I. A., Jawad, A. M., and al Hakiem, M. H. Hypoglycaemic effect of aqueous extract of the leaves of Trigonella foenum-graecum in healthy volunteers. East Mediterr.Health J 2000;6(1):83-88. DOI
- Parvizpur, A., Ahmadiani, A., and Kamalinejad, M. Probable role of spinal purinoceptors in the analgesic effect of Trigonella foenum (TFG) leaves extract. J Ethnopharmacol 3-8-2006;104(1-2):108-112. PubMed
- Mora, A., Herrrera, A., Lopez, C., Dahbi, G., Mamani, R., Pita, J. M., Alonso, M. P., Llovo, J., Bernardez, M. I., Blanco, J. E., Blanco, M., and Blanco, J. Characteristics of the Shiga-toxin-producing enteroaggregative Escherichia coli O104:H4 German ou
- Blanco, J. [Stx2a-producing enteroaggregative Escherichia coli O104:H4-ST678. Microbiological diagnostic already, for this and other STEC/VTEC serotypes!]. Enferm.Infecc.Microbiol.Clin. 2012;30(2):84-89.
- Beutin, L. and Martin, A. Outbreak of Shiga toxin-producing Escherichia coli (STEC) O104:H4 infection in Germany causes a paradigm shift with regard to human pathogenicity of STEC strains. J Food Prot. 2012;75(2):408-418. PubMed
- King LA, Nogareda F, Weill FX, Mariani-Kurkdjian P, Loukiadis E, Gault G, Jourdan-DaSilva N, Bingen E, Macé M, Thevenot D, Ong N, Castor C, Noël H, Van Cauteren D, Charron M, Vaillant V, Aldabe B, Goulet V, Delmas G, Couturier E, Le Strat Y, Combe C, Delm
- Reeder C, Legrand A, O'Connor-Von SK. The Effect of Fenugreek on Milk Production and Prolactin Levels in Mothers of Preterm Infants. Clinical Lactation 2013;4(4):159-165. DOI
- Al-Jenoobi FI, Ahad A, Mahrous GM, Al-Mohizea AM, AlKharfy KM, Al-Suwayeh SA. Effects of fenugreek, garden cress, and black seed on theophylline pharmacokinetics in beagle dogs. Pharm Biol 2015;53(2):296-300. PubMed
- Rao A, Steels E, Inder WJ, Abraham S, Vitetta L. Testofen, a specialised Trigonella foenum-graecum seed extract reduces age-related symptoms of androgen decrease, increases testosterone levels and improves sexual function in healthy aging males in a doubl
- Steels E, Rao A, Vitetta L. Physiological aspects of male libido enhanced by standardized Trigonella foenum-graecum extract and mineral formulation. Phytother Res. 2011 Sep;25(9):1294-300.
- Gong J, Fang K, Dong H, Wang D, Hu M, Lu F. Effect of fenugreek on hyperglycaemia and hyperlipidemia in diabetes and prediabetes: A meta-analysis. J Ethnopharmacol. 2016 Dec 24;194:260-268. PubMed
- Ouzir M, El Bairi K, Amzazi S. Toxicological properties of fenugreek (Trigonella foenum graecum). Food Chem Toxicol. 2016 Oct;96:145-54. PubMed
- Khodamoradi K, Khosropanah MH, Ayati Z, et al. The Effects of Fenugreek on Cardiometabolic Risk Factors in Adults: A Systematic Review and Meta-analysis. Complement Ther Med. 2020;52:102416. PubMed
- Alkharfy K, Jan B, Alotaibi K, et al. Clopidogrel-herb Interactions: A Pharmacokinetic and Pharmacodynamic Assessment in a Rat Model. Curr Drug Metab 2021;22(12):969-977. PubMed
- Bin Jardan YA, Ahad A, Raish M, Alam MA, Al-Mohizea AM, Al-Jenoobi FI. Effects of garden cress, fenugreek and black seed on the pharmacodynamics of metoprolol: an herb-drug interaction study in rats with hypertension. Pharm Biol 2021;59(1):1088-1097. PubMed
- Al-Mohizea AM, Ahad A, El-Maghraby GM, et al. Effects of Nigella sativa, Lepidium sativum and Trigonella foenum-graecum on sildenafil disposition in beagle dogs. Eur J Drug Metab Pharmacokinet. 2015;40(2):219-24. PubMed
- Alkharfy KM, Al-Jenoobi FI, Al-Mohizea AM, et al. Effects of Lepidium sativum, Nigella sativa and Trigonella foenum-graceum on phenytoin pharmacokinetics in beagle dogs. Phytother Res. 2013;27(12):1800-4.
Echinacea 51 references
- Mullins RJ. Echinacea-associated anaphylaxis. Med J Aust 1998;168:170-1. PubMed
- Mullins RJ. Allergic reactions to Echinacea. J Allergy Clin Immunol 2000;104:S340-341 (Abstract 1003).
- Chavez ML, Chavez PI. Echinacea. Hosp Pharm 1998;33:180-8.
- Grimm W, Muller HH. A randomized controlled trial of the effect of fluid extract of Echinacea purpurea on the incidence and severity of colds and respiratory infections. Am J Med 1999;106:138-43. PubMed
- Taylor JA, Weber W, Standish L, et al. Efficacy and safety of echinacea in treating upper respiratory tract infections in children: a randomized controlled trial. JAMA 2003;290:2824-30.. PubMed
- Luettig B, Steinmuller C, Gifford GE, et al. Macrophage activation by the polysaccharide arabinogalactan isolated from plant cell cultures of Echinacea purpurea. J Natl Cancer Inst 1989;81:669-75. PubMed
- Stimpel M, Proksch A, Wagner H, et al. Macrophage activation and induction of macrophage cytotoxicity by purified polysaccharide fractions from the plant Echinacea purpurea. Infect Immun 1984;46:845-9. PubMed
- Budzinski JW, Foster BC, Vandenhoek S, Arnason JT. An in vitro evaluation of human cytochrome P450 3A4 inhibition by selected commercial herbal extracts and tinctures. Phytomedicine 2000;7:273-82. PubMed
- Gallo M, Sarkar M, Au W, et al. Pregnancy outcome following gestational exposure to echinacea: A prospective controlled study. Arch Intern Med 2000;160:3141-3. PubMed
- Soon SL, Crawford RI. Recurrent erythema nodosum associated with echinacea herbal therapy. J Am Acad Dermatol 2001;44:298-9. PubMed
- Mullins RJ, Heddle R. Adverse reactions associated with echinacea: the Australian experience. Ann Allergy Asthma Immunol 2002;88:42-51. PubMed
- Logan JL, Ahmed J. Critical hypokalemic renal tubular acidosis due to Sjogren's syndrome: association with the purported immune stimulant echinacea. Clin Rheumatol 2003;22:158-9.
- Schulten B, Bulitta M, Ballering-Bruhl B, et al. Efficacy of Echinacea purpurea in patients with a common cold. A placebo-controlled, randomised, double-blind clinical trial. Arzneimittelforschung 2001;51:563-8.. PubMed
- Yale SH, Glurich I. Analysis of the inhibitory potential of Ginkgo biloba, Echinacea purpurea, and Serenoa repens on the metabolic activity of cytochrome P450 3A4, 2D6, and 2C9. J Altern Complement Med 2005;11:433-9.
- Yale SH, Liu K. Echinacea purpurea therapy for the treatment of the common cold: a randomized, double-blind, placebo-controlled clinical trial. Arch Intern Med 2004;164:1237-41. PubMed
- Gorski JC, Huang S, Zaheer NA, et al. The effect of echinacea (Echinacea purpurea root) on cytochrome P450 activity in vivo.Clin Pharmacol Ther 2003;73 (Abstract PDII-A-8):P94. PubMed
- Lee AN, Werth VP. Activation of autoimmunity following use of immunostimulatory herbal supplements. Arch Dermatol 2004;140:723-7. PubMed
- Goel V, Lovlin R, Barton R, et al. Efficacy of a standardized echinacea preparation (Echinilin) for the treatment of the common cold: a randomized, double-blind, placebo-controlled trial. J Clin Pharm Ther 2004;29:75-83.
- Barrett B. Medicinal properties of Echinacea: a critical review. Phytomedicine 2003;10:66-86. PubMed
- Huntley AL, Thompson Coon J, Ernst E. The safety of herbal medicinal products derived from Echinacea species: a systematic review. Drug Saf 2005;28:387-400. PubMed
- Turner RB, Bauer R, Woelkart K, et al. An evaluation of Echinacea angustifolia in experimental rhinovirus infections. N Engl J Med 2005;353:341-8.
- Gurley BJ, Gardner SF, Hubbard MA, et al. In vivo assessment of botanical supplementation on human cytochrome P450 phenotypes: Citrus aurantium, Echinacea purpurea, milk thistle, and saw palmetto. Clin Pharmacol Ther 2004;76:428-40. .
- Perri D, Dugoua JJ, Mills E, Koren G. Safety and efficacy of echinacea (Echinacea augustafolia, e. purpurea and e. pallida) during pregnancy and lactation. Can J Clin Pharmacol 2006;13:e262-7.
- Kocaman O, Hulagu S, Senturk O. Echinacea-induced severe acute hepatitis with features of cholestatic autoimmune hepatitis. Eur J Intern Med 2008;19:148. PubMed
- Barrett B, Brown R, Rakel D. et al. Echinacea for treating the common cold: a randomized trial. Ann Intern Med 2010;153:769-77. PubMed
- Press Release: Echinacea herbal products should not be used in children under 12 years old. Medicines and Healthcare Products Regulatory Agency (UK). August 20, 2012. Available at: www.mhra.gov.uk/NewsCentre/Pressreleases/CON180627. (Accessed 21 October
- Barrett B, Brown R, Rakel D, Rabago D, et al. Placebo effects and the common cold: a randomized controlled trial. Ann.Fam.Med 2011;9:312-22. PubMed
- Haller J, Freund, TF, Pelczer, KG, et al. The anxiolytic potential and psychotropic side effects of an echinacea preparation in laboratory animals and healthy volunteers. Phytother.Res. 2013;27:54-61.
- Grbic J, Wexler I, Celenti R, et al. A phase II trial of a transmucosal herbal patch for the treatment of gingivitis. J Am Dent.Assoc. 2011;142:1168-75. PubMed
- Schapowal A, Berger D, Klein P, et al. Echinacea/sage or chlorhexidine/lidocaine for treating acute sore throats: a randomized double-blind trial. Eur.J Med Res 9-1-2009;14:406-12. PubMed
- Bossaer JB and Odle BL. Probable etoposide interaction with Echinacea. J.Diet.Suppl 2012;9:90-5.
- Abdul MI, Jiang X, Williams KM, et al. Pharmacokinetic and pharmacodynamic interactions of echinacea and policosanol with warfarin in healthy subjects. Br J Clin.Pharmacol. 2010;69:508-15. PubMed
- Kemp, D. E. and Franco, K. N. Possible leukopenia associated with long-term use of echinacea. J Am Board Fam.Pract. 2002;15(5):417-419.
- Liatsos, G., Elefsiniotis, I., Todorova, R., and Moulakakis, A. Severe thrombotic thrombocytopenic purpura (TTP) induced or exacerbated by the immunostimulatory herb Echinacea. Am J Hematol. 2006;81(3):224.
- Penzak, S. R., Robertson, S. M., Hunt, J. D., Chairez, C., Malati, C. Y., Alfaro, R. M., Stevenson, J. M., and Kovacs, J. A. Echinacea purpurea significantly induces cytochrome P450 3A activity but does not alter lopinavir-ritonavir exposure in healthy s
- Maskatia, Z. K. and Baker, K. Hypereosinophilia associated with echinacea use. South.Med J 2010;103(11):1173-1174. PubMed
- Parnham MJ. Benefit-risk assessment of the squeezed sap of the purple coneflower (Echinacea purpurea) for long-term oral immunostimulation. Phytomed 1996;3:95-102. PubMed
- Schroder-Aasen T, Molden G, Nilsen OG. In vitro inhibition of CYP3A4 by the multiherbal commercial product Sambucus Force and its main constituents Echinacea purpurea and Sambucus nigra. Phytother Res 2012;26(11):1606-13.
- Moltó J, Valle M, Miranda C, et al. Herb-drug interaction between Echinacea purpurea and darunavir-ritonavir in HIV-infected patients. Antimicrob Agents Chemother 2011;55(1):326-30.
- Goey AK, Meijerman I, Rosing H, et al. The effect of Echinacea purpurea on the pharmacokinetics of docetaxel. Br J Clin Pharmacol 2013;76(3):467-74.
- Moltó J, Valle M, Miranda C, et al. Herb-drug interaction between Echinacea purpurea and etravirine in HIV-infected patients. Antimicrob Agents Chemother 2012;56(10):5328-31. PubMed
- Lawrenson JA, Walls T, Day AS. Echinacea-induced acute liver failure in a child. J Paediatr Child Health 2014;50(10):841.
- Hansen TS, Nilsen OG. In vitro CYP3A4 metabolism: inhibition by Echinacea purpurea and choice of substrate for the evaluation of herbal inhibition. Basic Clin Pharmacol Toxicol 2008;103:445-9.
- Gabranis I, Koufakis T1, Papakrivos I, Batala S. Echinacea-associated acute cholestatic hepatitis. J Postgrad Med. 2015;61(3):211-2. PubMed
- Jalloh MA, Gregory PJ, Hein D, et al. Dietary supplement interactions with antiretrovirals: a systematic review. Int J STD AIDS. 2017 Jan;28(1):4-15. PubMed
- Karsch-Völk M, Barrett B, Kiefer D, Bauer R, Ardjomand-Woelkart K, Linde K. Echinacea for preventing and treating the common cold. Cochrane Database Syst Rev.2014;(2):CD000530. doi: 10.1002/14651858.CD000530.pub3. PubMed
- Hoban CL, Byard RW, Musgrave IF. Analysis of spontaneous adverse drug reactions to echinacea, valerian, black cohosh and ginkgo in Australia from 2000 to 2015. J Integr Med. 2019;17(5):338-343. PubMed
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