Major interaction on record — check this product against your medications before combining. Based on 4 of 5 ingredients. Check your meds →
Dietary supplement

Maximum Strength Cosamin ASU Ingredients & Drug Interactions

by Nutramax Laboratories Consumer Care

Maximum Strength Cosamin ASU label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Maximum Strength Cosamin ASU against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Maximum Strength Cosamin ASU is a dietary supplement by Nutramax Laboratories Consumer Care with 5 active ingredients. Its ingredients are commonly taken for replacing fluids and electrolytes, preventing dehydration during exercise or illness, treating low blood sodium (under medical care).Based on those ingredients, 1,395 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Sodium, Glucosamine HCl, Sodium Chondroitin Sulfate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Maximum Strength Cosamin ASU by Nutramax Laboratories Consumer Care

Ask about any prescription or over-the-counter medication and we check it for interactions with Maximum Strength Cosamin ASU by Nutramax Laboratories Consumer Care — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Maximum Strength Cosamin ASU by Nutramax Laboratories Consumer Care

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 20, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 3 of its 9 active ingredients.
  • “Avocado/Soybean Unsaponifiables (ASU) powder” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.
  • “Sodium Chondroitin Sulfate” is listed as a grouped ingredient — the label gives one combined amount (800 mg) without saying how much of each component you get.

Maximum Strength Cosamin ASU contains 9 ingredients, of which glucosamine HCl and several others are active. The product features glucosamine HCl for joint support, along with an ASU (avocado and soybean unsaponifiables) blend intended for cartilage health.

It also includes mixed tocopherols (vitamin E), green tea extract, soy protein isolate, and sodium for its formula, rounded out with silicon dioxide and other excipients such as gelatin and gum resin.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: Cartilage and joint structure support.
  • We looked for evidence on: Aromatase inhibitor-induced arthralgia, Back pain, Carpal tunnel syndrome, Joint health, Cartilage health, Joint stiffness.
  • The closest evidence on file: Glucosamine is rated "Insufficient Reliable Evidence To Rate" for Back pain (Natural Medicines).
  • Also on file: Vitamin E is rated "Insufficient Reliable Evidence To Rate" for Carpal tunnel syndrome.

Glucosamine HCl is Likely Effective for osteoarthritis. Green tea extract is Likely Effective for human papillomavirus (HPV) and Possibly Effective for ovarian cancer and high cholesterol levels.

Silicon dioxide (from the silica in this formulation) is Possibly Effective for osteoporosis. Avocado unsaponifiables in the ASU blend are Possibly Effective for high cholesterol and have Insufficient Reliable Evidence for metabolic syndrome, aging skin, or obesity.

For the other active ingredients or the product as a whole for joint or bone health beyond osteoarthritis, the evidence we hold does not establish effectiveness.

The evidence, ingredient by ingredient Sodium Glucosamine Chondroitin Sulfate Green Tea

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 6 of the 6 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 6 of 6.
  • General safety write-ups exist for 6 of 6.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Glucosamine HCl is generally well tolerated, though the most common side effects are bloating, constipation, cramps, diarrhea, heartburn, and nausea. A small number of people report allergic reactions ranging from mild rash to, rarely, severe reactions or asthma flare-ups.

Sodium in this product is well tolerated at normal dietary amounts, but excess intake is linked to high blood pressure and heart and kidney strain—long-term high sodium intake is associated with gastric cancer risk in population studies. Mixed tocopherols (vitamin E) are generally well tolerated at usual dietary levels, but high-dose long-term use carries a rare risk of bleeding and hemorrhagic stroke.

Green tea extract is generally well tolerated but poses a rare risk of liver injury at high doses, and it contains caffeine which passes into breast milk. Avocado is widely eaten and well tolerated as a food; concentrates and extracts are less studied.

Pregnancy data for glucosamine indicates it is best avoided, and silicon dioxide is best avoided in pregnancy; vitamin E from supplements is possibly safe but high doses should be avoided; green tea is possibly safe but caffeine should be limited; avocado as a supplement has insufficient data. For breastfeeding, silicon dioxide and glucosamine are best avoided, vitamin E and green tea require caution with high doses, and avocado safety is unknown.

Side effects, ingredient by ingredient Sodium Glucosamine Chondroitin Sulfate Green Tea

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 5 of the 6 matched ingredients can interact with medications — Glucosamine, Avocado, Vitamin E, Green Tea, Sodium.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; cancer treatments; diabetes medications; lithium.
  • For scale: 1,396 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you use warfarin or other blood thinners—glucosamine and avocado may increase bleeding risk, and vitamin E may also thin your blood further. If you take nadolol, atorvastatin, or ephedrine, green tea extract in this formula may reduce drug effectiveness or cause dangerous stimulant effects.

Blood pressure medications, corticosteroids, lithium, and seizure medications (felbamate, valproate, ethosuximide, phenytoin) also warrant review because of sodium and green tea interactions. Diabetes medications, acetaminophen, and dipyridamole have documented Minor to Moderate interactions as well.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Major medication interactions have been identified, and safety information is well characterized.

This product is geared toward people with osteoarthritis seeking joint support through glucosamine and ASU, along with antioxidant and heart-health compounds from green tea and vitamin E. If you take blood thinners (especially warfarin), heart medications, blood pressure drugs, seizure medicines, or diabetes treatments, you need to check with your doctor or pharmacist before adding this supplement—the interactions are real and sometimes serious.

If you're pregnant or breastfeeding, discuss this product with your doctor or pharmacist first, as several of its active ingredients are not well studied or are cautioned against in these periods.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 6 of 9 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 23, 2015.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Maximum Strength Cosamin ASU, straight from the product label.

Brand Nutramax Laboratories Consumer Care
Barcode (UPC) 755970824001
Net contents 180 Capsule(s)
Market status On market
Date entered into DSLD Dec 23, 2015
DSLD ID 54983
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Maximum Strength Cosamin ASU by Nutramax Laboratories Consumer Care, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
4 Capsule(s)
Maximum serving Sizes:
4 Capsule(s)
Servings per container
45
UPC/BARCODE
755970824001
IngredientAmount% DV
Calories15 {Calories}--
Total Carbohydrates1 Gram(s)1%
Sodium70 mg3%
Silicon Dioxide0 NP--
Protein1 Gram(s)--
Mixed Tocopherols0 NP--
Soy Protein isolate0 NP--
Glucosamine HCl1.5 Gram(s)--
Green Tea extract0 NP--
ASU Blend400 mg--
Avocado/Soybean Unsaponifiables (ASU) powder0 NP--
Sodium Chondroitin Sulfate800 mg--
Soy Unsaponifiables0 NP--
Avocado Unsaponifiables0 NP--

Other ingredients: Gelatin, Gum Resin, Contains <2% of:

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Containing a minimum of 300 mg of ASU powder standardized to contain a minimum of 30%

Glucosamine HCI Chondroitin Sulfate ASU

Contains: Soy, Glucosamine derived from crab and shrimp.

Brand IP Statement(s)

U.S. Patent Nos. 6,797,289 and 8,568,803.

2014 Nutramax Laboratories, Inc.

General Statements

Psalm 86:12

For more information visit CosaminASU.com or call Customer Service at 1-877-COSAMIN (1-877-267-2646).

Tested and Certified by NSF.

JOINT HEALTH SUPPLEMENT*

ADVANCED FORMULA

^Based on published studies in U.S. peer-reviewed journals, the Cosamin brand, which includes Cosamin DS and Cosamin ASU, is the most researched glucosamine/chondroitin brand.

General

10-1049-06

Seals/Symbols

NSF Contents Tested & Certified www.nsf.org

#1 RESEARCHED Glucosamine/Chondroitin Brand

FDA Statement of Identity

Dietary Supplement

Precautions

Contains: Soy, Glucosamine derived from crab and shrimp.

If you have any condition that requires medical attention, always consult your physician before taking any dietary supplement.

Important: Tamper evident seal under cap. Do not use if seal is broken or missing.

FDA Disclaimer Statement

*These statements have not been evaluated by the Food AND Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Suggested/Recommended/Usage/Directions

Directions for Use: Take 4 capsules daily until desired comfort level is reached. Then gradually reduce number of capsules taken daily to maintain comfort level. Capsules may be taken all at once or divided with meals throughout the day.*

Storage

Keep in a cool, dry place.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Maximum Strength Cosamin ASU by Nutramax Laboratories Consumer Care label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Maximum Strength Cosamin ASU label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Maximum Strength Cosamin ASU by Nutramax Laboratories Consumer Care

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size4 Capsule(s) Dosage formCapsule Servings per container45 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Sodium

Interacts with
205 drugs
70 mg per serving

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets g...

Sodium monograph & interactions

Protein

1 Gram(s) per serving

Glucosamine HCl

Interacts with
170 drugs
1.5 Gram(s) per serving

Glucosamine is a natural compound found in cartilage and joint fluid, and it is one of the most popular supplements for osteoarthritis, especially of...

Glucosamine HCl monograph & interactions

ASU Blend

400 mg per serving

Sodium Chondroitin Sulfate

Interacts with
2 drugs
800 mg per serving

Chondroitin sulfate is a naturally occurring building block of cartilage that is widely taken, often with glucosamine, for osteoarthritis joint pain....

Sodium Chondroitin Sulfate monograph & interactions

Other (inactive) ingredients: Gelatin, Gum Resin, Contains <2% of:. These complete the product’s ingredient list but are not active constituents.

Interaction report

Maximum Strength Cosamin ASU by Nutramax Laboratories Consumer Care Drug Interactions

Want to check YOUR meds against Maximum Strength Cosamin ASU?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,395Drugs
15 Major 1,296 Moderate 84 Minor

Ingredients driving the most interactions

Sodium 205
Glucosamine HCl 170
Sodium Chondroitin Sulfate 2

Individual Drug Interactions

The ingredients in Maximum Strength Cosamin ASU interact with 1,395 drugs. Click any drug to see the details.

3 of the 5 ingredients in Maximum Strength Cosamin ASU interact with drugs. Each result below shows which ingredient is responsible. Sodium Glucosamine HCl Sodium Chondroitin Sulfate

Each ingredient & the kinds of drugs it affects

For each ingredient in Maximum Strength Cosamin ASU with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Sodium7 drug types · 205 drugs

Antihypertensive Drugs

Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
High intake of dietary sodium can increase systolic and diastolic blood pressure. Also, high intake of sodium may necessitate increased use of antihypertensive medications to achieve blood pressure control in some patients, such as those with chronic kidney disease.

Likelihood Probable Evidence A
Corticosteroids

Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Mineralocorticoids and some glucocorticoids (corticosteroids) cause sodium retention. This effect is dose-related and depends on mineralocorticoid potency. It is most common with hydrocortisone, cortisone, and fludrocortisone, followed by prednisone and prednisolone.

Likelihood Possible Evidence D
Didanosine (Videx)

Concomitant use of didanosine with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia.
Didanosine formulations contain a significant amount of sodium.

Likelihood Probable Evidence C
Lithium

Altering dietary intake of sodium might alter the levels and clinical effects of lithium.
High sodium intake can reduce plasma concentrations of lithium by increasing lithium excretion. Reducing sodium intake can significantly increase plasma concentrations of lithium and cause lithium toxicity in patients being treated with lithium carbonate. Stabilizing sodium intake is shown to reduce the percentage of patients with lithium level fluctuations above 0.8 mEq/L. Patients taking lithium should avoid significant alterations in their dietary intake of sodium.

Likelihood Probable Evidence B
Sodium Phosphates

Theoretically, concomitant use of sodium phosphate with sodium supplements might increase the risk of hypernatremia.
Use of high doses (> 45 mL in 24 hours) of sodium phosphate, such as those used for bowel cleansing before surgery, can lead to serious electrolyte disturbances, including hypernatremia. The risk of hypernatremia is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Sodium-Containing Drugs

Concomitant use of sodium-containing drugs with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia and long-term sodium-related complications.
The Chronic Disease Risk Reduction (CDRR) intake level of 2.3 grams of sodium daily indicates the intake at which it is believed that chronic disease risk increases for the apparently healthy population. Some medications contain high quantities of sodium. When used in conjunction with sodium supplements or high-sodium diets, the CDRR may be exceeded. Additionally, concomitant use may increase the risk for hypernatremia; this risk is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Tolvaptan (Samsca)

Theoretically, concomitant use of tolvaptan with sodium might increase the risk of hypernatremia.
Tolvaptan is a vasopressin receptor 2 antagonist that is used to increase sodium levels in patients with hyponatremia. Patients taking tolvaptan should use caution with the use of sodium salts such as sodium chloride.

Likelihood Probable Evidence C
Sodium full monograph & interactions

Glucosamine HCl4 drug types · 170 drugs

Warfarin (Coumadin)

Glucosamine might increase the anticoagulant effects of warfarin and increase the risk of bruising and bleeding.
In two individual case reports, glucosamine/chondroitin combinations were associated with a significant increase in international normalized ratio (INR) in patients previously stabilized on warfarin. In one case, the increase in INR occurred only after tripling the dose of a glucosamine/chondroitin supplement from 500 mg/400 mg daily to 1500/1200 mg daily. Additionally, 20 voluntary case reports to the U.S. Food & Drug Administration (FDA) have linked glucosamine plus chondroitin with increased INR, bruising, and bleeding in patients who were also taking warfarin. There have also been 20 additional case reports to the World Health Organization (WHO) that link glucosamine alone to increased INR in patients taking warfarin. The mechanism of this interaction is unclear. Glucosamine is a small component of heparin, but is not thought to have anticoagulant activity; however, animal research suggests that it might have antiplatelet activity.

Likelihood Probable Evidence D
Topoisomerase Ii Inhibitors

Theoretically glucosamine may induce resistance to topoisomerase II inhibitors.
In vitro research suggests that glucosamine might induce resistance to etoposide (VP16, VePesid) and doxorubicin (Adriamycin) by reducing inhibition of topoisomerase II, an enzyme required for DNA replication in tumor cells. This effect has not been reported in humans.

Likelihood Possible Evidence D
Acetaminophen (Tylenol, Others)

Acetaminophen might interfere with the activity of glucosamine sulfate by interacting with the sulfate portion.
Anecdotal reports suggest that adding glucosamine to an acetaminophen regimen might decrease pain control in patients with osteoarthritis. Some research suggests that the sulfate portion of glucosamine sulfate might contribute to its effect in osteoarthritis. Since acetaminophen metabolism requires sulfur and reduces serum sulfate concentrations, acetaminophen could theoretically interfere with the action of glucosamine sulfate. Conversely, the administration of sulfate could theoretically decrease the effectiveness of acetaminophen in sulfate-deficient people by increasing its clearance.

Likelihood Possible Evidence B
Antidiabetes Drugs

Despite initial concerns, it is unlikely that glucosamine will interfere with the effects of antidiabetes drugs.
In vitro and animal research has suggested that glucosamine might increase insulin resistance or decrease insulin production. This has raised concerns that taking glucosamine might worsen diabetes and decrease the effectiveness of diabetes drugs. However, clinical research suggests that glucosamine does not have adverse effects on blood glucose or glycated hemoglobin (HbA1C) in healthy, obese, or type 2 diabetes patients.

Likelihood Unlikely Evidence B
Glucosamine HCl full monograph & interactions

Sodium Chondroitin Sulfate1 drug type · 2 drugs

Warfarin (Coumadin)

Taking chondroitin in combination with glucosamine might increase the anticoagulant effects of warfarin. However, the effect of chondroitin alone is unclear.
There have been multiple reports of increased international normalized ratio (INR) in patients taking warfarin with glucosamine, with or without chondroitin. The lack of reports with chondroitin alone seem to suggest that the interactions occurring in these reports may have been due to glucosamine. In two individual case reports, glucosamine/chondroitin combinations were associated with a significant increase in INR in patients previously stabilized on warfarin. Additionally, 20 voluntary case reports to the US Food & Drug Administration (FDA) have linked glucosamine plus chondroitin with increased INR, bruising, and bleeding in patients who were also taking warfarin. There have also been 20 additional case reports to the World Health Organization (WHO) that link glucosamine alone, without chondroitin, to increased INR in patients taking warfarin.

Likelihood Unlikely Evidence D
Sodium Chondroitin Sulfate full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Maximum Strength Cosamin ASU, from the product label.

Nutramax Laboratories Consumer Care

See all Nutramax Laboratories Consumer Care products
Name
Nutramax Laboratories Consumer Care, Inc.
City
Edgewood
State
MD
ZipCode
21040
Phone Number
1-800-925-5187
Web Address
NutramaxLabs.com
Pharmacist Counseling Corner

Maximum Strength Cosamin ASU by Nutramax Laboratories Consumer Care: Common Questions

Does Maximum Strength Cosamin ASU by Nutramax Laboratories Consumer Care interact with any medications?
Yes. Based on its ingredients, Maximum Strength Cosamin ASU has a known interaction with 1,395 medications, including 15 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Maximum Strength Cosamin ASU contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this product safe to take if I'm pregnant?
Data on this product in pregnancy is mixed. Glucosamine and silicon dioxide are best avoided during pregnancy. Vitamin E from supplements should be kept to lower doses if used at all. Green tea extract is possibly safe but caffeine intake should be limited. Talk with your doctor or pharmacist about whether this supplement is right for you during pregnancy—they know your full health picture.
Does this actually work for joint pain and osteoarthritis?
Glucosamine HCl, the main active ingredient here, is Likely Effective for osteoarthritis. The ASU blend (avocado and soybean unsaponifiables) may also help, though evidence is less established. Results vary person to person, and the product's quality and benefit can differ between brands.
What are the most common side effects?
From glucosamine, the most common side effects are bloating, constipation, cramps, diarrhea, heartburn, and nausea. Green tea extract may cause similar gastrointestinal upset, especially at higher doses. Most people tolerate the supplement well, but individual responses vary.
Can I take this with my blood pressure medication?
The sodium in this product may reduce how well your blood pressure medication works, and the vitamin E might have other effects. Don't start this supplement without checking with your doctor or pharmacist—they'll know your specific medications and can tell you whether it's safe to combine.
What's in this product besides glucosamine?
This product contains glucosamine HCl, an ASU blend (avocado and soybean unsaponifiables), mixed tocopherols (vitamin E), green tea extract, soy protein isolate, silicon dioxide, and sodium, plus inactive ingredients like gelatin and gum resin. The combination is designed for joint and cartilage support, with added antioxidant and heart-health ingredients.
Is the sodium amount in this product a concern?
Sodium is essential in small amounts, but excess intake over time is linked to high blood pressure and heart strain. If you have high blood pressure, heart disease, kidney problems, or take sodium-regulating medications, discuss this product's sodium content with your doctor or pharmacist before using it.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Maximum Strength Cosamin ASU label
Go deeper

The Full Monographs Behind Maximum Strength Cosamin ASU’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Sodium

Interacts with 205 drugs

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets get more than enough—often too much—from...

Read the full Sodium monograph → Herb & supplement monograph

Glucosamine

Interacts with 170 drugs

Glucosamine is a natural compound found in cartilage and joint fluid, and it is one of the most popular supplements for osteoarthritis, especially of the knee. The evidence is mixed, with so...

Read the full Glucosamine monograph → Herb & supplement monograph

Chondroitin Sulfate

Interacts with 2 drugs

Chondroitin sulfate is a naturally occurring building block of cartilage that is widely taken, often with glucosamine, for osteoarthritis joint pain. The evidence is mixed—some people report...

Read the full Chondroitin Sulfate monograph → Herb & supplement monograph

Green Tea

Interacts with 1,293 drugs

Green tea is a popular beverage rich in antioxidants called catechins, and drinking it in normal amounts is considered safe for most people. Concentrated green tea extracts are a different s...

Read the full Green Tea monograph →
Sources

Sources & How We Checked

Maximum Strength Cosamin ASU's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 430 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Sodium 38 references
  1. Garabedian-Ruffalo SM, Ruffalo RL. Drug and nutrient interactions. Am Fam Physician 1986;33:165-74.
  2. Food and Drug Administration Science Background: Safety of Sodium Phosphates Oral Solution. September 17, 2001. Available at: http://www.fda.gov/cder/drug/safety/sodiumphospate.htm
  3. Coton T, Mallaret C, Coilliot C, Carre D, Guisset M. Severe acute ulcerated gastritis induced by salt. Presse Med 2009;38(3):499-500. PubMed
  4. Frings-Meuthen P, Buehlmeier J, Baecker N, et al. High sodium chloride intake exacerbates immobilization-induced bone resorption and protein losses. J Appl Physiol 2011;111(2):537-542. PubMed
  5. Frings-Meuthen P, Baecker N, Heer M. Low-grade metabolic acidosis may be the cause of sodium chloride-induced exaggerated bone resorption. J Bone Miner Res 2008;23(4):517-524. PubMed
  6. Alam S, Johnson AG. A meta-analysis of randomised controlled trials (RCT) among healthy normotensive and essential hypertensive elderly patients to determine the effect of high salt (NaCl) diet of blood pressure. J Hum Hypertens 1999;13(6):367-74.
  7. Boudville N, Ward S, Benaroia M, House AA. Increased sodium intake correlates with greater use of antihypertensive agents by subjects with chronic kidney disease. Am J Hypertens 2005;18(10):1300-5. PubMed
  8. Bennett WM. Drug interactions and consequences of sodium restriction. Am J Clin Nutr 1997;65(2 Suppl):678S-681S. PubMed
  9. Okusa MD, Crystal LJ. Clinical manifestations and management of acute lithium intoxication. Am J Med 1994;97(4):383-9. PubMed
  10. Food and Nutrition Board, Institute of Medicine. Dietary reference intakes for water, potassium, sodium, chloride, and sulfate. Washington, DC: National Academy Press, 2005. Available at: http://www.nap.edu/openbook.php?record_id=10925. DOI
  11. D'Elia L, Rossi G, Ippolito R, Cappuccio FP, Strazzullo P. Habitual salt intake and risk of gastric cancer: a meta-analysis of prospective studies. Clin Nutr 2012;31(4):489-98. PubMed
  12. Goldsmith SR. Hyponatremia in heart failure: time for a trial. J Card Fail 2013;19(6):398-400. PubMed
  13. Willocks L, Brettle R, Keen J, Valentine C, Pinching AJ. Formulations of didanosine (ddI) and salt overload. Lancet 1992;339(8786):190.
  14. Chen L, Zhang Z, Chen W, Whelton PK, Appel LJ. Lower Sodium Intake and Risk of Headaches: Results From the Trial of Nonpharmacologic Interventions in the Elderly. Am J Public Health. 2016;106(7):1270-5. PubMed
  15. Cook NR, Appel LJ, Whelton PK. Lower levels of sodium intake and reduced cardiovascular risk. Circulation. 2014;129(9):981-9. PubMed
  16. Cook NR, Appel LJ, Whelton PK. Sodium Intake and All-Cause Mortality Over 20 Years in the Trials of Hypertension Prevention. J Am Coll Cardiol. 2016;68(15):1609-1617. PubMed
  17. Mente A, O'Donnell M, Rangarajan S, et al. Associations of urinary sodium excretion with cardiovascular events in individuals with and without hypertension: a pooled analysis of data from four studies. Lancet. 2016;388(10043):465-75. PubMed
  18. Moosavian SP, Haghighatdoost F, Surkan PJ, Azadbakht L. Salt and obesity: a systematic review and meta-analysis of observational studies. Int J Food Sci Nutr. 2017;68(3):265-277. PubMed
  19. O'Donnell M, Mente A, Rangarajan S, et al. Urinary sodium and potassium excretion, mortality, and cardiovascular events. N Engl J Med. 2014;371(7):612-23. DOI
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Silicon 19 references
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See these in context on the Glucosamine monograph →

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  19. Ossendza RA, Grandval P, Chinoune F, Rocher F, Chapel F, Bernardini D. [Acute cholestatic hepatitis due to glucosamine forte]. Gastroenterol Clin Biol. 2007 Apr;31(4):449-50.
  20. Greenlee H, Crew KD, Shao T, Kranwinkel G, Kalinsky K, Maurer M, Brafman L, Insel B, Tsai WY, Hershman DL. Phase II study of glucosamine with chondroitin on aromatase inhibitor-associated joint symptoms in women with breast cancer. Support Care Cancer 201 PubMed
  21. Chu EC, Huang KHK, Cheung G, Ng G, Lin A. Delayed Skin Allergy to Glucosamine Chondroitin Supplement. Cureus 2023;15(3):e36310. PubMed
  22. Lila AM, Alekseeva LI, Baranov AA, et al. Chondroitin sulfate and glucosamine combination in patients with knee and hip osteoarthritis: A long-term observational study in Russia. World J Orthop 2023;14(6):443-457. PubMed

See these in context on the Chondroitin Sulfate monograph →

Avocado 10 references
  1. Blickstein D, Shaklai M, Inbal A. Warfarin antagonism by avocado. Lancet 1991;337:914-5. PubMed
  2. Blanco C, Diaz-Perales A, Collada C, et al. Class I chitinases as potential panallergens involved in the latex-fruit syndrome. J Allergy Clin Immunol 1999;103(3 Pt 1):507-13. PubMed
  3. Diaz-Perales A, Collada C, Blanco C, et al. Cross-reactions in the latex-fruit syndrome: A relevant role of chitinases but not of complex asparagine-linked glycans. J Allergy Clin Immunol 1999;104:681-7. PubMed
  4. Stucker M, Memmel U, Hoffmann M, et al. Vitamin B(12) cream containing avocado oil in the therapy of plaque psoriasis. Dermatology 2001;203:141-7.
  5. Ahlroth, M., Alenius, H., Turjanmaa, K., Makinen-Kiljunen, S., Reunala, T., and Palosuo, T. Cross-reacting allergens in natural rubber latex and avocado. J.Allergy Clin.Immunol. 1995;96(2):167-173. PubMed
  6. de Groot, A. C., van der Meeren, H. L., and Weyland, J. W. Contact allergy to avocado oil in a sunscreen. Contact Dermatitis 1987;16(2):108-109. PubMed
  7. Blanco, C., Carrillo, T., Castillo, R., Quiralte, J., and Cuevas, M. Avocado hypersensitivity. Allergy 1994;49(6):454-459. PubMed
  8. Crisi, G. and Belsito, D. V. Contact urticaria from latex in a patient with immediate hypersensitivity to banana, avocado and peach. Contact Dermatitis 1993;28(4):247-248.
  9. Cherian S, Neupert K, Varshney P. Avocado as an emerging trigger for food protein-induced enterocolitis syndrome. Ann Allergy Asthma Immunol. 2018;121(3):369-71. PubMed
  10. Lichtenstein AH, Kris-Etherton PM, Petersen KS, et al. Effect of Incorporating 1 Avocado Per Day Versus Habitual Diet on Visceral Adiposity: A Randomized Trial. J Am Heart Assoc 2022;11(14):e025657.

See these in context on the Avocado monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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