Interactions on record — worth a quick check against your medications. Based on 4 of 5 ingredients. Check your meds →
Dietary supplement

Mass Construction Ingredients & Drug Interactions

by Nutra Innovations

Mass Construction label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Mass Construction against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Mass Construction is a dietary supplement by Nutra Innovations with 5 active ingredients. Its ingredients are commonly taken for flavoring and culinary use, digestive complaints like bloating and indigestion, boosting absorption of other supplements.Based on those ingredients, 1,034 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bioperine, Longjack. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Mass Construction by Nutra Innovations

Ask about any prescription or over-the-counter medication and we check it for interactions with Mass Construction by Nutra Innovations — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Mass Construction by Nutra Innovations

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 20, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 5 of its 5 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Mass Construction contains five active ingredients. Bioperine is black pepper extract, included as a bioavailability enhancer to help your body absorb other compounds.

Longjack (Eurycoma longifolia) is an herbal extract traditionally used to support sexual function and athletic performance. Ajuga turkestanica extract, ecdysterone, and Fadogia agrestris round out the formula — each targeted at muscle-building and physical performance support.

The product also contains inactive ingredients (gelatin capsule, magnesium stearate, silicon dioxide, and FD&C Red #40) that serve as binders and colorants.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: increase lean muscle mass, improve recovery, increase strength.
  • We looked for evidence on: Athletic performance, Muscle strength, Muscle hypertrophy, Exercise recovery, Strength gains.
  • The closest evidence on file: Eurycoma Longifolia is rated "Possibly Ineffective" for Athletic performance (Natural Medicines).
  • Also on file: Black Pepper is rated "Insufficient Reliable Evidence To Rate" for Athletic performance.
  • Also on file: Eurycoma Longifolia is rated "Insufficient Reliable Evidence To Rate" for Muscle strength.

The evidence supporting these ingredients is limited. Longjack is rated possibly effective for sexual desire, but for athletic performance it's rated possibly ineffective — so don't expect a performance boost from that one.

Bioperine's uses (hay fever, asthma, athletic performance, headache, depression, and diarrhea) all carry insufficient evidence to rate. The same goes for Ajuga turkestanica (cough), Fadogia agrestris (athletic performance, erectile dysfunction, and malaria), and ecdysterone — we hold no effectiveness data for ecdysterone.

In short, this product is marketed for muscle building and performance, but solid evidence for those claims isn't established in our data.

The evidence, ingredient by ingredient Black Pepper Ajuga Nipponensis Fadogia Agrestis Eurycoma Longifolia

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Bioperine (black pepper) is generally well tolerated in food amounts and at single medicinal doses, though concentrated supplements warrant more caution. Common side effects are mild — burning aftertaste, dyspepsia (indigestion), reduced taste perception, and cough if inhaled.

Rare allergic reactions can occur in sensitive individuals. Ajuga turkestanica extract and Fadogia agrestris have significant safety gaps.

Ajuga has caused diarrhea, nausea, and vomiting in some people, and a case of acute kidney failure was reported in someone with liver cirrhosis who took a very large dose. Fadogia agrestris human safety data are lacking, but animal studies hint at possible toxicity to the testicles, liver, and kidneys.

Longjack is generally tolerated short-term in studies, though long-term safety and product quality are uncertain. Some research suggests it may raise testosterone, which carries risks of acne, insulin resistance, and liver toxicity if levels climb too high.

Side effects, ingredient by ingredient Black Pepper Ajuga Nipponensis Fadogia Agrestis Eurycoma Longifolia

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 4 matched ingredients can interact with medications — Black Pepper, Eurycoma Longifolia.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications; lithium.
  • For scale: 1,035 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before starting Mass Construction, double-check these medication types with your doctor or pharmacist. Most serious are blood pressure drugs like propranolol (Inderal), which Bioperine can raise to unsafe levels.

Also watch for antivirals (nevirapine), antibiotics (rifampin), seizure medications (phenytoin), immunosuppressants (cyclosporine), sedatives (pentobarbital), cholesterol drugs (atorvastatin), and heart/asthma medications (theophylline). Longjack may weaken propranolol further and theoretically increase levels of certain enzyme-processed drugs (CYP1A2, CYP2C19, and CYP2A6 substrates).

If you take testosterone, Longjack may push levels higher. No interactions are documented for the other ingredients we could check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

If you take propranolol, nevirapine, rifampin, phenytoin, cyclosporine, pentobarbital, atorvastatin, or theophylline, or if you're on any testosterone therapy, you should check with your doctor or pharmacist before starting this product because of documented interactions with Bioperine. The evidence for this product's effectiveness in muscle building is thin, and Ajuga and Fadogia have poorly understood safety profiles — talk it over with your healthcare provider before taking it, especially if you have liver or kidney disease.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 22, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Mass Construction, straight from the product label.

Brand Nutra Innovations
Net contents 120 Capsule(s)
Market status On market
Date entered into DSLD Jun 22, 2023
DSLD ID 287104
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Mass Construction by Nutra Innovations, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
IngredientAmount% DV
Bioperine10 mg--
Ajuga turkestanica extract1000 mg--
Ecdysterone300 mg--
Fadogia agrestris600 mg--
Longjack300 mg--

Other ingredients: Gelatin, Magnesium Stearate, Silicon Dioxide, FD&C Red #40

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Mass builder Mass Construction is a comprehensive formula designed to increase lean muscle mass, improve recovery and increase strength. Increase muscle mass Improve recovery Increase strength

Mass construction Lean mass builder

Manufactured in the USA for Nutra Innovations

General Statements

Did you love it? We hope you did & we'd love to hear your feedback. 1. Open your camera app & scan the QR code 2. Give us a follow & DM us what you think! Join the conversation Instagram Twitter Facebook @nutrainnovation www.nutrainnovations.com

Precautions

Warning: Keep out of reach of children. Not for use of persons under the age of 18.

Do not use if you are currently breast feeding, pregnant or plan to become pregnant. Consult your doctor prior to use if you have any medical conditions or if you are taking any other medications.

Discontinue use immediately if you experience rapid heartbeat, dizziness, vomiting or other similar symptoms.

Do not exceed recommended dosage. Do not take longer than 4 weeks without a 4 week off period.

Seals/Symbols

FDA Registered Facility Good Manufacturing Practice GMP Made in USA

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested use: Take (2) capsules twice daily with food. Do not exceed recommended dosage. Do not take longer than 4 weeks without a 4 week off period.

Brand IP Statement(s)

BioPerine is a trademark of Sabinsa Corp.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Mass Construction by Nutra Innovations label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Mass Construction label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Mass Construction by Nutra Innovations

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Bioperine

Interacts with
1,019 drugs
10 mg per serving Form: Black Pepper Fruit Extract

Black pepper is a common kitchen spice that is generally safe in the amounts used in food. Its extract, piperine, is mostly added to supplements to he...

Bioperine monograph & interactions

Ajuga turkestanica extract

No known
interactions
1000 mg per serving Form: Turkesterone

Ajuga nipponensis is a perennial plant from East Asia used in traditional medicine for cough and respiratory complaints. There is very little human re...

Ajuga turkestanica extract monograph & interactions

Ecdysterone

300 mg per serving Form: 20-hydroxyecdysone

Fadogia agrestris

No known
interactions
600 mg per serving

Fadogia agrestis is a West African shrub marketed as a testosterone booster, but human evidence is essentially nonexistent and what we know comes most...

Fadogia agrestris monograph & interactions

Longjack

Interacts with
248 drugs
300 mg per serving

Eurycoma longifolia (tongkat ali) is a Southeast Asian herb most popular for supporting testosterone, libido, and male fertility, with some small huma...

Longjack monograph & interactions

Other (inactive) ingredients: Gelatin, Magnesium Stearate, Silicon Dioxide, FD&C Red #40. These complete the product’s ingredient list but are not active constituents.

Interaction report

Mass Construction by Nutra Innovations Drug Interactions

Want to check YOUR meds against Mass Construction?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,034Drugs
976 Moderate 58 Minor

Ingredients driving the most interactions

Bioperine 1,019
Longjack 248

Individual Drug Interactions

The ingredients in Mass Construction interact with 1,034 drugs. Click any drug to see the details.

2 of the 5 ingredients in Mass Construction interact with drugs. Each result below shows which ingredient is responsible. Bioperine Longjack

Each ingredient & the kinds of drugs it affects

For each ingredient in Mass Construction with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Bioperine17 drug types · 1,019 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, black pepper might increase the risk of bleeding when taken with antiplatelet or anticoagulant drugs.
In vitro research shows that piperine, a constituent of black pepper, seems to inhibit platelet aggregation. This has not been reported in humans.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, black pepper might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal research shows that piperine, a constituent of black pepper, can reduce blood glucose levels. Monitor blood glucose levels closely. Dose adjustments might be necessary.

Likelihood Possible Evidence D
Atorvastatin (Lipitor)

Theoretically, black pepper might increase blood levels of atorvastatin.
Animal research shows that taking piperine, a constituent of black pepper, 35 mg/kg can increase the maximum serum concentration of atorvastatin three-fold. This has not been reported in humans.

Likelihood Possible Evidence D
Cyclosporine (Neoral, Sandimmune)

Theoretically, black pepper might increase the effects and side effects of cyclosporine.
In vitro research shows that piperine, a constituent of black pepper, increases the bioavailability of cyclosporine. This has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, black pepper might increase levels of drugs metabolized by CYP2D6.
In vitro research suggests that some constituents of black pepper inhibit CYP2D6. This has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, black pepper might increase levels of drugs metabolized by CYP3A4.
In vitro research and pharmacokinetic simulation data suggest that piperine, a constituent of black pepper, as well as the pepper fruit seem to inhibit CYP3A4. This has not been reported in humans.

Likelihood Possible Evidence D
Lithium

Theoretically, black pepper might increase blood levels of lithium due to its diuretic effects. The dose of lithium might need to be reduced.
Black pepper is thought to have diuretic properties.

Likelihood Probable Evidence D
Nevirapine (Viramune)

Black pepper might increase blood levels of nevirapine.
Clinical research shows that piperine, a constituent of black pepper, increases the plasma concentration of nevirapine. However, no adverse effects were observed in this study.

Likelihood Probable Evidence D
P-Glycoprotein Substrates

Theoretically, black pepper might increase levels of P-glycoprotein substrates.
In vitro research shows that piperine, a constituent of black pepper, seems to inhibit P-glycoprotein.

Likelihood Possible Evidence D
Pentobarbital (Nembutal)

Theoretically, black pepper might increase the sedative effects of pentobarbital.
Animal research shows that piperine, a constituent of black pepper, increases pentobarbital-induced sleeping time.

Likelihood Possible Evidence D
Phenytoin (Dilantin)

Black pepper might increase blood levels of phenytoin.
Clinical research shows that piperine, a constituent of black pepper, seems to increase absorption, slow elimination, and increase levels of phenytoin. Taking a single dose of black pepper 1 gram along with phenytoin seems to double the serum concentration of phenytoin. Consuming a soup with black pepper providing piperine 44 mg/200 mL of soup along with phenytoin also seems to increase phenytoin levels when compared with consuming the same soup without black pepper.

Likelihood Possible Evidence B
Propranolol (Inderal)

Black pepper might increase blood levels of propranolol.
Clinical research shows that piperine, a constituent of black pepper, seems to increase absorption and slow elimination of propranolol.

Likelihood Possible Evidence B
Rifampin (Rifadin)

Black pepper might increase blood levels of rifampin.
Clinical research shows that piperine, a constituent of black pepper, seems to increase absorption and serum levels of rifampin.

Likelihood Possible Evidence B
Theophylline

Black pepper might increase blood levels of theophylline.
Clinical research shows that piperine, a constituent of black pepper, seems to increase absorption and slow elimination of theophylline.

Likelihood Possible Evidence D
Amoxicillin (Amoxil, Trimox)

Theoretically, black pepper might increase the effects and side effects of amoxicillin.
Animal research shows that taking piperine, a constituent of black pepper, with amoxicillin increases plasma levels of amoxicillin. This has not been reported in humans.

Likelihood Possible Evidence D
Carbamazepine (Tegretol)

Theoretically, black pepper might increase blood levels of carbamazepine, potentially increasing the effects and side effects of carbamazepine.
One clinical study in patients taking carbamazepine 300 mg or 500 mg twice daily shows that taking a single 20 mg dose of purified piperine, a constituent of black pepper, increases carbamazepine levels. Piperine may increase carbamazepine absorption by increasing blood flow to the GI tract, increasing the surface area of the small intestine, or inhibiting cytochrome P450 3A4 (CYP3A4) in the gut wall. Absorption was significantly increased by 7-10 mcg/mL/hour. The time to eliminate carbamazepine was also increased by 4-8 hours. Although carbamazepine levels were increased, this did not appear to increase side effects. In vitro research also shows that piperine can increase carbamazepine levels by 11% in a time-dependent manner.

Likelihood Possible Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, black pepper might decrease levels and clinical effects of drugs metabolized by CYP1A2.
In vitro research suggests that black pepper induces CYP1A2. This has not been reported in humans.

Likelihood Possible Evidence D
Bioperine full monograph & interactions

Longjack5 drug types · 248 drugs

Propranolol (Inderal)

Eurycoma longifolia can reduce the levels and clinical effects of propranolol.
A small clinical study in healthy persons shows that taking a single dose of a water-based Eurycoma longifolia extract 200 mg, in combination with a single dose of propranolol 80 mg, reduces the propranolol area under the curve (AUC) by 29%, reduces the peak concentration by 42%, and increases time to peak concentration by 86% when compared with control. Since the elimination half-life of propranolol did not change, it seems that Eurycoma longifolia alters the kinetics of propranolol by decreasing its absorption in the gut, and not by altering its metabolism. It is not known if separating administration will prevent this interaction.

Likelihood Probable Evidence A
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, Eurycoma longifolia might increase levels CYP1A2 substrates.
In vitro research suggests that methanolic Eurycoma longifolia root extract weakly inhibits CYP1A2 enzymes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2A6 (Cyp2A6) Substrates

Theoretically, Eurycoma longifolia might increase levels of CYP2A6 substrates.
In vitro research suggests that methanolic Eurycoma longifolia root extract weakly inhibits CYP2A6 enzymes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, Eurycoma longifolia might increase levels of CYP2C19 substrates.
In vitro research suggests that methanolic Eurycoma longifolia root extract weakly inhibits CYP2C19 enzymes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Testosterone

Theoretically, Eurycoma longifolia may further increase levels of testosterone.
A clinical study in aging males with testosterone levels below 300 ng/dL shows that taking a specific water extract of Eurycoma longifolia roots (Physta; Biotropics Malaysia) 100-200 mg daily with breakfast for 12 weeks increases total testosterone levels by 8% to 11% when compared with placebo. It is unclear whether this increase would occur in individuals with normal testosterone levels.

Likelihood Possible Evidence D
Longjack full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Mass Construction, from the product label.

Nutra Innovations

See all Nutra Innovations products
Name
Nutra Innovations
Street Address
6290 McDonough Dr Suite E
City
Norcross
State
GA
ZipCode
30093
Web Address
www.NutraInnovations.com
Pharmacist Counseling Corner

Mass Construction by Nutra Innovations: Common Questions

Does Mass Construction by Nutra Innovations interact with any medications?
Yes. Based on its ingredients, Mass Construction has a known interaction with 1,034 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Mass Construction contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is Bioperine safe to take during pregnancy?
The safety data for Bioperine is mixed: it's rated likely safe in pregnancy, but also likely unsafe. Because of this contradiction in the data, you should not take this product during pregnancy without talking to your doctor first — they can weigh the specific risks and benefits for you.
Can I take this while breastfeeding?
Bioperine is rated likely safe during breastfeeding. However, Ajuga turkestanica extract and Fadogia agrestris have no safety data for breastfeeding and should be avoided. Because this product contains multiple ingredients with unknown or unfavorable breastfeeding safety profiles, talk with your doctor or pharmacist before using it.
What are the common side effects of this product?
The main reported side effect from Bioperine (black pepper) is a burning aftertaste, along with occasional indigestion or reduced taste perception. Ajuga turkestanica extract can cause diarrhea, nausea, and vomiting. Most people tolerate Longjack short-term, though long-term side effects aren't well studied.
Does this actually help with muscle building?
The ingredients are marketed for muscle and athletic performance, but the evidence isn't strong. Longjack is rated possibly ineffective for athletic performance, and the others lack solid evidence to support their use for muscle building. Talk to your trainer or doctor about whether this product fits your fitness goals.
Is it safe if I have liver or kidney disease?
No — Ajuga turkestanica extract has been reported to cause acute kidney failure, even at high doses, and Fadogia agrestris may be toxic to the kidneys and liver according to animal studies. If you have liver or kidney disease, do not take this product without explicit clearance from your doctor.
What's Bioperine for?
Bioperine is black pepper extract (piperine) added to help your body absorb the other ingredients more efficiently. It's not meant to work on its own but to boost how well the formula is taken up.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Mass Construction label
Go deeper

The Full Monographs Behind Mass Construction’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Black Pepper

Interacts with 1,019 drugs

Black pepper is a common kitchen spice that is generally safe in the amounts used in food. Its extract, piperine, is mostly added to supplements to help the body absorb other ingredients (li...

Read the full Black Pepper monograph → Herb & supplement monograph

Ajuga Nipponensis

Ajuga nipponensis is a perennial plant from East Asia used in traditional medicine for cough and respiratory complaints. There is very little human research to confirm any health benefits, s...

Read the full Ajuga Nipponensis monograph → Herb & supplement monograph

Fadogia Agrestis

Fadogia agrestis is a West African shrub marketed as a testosterone booster, but human evidence is essentially nonexistent and what we know comes mostly from a few small rat studies. Animal...

Read the full Fadogia Agrestis monograph → Herb & supplement monograph

Eurycoma Longifolia

Interacts with 248 drugs

Eurycoma longifolia (tongkat ali) is a Southeast Asian herb most popular for supporting testosterone, libido, and male fertility, with some small human studies suggesting possible benefits....

Read the full Eurycoma Longifolia monograph →
Sources

Sources & How We Checked

Mass Construction's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 36 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Black Pepper 29 references
  1. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  2. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  3. Bano G, Amla V, Raina RK, et al. The effect of piperine on pharmacokinetics of phenytoin in healthy volunteers. Planta Med 1987;53:568-9. PubMed
  4. Bano G, et al. Effect of piperine on bioavailability and pharmacokinetics of propranolol and theophylline in healthy volunteers. Eur J Clin Pharmacol 1991;41;615-7. PubMed
  5. Cohle SD, Trestrail JD III, Graham MA, et al. Fatal pepper aspiration. Am J Dis Child 1988;142:633-6. PubMed
  6. Bhardwaj RK, Glaeser H, Becquemont L, et al. Piperine, a major constituent of black pepper, inhibits human P-glycoprotein and CYP3A4. J Pharmacol Exp Ther 2002;302:645-50. PubMed
  7. Velpandian T, Jasuja R, Bhardwaj RK, et al. Piperine in food: interference in the pharmacokinetics of phenytoin. Eur J Drug Metab Pharmacokinet 2001;26:241-7. PubMed
  8. Pattanaik S, Hota D, Prabhakar S, et al. Pharmacokinetic interaction of a single dose of piperine with steady-state carbamazepine in epilepsy patients. Phytother Res 2009;23:1281-6.
  9. Munakata, M., Kobayashi, K., Niisato-Nezu, J., Tanaka, S., Kakisaka, Y., Ebihara, T., Ebihara, S., Haginoya, K., Tsuchiya, S., and Onuma, A. Olfactory stimulation using black pepper oil facilitates oral feeding in pediatric patients receiving long-term en
  10. Myers, B. M., Smith, J. L., and Graham, D. Y. Effect of red pepper and black pepper on the stomach. Am J Gastroenterol 1987;82(3):211-214.
  11. Raghavendra, R. H. and Naidu, K. A. Spice active principles as the inhibitors of human platelet aggregation and thromboxane biosynthesis. Prostaglandins Leukot.Essent.Fatty Acids 2009;81(1):73-78. PubMed
  12. Subehan, Usia, T., Kadota, S., and Tezuka, Y. Mechanism-based inhibition of human liver microsomal cytochrome P450 2D6 (CYP2D6) by alkamides of Piper nigrum. Planta Med 2006;72(6):527-532.
  13. Kasibhatta, R. and Naidu, M. U. Influence of piperine on the pharmacokinetics of nevirapine under fasting conditions: a randomised, crossover, placebo-controlled study. Drugs R.D. 2007;8(6):383-391. PubMed
  14. Usia, T., Iwata, H., Hiratsuka, A., Watabe, T., Kadota, S., and Tezuka, Y. CYP3A4 and CYP2D6 inhibitory activities of Indonesian medicinal plants. Phytomedicine. 2006;13(1-2):67-73. PubMed
  15. Mujumdar, A. M., Dhuley, J. N., Deshmukh, V. K., Raman, P. H., Thorat, S. L., and Naik, S. R. Effect of piperine on pentobarbitone induced hypnosis in rats. Indian J Exp.Biol. 1990;28(5):486-487.
  16. Panda, S. and Kar, A. Piperine lowers the serum concentrations of thyroid hormones, glucose and hepatic 5'D activity in adult male mice. Horm.Metab Res. 2003;35(9):523-526. PubMed
  17. Lawless, H. and Stevens, D. A. Effects of oral chemical irritation on taste. Physiol Behav. 1984;32(6):995-998. PubMed
  18. Hiwale, A. R., Dhuley, J. N., and Naik, S. R. Effect of co-administration of piperine on pharmacokinetics of beta-lactam antibiotics in rats. Indian J Exp.Biol. 2002;40(3):277-281.
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See these in context on the Black Pepper monograph →

Ajuga Nipponensis 1 reference
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See these in context on the Ajuga Nipponensis monograph →

Fadogia Agrestis 2 references
  1. Dietary Supplements: What You Need to Know — NIH Office of Dietary Supplements Source
  2. Using Dietary Supplements Wisely — NIH NCCIH Source

See these in context on the Fadogia Agrestis monograph →

Eurycoma Longifolia 4 references
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  2. Tambi MI, Imran MK, Henkel RR. Standardised water-soluble extract of Eurycoma longifolia, Tongkat ali, as testosterone booster for managing men with late-onset hypogonadism? Andrologia 2011 Jun 15. doi: 10.1111/j.1439-0272.2011.01168.x. [Epub ahead of pri PubMed
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See these in context on the Eurycoma Longifolia monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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